SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1px5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_A_CAMA502_0
(CYTOCHROME P450-CAM)		 1px5 2'-5'-OLIGOADENYLATE
SYNTHETASE 1
(Sus
scrofa) 		4 / 6 LEU A 197
VAL A 237
VAL A 308
ASP A 300
 None
 1.18A 1dz4A-1px5A:
undetectable		 1dz4A-1px5A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_B_CAMB502_0
(CYTOCHROME P450-CAM)		 1px5 2'-5'-OLIGOADENYLATE
SYNTHETASE 1
(Sus
scrofa) 		4 / 6 LEU A 197
VAL A 237
VAL A 308
ASP A 300
 None
 1.14A 1dz4B-1px5A:
undetectable		 1dz4B-1px5A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_A_CAMA503_0
(CYTOCHROME P450-CAM)		 1px5 2'-5'-OLIGOADENYLATE
SYNTHETASE 1
(Sus
scrofa) 		4 / 8 LEU A 197
VAL A 237
VAL A 308
ASP A 300
 None
 1.16A 1dz9A-1px5A:
undetectable		 1dz9A-1px5A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_B_CAMB1420_0
(CYTOCHROME P450-CAM)		 1px5 2'-5'-OLIGOADENYLATE
SYNTHETASE 1
(Sus
scrofa) 		4 / 8 LEU A 197
VAL A 237
VAL A 308
ASP A 300
 None
 1.06A 1o76B-1px5A:
undetectable		 1o76B-1px5A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_A_CAMA1416_0
(CYTOCHROME P450-CAM)		 1px5 2'-5'-OLIGOADENYLATE
SYNTHETASE 1
(Sus
scrofa) 		4 / 8 LEU A 197
VAL A 237
VAL A 308
ASP A 300
 None
 1.17A 1uyuA-1px5A:
0.0		 1uyuA-1px5A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_B_CAMB1416_0
(CYTOCHROME P450-CAM)		 1px5 2'-5'-OLIGOADENYLATE
SYNTHETASE 1
(Sus
scrofa) 		4 / 8 LEU A 197
VAL A 237
VAL A 308
ASP A 300
 None
 1.06A 1uyuB-1px5A:
0.0		 1uyuB-1px5A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 1px5 2'-5'-OLIGOADENYLATE
SYNTHETASE 1
(Sus
scrofa) 		4 / 8 ARG A 110
GLU A 111
PHE A  39
VAL A 120
 None
 1.02A 2fl5E-1px5A:
0.3
2fl5F-1px5A:
0.0		 2fl5E-1px5A:
19.49
2fl5F-1px5A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAW_A_CAMA422_0
(CYTOCHROME P450-CAM)		 1px5 2'-5'-OLIGOADENYLATE
SYNTHETASE 1
(Sus
scrofa) 		4 / 6 LEU A 197
VAL A 237
VAL A 308
ASP A 300
 None
 1.12A 2zawA-1px5A:
undetectable		 2zawA-1px5A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)		 1px5 2'-5'-OLIGOADENYLATE
SYNTHETASE 1
(Sus
scrofa) 		4 / 5 VAL A  78
VAL A  79
PHE A 185
ARG A 102
 None
 1.36A 3bjwB-1px5A:
0.0		 3bjwB-1px5A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 1px5 2'-5'-OLIGOADENYLATE
SYNTHETASE 1
(Sus
scrofa) 		4 / 6 LEU A 197
VAL A 237
VAL A 308
ASP A 300
 None
 1.13A 3fwgA-1px5A:
0.0		 3fwgA-1px5A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 1px5 2'-5'-OLIGOADENYLATE
SYNTHETASE 1
(Sus
scrofa) 		5 / 10 SER A 315
LEU A 235
ILE A 298
PRO A 296
GLY A 309
 None
 1.34A 3ik6B-1px5A:
undetectable
3ik6E-1px5A:
undetectable		 3ik6B-1px5A:
19.67
3ik6E-1px5A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)		 1px5 2'-5'-OLIGOADENYLATE
SYNTHETASE 1
(Sus
scrofa) 		5 / 11 VAL A 148
VAL A  36
ALA A 107
LEU A  77
LEU A 131
 None
YCM  A  37 ( 3.0A)
None
None
None
 0.98A 3sm2B-1px5A:
undetectable		 3sm2B-1px5A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1px5 2'-5'-OLIGOADENYLATE
SYNTHETASE 1
(Sus
scrofa) 		4 / 5 ARG A   9
VAL A 340
LEU A 339
SER A 338
 None
 0.93A 4e1gA-1px5A:
undetectable		 4e1gA-1px5A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		 1px5 2'-5'-OLIGOADENYLATE
SYNTHETASE 1
(Sus
scrofa) 		5 / 10 VAL A  57
LEU A  77
VAL A  79
LEU A 105
VAL A 148
 YCM  A  37 ( 4.3A)
None
None
None
None
 0.93A 4e3hA-1px5A:
undetectable		 4e3hA-1px5A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_D_NCTD501_1
(CYTOCHROME P450 2A13)		 1px5 2'-5'-OLIGOADENYLATE
SYNTHETASE 1
(Sus
scrofa) 		4 / 6 PHE A 118
PHE A 114
ALA A 107
LEU A  40
 None
None
None
YCM  A  37 ( 4.6A)
 0.98A 4ejgD-1px5A:
undetectable		 4ejgD-1px5A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 1px5 2'-5'-OLIGOADENYLATE
SYNTHETASE 1
(Sus
scrofa) 		3 / 3 ASP A  12
TRP A 326
SER A 250
 None
 0.84A 4lrhA-1px5A:
0.0		 4lrhA-1px5A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 1px5 2'-5'-OLIGOADENYLATE
SYNTHETASE 1
(Sus
scrofa) 		4 / 5 GLY A 254
ALA A 342
PHE A 255
GLU A 260
 None
 1.05A 4m93B-1px5A:
undetectable
4m93C-1px5A:
undetectable		 4m93B-1px5A:
20.12
4m93C-1px5A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 1px5 2'-5'-OLIGOADENYLATE
SYNTHETASE 1
(Sus
scrofa) 		3 / 3 GLU A 111
ARG A 110
GLN A  46
 None
 0.79A 4rtbA-1px5A:
undetectable		 4rtbA-1px5A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 1px5 2'-5'-OLIGOADENYLATE
SYNTHETASE 1
(Sus
scrofa) 		4 / 6 LEU A  81
LEU A  91
THR A 187
VAL A  78
 None
 1.11A 4udaA-1px5A:
undetectable		 4udaA-1px5A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1px5 2'-5'-OLIGOADENYLATE
SYNTHETASE 1
(Sus
scrofa) 		6 / 12 ILE A  15
VAL A 211
ALA A 323
VAL A 258
LEU A 327
GLY A 328
 None
 1.40A 5igtA-1px5A:
undetectable		 5igtA-1px5A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 1px5 2'-5'-OLIGOADENYLATE
SYNTHETASE 1
(Sus
scrofa) 		5 / 12 VAL A  78
ASP A  76
LEU A 172
ALA A 151
ARG A  94
 None
 0.96A 5nd2B-1px5A:
undetectable		 5nd2B-1px5A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 1px5 2'-5'-OLIGOADENYLATE
SYNTHETASE 1
(Sus
scrofa) 		5 / 12 VAL A  78
ASP A  76
LEU A 172
ALA A 151
ARG A  94
 None
 0.76A 5nd3B-1px5A:
undetectable		 5nd3B-1px5A:
22.71