SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pyt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 1pyt CHYMOTRYPSINOGEN C
(Bos
taurus) 		4 / 8 HIS D 757
SER D 895
VAL D 913
GLY D 916
 None
 0.48A 1aq7A-1pytD:
30.5		 1aq7A-1pytD:
33.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1pyt CHYMOTRYPSINOGEN C
(Bos
taurus) 		4 / 6 TRP D 727
GLY D 719
GLY D 893
GLN D 860
 None
 1.04A 2qx6A-1pytD:
undetectable
2qx6B-1pytD:
undetectable		 2qx6A-1pytD:
21.38
2qx6B-1pytD:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 1pyt PROCARBOXYPEPTIDASE
A
(Bos
taurus) 		6 / 10 LEU A  61
ALA A  63
LEU A  29
LEU A  35
VAL A  56
ILE A  15
 None
 1.48A 2w9gA-1pytA:
undetectable		 2w9gA-1pytA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 1pyt PROCARBOXYPEPTIDASE
A
(Bos
taurus) 		4 / 7 PHE A  67
LEU A  29
LEU A  34
LEU A  32
 None
 0.76A 3bgdB-1pytA:
undetectable		 3bgdB-1pytA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 1pyt CHYMOTRYPSINOGEN C
(Bos
taurus) 		4 / 7 VAL D 790
ILE D 912
GLY D 911
ARG D 930
 None
 0.66A 3bjwB-1pytD:
undetectable		 3bjwB-1pytD:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 1pyt CHYMOTRYPSINOGEN C
(Bos
taurus) 		4 / 7 VAL D 790
ILE D 912
GLY D 911
ARG D 930
 None
 0.67A 3bjwH-1pytD:
undetectable		 3bjwH-1pytD:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 1pyt PROCARBOXYPEPTIDASE
A
(Bos
taurus) 		6 / 11 LEU A  61
ALA A  63
LEU A  29
LEU A  35
VAL A  56
ILE A  15
 None
 1.45A 3frbX-1pytA:
undetectable		 3frbX-1pytA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 1pyt PROCARBOXYPEPTIDASE
A
(Bos
taurus) 		5 / 9 ALA A  63
LEU A  29
LEU A  35
VAL A  56
ILE A  15
 None
 1.27A 3freX-1pytA:
undetectable		 3freX-1pytA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_D_URFD254_1
(URIDINE
PHOSPHORYLASE)		 1pyt CHYMOTRYPSINOGEN C
(Bos
taurus) 		4 / 6 GLY D 896
GLN D 730
ILE D 912
VAL D 913
 None
 1.14A 3kvvD-1pytD:
undetectable		 3kvvD-1pytD:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 1pyt PROCARBOXYPEPTIDASE
A
CHYMOTRYPSINOGEN C
(Bos
taurus;
Bos
taurus) 		4 / 8 GLU A  91
TYR D 735
LEU D 762
PHE A  94
 None
 1.14A 3rqwC-1pytA:
undetectable
3rqwD-1pytA:
undetectable		 3rqwC-1pytA:
16.72
3rqwD-1pytA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 1pyt PROCARBOXYPEPTIDASE
A
CHYMOTRYPSINOGEN C
(Bos
taurus;
Bos
taurus) 		4 / 8 GLU A  91
TYR D 735
LEU D 762
PHE A  94
 None
 1.14A 3rqwF-1pytA:
undetectable
3rqwJ-1pytA:
undetectable		 3rqwF-1pytA:
16.72
3rqwJ-1pytA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 1pyt CHYMOTRYPSINOGEN C
(Bos
taurus) 		5 / 12 GLN D 730
GLY D 842
GLY D 840
ASP D 894
ALA D 852
 None
 1.29A 3t7sB-1pytD:
undetectable		 3t7sB-1pytD:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)		 1pyt CHYMOTRYPSINOGEN C
(Bos
taurus) 		5 / 12 GLN D 730
GLY D 842
GLY D 840
ASP D 894
ALA D 852
 None
 1.28A 3t7sD-1pytD:
undetectable		 3t7sD-1pytD:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1pyt CHYMOTRYPSINOGEN C
(Bos
taurus) 		5 / 11 ILE D 938
ILE D 747
VAL D 820
LEU D 746
VAL D 812
 None
 1.04A 3w67A-1pytD:
undetectable		 3w67A-1pytD:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1pyt CHYMOTRYPSINOGEN C
(Bos
taurus) 		4 / 8 HIS D 791
THR D 879
TRP D 937
LEU D 829
 None
 1.17A 3wg7A-1pytD:
undetectable
3wg7C-1pytD:
undetectable
3wg7P-1pytD:
undetectable		 3wg7A-1pytD:
17.62
3wg7C-1pytD:
22.07
3wg7P-1pytD:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1pyt CHYMOTRYPSINOGEN C
(Bos
taurus) 		4 / 8 LEU D 829
HIS D 791
THR D 879
TRP D 937
 None
 1.19A 3wg7C-1pytD:
undetectable
3wg7N-1pytD:
undetectable
3wg7P-1pytD:
undetectable		 3wg7C-1pytD:
22.07
3wg7N-1pytD:
17.62
3wg7P-1pytD:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 1pyt CHYMOTRYPSINOGEN C
(Bos
taurus) 		4 / 8 ILE D 803
ASP D 802
ILE D 912
GLY D 744
 None
 0.84A 4ac9C-1pytD:
undetectable		 4ac9C-1pytD:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1pyt CHYMOTRYPSINOGEN C
(Bos
taurus) 		4 / 8 GLY D 779
GLY D 815
LEU D 814
VAL D 812
 None
 0.90A 4fgzA-1pytD:
undetectable		 4fgzA-1pytD:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1pyt CHYMOTRYPSINOGEN C
(Bos
taurus) 		4 / 8 GLY D 779
GLY D 815
LEU D 814
VAL D 812
 None
 0.89A 4fgzB-1pytD:
undetectable		 4fgzB-1pytD:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1pyt CHYMOTRYPSINOGEN C
(Bos
taurus) 		3 / 3 SER D 780
ALA D 767
VAL D 766
 None
 0.59A 4x20C-1pytD:
undetectable		 4x20C-1pytD:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)		 1pyt PROCARBOXYPEPTIDASE
A
(Bos
taurus) 		3 / 3 ARG A  55
ASP A  36
TRP A  38
 None
 0.90A 4xdqA-1pytA:
undetectable		 4xdqA-1pytA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1pyt CHYMOTRYPSINOGEN C
(Bos
taurus) 		4 / 8 HIS D 791
THR D 879
TRP D 937
LEU D 829
 None
 1.20A 5b1aA-1pytD:
undetectable
5b1aC-1pytD:
undetectable
5b1aP-1pytD:
undetectable		 5b1aA-1pytD:
17.62
5b1aC-1pytD:
22.07
5b1aP-1pytD:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1pyt CHYMOTRYPSINOGEN C
(Bos
taurus) 		4 / 8 HIS D 791
THR D 879
TRP D 937
LEU D 829
 None
 1.21A 5b3sA-1pytD:
undetectable
5b3sC-1pytD:
undetectable
5b3sP-1pytD:
undetectable		 5b3sA-1pytD:
17.62
5b3sC-1pytD:
22.07
5b3sP-1pytD:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1pyt CHYMOTRYPSINOGEN C
(Bos
taurus) 		4 / 7 SER D 711
ASP D 886
GLY D 884
THR D 867
 None
 1.01A 5btfA-1pytD:
0.0
5btfC-1pytD:
0.0
5btfD-1pytD:
undetectable		 5btfA-1pytD:
18.58
5btfC-1pytD:
18.58
5btfD-1pytD:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 1pyt CHYMOTRYPSINOGEN C
(Bos
taurus) 		5 / 8 VAL D 812
ILE D 818
VAL D 766
HIS D 751
VAL D 783
 None
 1.32A 5l94A-1pytD:
undetectable		 5l94A-1pytD:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA CHAIN)		 1pyt CHYMOTRYPSINOGEN C
(Bos
taurus) 		3 / 3 SER D 780
ALA D 767
VAL D 766
 None
 0.43A 5xiwC-1pytD:
undetectable		 5xiwC-1pytD:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1pyt CHYMOTRYPSINOGEN C
(Bos
taurus) 		4 / 8 HIS D 791
THR D 879
TRP D 937
LEU D 829
 None
 1.22A 5z85A-1pytD:
undetectable
5z85C-1pytD:
undetectable
5z85P-1pytD:
undetectable		 5z85A-1pytD:
17.62
5z85C-1pytD:
22.07
5z85P-1pytD:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1pyt CHYMOTRYPSINOGEN C
(Bos
taurus) 		4 / 8 HIS D 791
THR D 879
TRP D 937
LEU D 829
 None
 1.19A 5zcoA-1pytD:
undetectable
5zcoC-1pytD:
undetectable
5zcoP-1pytD:
undetectable		 5zcoA-1pytD:
17.62
5zcoC-1pytD:
22.07
5zcoP-1pytD:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1pyt CHYMOTRYPSINOGEN C
(Bos
taurus) 		4 / 8 HIS D 791
THR D 879
TRP D 937
LEU D 829
 None
 1.22A 5zcqA-1pytD:
undetectable
5zcqC-1pytD:
undetectable
5zcqP-1pytD:
undetectable		 5zcqA-1pytD:
17.62
5zcqC-1pytD:
22.07
5zcqP-1pytD:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA606_0
(ALPHA-AMYLASE)		 1pyt CHYMOTRYPSINOGEN C
(Bos
taurus) 		6 / 7 GLY D 842
GLY D 893
GLY D 897
PRO D 898
GLY D 744
GLY D 743
 None
 1.09A 6ag0A-1pytD:
undetectable		 6ag0A-1pytD:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA810_0
(GEPHYRIN)		 1pyt CHYMOTRYPSINOGEN C
(Bos
taurus) 		3 / 3 LEU D 798
SER D 796
PHE D 797
 None
 0.53A 6fgcA-1pytD:
undetectable		 6fgcA-1pytD:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 1pyt CHYMOTRYPSINOGEN C
(Bos
taurus) 		3 / 3 TRP D 794
ILE D 803
ASP D 802
 None
 0.90A 6i0y7-1pytD:
undetectable		 6i0y7-1pytD:
6.90