SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1q1l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4002_1
(SERUM ALBUMIN)		 1q1l CHORISMATE SYNTHASE
(Aquifex
aeolicus) 		4 / 4 ARG A  43
ALA A 147
ALA A 365
GLU A 361
 None
 1.22A 1e7bB-1q1lA:
0.5		 1e7bB-1q1lA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1q1l CHORISMATE SYNTHASE
(Aquifex
aeolicus) 		4 / 8 THR A 139
ALA A 355
ALA A 352
ILE A 323
 None
 0.70A 1gtnI-1q1lA:
undetectable
1gtnJ-1q1lA:
undetectable		 1gtnI-1q1lA:
11.83
1gtnJ-1q1lA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1q1l CHORISMATE SYNTHASE
(Aquifex
aeolicus) 		4 / 5 SER A 162
PHE A 228
GLU A 361
GLY A 360
 None
 1.11A 1icrA-1q1lA:
0.7
1icrB-1q1lA:
undetectable		 1icrA-1q1lA:
19.70
1icrB-1q1lA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1q1l CHORISMATE SYNTHASE
(Aquifex
aeolicus) 		4 / 5 GLU A 361
GLY A 360
SER A 162
PHE A 228
 None
 1.10A 1icrA-1q1lA:
0.7
1icrB-1q1lA:
undetectable		 1icrA-1q1lA:
19.70
1icrB-1q1lA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_A_NIOA221_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1q1l CHORISMATE SYNTHASE
(Aquifex
aeolicus) 		4 / 6 SER A 162
PHE A 228
GLU A 361
GLY A 360
 None
 1.08A 1icuA-1q1lA:
0.7
1icuB-1q1lA:
undetectable		 1icuA-1q1lA:
19.70
1icuB-1q1lA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_B_NIOB219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1q1l CHORISMATE SYNTHASE
(Aquifex
aeolicus) 		4 / 6 GLU A 361
GLY A 360
SER A 162
PHE A 228
 None
 1.06A 1icuA-1q1lA:
0.7
1icuB-1q1lA:
undetectable		 1icuA-1q1lA:
19.70
1icuB-1q1lA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_C_NIOC225_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1q1l CHORISMATE SYNTHASE
(Aquifex
aeolicus) 		4 / 6 SER A 162
PHE A 228
GLU A 361
GLY A 360
 None
 1.13A 1icuC-1q1lA:
0.9
1icuD-1q1lA:
1.1		 1icuC-1q1lA:
19.70
1icuD-1q1lA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_A_NIOA704_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1q1l CHORISMATE SYNTHASE
(Aquifex
aeolicus) 		4 / 4 SER A 162
PHE A 228
GLU A 361
GLY A 360
 None
 1.14A 1icvA-1q1lA:
0.9
1icvB-1q1lA:
0.3		 1icvA-1q1lA:
19.70
1icvB-1q1lA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1q1l CHORISMATE SYNTHASE
(Aquifex
aeolicus) 		4 / 5 SER A 162
PHE A 228
GLU A 361
GLY A 360
 None
 1.05A 1icvC-1q1lA:
1.2
1icvD-1q1lA:
1.3		 1icvC-1q1lA:
19.70
1icvD-1q1lA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1q1l CHORISMATE SYNTHASE
(Aquifex
aeolicus) 		4 / 5 GLU A 361
GLY A 360
SER A 162
PHE A 228
 None
 1.04A 1icvC-1q1lA:
1.2
1icvD-1q1lA:
1.3		 1icvC-1q1lA:
19.70
1icvD-1q1lA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_A_BEZA524_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1q1l CHORISMATE SYNTHASE
(Aquifex
aeolicus) 		4 / 6 SER A 162
PHE A 228
GLU A 361
GLY A 360
 None
 1.05A 1kqbA-1q1lA:
undetectable
1kqbB-1q1lA:
undetectable		 1kqbA-1q1lA:
20.45
1kqbB-1q1lA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1q1l CHORISMATE SYNTHASE
(Aquifex
aeolicus) 		4 / 5 GLU A 361
GLY A 360
SER A 162
PHE A 228
 None
 1.06A 1kqbA-1q1lA:
undetectable
1kqbB-1q1lA:
undetectable		 1kqbA-1q1lA:
20.45
1kqbB-1q1lA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_C_BEZC522_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1q1l CHORISMATE SYNTHASE
(Aquifex
aeolicus) 		4 / 6 SER A 162
PHE A 228
GLU A 361
GLY A 360
 None
 1.06A 1kqbC-1q1lA:
undetectable
1kqbD-1q1lA:
undetectable		 1kqbC-1q1lA:
20.45
1kqbD-1q1lA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_D_BEZD523_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1q1l CHORISMATE SYNTHASE
(Aquifex
aeolicus) 		4 / 6 GLU A 361
GLY A 360
SER A 162
PHE A 228
 None
 1.05A 1kqbC-1q1lA:
undetectable
1kqbD-1q1lA:
undetectable		 1kqbC-1q1lA:
20.45
1kqbD-1q1lA:
20.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 1q1l CHORISMATE SYNTHASE
(Aquifex
aeolicus) 		8 / 11 ARG A  44
ALA A 136
THR A 139
ILE A 260
MET A 320
ALA A 352
ALA A 356
VAL A 359
 None
 0.48A 2qhfA-1q1lA:
40.9		 2qhfA-1q1lA:
44.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 1q1l CHORISMATE SYNTHASE
(Aquifex
aeolicus) 		5 / 11 ARG A  44
MET A 320
ILE A 323
ALA A 352
ALA A 356
 None
 0.92A 2qhfA-1q1lA:
40.9		 2qhfA-1q1lA:
44.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 1q1l CHORISMATE SYNTHASE
(Aquifex
aeolicus) 		3 / 3 GLU A  40
HIS A 191
GLU A 361
 None
 0.88A 2x45C-1q1lA:
undetectable		 2x45C-1q1lA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 1q1l CHORISMATE SYNTHASE
(Aquifex
aeolicus) 		5 / 11 ALA A 262
GLY A 226
ILE A 260
VAL A 353
ALA A 356
 None
 0.85A 3dcmX-1q1lA:
undetectable		 3dcmX-1q1lA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 1q1l CHORISMATE SYNTHASE
(Aquifex
aeolicus) 		3 / 3 GLU A  40
SER A 162
VAL A 230
 None
 0.79A 3eeoA-1q1lA:
undetectable		 3eeoA-1q1lA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 1q1l CHORISMATE SYNTHASE
(Aquifex
aeolicus) 		4 / 6 GLY A  18
ARG A  44
GLU A 138
ARG A 133
 None
 1.48A 4bqfA-1q1lA:
undetectable		 4bqfA-1q1lA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1q1l CHORISMATE SYNTHASE
(Aquifex
aeolicus) 		4 / 8 PHE A 163
ILE A 201
VAL A 172
PHE A 203
 None
 0.98A 4dx7B-1q1lA:
2.5		 4dx7B-1q1lA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1q1l CHORISMATE SYNTHASE
(Aquifex
aeolicus) 		4 / 8 LEU A   6
LEU A 239
ILE A  26
VAL A 384
 None
 0.82A 4klaA-1q1lA:
undetectable		 4klaA-1q1lA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 1q1l CHORISMATE SYNTHASE
(Aquifex
aeolicus) 		3 / 3 ASN A 299
PHE A 231
TYR A 190
 None
 0.75A 4u15A-1q1lA:
undetectable		 4u15A-1q1lA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2G_B_CTCB222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 1q1l CHORISMATE SYNTHASE
(Aquifex
aeolicus) 		5 / 12 SER A 298
ASN A 299
PHE A 181
ARG A 276
VAL A 282
 None
 1.47A 4v2gB-1q1lA:
undetectable		 4v2gB-1q1lA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 1q1l CHORISMATE SYNTHASE
(Aquifex
aeolicus) 		4 / 6 PHE A 181
ARG A 317
GLU A 171
VAL A 172
 None
 1.38A 5h4dA-1q1lA:
undetectable		 5h4dA-1q1lA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 1q1l CHORISMATE SYNTHASE
(Aquifex
aeolicus) 		4 / 6 PHE A 181
ARG A 317
PHE A 163
VAL A 172
 None
 1.30A 5h4dA-1q1lA:
undetectable		 5h4dA-1q1lA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 1q1l CHORISMATE SYNTHASE
(Aquifex
aeolicus) 		3 / 3 LYS A 186
LYS A 178
SER A 179
 None
 1.44A 5odiA-1q1lA:
undetectable		 5odiA-1q1lA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_A_NIZA808_1
(CATALASE-PEROXIDASE)		 1q1l CHORISMATE SYNTHASE
(Aquifex
aeolicus) 		4 / 8 ARG A 137
GLU A 132
GLY A  12
LEU A  19
 None
 0.93A 5sxqA-1q1lA:
undetectable		 5sxqA-1q1lA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_A_NIZA807_1
(CATALASE-PEROXIDASE)		 1q1l CHORISMATE SYNTHASE
(Aquifex
aeolicus) 		4 / 8 ARG A 137
GLU A 132
GLY A  12
LEU A  19
 None
 0.89A 5sxtA-1q1lA:
undetectable		 5sxtA-1q1lA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_B_NIZB808_1
(CATALASE-PEROXIDASE)		 1q1l CHORISMATE SYNTHASE
(Aquifex
aeolicus) 		4 / 8 ARG A 137
GLU A 132
GLY A  12
LEU A  19
 None
 0.88A 5sxtB-1q1lA:
undetectable		 5sxtB-1q1lA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 1q1l CHORISMATE SYNTHASE
(Aquifex
aeolicus) 		4 / 8 ARG A 137
GLU A 132
GLY A  12
LEU A  19
 None
 0.93A 5syjB-1q1lA:
undetectable		 5syjB-1q1lA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 1q1l CHORISMATE SYNTHASE
(Aquifex
aeolicus) 		4 / 7 SER A 357
SER A 162
HIS A 191
GLY A 161
 None
 0.94A 6btxA-1q1lA:
undetectable		 6btxA-1q1lA:
22.40