SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pxt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_A_ESTA600_1
(ESTROGEN RECEPTOR)		 1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 129
ALA A 131
LEU A 121
MET A 402
ILE A 404
 None
 1.22A 1g50A-1pxtA:
undetectable		 1g50A-1pxtA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1502_0
(FERROCHELATASE)		 1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE
(Saccharomyces
cerevisiae) 		4 / 8 LEU A  67
PRO A 376
VAL A 152
GLY A 151
 None
 1.02A 1hrkA-1pxtA:
2.9		 1hrkA-1pxtA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2502_0
(FERROCHELATASE)		 1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE
(Saccharomyces
cerevisiae) 		4 / 8 LEU A  67
PRO A 376
VAL A 152
GLY A 151
 None
 1.03A 1hrkB-1pxtA:
2.9		 1hrkB-1pxtA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 405
GLY A 378
LEU A 377
SER A 127
 None
 0.75A 1jhvA-1pxtA:
undetectable		 1jhvA-1pxtA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_B_SAMB4001_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 128
GLY A 378
LEU A 150
VAL A 283
ILE A 135
 None
 0.95A 1zq9B-1pxtA:
undetectable		 1zq9B-1pxtA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_B_ADNB252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 405
THR A 380
ILE A 404
ASN A 343
 None
 0.97A 2a8tB-1pxtA:
undetectable		 2a8tB-1pxtA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 296
GLY A  72
ILE A  71
VAL A  39
 None
 0.65A 2aojB-1pxtA:
undetectable		 2aojB-1pxtA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE
(Saccharomyces
cerevisiae) 		5 / 11 GLY A 381
SER A 127
THR A 380
HIS A 375
PHE A 346
 None
 1.41A 2hmaA-1pxtA:
undetectable		 2hmaA-1pxtA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 285
ALA A 131
LEU A 150
ALA A 281
 None
 0.93A 2vcvB-1pxtA:
undetectable		 2vcvB-1pxtA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_D_ASDD1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 285
LEU A 148
ALA A 131
LEU A 150
ALA A 281
 None
 1.18A 2vcvD-1pxtA:
undetectable		 2vcvD-1pxtA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_E_ASDE1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 285
LEU A 148
ALA A 131
LEU A 150
ALA A 281
 None
 1.09A 2vcvE-1pxtA:
undetectable		 2vcvE-1pxtA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 285
ALA A 131
LEU A 150
ALA A 281
 None
 0.88A 2vcvF-1pxtA:
undetectable		 2vcvF-1pxtA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 285
ALA A 131
LEU A 150
ALA A 281
 None
 0.92A 2vcvG-1pxtA:
undetectable		 2vcvG-1pxtA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 285
LEU A 148
ALA A 131
LEU A 150
ALA A 281
 None
 1.15A 2vcvI-1pxtA:
undetectable		 2vcvI-1pxtA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 285
ALA A 131
LEU A 150
ALA A 281
 None
 0.93A 2vcvK-1pxtA:
undetectable		 2vcvK-1pxtA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  67
ILE A  85
ILE A  38
PHE A  70
VAL A 280
 None
 1.08A 2ygoA-1pxtA:
undetectable		 2ygoA-1pxtA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_D_SAMD603_0
(HYPOTHETICAL PROTEIN)		 1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE
(Saccharomyces
cerevisiae) 		5 / 12 THR A 130
GLY A 378
GLY A 128
ALA A 149
VAL A  93
 None
 1.18A 2yvlD-1pxtA:
undetectable		 2yvlD-1pxtA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)		 1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE
(Saccharomyces
cerevisiae) 		5 / 11 LEU A  62
GLY A 279
ILE A  46
LYS A  48
SER A 277
 None
 1.33A 3bjwH-1pxtA:
undetectable		 3bjwH-1pxtA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 157
ASN A  95
GLU A 153
 None
 0.68A 3kpdC-1pxtA:
0.0		 3kpdC-1pxtA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 157
ASN A  95
GLU A 153
 None
 0.87A 3kpdB-1pxtA:
0.0		 3kpdB-1pxtA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_C_VIBC223_1
(THIAMINE
PYROPHOSPHOKINASE)		 1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 203
LEU A 361
LEU A 351
ASN A 210
 None
 0.99A 3lm8A-1pxtA:
undetectable
3lm8C-1pxtA:
undetectable		 3lm8A-1pxtA:
20.81
3lm8C-1pxtA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 382
VAL A 385
LEU A 389
LEU A 284
 None
 0.69A 3roxA-1pxtA:
undetectable		 3roxA-1pxtA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE
(Saccharomyces
cerevisiae) 		3 / 3 GLY A  97
GLY A  99
THR A 101
 None
 0.43A 3si7B-1pxtA:
undetectable		 3si7B-1pxtA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EVY_B_TOYB201_1
(AMINOGLYCOSIDE
N(6')-ACETYLTRANSFER
ASE TYPE 1)		 1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE
(Saccharomyces
cerevisiae) 		5 / 10 ASN A 365
GLU A 344
ASP A 242
GLU A 227
GLY A 381
 None
 1.33A 4evyA-1pxtA:
undetectable
4evyB-1pxtA:
0.0		 4evyA-1pxtA:
17.44
4evyB-1pxtA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE
(Saccharomyces
cerevisiae) 		5 / 11 ILE A  85
LEU A  67
PHE A  74
TYR A  64
ALA A 109
 None
 1.19A 4fogD-1pxtA:
0.0		 4fogD-1pxtA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 415
PHE A 414
GLY A 300
ILE A 139
 None
 0.75A 4o8fB-1pxtA:
undetectable		 4o8fB-1pxtA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE
(Saccharomyces
cerevisiae) 		5 / 11 GLY A 374
LEU A 373
GLN A 275
ALA A 208
SER A 211
 None
 1.20A 4wnuA-1pxtA:
undetectable		 4wnuA-1pxtA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE
(Saccharomyces
cerevisiae) 		5 / 11 GLY A 374
LEU A 373
GLN A 275
ALA A 208
SER A 211
 None
 1.15A 4wnuC-1pxtA:
0.0		 4wnuC-1pxtA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 374
LEU A 373
GLN A 275
ALA A 208
SER A 211
 None
 1.01A 4wnwB-1pxtA:
0.0		 4wnwB-1pxtA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 128
GLY A 381
THR A 380
ILE A 404
PHE A 305
 None
 1.25A 4zvmA-1pxtA:
undetectable
4zvmB-1pxtA:
undetectable		 4zvmA-1pxtA:
18.97
4zvmB-1pxtA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 134
THR A 130
HIS A 375
LEU A 285
 None
 1.15A 5b1bA-1pxtA:
0.0
5b1bC-1pxtA:
undetectable
5b1bP-1pxtA:
undetectable		 5b1bA-1pxtA:
22.37
5b1bC-1pxtA:
18.53
5b1bP-1pxtA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 134
THR A 130
HIS A 375
LEU A 285
 None
 1.15A 5x19A-1pxtA:
0.0
5x19C-1pxtA:
undetectable
5x19P-1pxtA:
undetectable		 5x19A-1pxtA:
22.37
5x19C-1pxtA:
18.53
5x19P-1pxtA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE
(Saccharomyces
cerevisiae) 		4 / 7 ASP A 134
THR A 130
HIS A 375
LEU A 285
 None
 1.10A 5x1bA-1pxtA:
0.0
5x1bC-1pxtA:
undetectable
5x1bP-1pxtA:
undetectable		 5x1bA-1pxtA:
22.37
5x1bC-1pxtA:
18.53
5x1bP-1pxtA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA503_1
(CYTOCHROME P450 2C9)		 1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 112
LEU A 229
PRO A  77
LEU A  82
PHE A  74
 None
 1.12A 5xxiA-1pxtA:
undetectable		 5xxiA-1pxtA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE
(Saccharomyces
cerevisiae) 		5 / 12 VAL A  93
ILE A 228
LEU A 229
PHE A  66
ALA A 281
 None
 1.01A 6c2mA-1pxtA:
undetectable		 6c2mA-1pxtA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_2
(-)		 1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 148
GLY A  91
GLY A 151
GLY A 279
ASN A  68
 None
 1.13A 6ce2B-1pxtA:
undetectable		 6ce2B-1pxtA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 285
ASP A 134
THR A 130
HIS A 375
 None
 1.15A 6nknC-1pxtA:
undetectable
6nknN-1pxtA:
0.0
6nknP-1pxtA:
undetectable		 6nknC-1pxtA:
18.53
6nknN-1pxtA:
22.37
6nknP-1pxtA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE
(Saccharomyces
cerevisiae) 		4 / 7 ASP A 134
THR A 130
HIS A 375
LEU A 285
 None
 1.12A 6nmfA-1pxtA:
0.0
6nmfC-1pxtA:
undetectable
6nmfP-1pxtA:
undetectable		 6nmfA-1pxtA:
22.37
6nmfC-1pxtA:
18.53
6nmfP-1pxtA:
18.53