SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pxy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA8_0
(GRAMICIDIN A)		 1pxy FIMBRIN-LIKE PROTEIN
(Arabidopsis
thaliana) 		3 / 3 VAL A 561
TRP A 555
TRP A 564
 None
 1.33A 1c4dA-1pxyA:
undetectable
1c4dB-1pxyA:
undetectable		 1c4dA-1pxyA:
3.28
1c4dB-1pxyA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_B_ESTB1600_1
(ESTROGEN RECEPTOR)		 1pxy FIMBRIN-LIKE PROTEIN
(Arabidopsis
thaliana) 		5 / 12 LEU A 612
LEU A 553
LEU A 554
GLY A 547
LEU A 544
 None
 0.96A 1g50B-1pxyA:
undetectable		 1g50B-1pxyA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_C_ESTC2600_1
(ESTROGEN RECEPTOR)		 1pxy FIMBRIN-LIKE PROTEIN
(Arabidopsis
thaliana) 		5 / 11 LEU A 612
LEU A 553
LEU A 554
GLY A 547
LEU A 544
 None
 0.96A 1g50C-1pxyA:
undetectable		 1g50C-1pxyA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 1pxy FIMBRIN-LIKE PROTEIN
(Arabidopsis
thaliana) 		5 / 11 ASN A 524
ILE A 536
LEU A 544
THR A 613
PHE A 550
 None
 1.40A 1tw4A-1pxyA:
undetectable		 1tw4A-1pxyA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 1pxy FIMBRIN-LIKE PROTEIN
(Arabidopsis
thaliana) 		3 / 3 LEU A 596
LEU A 400
MET A 494
 None
 0.74A 1ya3B-1pxyA:
0.0		 1ya3B-1pxyA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_A_STRA401_1
(MINERALOCORTICOID
RECEPTOR)		 1pxy FIMBRIN-LIKE PROTEIN
(Arabidopsis
thaliana) 		5 / 12 LEU A 308
ASN A 309
LEU A 311
ALA A 312
THR A 320
 None
 1.28A 2aa6A-1pxyA:
undetectable		 2aa6A-1pxyA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 1pxy FIMBRIN-LIKE PROTEIN
(Arabidopsis
thaliana) 		4 / 8 ARG A 419
LEU A 425
VAL A 459
VAL A 479
 None
 1.01A 2bdmA-1pxyA:
undetectable		 2bdmA-1pxyA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 1pxy FIMBRIN-LIKE PROTEIN
(Arabidopsis
thaliana) 		4 / 7 ARG A 588
THR A 581
ILE A 178
ASN A 171
 None
 1.25A 2jc9A-1pxyA:
undetectable		 2jc9A-1pxyA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 1pxy FIMBRIN-LIKE PROTEIN
(Arabidopsis
thaliana) 		4 / 7 ALA A 319
THR A 320
ALA A 323
ARG A 329
 None
 0.84A 2ql8A-1pxyA:
undetectable
2ql8B-1pxyA:
undetectable		 2ql8A-1pxyA:
15.32
2ql8B-1pxyA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1pxy FIMBRIN-LIKE PROTEIN
(Arabidopsis
thaliana) 		4 / 7 GLY A 406
VAL A 213
ILE A 402
VAL A 427
 None
 0.84A 3fi0E-1pxyA:
undetectable		 3fi0E-1pxyA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		 1pxy FIMBRIN-LIKE PROTEIN
(Arabidopsis
thaliana) 		5 / 12 LEU A 169
LEU A 166
ILE A 133
LEU A 147
ASP A 140
 None
 0.97A 3gwvA-1pxyA:
0.0		 3gwvA-1pxyA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I45_A_NIOA500_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN)		 1pxy FIMBRIN-LIKE PROTEIN
(Arabidopsis
thaliana) 		4 / 8 SER A 435
LEU A 428
PHE A 496
LEU A 493
 None
 0.74A 3i45A-1pxyA:
undetectable		 3i45A-1pxyA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 1pxy FIMBRIN-LIKE PROTEIN
(Arabidopsis
thaliana) 		5 / 12 GLU A 395
VAL A 427
ASP A 417
ILE A 423
GLU A 426
 None
 1.36A 3jayA-1pxyA:
0.1		 3jayA-1pxyA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 1pxy FIMBRIN-LIKE PROTEIN
(Arabidopsis
thaliana) 		5 / 12 ASN A 190
PRO A 191
GLY A 163
ILE A 183
GLU A 180
 None
 1.40A 3jb2A-1pxyA:
0.0		 3jb2A-1pxyA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 1pxy FIMBRIN-LIKE PROTEIN
(Arabidopsis
thaliana) 		5 / 12 GLU A 395
VAL A 427
ASP A 417
ILE A 423
GLU A 426
 None
 1.38A 3jb3A-1pxyA:
0.0		 3jb3A-1pxyA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1pxy FIMBRIN-LIKE PROTEIN
(Arabidopsis
thaliana) 		4 / 8 LEU A 149
GLN A 155
SER A 153
HIS A 152
 None
 1.09A 3kp2A-1pxyA:
undetectable
3kp2B-1pxyA:
undetectable		 3kp2A-1pxyA:
16.44
3kp2B-1pxyA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1pxy FIMBRIN-LIKE PROTEIN
(Arabidopsis
thaliana) 		5 / 8 LEU A 466
LEU A 493
ILE A 460
VAL A 459
LEU A 428
 None
 1.36A 3kp6A-1pxyA:
undetectable
3kp6B-1pxyA:
undetectable		 3kp6A-1pxyA:
16.44
3kp6B-1pxyA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEC_A_65BA561_0
(P66 REVERSE
TRANSCRIPTASE)		 1pxy FIMBRIN-LIKE PROTEIN
(Arabidopsis
thaliana) 		5 / 12 LEU A 307
GLY A 285
TRP A 277
LEU A 311
PRO A 313
 None
 1.11A 3mecA-1pxyA:
undetectable		 3mecA-1pxyA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 1pxy FIMBRIN-LIKE PROTEIN
(Arabidopsis
thaliana) 		5 / 12 LEU A 612
LEU A 553
LEU A 554
GLY A 547
LEU A 544
 None
 1.00A 3olsA-1pxyA:
0.0		 3olsA-1pxyA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_B_017B202_1
(PROTEASE)		 1pxy FIMBRIN-LIKE PROTEIN
(Arabidopsis
thaliana) 		4 / 7 PRO A 449
LYS A 447
ARG A 451
PRO A 445
 None
 1.16A 3ucbB-1pxyA:
undetectable		 3ucbB-1pxyA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1pxy FIMBRIN-LIKE PROTEIN
(Arabidopsis
thaliana) 		4 / 8 LEU A 424
VAL A 411
TYR A 398
LEU A 493
 None
 1.03A 3v81A-1pxyA:
2.4		 3v81A-1pxyA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_A_ADNA901_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 1pxy FIMBRIN-LIKE PROTEIN
(Arabidopsis
thaliana) 		5 / 9 ALA A 305
ASP A 300
LEU A 298
ASN A 359
ILE A 351
 None
 1.47A 3wdmA-1pxyA:
undetectable		 3wdmA-1pxyA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J5J_B_478B402_1
(PROTEASE)		 1pxy FIMBRIN-LIKE PROTEIN
(Arabidopsis
thaliana) 		4 / 5 PRO A 449
LYS A 447
ARG A 451
PRO A 445
 None
 1.20A 4j5jB-1pxyA:
undetectable		 4j5jB-1pxyA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 1pxy FIMBRIN-LIKE PROTEIN
(Arabidopsis
thaliana) 		3 / 3 LEU A 578
LEU A 554
ASN A 563
 None
 0.75A 4otwA-1pxyA:
undetectable		 4otwA-1pxyA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 1pxy FIMBRIN-LIKE PROTEIN
(Arabidopsis
thaliana) 		3 / 3 LEU A 612
LEU A 400
ASN A 203
 None
 0.76A 4otwA-1pxyA:
undetectable		 4otwA-1pxyA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1pxy FIMBRIN-LIKE PROTEIN
(Arabidopsis
thaliana) 		5 / 12 ALA A 587
LEU A 553
ILE A 609
LEU A 544
ILE A 601
 None
 1.10A 4pstA-1pxyA:
undetectable		 4pstA-1pxyA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 1pxy FIMBRIN-LIKE PROTEIN
(Arabidopsis
thaliana) 		4 / 5 ILE A 170
GLY A 163
ILE A 178
LEU A 166
 None
 0.85A 5dzki-1pxyA:
undetectable
5dzkj-1pxyA:
undetectable
5dzkx-1pxyA:
undetectable		 5dzki-1pxyA:
18.31
5dzkj-1pxyA:
18.31
5dzkx-1pxyA:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1pxy FIMBRIN-LIKE PROTEIN
(Arabidopsis
thaliana) 		4 / 5 ILE A 170
GLY A 163
ILE A 178
LEU A 166
 None
 0.93A 5dzkd-1pxyA:
undetectable
5dzkk-1pxyA:
undetectable
5dzky-1pxyA:
undetectable		 5dzkd-1pxyA:
16.63
5dzkk-1pxyA:
18.31
5dzky-1pxyA:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		 1pxy FIMBRIN-LIKE PROTEIN
(Arabidopsis
thaliana) 		4 / 5 LEU A 137
LEU A 156
LEU A 166
HIS A 132
 None
 0.98A 5gtrA-1pxyA:
undetectable		 5gtrA-1pxyA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 1pxy FIMBRIN-LIKE PROTEIN
(Arabidopsis
thaliana) 		4 / 7 ARG A 525
THR A 613
ILE A 616
LEU A 553
 None
 0.84A 5te8A-1pxyA:
undetectable		 5te8A-1pxyA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 1pxy FIMBRIN-LIKE PROTEIN
(Arabidopsis
thaliana) 		4 / 8 ARG A 525
THR A 613
ILE A 616
LEU A 553
 None
 0.74A 5te8B-1pxyA:
0.0		 5te8B-1pxyA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 1pxy FIMBRIN-LIKE PROTEIN
(Arabidopsis
thaliana) 		4 / 5 GLY A 138
ASP A 139
ARG A 135
GLN A 239
 None
 1.27A 5zrfB-1pxyA:
undetectable		 5zrfB-1pxyA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 1pxy FIMBRIN-LIKE PROTEIN
(Arabidopsis
thaliana) 		4 / 5 TYR A 345
GLN A 131
GLY A 230
ILE A 236
 None
 1.21A 6debB-1pxyA:
undetectable		 6debB-1pxyA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_2
(PROTEASE)		 1pxy FIMBRIN-LIKE PROTEIN
(Arabidopsis
thaliana) 		3 / 3 LEU A 590
ASP A 179
ILE A 183
 None
 0.63A 6dh0B-1pxyA:
undetectable		 6dh0B-1pxyA:
11.48