SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pzn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 1pzn DNA REPAIR AND
RECOMBINATION
PROTEIN RAD51
(Pyrococcus
furiosus) 		4 / 8 ASP A 238
ASP A 172
TRP A 170
ARG A 181
 None
 1.25A 1ceaA-1pznA:
undetectable
1ceaB-1pznA:
undetectable		 1ceaA-1pznA:
11.71
1ceaB-1pznA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_B_ACAB90_1
(PLASMINOGEN)		 1pzn DNA REPAIR AND
RECOMBINATION
PROTEIN RAD51
(Pyrococcus
furiosus) 		4 / 7 ASP A 238
ASP A 172
TRP A 170
ARG A 181
 None
 1.30A 1ceaB-1pznA:
undetectable		 1ceaB-1pznA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 1pzn DNA REPAIR AND
RECOMBINATION
PROTEIN RAD51
(Pyrococcus
furiosus) 		5 / 9 GLY A 163
GLY A 111
GLY A 127
GLY A 126
ASP A 121
 None
 1.16A 1mxdA-1pznA:
undetectable		 1mxdA-1pznA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		 1pzn DNA REPAIR AND
RECOMBINATION
PROTEIN RAD51
(Pyrococcus
furiosus) 		3 / 3 LEU A 123
LEU A 120
SER A 117
 None
 0.67A 1tlmA-1pznA:
undetectable		 1tlmA-1pznA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 1pzn DNA REPAIR AND
RECOMBINATION
PROTEIN RAD51
(Pyrococcus
furiosus) 		5 / 10 LEU A 261
ALA A 306
ILE A 133
ASP A 267
LEU A 268
 None
 1.08A 1yi4A-1pznA:
undetectable		 1yi4A-1pznA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1pzn DNA REPAIR AND
RECOMBINATION
PROTEIN RAD51
(Pyrococcus
furiosus) 		4 / 7 LEU A 234
GLY A 346
ILE A 347
VAL A 155
 None
 0.80A 2aojB-1pznA:
undetectable		 2aojB-1pznA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1pzn DNA REPAIR AND
RECOMBINATION
PROTEIN RAD51
(Pyrococcus
furiosus) 		5 / 11 ASN A 165
ALA A 278
ILE A 277
VAL A 155
ILE A 200
 None
 0.98A 2h42A-1pznA:
undetectable		 2h42A-1pznA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1pzn DNA REPAIR AND
RECOMBINATION
PROTEIN RAD51
(Pyrococcus
furiosus) 		4 / 6 LEU A  51
ALA A  61
LEU A  59
ALA A  88
 None
 0.97A 2vcvB-1pznA:
undetectable		 2vcvB-1pznA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 1pzn DNA REPAIR AND
RECOMBINATION
PROTEIN RAD51
(Pyrococcus
furiosus) 		4 / 6 THR A 241
PHE A 244
GLN A 211
LEU A 265
 None
 1.12A 3bgdA-1pznA:
undetectable		 3bgdA-1pznA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1pzn DNA REPAIR AND
RECOMBINATION
PROTEIN RAD51
(Pyrococcus
furiosus) 		5 / 11 GLY A  42
ALA A  81
THR A  80
ALA A  65
ALA A  48
 None
 0.99A 3g88A-1pznA:
undetectable		 3g88A-1pznA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1pzn DNA REPAIR AND
RECOMBINATION
PROTEIN RAD51
(Pyrococcus
furiosus) 		5 / 11 GLY A  42
ALA A  81
THR A  80
ALA A  65
ALA A  48
 None
 0.99A 3g88B-1pznA:
undetectable		 3g88B-1pznA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1pzn DNA REPAIR AND
RECOMBINATION
PROTEIN RAD51
(Pyrococcus
furiosus) 		5 / 12 GLY A  42
ALA A  81
THR A  80
ALA A  65
ALA A  48
 None
 1.02A 3g89A-1pznA:
undetectable		 3g89A-1pznA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1pzn DNA REPAIR AND
RECOMBINATION
PROTEIN RAD51
(Pyrococcus
furiosus) 		5 / 11 GLY A  42
ALA A  81
THR A  80
ALA A  65
ALA A  48
 None
 1.01A 3g89B-1pznA:
undetectable		 3g89B-1pznA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1pzn DNA REPAIR AND
RECOMBINATION
PROTEIN RAD51
(Pyrococcus
furiosus) 		5 / 12 GLY A  42
ALA A  81
THR A  80
ALA A  65
ALA A  48
 None
 1.06A 3g8bA-1pznA:
undetectable		 3g8bA-1pznA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1pzn DNA REPAIR AND
RECOMBINATION
PROTEIN RAD51
(Pyrococcus
furiosus) 		5 / 12 GLY A  42
ALA A  81
THR A  80
ALA A  65
ALA A  48
 None
 1.02A 3g8bB-1pznA:
undetectable		 3g8bB-1pznA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1pzn DNA REPAIR AND
RECOMBINATION
PROTEIN RAD51
(Pyrococcus
furiosus) 		3 / 3 GLY A 141
GLY A 143
THR A 145
 SO4  A 350 (-3.3A)
SO4  A 350 (-3.2A)
SO4  A 350 (-3.5A)
 0.41A 3si7B-1pznA:
undetectable		 3si7B-1pznA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1pzn DNA REPAIR AND
RECOMBINATION
PROTEIN RAD51
(Pyrococcus
furiosus) 		4 / 5 LEU A 311
LEU A 124
GLY A 125
GLY A 127
 None
 0.82A 3si7C-1pznA:
undetectable
3si7D-1pznA:
undetectable		 3si7C-1pznA:
22.43
3si7D-1pznA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_0
(GLYCINE
N-METHYLTRANSFERASE)		 1pzn DNA REPAIR AND
RECOMBINATION
PROTEIN RAD51
(Pyrococcus
furiosus) 		4 / 6 LEU A 305
HIS A 307
THR A 241
ARG A 245
 None
 1.19A 3thrB-1pznA:
undetectable		 3thrB-1pznA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 1pzn DNA REPAIR AND
RECOMBINATION
PROTEIN RAD51
(Pyrococcus
furiosus) 		5 / 12 ILE A  62
LEU A  70
ILE A  76
ALA A  81
ILE A  37
 None
 1.07A 3vrmA-1pznA:
undetectable		 3vrmA-1pznA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_1
(PROTEASE)		 1pzn DNA REPAIR AND
RECOMBINATION
PROTEIN RAD51
(Pyrococcus
furiosus) 		5 / 9 ARG A 312
ASP A 267
VAL A 279
LEU A 235
ILE A 133
 None
 1.07A 3wsjA-1pznA:
undetectable		 3wsjA-1pznA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 1pzn DNA REPAIR AND
RECOMBINATION
PROTEIN RAD51
(Pyrococcus
furiosus) 		4 / 7 LEU A 234
THR A 282
THR A 134
VAL A 136
 None
 0.72A 4ik7A-1pznA:
undetectable		 4ik7A-1pznA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 1pzn DNA REPAIR AND
RECOMBINATION
PROTEIN RAD51
(Pyrococcus
furiosus) 		4 / 7 VAL A 313
ALA A 325
LEU A 333
LEU A 147
 None
 0.81A 4l9iA-1pznA:
undetectable		 4l9iA-1pznA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1pzn DNA REPAIR AND
RECOMBINATION
PROTEIN RAD51
(Pyrococcus
furiosus) 		4 / 7 THR A 176
THR A 173
THR A 282
THR A 145
 None
None
None
SO4  A 350 (-3.5A)
 0.87A 4z90A-1pznA:
undetectable
4z90B-1pznA:
undetectable
4z90C-1pznA:
undetectable
4z90D-1pznA:
undetectable
4z90E-1pznA:
undetectable		 4z90A-1pznA:
21.45
4z90B-1pznA:
21.45
4z90C-1pznA:
21.45
4z90D-1pznA:
21.45
4z90E-1pznA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1pzn DNA REPAIR AND
RECOMBINATION
PROTEIN RAD51
(Pyrococcus
furiosus) 		4 / 7 THR A 176
THR A 173
THR A 282
THR A 145
 None
None
None
SO4  A 350 (-3.5A)
 0.91A 4z91F-1pznA:
undetectable
4z91G-1pznA:
undetectable
4z91H-1pznA:
undetectable
4z91I-1pznA:
undetectable
4z91J-1pznA:
undetectable		 4z91F-1pznA:
21.45
4z91G-1pznA:
21.45
4z91H-1pznA:
21.45
4z91I-1pznA:
21.45
4z91J-1pznA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1pzn DNA REPAIR AND
RECOMBINATION
PROTEIN RAD51
(Pyrococcus
furiosus) 		4 / 7 THR A 282
THR A 145
THR A 176
THR A 173
 None
SO4  A 350 (-3.5A)
None
None
 0.91A 4z91F-1pznA:
undetectable
4z91G-1pznA:
undetectable
4z91H-1pznA:
undetectable
4z91I-1pznA:
undetectable
4z91J-1pznA:
undetectable		 4z91F-1pznA:
21.45
4z91G-1pznA:
21.45
4z91H-1pznA:
21.45
4z91I-1pznA:
21.45
4z91J-1pznA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_B_1FLB1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 1pzn DNA REPAIR AND
RECOMBINATION
PROTEIN RAD51
(Pyrococcus
furiosus) 		5 / 9 LEU A 151
THR A 115
LEU A 120
PRO A 334
LEU A 123
 None
 1.29A 5g48B-1pznA:
undetectable		 5g48B-1pznA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 1pzn DNA REPAIR AND
RECOMBINATION
PROTEIN RAD51
(Pyrococcus
furiosus) 		5 / 12 ILE A  37
VAL A  43
LEU A  40
LEU A  59
ALA A  61
 None
 1.13A 6ajiA-1pznA:
undetectable		 6ajiA-1pznA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA607_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 1pzn DNA REPAIR AND
RECOMBINATION
PROTEIN RAD51
(Pyrococcus
furiosus) 		4 / 4 GLY A 163
ARG A 230
ASN A 165
LEU A 157
 None
 1.20A 6b58A-1pznA:
undetectable		 6b58A-1pznA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 1pzn DNA REPAIR AND
RECOMBINATION
PROTEIN RAD51
(Pyrococcus
furiosus) 		4 / 6 PHE A 340
VAL A 136
LEU A 124
LEU A 120
 None
 1.02A 6e43C-1pznA:
undetectable		 6e43C-1pznA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1pzn DNA REPAIR AND
RECOMBINATION
PROTEIN RAD51
(Pyrococcus
furiosus) 		4 / 6 ASP A 267
ARG A 270
GLU A  60
GLU A  38
 None
 1.48A 6mn5D-1pznA:
undetectable		 6mn5D-1pznA:
14.11