SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1q0z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 1q0z ACLACINOMYCIN
METHYLESTERASE
(Streptomyces
purpurascens) 		5 / 12 ALA A 245
LEU A 126
LEU A 278
THR A 123
LEU A  47
 None
None
1PE  A2712 ( 4.5A)
None
None
 1.11A 1bzfA-1q0zA:
undetectable		 1bzfA-1q0zA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 1q0z ACLACINOMYCIN
METHYLESTERASE
(Streptomyces
purpurascens) 		5 / 12 ILE A 107
ALA A  82
PRO A  74
LEU A 222
TYR A  57
 None
 1.22A 1dlsA-1q0zA:
undetectable		 1dlsA-1q0zA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1q0z ACLACINOMYCIN
METHYLESTERASE
(Streptomyces
purpurascens) 		4 / 8 VAL A  29
VAL A  98
SER A 121
LEU A  88
 None
 0.83A 1igxA-1q0zA:
undetectable		 1igxA-1q0zA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 1q0z ACLACINOMYCIN
METHYLESTERASE
(Streptomyces
purpurascens) 		5 / 12 THR A 106
GLY A 104
GLY A  31
GLY A  32
VAL A  29
 AKA  A 600 (-3.8A)
None
None
AKA  A 600 (-4.3A)
None
 0.96A 1n2xB-1q0zA:
3.4		 1n2xB-1q0zA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 1q0z ACLACINOMYCIN
METHYLESTERASE
(Streptomyces
purpurascens) 		5 / 12 ALA A 251
ASP A 248
PRO A 279
LEU A 286
PRO A 285
 AKA  A 600 ( 3.8A)
None
None
None
None
 1.33A 3cl9A-1q0zA:
undetectable		 3cl9A-1q0zA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 1q0z ACLACINOMYCIN
METHYLESTERASE
(Streptomyces
purpurascens) 		5 / 12 ILE A 107
ALA A  82
PRO A  74
LEU A 222
TYR A  57
 None
 1.33A 3eigA-1q0zA:
undetectable		 3eigA-1q0zA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1q0z ACLACINOMYCIN
METHYLESTERASE
(Streptomyces
purpurascens) 		4 / 7 VAL A  29
VAL A  98
LEU A 122
SER A 121
 None
 0.78A 3hs6B-1q0zA:
undetectable		 3hs6B-1q0zA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 1q0z ACLACINOMYCIN
METHYLESTERASE
(Streptomyces
purpurascens) 		4 / 8 SER A  65
ASP A  83
LEU A  80
ASP A  61
 None
 1.10A 3n2oC-1q0zA:
undetectable
3n2oD-1q0zA:
2.2		 3n2oC-1q0zA:
17.82
3n2oD-1q0zA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)		 1q0z ACLACINOMYCIN
METHYLESTERASE
(Streptomyces
purpurascens) 		3 / 3 ASP A  94
ARG A  95
ASP A  89
 None
 0.82A 4fp9A-1q0zA:
undetectable		 4fp9A-1q0zA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 1q0z ACLACINOMYCIN
METHYLESTERASE
(Streptomyces
purpurascens) 		3 / 3 SER A 187
TYR A 198
PRO A 249
 None
1PE  A2712 (-4.2A)
None
 0.86A 4k8cA-1q0zA:
4.2		 4k8cA-1q0zA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1q0z ACLACINOMYCIN
METHYLESTERASE
(Streptomyces
purpurascens) 		3 / 3 SER A 187
TYR A 198
PRO A 249
 None
1PE  A2712 (-4.2A)
None
 0.87A 4kahA-1q0zA:
4.2		 4kahA-1q0zA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1q0z ACLACINOMYCIN
METHYLESTERASE
(Streptomyces
purpurascens) 		3 / 3 SER A 187
TYR A 198
PRO A 249
 None
1PE  A2712 (-4.2A)
None
 0.84A 4kanA-1q0zA:
4.1		 4kanA-1q0zA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1q0z ACLACINOMYCIN
METHYLESTERASE
(Streptomyces
purpurascens) 		3 / 3 SER A 187
TYR A 198
PRO A 249
 None
1PE  A2712 (-4.2A)
None
 0.85A 4kanB-1q0zA:
3.8		 4kanB-1q0zA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1q0z ACLACINOMYCIN
METHYLESTERASE
(Streptomyces
purpurascens) 		3 / 3 SER A 187
TYR A 198
PRO A 249
 None
1PE  A2712 (-4.2A)
None
 0.87A 4kbeA-1q0zA:
4.1		 4kbeA-1q0zA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1q0z ACLACINOMYCIN
METHYLESTERASE
(Streptomyces
purpurascens) 		3 / 3 SER A 187
TYR A 198
PRO A 249
 None
1PE  A2712 (-4.2A)
None
 0.86A 4lbgA-1q0zA:
3.9		 4lbgA-1q0zA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1q0z ACLACINOMYCIN
METHYLESTERASE
(Streptomyces
purpurascens) 		3 / 3 SER A 187
TYR A 198
PRO A 249
 None
1PE  A2712 (-4.2A)
None
 0.85A 4lbgB-1q0zA:
3.8		 4lbgB-1q0zA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1q0z ACLACINOMYCIN
METHYLESTERASE
(Streptomyces
purpurascens) 		4 / 6 ARG A   4
ILE A   5
ILE A  55
ASP A  17
 None
 1.17A 4w5qA-1q0zA:
3.6		 4w5qA-1q0zA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1q0z ACLACINOMYCIN
METHYLESTERASE
(Streptomyces
purpurascens) 		4 / 6 ARG A   4
ILE A   5
ILE A  55
ASP A  17
 None
 1.19A 4w5tA-1q0zA:
3.5		 4w5tA-1q0zA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 1q0z ACLACINOMYCIN
METHYLESTERASE
(Streptomyces
purpurascens) 		4 / 6 ARG A   4
ILE A   5
ILE A  55
ASP A  17
 None
 1.14A 4z4cA-1q0zA:
0.0		 4z4cA-1q0zA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1q0z ACLACINOMYCIN
METHYLESTERASE
(Streptomyces
purpurascens) 		4 / 6 ARG A   4
ILE A   5
ILE A  55
ASP A  17
 None
 1.14A 4z4dA-1q0zA:
3.4		 4z4dA-1q0zA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)		 1q0z ACLACINOMYCIN
METHYLESTERASE
(Streptomyces
purpurascens) 		4 / 5 ARG A 267
THR A 294
HIS A 293
ALA A 297
 None
 1.45A 5mfxA-1q0zA:
undetectable		 5mfxA-1q0zA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 1q0z ACLACINOMYCIN
METHYLESTERASE
(Streptomyces
purpurascens) 		5 / 12 LEU A 101
PHE A 193
ALA A 251
ILE A 185
GLY A 188
 1PE  A2712 (-4.8A)
None
AKA  A 600 ( 3.8A)
None
None
 0.88A 5veuB-1q0zA:
undetectable		 5veuB-1q0zA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 1q0z ACLACINOMYCIN
METHYLESTERASE
(Streptomyces
purpurascens) 		5 / 12 ALA A 251
PRO A 252
GLY A 153
GLY A 104
LEU A  34
 AKA  A 600 ( 3.8A)
None
None
None
SO4  A3482 (-4.6A)
 1.12A 5wwsA-1q0zA:
undetectable		 5wwsA-1q0zA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 1q0z ACLACINOMYCIN
METHYLESTERASE
(Streptomyces
purpurascens) 		4 / 6 LEU A  88
LEU A 119
ARG A 267
ARG A 295
 None
 1.08A 6ew0G-1q0zA:
2.8		 6ew0G-1q0zA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 1q0z ACLACINOMYCIN
METHYLESTERASE
(Streptomyces
purpurascens) 		5 / 10 ALA A  96
LEU A 119
VAL A  98
ILE A 107
ALA A  81
 None
 1.30A 6h1lA-1q0zA:
undetectable		 6h1lA-1q0zA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 1q0z ACLACINOMYCIN
METHYLESTERASE
(Streptomyces
purpurascens) 		5 / 11 ALA A  96
VAL A  98
ILE A 107
ALA A  81
ALA A  86
 None
 1.15A 6h1lB-1q0zA:
undetectable		 6h1lB-1q0zA:
22.01