SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pz5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Q0Y_H_MOIH401_1
(FAB 9B1, HEAVY CHAIN
FAB 9B1, LIGHT CHAIN)		 1pz5 HEAVY CHAIN OF FAB
(SYA/J6)
(Mus
musculus) 		4 / 7 GLU B  35
ILE B  69
TRP B  33
LEU B  52
 None
 1.44A 1q0yH-1pz5B:
20.3
1q0yL-1pz5B:
17.3		 1q0yH-1pz5B:
54.22
1q0yL-1pz5B:
28.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_A_5FWA601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 1pz5 HEAVY CHAIN OF FAB
(SYA/J6)
(Mus
musculus) 		5 / 12 VAL B 163
VAL B 181
SER B 179
ASN B 196
ASN B 155
 None
 1.44A 2y03A-1pz5B:
undetectable		 2y03A-1pz5B:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NYA_A_JTZA1203_1
(BETA-2 ADRENERGIC
RECEPTOR, LYSOZYME)		 1pz5 HEAVY CHAIN OF FAB
(SYA/J6)
(Mus
musculus) 		5 / 12 VAL B 163
VAL B 181
SER B 179
ASN B 196
ASN B 155
 None
 1.43A 3nyaA-1pz5B:
undetectable		 3nyaA-1pz5B:
20.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 1pz5 HEAVY CHAIN OF FAB
(SYA/J6)
(Mus
musculus) 		5 / 12 VAL B   2
ALA B  24
MET B  34
ARG B  71
VAL B  78
 None
 0.83A 3qxtA-1pz5B:
20.2		 3qxtA-1pz5B:
52.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 1pz5 HEAVY CHAIN OF FAB
(SYA/J6)
(Mus
musculus) 		6 / 12 VAL B   2
ALA B  24
MET B  34
ARG B  71
VAL B  78
TYR B 102
 None
 1.02A 3qxvB-1pz5B:
20.1		 3qxvB-1pz5B:
51.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_C_MTXC2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 1pz5 HEAVY CHAIN OF FAB
(SYA/J6)
(Mus
musculus) 		5 / 11 VAL B   2
ALA B  24
MET B  34
ARG B  71
VAL B  78
 None
 0.83A 3qxvC-1pz5B:
20.2		 3qxvC-1pz5B:
51.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_D_MTXD2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 1pz5 HEAVY CHAIN OF FAB
(SYA/J6)
(Mus
musculus) 		5 / 12 VAL B   2
ALA B  24
MET B  34
ARG B  71
VAL B  78
 None
 0.79A 3qxvD-1pz5B:
19.9		 3qxvD-1pz5B:
51.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 1pz5 HEAVY CHAIN OF FAB
(SYA/J6)
(Mus
musculus) 		5 / 12 ALA B  24
MET B  34
ARG B  71
VAL B  78
TYR B 102
 None
 0.94A 3qxvE-1pz5B:
16.4		 3qxvE-1pz5B:
51.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MTH_A_ACTA302_0
(ANTIBODY FAB HEAVY
CHAIN)		 1pz5 HEAVY CHAIN OF FAB
(SYA/J6)
(Mus
musculus) 		4 / 5 SER B 112
ALA B 114
PHE B 146
LEU B 170
 None
 0.36A 5mthA-1pz5B:
26.7		 5mthA-1pz5B:
56.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7M_B_68HB405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 1pz5 HEAVY CHAIN OF FAB
(SYA/J6)
(Mus
musculus) 		5 / 12 VAL B 163
VAL B 181
SER B 179
ASN B 196
ASN B 155
 None
 1.46A 6h7mB-1pz5B:
undetectable		 6h7mB-1pz5B:
17.80