SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1q18'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1q18 GLUCOKINASE
(Escherichia
coli) 		5 / 12 GLY A 140
GLY A 305
ASP A   9
CYH A  60
ALA A 103
 None
 0.89A 2bm9F-1q18A:
undetectable		 2bm9F-1q18A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1q18 GLUCOKINASE
(Escherichia
coli) 		5 / 12 PHE A 101
VAL A 300
ALA A 142
ALA A 131
THR A 254
 None
 1.25A 2x2nC-1q18A:
undetectable		 2x2nC-1q18A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 1q18 GLUCOKINASE
(Escherichia
coli) 		6 / 12 GLY A 310
GLY A 308
ASP A  58
ALA A   5
HIS A 319
ILE A  22
 None
 1.40A 3fuuA-1q18A:
undetectable		 3fuuA-1q18A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1q18 GLUCOKINASE
(Escherichia
coli) 		5 / 12 LEU A 306
ALA A  15
GLY A  11
GLY A   8
LEU A  17
 None
 1.26A 3ou7D-1q18A:
undetectable		 3ou7D-1q18A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA601_0
(LACCASE-1)		 1q18 GLUCOKINASE
(Escherichia
coli) 		4 / 5 CYH A  60
ILE A  98
HIS A 312
LEU A 313
 None
 0.98A 3qpkA-1q18A:
undetectable		 3qpkA-1q18A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 1q18 GLUCOKINASE
(Escherichia
coli) 		4 / 5 LEU A 298
GLY A 262
MET A 241
PHE A 268
 None
 1.23A 3uq6B-1q18A:
undetectable		 3uq6B-1q18A:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 1q18 GLUCOKINASE
(Escherichia
coli) 		5 / 10 ALA A 186
LEU A 139
ILE A 260
ALA A 261
ALA A 142
 None
 0.88A 4j14A-1q18A:
0.6		 4j14A-1q18A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1q18 GLUCOKINASE
(Escherichia
coli) 		4 / 9 SER A 191
ALA A 135
LEU A 234
ILE A 218
 None
 0.95A 4xtaA-1q18A:
undetectable		 4xtaA-1q18A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)		 1q18 GLUCOKINASE
(Escherichia
coli) 		5 / 8 ALA A 261
VAL A 104
PHE A 101
GLY A 134
ALA A 135
 None
 1.36A 4zjzB-1q18A:
undetectable		 4zjzB-1q18A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1q18 GLUCOKINASE
(Escherichia
coli) 		4 / 8 LEU A  95
ILE A  98
GLY A   8
LEU A  41
 None
 0.84A 5eseA-1q18A:
0.6		 5eseA-1q18A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 1q18 GLUCOKINASE
(Escherichia
coli) 		5 / 7 GLY A 242
PHE A 244
GLY A 245
VAL A 296
LEU A 248
 None
 1.34A 5izjB-1q18A:
undetectable		 5izjB-1q18A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 1q18 GLUCOKINASE
(Escherichia
coli) 		5 / 12 PRO A 193
VAL A 196
ASN A 197
ALA A 201
LYS A 204
 None
 0.52A 5j2tC-1q18A:
undetectable		 5j2tC-1q18A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_0
(SERUM ALBUMIN)		 1q18 GLUCOKINASE
(Escherichia
coli) 		5 / 12 ILE A 218
VAL A 258
LEU A 248
ALA A 233
PHE A 277
 None
 1.44A 6a7pB-1q18A:
0.2		 6a7pB-1q18A:
18.54