SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pz1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1pz1 GENERAL STRESS
PROTEIN 69
(Bacillus
subtilis) 		5 / 12 THR A  20
GLY A 153
THR A  83
ALA A  82
LEU A 121
 None
 1.07A 1jg4A-1pz1A:
undetectable		 1jg4A-1pz1A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1pz1 GENERAL STRESS
PROTEIN 69
(Bacillus
subtilis) 		4 / 6 HIS A 125
ALA A  56
GLY A  58
TYR A  57
 NAP  A 500 ( 4.8A)
None
None
None
 1.15A 1l5qA-1pz1A:
undetectable		 1l5qA-1pz1A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1pz1 GENERAL STRESS
PROTEIN 69
(Bacillus
subtilis) 		4 / 6 HIS A 125
ALA A  56
GLY A  58
TYR A  57
 NAP  A 500 ( 4.8A)
None
None
None
 1.14A 1l5qB-1pz1A:
undetectable		 1l5qB-1pz1A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1pz1 GENERAL STRESS
PROTEIN 69
(Bacillus
subtilis) 		4 / 6 HIS A 125
ALA A  56
GLY A  58
TYR A  57
 NAP  A 500 ( 4.8A)
None
None
None
 1.11A 1l7xA-1pz1A:
undetectable		 1l7xA-1pz1A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1pz1 GENERAL STRESS
PROTEIN 69
(Bacillus
subtilis) 		4 / 6 HIS A 125
ALA A  56
GLY A  58
TYR A  57
 NAP  A 500 ( 4.8A)
None
None
None
 1.13A 1l7xB-1pz1A:
1.1		 1l7xB-1pz1A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)		 1pz1 GENERAL STRESS
PROTEIN 69
(Bacillus
subtilis) 		4 / 7 SER A  36
ILE A  70
ILE A  40
THR A  20
 None
 0.99A 1sbrB-1pz1A:
undetectable		 1sbrB-1pz1A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2INE_A_PACA317_0
(ALDOSE REDUCTASE)		 1pz1 GENERAL STRESS
PROTEIN 69
(Bacillus
subtilis) 		4 / 5 TRP A  21
TYR A  57
HIS A 125
TRP A 126
 None
None
NAP  A 500 ( 4.8A)
None
 0.64A 2ineA-1pz1A:
25.7		 2ineA-1pz1A:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ISF_A_PACA317_0
(ALDOSE REDUCTASE)		 1pz1 GENERAL STRESS
PROTEIN 69
(Bacillus
subtilis) 		4 / 5 TRP A  21
TYR A  57
HIS A 125
TRP A 126
 None
None
NAP  A 500 ( 4.8A)
None
 0.55A 2isfA-1pz1A:
25.8		 2isfA-1pz1A:
26.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 1pz1 GENERAL STRESS
PROTEIN 69
(Bacillus
subtilis) 		3 / 3 ARG A  76
ASN A 109
THR A  83
 None
 0.68A 2q63A-1pz1A:
undetectable		 2q63A-1pz1A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1pz1 GENERAL STRESS
PROTEIN 69
(Bacillus
subtilis) 		3 / 3 GLY A 280
GLY A  17
GLY A  19
 NAP  A 500 (-3.8A)
None
NAP  A 500 (-3.1A)
 0.40A 3bogC-1pz1A:
undetectable		 3bogC-1pz1A:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 1pz1 GENERAL STRESS
PROTEIN 69
(Bacillus
subtilis) 		5 / 12 ILE A  16
ASP A 270
ILE A 276
ASP A 275
GLY A  17
 None
 0.94A 3bwcB-1pz1A:
undetectable		 3bwcB-1pz1A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1pz1 GENERAL STRESS
PROTEIN 69
(Bacillus
subtilis) 		4 / 6 HIS A 125
ALA A  56
GLY A  58
TYR A  57
 NAP  A 500 ( 4.8A)
None
None
None
 1.15A 3dd1A-1pz1A:
2.0		 3dd1A-1pz1A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1pz1 GENERAL STRESS
PROTEIN 69
(Bacillus
subtilis) 		4 / 6 HIS A 125
ALA A  56
GLY A  58
TYR A  57
 NAP  A 500 ( 4.8A)
None
None
None
 1.13A 3dd1B-1pz1A:
undetectable		 3dd1B-1pz1A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1pz1 GENERAL STRESS
PROTEIN 69
(Bacillus
subtilis) 		4 / 6 HIS A 125
ALA A  56
GLY A  58
TYR A  57
 NAP  A 500 ( 4.8A)
None
None
None
 1.14A 3ddsB-1pz1A:
undetectable		 3ddsB-1pz1A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1pz1 GENERAL STRESS
PROTEIN 69
(Bacillus
subtilis) 		4 / 6 HIS A 125
ALA A  56
GLY A  58
TYR A  57
 NAP  A 500 ( 4.8A)
None
None
None
 1.13A 3ddwB-1pz1A:
0.6		 3ddwB-1pz1A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1pz1 GENERAL STRESS
PROTEIN 69
(Bacillus
subtilis) 		5 / 12 HIS A 125
LEU A 278
ALA A  56
ALA A  82
LEU A  50
 NAP  A 500 ( 4.8A)
NAP  A 500 (-4.0A)
None
None
None
 1.07A 3ln1A-1pz1A:
undetectable		 3ln1A-1pz1A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1pz1 GENERAL STRESS
PROTEIN 69
(Bacillus
subtilis) 		5 / 12 HIS A 125
LEU A 278
ALA A  56
ALA A  82
LEU A  50
 NAP  A 500 ( 4.8A)
NAP  A 500 (-4.0A)
None
None
None
 1.07A 3ln1B-1pz1A:
undetectable		 3ln1B-1pz1A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1pz1 GENERAL STRESS
PROTEIN 69
(Bacillus
subtilis) 		5 / 12 HIS A 125
LEU A 278
ALA A  56
ALA A  82
LEU A  50
 NAP  A 500 ( 4.8A)
NAP  A 500 (-4.0A)
None
None
None
 1.07A 3ln1C-1pz1A:
undetectable		 3ln1C-1pz1A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1pz1 GENERAL STRESS
PROTEIN 69
(Bacillus
subtilis) 		5 / 12 HIS A 125
LEU A 278
ALA A  56
ALA A  82
LEU A  50
 NAP  A 500 ( 4.8A)
NAP  A 500 (-4.0A)
None
None
None
 1.06A 3ln1D-1pz1A:
undetectable		 3ln1D-1pz1A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R4X_A_PZAA598_0
(LACTOPEROXIDASE)		 1pz1 GENERAL STRESS
PROTEIN 69
(Bacillus
subtilis) 		4 / 5 PHE A  95
ARG A 328
GLU A 329
PRO A 332
 None
 1.38A 3r4xA-1pz1A:
0.0		 3r4xA-1pz1A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROZ_A_NCAA266_0
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 1pz1 GENERAL STRESS
PROTEIN 69
(Bacillus
subtilis) 		4 / 6 LEU A 121
ALA A   7
ASP A   8
THR A 173
 None
 1.09A 3rozA-1pz1A:
2.0		 3rozA-1pz1A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3G_A_TLTA317_1
(ALDOSE REDUCTASE)		 1pz1 GENERAL STRESS
PROTEIN 69
(Bacillus
subtilis) 		4 / 7 TRP A  21
TYR A  57
HIS A 125
TRP A 126
 None
None
NAP  A 500 ( 4.8A)
None
 0.69A 3s3gA-1pz1A:
25.0		 3s3gA-1pz1A:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_1
(PROTEASE)		 1pz1 GENERAL STRESS
PROTEIN 69
(Bacillus
subtilis) 		5 / 9 ALA A  82
ASP A  52
GLY A 153
ILE A 152
ILE A  11
 None
NAP  A 500 (-4.0A)
None
None
None
 0.85A 3s45A-1pz1A:
undetectable		 3s45A-1pz1A:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_1
(PROTEASE)		 1pz1 GENERAL STRESS
PROTEIN 69
(Bacillus
subtilis) 		5 / 12 ALA A  82
ASP A  52
GLY A 153
ILE A 152
ILE A  11
 None
NAP  A 500 (-4.0A)
None
None
None
 0.89A 3s54A-1pz1A:
undetectable		 3s54A-1pz1A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		 1pz1 GENERAL STRESS
PROTEIN 69
(Bacillus
subtilis) 		5 / 12 MET A 140
LEU A 143
GLY A 147
LEU A 111
ILE A 152
 None
 1.41A 4p6xA-1pz1A:
undetectable		 4p6xA-1pz1A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1pz1 GENERAL STRESS
PROTEIN 69
(Bacillus
subtilis) 		4 / 5 THR A  53
ALA A  54
THR A  83
TYR A 122
 None
 1.24A 5ecmA-1pz1A:
undetectable		 5ecmA-1pz1A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1pz1 GENERAL STRESS
PROTEIN 69
(Bacillus
subtilis) 		5 / 12 HIS A 125
LEU A 278
ALA A  56
ALA A  82
LEU A  50
 NAP  A 500 ( 4.8A)
NAP  A 500 (-4.0A)
None
None
None
 1.00A 5jw1A-1pz1A:
undetectable		 5jw1A-1pz1A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 1pz1 GENERAL STRESS
PROTEIN 69
(Bacillus
subtilis) 		5 / 10 LEU A 290
ILE A 261
LEU A 206
ALA A 277
LEU A 269
 None
None
NAP  A 500 (-3.9A)
None
None
 1.06A 5y7pG-1pz1A:
0.0		 5y7pG-1pz1A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 1pz1 GENERAL STRESS
PROTEIN 69
(Bacillus
subtilis) 		4 / 6 GLU A 108
LEU A 111
LYS A 148
LEU A 143
 None
 1.10A 5yvnA-1pz1A:
undetectable		 5yvnA-1pz1A:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_B_IXXB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 1pz1 GENERAL STRESS
PROTEIN 69
(Bacillus
subtilis) 		4 / 5 ARG A  96
ALA A  98
GLN A 161
ILE A 133
 None
 1.18A 6g9bA-1pz1A:
0.0
6g9bB-1pz1A:
0.0		 6g9bA-1pz1A:
12.35
6g9bB-1pz1A:
13.04