SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pyf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D0V_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1pyf IOLS PROTEIN
(Bacillus
subtilis) 		4 / 8 GLY A  19
GLY A  24
SER A  63
GLY A  37
 None
 0.72A 1d0vA-1pyfA:
undetectable		 1d0vA-1pyfA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1pyf IOLS PROTEIN
(Bacillus
subtilis) 		4 / 7 VAL A 171
LEU A 162
SER A 158
PHE A 157
 None
 0.67A 1j8uA-1pyfA:
undetectable		 1j8uA-1pyfA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1pyf IOLS PROTEIN
(Bacillus
subtilis) 		5 / 12 THR A  20
GLY A 153
THR A  83
ALA A  82
LEU A 121
 None
 1.11A 1jg4A-1pyfA:
undetectable		 1jg4A-1pyfA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHA_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1pyf IOLS PROTEIN
(Bacillus
subtilis) 		4 / 8 GLY A  19
GLY A  24
SER A  63
GLY A  37
 None
 0.72A 1jhaA-1pyfA:
undetectable		 1jhaA-1pyfA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1pyf IOLS PROTEIN
(Bacillus
subtilis) 		4 / 8 GLY A  19
GLY A  24
SER A  63
GLY A  37
 None
 0.69A 1jhqA-1pyfA:
undetectable		 1jhqA-1pyfA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1pyf IOLS PROTEIN
(Bacillus
subtilis) 		4 / 8 GLY A  19
GLY A  24
SER A  63
GLY A  37
 None
 0.65A 1jhvA-1pyfA:
undetectable		 1jhvA-1pyfA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHU_A_ESTA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 1pyf IOLS PROTEIN
(Bacillus
subtilis) 		5 / 12 SER A 199
LEU A 121
MET A  51
ILE A 275
LEU A   6
 EDO  A 313 ( 4.3A)
None
None
None
None
 1.12A 1lhuA-1pyfA:
0.0		 1lhuA-1pyfA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		 1pyf IOLS PROTEIN
(Bacillus
subtilis) 		3 / 3 LEU A  11
LEU A   6
SER A 199
 None
None
EDO  A 313 ( 4.3A)
 0.67A 1tlmA-1pyfA:
undetectable		 1tlmA-1pyfA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_1
(PHOSPHOLIPASE A2)		 1pyf IOLS PROTEIN
(Bacillus
subtilis) 		5 / 10 VAL A  70
GLU A  73
GLY A  68
THR A  54
ARG A  42
 None
 1.44A 3bjwD-1pyfA:
undetectable		 3bjwD-1pyfA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_0
(YAEB-LIKE PROTEIN
RPA0152)		 1pyf IOLS PROTEIN
(Bacillus
subtilis) 		3 / 3 LYS A 187
ARG A 270
LYS A 244
 None
 1.30A 3okxA-1pyfA:
undetectable		 3okxA-1pyfA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA214_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 1pyf IOLS PROTEIN
(Bacillus
subtilis) 		5 / 10 PHE A 233
TYR A 215
PHE A 238
GLY A 213
ASN A 246
 None
 1.47A 3r6wA-1pyfA:
0.7
3r6wB-1pyfA:
2.5		 3r6wA-1pyfA:
21.56
3r6wB-1pyfA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1pyf IOLS PROTEIN
(Bacillus
subtilis) 		4 / 6 THR A  54
GLY A  19
ILE A 277
LEU A  52
 None
 0.98A 4acbC-1pyfA:
3.0		 4acbC-1pyfA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 1pyf IOLS PROTEIN
(Bacillus
subtilis) 		5 / 10 THR A  20
GLY A  17
VAL A  79
ILE A  81
VAL A  80
 None
 1.19A 4jx1B-1pyfA:
undetectable		 4jx1B-1pyfA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1pyf IOLS PROTEIN
(Bacillus
subtilis) 		4 / 4 LEU A 180
TYR A 215
PRO A 260
ILE A 262
 None
 1.10A 5esgA-1pyfA:
0.0		 5esgA-1pyfA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1pyf IOLS PROTEIN
(Bacillus
subtilis) 		4 / 5 TYR A 267
LEU A 248
PRO A 260
LEU A 181
 None
 1.49A 5eshA-1pyfA:
undetectable		 5eshA-1pyfA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_2
(CDL2.2)		 1pyf IOLS PROTEIN
(Bacillus
subtilis) 		5 / 12 LEU A 180
LEU A 276
ILE A 262
ALA A 269
LEU A 297
 None
 1.22A 5ienB-1pyfA:
0.0		 5ienB-1pyfA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 1pyf IOLS PROTEIN
(Bacillus
subtilis) 		4 / 8 VAL A 173
MET A  51
ILE A 275
ASP A 274
 None
None
None
EDO  A 313 (-3.1A)
 0.76A 5y9mA-1pyfA:
undetectable		 5y9mA-1pyfA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 1pyf IOLS PROTEIN
(Bacillus
subtilis) 		4 / 7 VAL A 173
MET A  51
ILE A 275
ASP A 274
 None
None
None
EDO  A 313 (-3.1A)
 0.79A 5yf9B-1pyfA:
undetectable		 5yf9B-1pyfA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 1pyf IOLS PROTEIN
(Bacillus
subtilis) 		5 / 9 VAL A 173
GLY A   7
ILE A  16
LEU A 276
ASP A  53
 None
EDO  A 313 (-3.3A)
None
None
None
 1.44A 6c2mC-1pyfA:
undetectable		 6c2mC-1pyfA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1pyf IOLS PROTEIN
(Bacillus
subtilis) 		4 / 8 GLY A  37
LEU A  40
VAL A  70
LEU A  18
 None
 0.86A 6czmD-1pyfA:
undetectable
6czmF-1pyfA:
undetectable		 6czmD-1pyfA:
22.13
6czmF-1pyfA:
22.13