SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pzx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 1pzx HYPOTHETICAL PROTEIN
APC36103
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A  91
ILE A 263
GLY A 272
ALA A 271
LEU A 169
 PLM  A 702 ( 4.5A)
PLM  A 702 (-4.4A)
None
PLM  A 702 ( 4.7A)
None
 0.98A 1cqeA-1pzxA:
undetectable		 1cqeA-1pzxA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 1pzx HYPOTHETICAL PROTEIN
APC36103
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A  91
ILE A 263
GLY A 272
ALA A 271
LEU A 169
 PLM  A 702 ( 4.5A)
PLM  A 702 (-4.4A)
None
PLM  A 702 ( 4.7A)
None
 0.98A 1cqeB-1pzxA:
undetectable		 1cqeB-1pzxA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)		 1pzx HYPOTHETICAL PROTEIN
APC36103
(Geobacillus
stearothermophil
us) 		4 / 8 LEU A 105
LEU A  73
ALA A  76
LYS A  77
 None
 0.73A 1e7cA-1pzxA:
undetectable		 1e7cA-1pzxA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1pzx HYPOTHETICAL PROTEIN
APC36103
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A  91
ILE A 263
GLY A 272
ALA A 271
LEU A 169
 PLM  A 702 ( 4.5A)
PLM  A 702 (-4.4A)
None
PLM  A 702 ( 4.7A)
None
 1.01A 1eqhA-1pzxA:
undetectable		 1eqhA-1pzxA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1pzx HYPOTHETICAL PROTEIN
APC36103
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A  91
ILE A 263
GLY A 272
ALA A 271
LEU A 169
 PLM  A 702 ( 4.5A)
PLM  A 702 (-4.4A)
None
PLM  A 702 ( 4.7A)
None
 0.99A 1eqhB-1pzxA:
undetectable		 1eqhB-1pzxA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 1pzx HYPOTHETICAL PROTEIN
APC36103
(Geobacillus
stearothermophil
us) 		5 / 12 ALA A 133
GLY A 125
GLY A 127
ILE A  85
CYH A 154
 None
 0.94A 1x1aA-1pzxA:
undetectable		 1x1aA-1pzxA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1pzx HYPOTHETICAL PROTEIN
APC36103
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A  91
ILE A 263
GLY A 272
ALA A 271
LEU A 169
 PLM  A 702 ( 4.5A)
PLM  A 702 (-4.4A)
None
PLM  A 702 ( 4.7A)
None
 0.99A 2aylB-1pzxA:
undetectable		 2aylB-1pzxA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		 1pzx HYPOTHETICAL PROTEIN
APC36103
(Geobacillus
stearothermophil
us) 		4 / 7 LEU A 169
PHE A 161
ILE A 200
GLY A 172
 None
PLM  A 702 ( 4.2A)
None
None
 0.85A 2v0mC-1pzxA:
undetectable		 2v0mC-1pzxA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1pzx HYPOTHETICAL PROTEIN
APC36103
(Geobacillus
stearothermophil
us) 		4 / 7 LEU A  91
ALA A 271
ALA A 277
PHE A 279
 PLM  A 702 ( 4.5A)
PLM  A 702 ( 4.7A)
PLM  A 702 (-3.1A)
None
 0.97A 2vcvG-1pzxA:
undetectable		 2vcvG-1pzxA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1pzx HYPOTHETICAL PROTEIN
APC36103
(Geobacillus
stearothermophil
us) 		5 / 9 PHE A 161
LEU A  91
ALA A 271
ALA A 277
PHE A 279
 PLM  A 702 ( 4.2A)
PLM  A 702 ( 4.5A)
PLM  A 702 ( 4.7A)
PLM  A 702 (-3.1A)
None
 1.24A 2vcvI-1pzxA:
undetectable		 2vcvI-1pzxA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 1pzx HYPOTHETICAL PROTEIN
APC36103
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 260
ILE A 231
LEU A 226
ILE A 233
PHE A 258
 None
 0.96A 2ygqA-1pzxA:
undetectable		 2ygqA-1pzxA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1pzx HYPOTHETICAL PROTEIN
APC36103
(Geobacillus
stearothermophil
us) 		5 / 10 ALA A  67
LEU A  26
VAL A 101
ALA A  24
LEU A 114
 None
 1.08A 3fl9F-1pzxA:
undetectable		 3fl9F-1pzxA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1pzx HYPOTHETICAL PROTEIN
APC36103
(Geobacillus
stearothermophil
us) 		5 / 10 ALA A  67
VAL A 101
ALA A  24
ILE A   6
LEU A 114
 None
 1.20A 3fl9F-1pzxA:
undetectable		 3fl9F-1pzxA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_2
(ADENOSYLHOMOCYSTEINA
SE)		 1pzx HYPOTHETICAL PROTEIN
APC36103
(Geobacillus
stearothermophil
us) 		3 / 3 THR A 230
GLU A 135
HIS A  21
 None
 0.82A 3g1uB-1pzxA:
2.4		 3g1uB-1pzxA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IXL_A_PACA5000_0
(ARYLMALONATE
DECARBOXYLASE)		 1pzx HYPOTHETICAL PROTEIN
APC36103
(Geobacillus
stearothermophil
us) 		5 / 10 CYH A 154
SER A 119
MET A 157
GLY A 125
GLY A 127
 None
 1.45A 3ixlA-1pzxA:
1.9		 3ixlA-1pzxA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1pzx HYPOTHETICAL PROTEIN
APC36103
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A  91
ILE A 263
GLY A 272
ALA A 271
LEU A 169
 PLM  A 702 ( 4.5A)
PLM  A 702 (-4.4A)
None
PLM  A 702 ( 4.7A)
None
 1.04A 3n8xB-1pzxA:
0.0		 3n8xB-1pzxA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_A_RGZA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 1pzx HYPOTHETICAL PROTEIN
APC36103
(Geobacillus
stearothermophil
us) 		5 / 11 TYR A 284
LEU A 245
GLN A 229
ILE A 249
TYR A 153
 None
 1.27A 4a7aA-1pzxA:
0.8		 4a7aA-1pzxA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1pzx HYPOTHETICAL PROTEIN
APC36103
(Geobacillus
stearothermophil
us) 		5 / 11 GLY A 232
SER A 123
ALA A 122
ILE A 267
ILE A 160
 None
PLM  A 702 (-3.7A)
PLM  A 702 ( 4.0A)
PLM  A 702 ( 4.4A)
None
 1.14A 4xumB-1pzxA:
undetectable		 4xumB-1pzxA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		 1pzx HYPOTHETICAL PROTEIN
APC36103
(Geobacillus
stearothermophil
us) 		4 / 7 TYR A  75
TYR A 143
GLU A   4
PHE A 112
 None
 0.90A 5aclA-1pzxA:
undetectable		 5aclA-1pzxA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 1pzx HYPOTHETICAL PROTEIN
APC36103
(Geobacillus
stearothermophil
us) 		5 / 10 ALA A 277
ILE A 276
PHE A 161
ALA A 236
ASP A 262
 PLM  A 702 (-3.1A)
None
PLM  A 702 ( 4.2A)
None
None
 1.18A 5ajqB-1pzxA:
undetectable		 5ajqB-1pzxA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 1pzx HYPOTHETICAL PROTEIN
APC36103
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 268
ALA A 266
SER A 261
PHE A 279
CYH A 121
 None
PLM  A 702 ( 4.6A)
None
None
None
 1.49A 5cprB-1pzxA:
undetectable		 5cprB-1pzxA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 1pzx HYPOTHETICAL PROTEIN
APC36103
(Geobacillus
stearothermophil
us) 		5 / 9 LEU A  26
LEU A  71
ALA A  11
VAL A 130
ALA A  24
 None
 1.39A 5g44A-1pzxA:
undetectable		 5g44A-1pzxA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 1pzx HYPOTHETICAL PROTEIN
APC36103
(Geobacillus
stearothermophil
us) 		4 / 5 ASP A  12
VAL A  30
GLY A 268
ALA A 269
 None
 0.98A 5hwaA-1pzxA:
0.0		 5hwaA-1pzxA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MQT_A_STIA302_1
(DEOXYCYTIDINE KINASE)		 1pzx HYPOTHETICAL PROTEIN
APC36103
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A  23
GLU A 151
SER A 119
CYH A 154
GLU A   4
 None
 1.46A 5mqtA-1pzxA:
0.0		 5mqtA-1pzxA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1pzx HYPOTHETICAL PROTEIN
APC36103
(Geobacillus
stearothermophil
us) 		4 / 4 SER A 119
ALA A  86
GLN A  96
THR A  94
 None
 1.11A 5n0rA-1pzxA:
1.4		 5n0rA-1pzxA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1pzx HYPOTHETICAL PROTEIN
APC36103
(Geobacillus
stearothermophil
us) 		4 / 4 SER A 119
ALA A  86
GLN A  96
THR A  94
 None
 1.12A 5n0sA-1pzxA:
1.5		 5n0sA-1pzxA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1pzx HYPOTHETICAL PROTEIN
APC36103
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A 263
GLY A 268
HIS A 270
PHE A 161
ILE A 233
 PLM  A 702 (-4.4A)
None
PLM  A 702 (-3.5A)
PLM  A 702 ( 4.2A)
None
 1.10A 5n0tA-1pzxA:
undetectable		 5n0tA-1pzxA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1pzx HYPOTHETICAL PROTEIN
APC36103
(Geobacillus
stearothermophil
us) 		4 / 5 SER A 119
ALA A  86
GLN A  96
THR A  94
 None
 1.11A 5n0tA-1pzxA:
undetectable		 5n0tA-1pzxA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1pzx HYPOTHETICAL PROTEIN
APC36103
(Geobacillus
stearothermophil
us) 		4 / 4 SER A 119
ALA A  86
GLN A  96
THR A  94
 None
 1.11A 5n0wA-1pzxA:
1.5		 5n0wA-1pzxA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1pzx HYPOTHETICAL PROTEIN
APC36103
(Geobacillus
stearothermophil
us) 		4 / 5 SER A 119
ALA A  86
GLN A  96
THR A  94
 None
 1.14A 5n0wB-1pzxA:
undetectable		 5n0wB-1pzxA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1pzx HYPOTHETICAL PROTEIN
APC36103
(Geobacillus
stearothermophil
us) 		4 / 4 SER A 119
ALA A  86
GLN A  96
THR A  94
 None
 1.14A 5n0xA-1pzxA:
3.6		 5n0xA-1pzxA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1pzx HYPOTHETICAL PROTEIN
APC36103
(Geobacillus
stearothermophil
us) 		4 / 5 SER A 119
ALA A  86
GLN A  96
THR A  94
 None
 1.13A 5n4iA-1pzxA:
3.5		 5n4iA-1pzxA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)		 1pzx HYPOTHETICAL PROTEIN
APC36103
(Geobacillus
stearothermophil
us) 		4 / 8 ILE A   5
ALA A  24
LEU A 114
ILE A  85
 None
 0.89A 5uihA-1pzxA:
undetectable		 5uihA-1pzxA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1pzx HYPOTHETICAL PROTEIN
APC36103
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A  83
ILE A  85
CYH A 154
LEU A 281
HIS A 159
 None
 1.19A 5y2tB-1pzxA:
0.0		 5y2tB-1pzxA:
undetectable