SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pxv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6F_C_010C6_0
(INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE)		 1pxv CYSTEINE PROTEASE
(Staphylococcus
aureus) 		3 / 3 ASN A 240
LEU A 279
HIS A 264
 None
 0.62A 2q6fB-1pxvA:
1.2		 2q6fB-1pxvA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB5_0
(FERROCHELATASE)		 1pxv CYSTEINE PROTEASE
(Staphylococcus
aureus) 		3 / 3 PRO A 336
LEU A 338
ARG A 382
 None
 0.78A 3aqiB-1pxvA:
undetectable		 3aqiB-1pxvA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1pxv CYSTEINE PROTEASE
(Staphylococcus
aureus) 		4 / 4 GLY A 392
GLY A 321
THR A 255
LEU A 252
 None
 0.84A 3si7C-1pxvA:
undetectable
3si7D-1pxvA:
undetectable		 3si7C-1pxvA:
20.14
3si7D-1pxvA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1pxv CYSTEINE PROTEASE
(Staphylococcus
aureus) 		4 / 5 TYR A 393
SER A 247
ALA A 244
THR A 284
 None
 1.23A 5n0wB-1pxvA:
2.1		 5n0wB-1pxvA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1pxv CYSTEINE PROTEASE
(Staphylococcus
aureus) 		4 / 5 TYR A 393
SER A 247
ALA A 244
THR A 284
 None
 1.26A 5n4iA-1pxvA:
undetectable		 5n4iA-1pxvA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9K_F_ACTF802_0
(UNCHARACTERIZED
PROTEIN)		 1pxv CYSTEINE PROTEASE
(Staphylococcus
aureus) 		3 / 3 TYR A 358
ALA A 326
LEU A 378
 None
 0.65A 6d9kF-1pxvA:
undetectable		 6d9kF-1pxvA:
12.72