SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1q1a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_A_NIOA145_1
(LEGHEMOGLOBIN A)		 1q1a HST2 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 138
ILE A 117
PHE A  67
PHE A 183
 None
OAD  A1001 ( 4.4A)
OAD  A1001 ( 4.6A)
None
 0.69A 1fslA-1q1aA:
undetectable		 1fslA-1q1aA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_B_NIOB145_1
(LEGHEMOGLOBIN A)		 1q1a HST2 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 138
ILE A 117
PHE A  67
PHE A 183
 None
OAD  A1001 ( 4.4A)
OAD  A1001 ( 4.6A)
None
 0.73A 1fslB-1q1aA:
undetectable		 1fslB-1q1aA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		 1q1a HST2 PROTEIN
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 116
PHE A  96
VAL A  31
 None
 0.82A 1kijA-1q1aA:
undetectable		 1kijA-1q1aA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1q1a HST2 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 8 PHE A  67
LEU A 159
PHE A 183
SER A 137
 OAD  A1001 ( 4.6A)
None
None
None
 1.02A 1wrlC-1q1aA:
undetectable
1wrlD-1q1aA:
undetectable		 1wrlC-1q1aA:
15.11
1wrlD-1q1aA:
15.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 1q1a HST2 PROTEIN
(Saccharomyces
cerevisiae) 		6 / 6 ALA A  33
SER A  36
PHE A  44
ASN A 116
ILE A 117
ASP A 118
 OAD  A1001 (-3.9A)
None
OAD  A1001 (-3.5A)
None
OAD  A1001 ( 4.4A)
None
 0.70A 1yc2A-1q1aA:
20.4		 1yc2A-1q1aA:
33.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 1q1a HST2 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 5 ALA A  33
PHE A  44
ASN A 116
ILE A 117
ASP A 118
 OAD  A1001 (-3.9A)
OAD  A1001 (-3.5A)
None
OAD  A1001 ( 4.4A)
None
 0.60A 1yc2D-1q1aA:
20.1		 1yc2D-1q1aA:
33.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 1q1a HST2 PROTEIN
(Saccharomyces
cerevisiae) 		6 / 7 ILE A  41
PHE A  44
LEU A  51
ASN A 116
ILE A 117
ASP A 118
 None
OAD  A1001 (-3.5A)
None
None
OAD  A1001 ( 4.4A)
None
 0.72A 1yc2E-1q1aA:
21.2		 1yc2E-1q1aA:
33.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 1q1a HST2 PROTEIN
(Saccharomyces
cerevisiae) 		6 / 7 ALA A  33
SER A  36
ILE A  41
ASN A 116
ILE A 117
ASP A 118
 OAD  A1001 (-3.9A)
None
None
None
OAD  A1001 ( 4.4A)
None
 0.20A 1yc5A-1q1aA:
25.4		 1yc5A-1q1aA:
37.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 1q1a HST2 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 7 SER A  36
ILE A  41
ASP A  43
ASP A 118
 None
None
OAD  A1001 (-3.8A)
None
 0.84A 1yc5A-1q1aA:
25.4		 1yc5A-1q1aA:
37.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 1q1a HST2 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 5 ALA A  33
ILE A  41
ASN A 116
ILE A 117
ASP A 118
 OAD  A1001 (-3.9A)
None
None
OAD  A1001 ( 4.4A)
None
 0.23A 2h4jA-1q1aA:
20.9		 2h4jA-1q1aA:
37.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_A_NCAA900_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 1q1a HST2 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 5 ILE A  41
PRO A  42
PHE A  44
ILE A 117
 None
None
OAD  A1001 (-3.5A)
OAD  A1001 ( 4.4A)
 0.65A 2hjhA-1q1aA:
29.2		 2hjhA-1q1aA:
29.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1q1a HST2 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 8 ALA A 274
LEU A  99
LEU A 100
ILE A  35
VAL A 112
 None
 1.15A 2uxpA-1q1aA:
undetectable		 2uxpA-1q1aA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)		 1q1a HST2 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 7 ASP A 271
TYR A 269
GLN A 276
GLU A 275
 None
 1.17A 3s3oA-1q1aA:
undetectable		 3s3oA-1q1aA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 1q1a HST2 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 4 ASN A 116
ALA A  33
GLY A  32
THR A 224
 None
OAD  A1001 (-3.9A)
OAD  A1001 (-3.2A)
OAD  A1001 (-3.8A)
 1.26A 4bboC-1q1aA:
undetectable		 4bboC-1q1aA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 1q1a HST2 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 8 SER A 270
HIS A  97
ILE A  41
GLU A 121
 OAD  A1001 (-3.5A)
None
None
None
 1.22A 4ms4A-1q1aA:
3.5		 4ms4A-1q1aA:
21.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 1q1a HST2 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 135
PHE A  67
LEU A 188
PRO A 230
 OAD  A1001 (-3.8A)
OAD  A1001 ( 4.6A)
None
None
 1.37A 4o8zA-1q1aA:
28.4		 4o8zA-1q1aA:
41.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 1q1a HST2 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 5 PHE A  67
HIS A 135
LEU A 188
PRO A 230
 OAD  A1001 ( 4.6A)
OAD  A1001 (-3.8A)
None
None
 1.02A 4o8zA-1q1aA:
28.4		 4o8zA-1q1aA:
41.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 1q1a HST2 PROTEIN
(Saccharomyces
cerevisiae) 		6 / 7 ILE A  41
PHE A  44
LEU A  51
ASN A 116
ILE A 117
ASP A 118
 None
OAD  A1001 (-3.5A)
None
None
OAD  A1001 ( 4.4A)
None
 0.48A 4rmjA-1q1aA:
34.5		 4rmjA-1q1aA:
41.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 1q1a HST2 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 7 LEU A  86
ASN A 116
ILE A 117
ASP A 118
 None
None
OAD  A1001 ( 4.4A)
None
 0.74A 4rmjA-1q1aA:
34.5		 4rmjA-1q1aA:
41.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 1q1a HST2 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 120
GLY A  34
GLY A 223
LEU A 249
CYH A  39
 None
OAD  A1001 (-3.5A)
OAD  A1001 (-3.5A)
OAD  A1001 (-4.2A)
None
 1.19A 4x61A-1q1aA:
undetectable		 4x61A-1q1aA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_K_IPHK101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 1q1a HST2 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 6 VAL A 177
HIS A 142
CYH A 146
HIS A 140
 None
None
ZN  A 701 (-2.3A)
None
 1.42A 5hrqH-1q1aA:
undetectable
5hrqK-1q1aA:
undetectable
5hrqL-1q1aA:
undetectable		 5hrqH-1q1aA:
7.26
5hrqK-1q1aA:
6.05
5hrqL-1q1aA:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 1q1a HST2 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 219
ARG A 111
TYR A 113
TRP A 196
 None
 1.07A 5umwB-1q1aA:
0.0
5umwE-1q1aA:
0.0		 5umwB-1q1aA:
15.25
5umwE-1q1aA:
15.25