SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pzd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1pzd COATOMER GAMMA
SUBUNIT
(Bos
taurus) 		3 / 3 THR A 759
SER A 633
LYS A 631
 None
 1.16A 3aocC-1pzdA:
2.9		 3aocC-1pzdA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)		 1pzd COATOMER GAMMA
SUBUNIT
(Bos
taurus) 		3 / 3 MET A 659
CYH A 722
PRO A 713
 None
 1.19A 3h52C-1pzdA:
undetectable		 3h52C-1pzdA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM201_1
(PROTEIN S100-A4)		 1pzd COATOMER GAMMA
SUBUNIT
(Bos
taurus) 		4 / 7 GLY A 832
PHE A 655
PHE A 630
GLY A 837
 None
 0.99A 3ko0M-1pzdA:
undetectable
3ko0P-1pzdA:
undetectable		 3ko0M-1pzdA:
18.82
3ko0P-1pzdA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1pzd COATOMER GAMMA
SUBUNIT
(Bos
taurus) 		4 / 8 LEU A 830
VAL A 856
VAL A 869
LEU A 828
 None
 0.98A 4puoC-1pzdA:
3.3		 4puoC-1pzdA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1pzd COATOMER GAMMA
SUBUNIT
(Bos
taurus) 		5 / 10 GLY A 802
VAL A 801
VAL A 805
LEU A 791
LEU A 830
 None
 1.27A 4yb6A-1pzdA:
undetectable
4yb6E-1pzdA:
undetectable		 4yb6A-1pzdA:
21.16
4yb6E-1pzdA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1pzd COATOMER GAMMA
SUBUNIT
(Bos
taurus) 		5 / 10 GLY A 802
VAL A 801
VAL A 805
LEU A 791
LEU A 830
 None
 1.28A 4yb6B-1pzdA:
undetectable
4yb6C-1pzdA:
undetectable		 4yb6B-1pzdA:
21.16
4yb6C-1pzdA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1pzd COATOMER GAMMA
SUBUNIT
(Bos
taurus) 		5 / 10 LEU A 791
LEU A 830
GLY A 802
VAL A 801
VAL A 805
 None
 1.26A 4yb6B-1pzdA:
undetectable
4yb6F-1pzdA:
undetectable		 4yb6B-1pzdA:
21.16
4yb6F-1pzdA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 1pzd COATOMER GAMMA
SUBUNIT
(Bos
taurus) 		3 / 3 VAL A 679
GLN A 662
CYH A 665
 None
 0.79A 5icxC-1pzdA:
0.0
5icxF-1pzdA:
undetectable		 5icxC-1pzdA:
21.67
5icxF-1pzdA:
4.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ONL_A_010A302_0
(YNDL)		 1pzd COATOMER GAMMA
SUBUNIT
(Bos
taurus) 		4 / 5 GLU A 862
GLU A 782
GLU A 863
PHE A 783
 None
 1.47A 5onlA-1pzdA:
0.0		 5onlA-1pzdA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HRJ_A_010A302_0
(YNDL)		 1pzd COATOMER GAMMA
SUBUNIT
(Bos
taurus) 		4 / 5 GLU A 862
GLU A 782
GLU A 863
PHE A 783
 None
 1.46A 6hrjA-1pzdA:
0.0		 6hrjA-1pzdA:
21.50