SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1q15'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)		 1q15 CARA
(Pectobacterium
carotovorum) 		3 / 3 PHE A 351
LEU A 402
LEU A 227
 None
 0.65A 1mx1E-1q15A:
undetectable		 1mx1E-1q15A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_1
(ASPARTYLPROTEASE)		 1q15 CARA
(Pectobacterium
carotovorum) 		5 / 11 GLY A 379
ILE A 315
THR A 172
PRO A 173
VAL A 174
 None
 0.87A 1ohrA-1q15A:
undetectable		 1ohrA-1q15A:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		 1q15 CARA
(Pectobacterium
carotovorum) 		3 / 3 LEU A 405
LEU A 402
SER A 399
 None
 0.68A 1tlmA-1q15A:
undetectable		 1tlmA-1q15A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1q15 CARA
(Pectobacterium
carotovorum) 		5 / 9 PHE A 473
VAL A 477
PHE A 456
SER A 325
LEU A 496
 None
 1.11A 1wrkA-1q15A:
0.0
1wrkB-1q15A:
undetectable		 1wrkA-1q15A:
12.33
1wrkB-1q15A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1q15 CARA
(Pectobacterium
carotovorum) 		5 / 12 ALA A 321
ILE A 306
ILE A 315
LEU A 486
ILE A 488
 None
 1.12A 1xozA-1q15A:
undetectable		 1xozA-1q15A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2001_1
(SERUM ALBUMIN)		 1q15 CARA
(Pectobacterium
carotovorum) 		5 / 10 ALA A 287
ALA A 256
ARG A 260
LEU A 257
LEU A 253
 None
 1.08A 2bxqA-1q15A:
undetectable		 2bxqA-1q15A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 1q15 CARA
(Pectobacterium
carotovorum) 		5 / 12 PHE A 124
LEU A 402
THR A 375
VAL A 372
GLY A 344
 None
 1.07A 2cbrA-1q15A:
0.0		 2cbrA-1q15A:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 1q15 CARA
(Pectobacterium
carotovorum) 		3 / 3 ALA A 428
GLY A 248
SER A 347
 None
 0.56A 2ivuA-1q15A:
undetectable		 2ivuA-1q15A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_1
(PROTEASE)		 1q15 CARA
(Pectobacterium
carotovorum) 		5 / 11 GLY A 379
ILE A 315
THR A 172
PRO A 173
VAL A 174
 None
 0.90A 2nnpA-1q15A:
undetectable		 2nnpA-1q15A:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 1q15 CARA
(Pectobacterium
carotovorum) 		4 / 7 LEU A 496
PHE A 473
ILE A 307
PHE A 481
 None
 0.82A 2opxA-1q15A:
2.9		 2opxA-1q15A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 1q15 CARA
(Pectobacterium
carotovorum) 		5 / 12 TYR A 478
LEU A 482
LEU A 153
THR A 138
HIS A 384
 None
 1.23A 2qo6A-1q15A:
2.2		 2qo6A-1q15A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_D_ASDD1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1q15 CARA
(Pectobacterium
carotovorum) 		5 / 9 LEU A 231
LEU A 227
ALA A 256
LEU A 253
PHE A 397
 None
 1.21A 2vcvD-1q15A:
undetectable		 2vcvD-1q15A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_E_ASDE1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1q15 CARA
(Pectobacterium
carotovorum) 		5 / 9 LEU A 231
LEU A 227
ALA A 256
LEU A 253
PHE A 397
 None
 1.25A 2vcvE-1q15A:
undetectable		 2vcvE-1q15A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_H_ASDH1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1q15 CARA
(Pectobacterium
carotovorum) 		5 / 9 LEU A 231
LEU A 227
ALA A 256
LEU A 253
PHE A 397
 None
 1.26A 2vcvH-1q15A:
undetectable		 2vcvH-1q15A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1q15 CARA
(Pectobacterium
carotovorum) 		4 / 6 PRO A 173
GLU A 158
TYR A 475
CYH A 162
 None
 1.38A 2x7hA-1q15A:
2.6		 2x7hA-1q15A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9X_A_NIMA1_1
(LACTOTRANSFERRIN')		 1q15 CARA
(Pectobacterium
carotovorum) 		4 / 4 GLU A 150
GLY A 149
THR A 145
GLU A 148
 None
 1.15A 3e9xA-1q15A:
0.0		 3e9xA-1q15A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 1q15 CARA
(Pectobacterium
carotovorum) 		4 / 8 TYR A 171
HIS A 128
TYR A 478
LEU A 153
 None
 1.39A 3uzzB-1q15A:
undetectable		 3uzzB-1q15A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 1q15 CARA
(Pectobacterium
carotovorum) 		4 / 6 PHE A 262
ALA A 258
PRO A 230
LEU A 342
 None
 1.01A 4dtzB-1q15A:
undetectable		 4dtzB-1q15A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1q15 CARA
(Pectobacterium
carotovorum) 		5 / 12 LEU A  92
LEU A  88
LEU A  84
ARG A  91
THR A  63
 None
 1.06A 4f4dB-1q15A:
2.2		 4f4dB-1q15A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1q15 CARA
(Pectobacterium
carotovorum) 		4 / 5 LEU A 253
ARG A 260
PRO A 230
SER A 399
 None
 1.40A 4kmmB-1q15A:
undetectable		 4kmmB-1q15A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1q15 CARA
(Pectobacterium
carotovorum) 		5 / 10 LEU A  92
LEU A  88
LEU A  84
ARG A  91
THR A  63
 None
 1.10A 4mk4A-1q15A:
2.2		 4mk4A-1q15A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 1q15 CARA
(Pectobacterium
carotovorum) 		5 / 12 ILE A 223
ILE A 243
LEU A 245
GLY A 344
SER A 347
 None
 0.96A 4o1eA-1q15A:
undetectable		 4o1eA-1q15A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 1q15 CARA
(Pectobacterium
carotovorum) 		5 / 12 ILE A 223
ILE A 243
LEU A 245
GLY A 344
SER A 347
 None
 1.00A 4o1eB-1q15A:
undetectable		 4o1eB-1q15A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 1q15 CARA
(Pectobacterium
carotovorum) 		4 / 5 LEU A 253
VAL A 420
TYR A 427
ARG A 374
 None
 0.79A 4r7iA-1q15A:
undetectable		 4r7iA-1q15A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 1q15 CARA
(Pectobacterium
carotovorum) 		3 / 3 SER A  58
ASP A 239
ASP A 233
 None
 0.69A 4uckA-1q15A:
undetectable		 4uckA-1q15A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_I_DIFI1006_1
(SERUM ALBUMIN)		 1q15 CARA
(Pectobacterium
carotovorum) 		5 / 10 ARG A 425
PHE A 351
LEU A 220
ILE A 223
ALA A 428
 None
 1.39A 4z69I-1q15A:
0.9		 4z69I-1q15A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1q15 CARA
(Pectobacterium
carotovorum) 		5 / 9 PHE A 351
ILE A 423
PHE A 397
LEU A 257
LEU A 431
 None
 1.28A 4ze0A-1q15A:
undetectable		 4ze0A-1q15A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 1q15 CARA
(Pectobacterium
carotovorum) 		5 / 9 LEU A  97
LEU A  87
LEU A  88
LEU A  65
ALA A  69
 None
 0.96A 5dqfA-1q15A:
undetectable		 5dqfA-1q15A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 1q15 CARA
(Pectobacterium
carotovorum) 		4 / 6 TYR A 345
TYR A 331
GLY A 379
GLU A 380
 None
 1.29A 5emlA-1q15A:
4.3		 5emlA-1q15A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 1q15 CARA
(Pectobacterium
carotovorum) 		3 / 3 LEU A  55
LEU A  59
ARG A  91
 None
 0.65A 5hnzB-1q15A:
undetectable		 5hnzB-1q15A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1q15 CARA
(Pectobacterium
carotovorum) 		4 / 6 ARG A 394
ASP A  81
GLY A  57
ASP A 103
 None
 1.30A 5hp1A-1q15A:
undetectable		 5hp1A-1q15A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_1
(PROTEASE E35D-SQV)		 1q15 CARA
(Pectobacterium
carotovorum) 		5 / 12 GLY A 379
ILE A 315
THR A 172
PRO A 173
VAL A 174
 None
 0.86A 5kqxA-1q15A:
undetectable		 5kqxA-1q15A:
11.84