SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pwe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_CCSB381_0
(ESTROGEN RECEPTOR)		 1pwe L-SERINE DEHYDRATASE
(Rattus
norvegicus) 		3 / 3 GLU A 107
ALA A 116
SER A  63
 None
 0.64A 1errB-1pweA:
0.0		 1errB-1pweA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1pwe L-SERINE DEHYDRATASE
(Rattus
norvegicus) 		5 / 12 GLY A  46
ALA A  76
GLY A  69
ALA A  83
ILE A  85
 None
 1.00A 1gtnL-1pweA:
undetectable
1gtnV-1pweA:
undetectable		 1gtnL-1pweA:
13.98
1gtnV-1pweA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 1pwe L-SERINE DEHYDRATASE
(Rattus
norvegicus) 		4 / 8 GLY A 168
GLY A 170
GLY A 171
LEU A 173
 None
 0.63A 1qzzA-1pweA:
2.9		 1qzzA-1pweA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 1pwe L-SERINE DEHYDRATASE
(Rattus
norvegicus) 		4 / 8 GLY A 175
GLY A 171
GLY A 170
LEU A 172
 None
 0.67A 1qzzA-1pweA:
2.9		 1qzzA-1pweA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 1pwe L-SERINE DEHYDRATASE
(Rattus
norvegicus) 		5 / 12 VAL A 176
ILE A 163
TRP A 185
LEU A  13
LEU A 156
 None
 1.16A 1s19A-1pweA:
undetectable		 1s19A-1pweA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 1pwe L-SERINE DEHYDRATASE
(Rattus
norvegicus) 		4 / 5 TYR A 278
LEU A  19
VAL A 300
VAL A 266
 None
 1.20A 1t88B-1pweA:
0.0		 1t88B-1pweA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_L_TRPL81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1pwe L-SERINE DEHYDRATASE
(Rattus
norvegicus) 		5 / 12 GLY A  69
ALA A  83
ILE A  85
GLY A  46
ALA A  76
 None
 0.98A 1utdL-1pweA:
undetectable
1utdM-1pweA:
undetectable		 1utdL-1pweA:
13.98
1utdM-1pweA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_O_TRPO81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1pwe L-SERINE DEHYDRATASE
(Rattus
norvegicus) 		5 / 12 GLY A  69
ALA A  83
ILE A  85
GLY A  46
ALA A  76
 None
 0.99A 1utdO-1pweA:
undetectable
1utdP-1pweA:
undetectable		 1utdO-1pweA:
13.98
1utdP-1pweA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_P_TRPP81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1pwe L-SERINE DEHYDRATASE
(Rattus
norvegicus) 		5 / 11 GLY A  69
ALA A  83
ILE A  85
GLY A  46
ALA A  76
 None
 1.00A 1utdP-1pweA:
undetectable
1utdQ-1pweA:
undetectable		 1utdP-1pweA:
13.98
1utdQ-1pweA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1pwe L-SERINE DEHYDRATASE
(Rattus
norvegicus) 		5 / 12 GLY A 168
GLY A  66
CYH A  62
ASN A  67
ALA A  68
 None
 1.01A 2bm9F-1pweA:
2.6		 2bm9F-1pweA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M56_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 1pwe L-SERINE DEHYDRATASE
(Rattus
norvegicus) 		4 / 5 TYR A 278
LEU A  19
VAL A 300
VAL A 266
 None
 1.22A 2m56A-1pweA:
0.0		 2m56A-1pweA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 1pwe L-SERINE DEHYDRATASE
(Rattus
norvegicus) 		5 / 12 ALA A 273
GLY A 271
ALA A 251
LEU A 165
LEU A 285
 None
 1.03A 2nyuA-1pweA:
2.1		 2nyuA-1pweA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 1pwe L-SERINE DEHYDRATASE
(Rattus
norvegicus) 		5 / 12 ALA A 273
GLY A 271
ALA A 251
LEU A 165
VAL A  27
 None
 0.97A 2nyuA-1pweA:
2.1		 2nyuA-1pweA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1353_1
(PROSTAGLANDIN
REDUCTASE 2)		 1pwe L-SERINE DEHYDRATASE
(Rattus
norvegicus) 		5 / 9 THR A  11
VAL A   9
GLY A  38
PHE A  40
ILE A  42
 None
 1.24A 2w98A-1pweA:
4.2		 2w98A-1pweA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLD_A_ASCA130_0
(CYTOCHROME C')		 1pwe L-SERINE DEHYDRATASE
(Rattus
norvegicus) 		4 / 5 ALA A  73
GLY A  46
CYH A  49
LYS A  50
 None
 1.08A 2yldA-1pweA:
undetectable		 2yldA-1pweA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLG_A_ASCA130_0
(CYTOCHROME C')		 1pwe L-SERINE DEHYDRATASE
(Rattus
norvegicus) 		4 / 5 ALA A  73
GLY A  46
CYH A  49
LYS A  50
 None
 1.08A 2ylgA-1pweA:
undetectable		 2ylgA-1pweA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 1pwe L-SERINE DEHYDRATASE
(Rattus
norvegicus) 		4 / 5 ILE A 133
SER A 134
PRO A 135
PHE A 136
 None
 1.12A 3bjwC-1pweA:
undetectable		 3bjwC-1pweA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB500_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1pwe L-SERINE DEHYDRATASE
(Rattus
norvegicus) 		4 / 7 THR A 105
GLU A 107
VAL A  86
VAL A  61
 None
 0.62A 3em0B-1pweA:
undetectable		 3em0B-1pweA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 1pwe L-SERINE DEHYDRATASE
(Rattus
norvegicus) 		6 / 12 GLY A  38
GLY A  69
GLY A  66
SER A 134
GLU A 102
ALA A  71
 None
 1.39A 3kkzB-1pweA:
2.5		 3kkzB-1pweA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 1pwe L-SERINE DEHYDRATASE
(Rattus
norvegicus) 		4 / 5 LEU A 298
ILE A 190
PRO A 189
PHE A 242
 None
 1.16A 3s3vA-1pweA:
2.6		 3s3vA-1pweA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1pwe L-SERINE DEHYDRATASE
(Rattus
norvegicus) 		4 / 8 LEU A 274
VAL A  27
VAL A 164
TYR A 278
 None
 0.78A 3v81C-1pweA:
undetectable		 3v81C-1pweA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZWI_A_ASCA156_0
(CYTOCHROME C')		 1pwe L-SERINE DEHYDRATASE
(Rattus
norvegicus) 		4 / 5 ALA A  73
GLY A  46
CYH A  49
LYS A  50
 None
 1.11A 3zwiA-1pweA:
undetectable		 3zwiA-1pweA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_A_ADNA401_1
(APH(2'')-ID)		 1pwe L-SERINE DEHYDRATASE
(Rattus
norvegicus) 		5 / 11 ALA A 315
PRO A 268
ILE A 255
LEU A 265
ILE A 308
 None
 1.05A 4dt8A-1pweA:
undetectable		 4dt8A-1pweA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)		 1pwe L-SERINE DEHYDRATASE
(Rattus
norvegicus) 		5 / 10 ALA A 315
PRO A 268
ILE A 255
LEU A 265
ILE A 308
 None
 1.04A 4dt8B-1pweA:
undetectable		 4dt8B-1pweA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 1pwe L-SERINE DEHYDRATASE
(Rattus
norvegicus) 		5 / 10 ALA A 315
PRO A 268
ILE A 255
LEU A 265
ILE A 308
 None
 1.08A 4dtaA-1pweA:
undetectable		 4dtaA-1pweA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L49_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 1pwe L-SERINE DEHYDRATASE
(Rattus
norvegicus) 		4 / 5 TYR A 278
LEU A  19
VAL A 300
VAL A 266
 None
 1.19A 4l49A-1pweA:
0.0		 4l49A-1pweA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 1pwe L-SERINE DEHYDRATASE
(Rattus
norvegicus) 		4 / 6 ILE A 301
ASP A  32
ARG A  43
GLY A 175
 None
 1.07A 4oltA-1pweA:
0.0		 4oltA-1pweA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 1pwe L-SERINE DEHYDRATASE
(Rattus
norvegicus) 		4 / 6 ILE A 301
ASP A  32
ARG A  43
GLY A 175
 None
 1.05A 4oltB-1pweA:
undetectable		 4oltB-1pweA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1pwe L-SERINE DEHYDRATASE
(Rattus
norvegicus) 		4 / 8 LEU A 274
VAL A  27
VAL A 164
TYR A 278
 None
 0.81A 4puoC-1pweA:
undetectable		 4puoC-1pweA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1pwe L-SERINE DEHYDRATASE
(Rattus
norvegicus) 		4 / 8 LEU A 274
VAL A  27
VAL A 164
TYR A 278
 None
 0.74A 4pwdC-1pweA:
undetectable		 4pwdC-1pweA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)		 1pwe L-SERINE DEHYDRATASE
(Rattus
norvegicus) 		4 / 7 LEU A  29
GLU A 262
SER A  16
VAL A  22
 None
 1.17A 4tvtA-1pweA:
0.0		 4tvtA-1pweA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1pwe L-SERINE DEHYDRATASE
(Rattus
norvegicus) 		3 / 3 VAL A 176
LEU A 180
VAL A 149
 None
 0.46A 4wq4A-1pweA:
undetectable		 4wq4A-1pweA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 1pwe L-SERINE DEHYDRATASE
(Rattus
norvegicus) 		5 / 10 ILE A 264
CYH A 270
GLY A 271
LEU A 274
ASP A 261
 None
 1.32A 5ajqB-1pweA:
undetectable		 5ajqB-1pweA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_C_IPHC101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 1pwe L-SERINE DEHYDRATASE
(Rattus
norvegicus) 		4 / 5 CYH A 270
ILE A 301
CYH A 303
LEU A 274
 None
 1.39A 5hrqC-1pweA:
undetectable
5hrqD-1pweA:
undetectable
5hrqL-1pweA:
undetectable		 5hrqC-1pweA:
4.29
5hrqD-1pweA:
6.92
5hrqL-1pweA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLI_A_ASCA202_0
(CYTOCHROME C')		 1pwe L-SERINE DEHYDRATASE
(Rattus
norvegicus) 		4 / 5 ALA A  73
GLY A  46
CYH A  49
LYS A  50
 None
 1.04A 5jliA-1pweA:
undetectable		 5jliA-1pweA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JT4_A_ASCA202_0
(CYTOCHROME C')		 1pwe L-SERINE DEHYDRATASE
(Rattus
norvegicus) 		4 / 5 ALA A  73
GLY A  46
CYH A  49
LYS A  50
 None
 1.09A 5jt4A-1pweA:
undetectable		 5jt4A-1pweA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1pwe L-SERINE DEHYDRATASE
(Rattus
norvegicus) 		3 / 3 GLY A  69
THR A 227
PRO A 135
 None
 0.62A 5v5zA-1pweA:
undetectable		 5v5zA-1pweA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 1pwe L-SERINE DEHYDRATASE
(Rattus
norvegicus) 		5 / 10 SER A 147
SER A  39
LYS A  30
ILE A  45
GLY A  46
 None
 0.91A 6dlzA-1pweA:
undetectable
6dlzD-1pweA:
2.9		 6dlzA-1pweA:
14.19
6dlzD-1pweA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 1pwe L-SERINE DEHYDRATASE
(Rattus
norvegicus) 		5 / 10 ILE A  45
GLY A  46
SER A 147
SER A  39
LYS A  30
 None
 0.91A 6dlzB-1pweA:
2.9
6dlzC-1pweA:
undetectable		 6dlzB-1pweA:
14.19
6dlzC-1pweA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 1pwe L-SERINE DEHYDRATASE
(Rattus
norvegicus) 		5 / 10 SER A 147
SER A  39
LYS A  30
ILE A  45
GLY A  46
 None
 0.90A 6dm1A-1pweA:
undetectable
6dm1D-1pweA:
undetectable		 6dm1A-1pweA:
14.19
6dm1D-1pweA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 1pwe L-SERINE DEHYDRATASE
(Rattus
norvegicus) 		5 / 10 ILE A  45
GLY A  46
SER A 147
SER A  39
LYS A  30
 None
 0.90A 6dm1B-1pweA:
undetectable
6dm1C-1pweA:
undetectable		 6dm1B-1pweA:
14.19
6dm1C-1pweA:
14.19