SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1q20'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		 1q20 SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
B
(Homo
sapiens) 		3 / 3 ASP A  61
PHE A  64
VAL A  58
 None
 0.70A 1kijB-1q20A:
undetectable		 1kijB-1q20A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 1q20 SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
B
(Homo
sapiens) 		4 / 7 TYR A 159
HIS A 192
TYR A  68
GLY A 146
 None
 1.27A 1mxgA-1q20A:
undetectable		 1mxgA-1q20A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1q20 SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
B
(Homo
sapiens) 		5 / 10 ILE A  66
LEU A 206
LYS A 141
ILE A  80
ILE A  65
 None
 1.28A 1rb3A-1q20A:
undetectable		 1rb3A-1q20A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 1q20 SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
B
(Homo
sapiens) 		4 / 4 LEU A 121
PRO A  89
ILE A  83
LEU A  84
 None
 1.03A 1ya4B-1q20A:
0.5		 1ya4B-1q20A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 1q20 SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
B
(Homo
sapiens) 		4 / 4 LEU A 121
PRO A  89
ILE A  83
LEU A  84
 None
 1.01A 1ya4C-1q20A:
0.2		 1ya4C-1q20A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 1q20 SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
B
(Homo
sapiens) 		4 / 6 TYR A  34
GLY A 109
PHE A 111
SER A 112
 None
 1.28A 2a3cA-1q20A:
undetectable		 2a3cA-1q20A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 1q20 SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
B
(Homo
sapiens) 		4 / 6 TYR A  34
GLY A 109
PHE A 111
SER A 112
 None
 1.35A 2a3cB-1q20A:
undetectable		 2a3cB-1q20A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 1q20 SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
B
(Homo
sapiens) 		3 / 3 GLU A 211
ASP A 310
TYR A 297
 None
 0.65A 2yvlB-1q20A:
undetectable		 2yvlB-1q20A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 1q20 SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
B
(Homo
sapiens) 		5 / 12 ASP A  19
THR A 106
SER A  48
LEU A 113
PRO A 114
 None
PLO  A 401 ( 4.0A)
None
None
None
 1.29A 3cl9A-1q20A:
undetectable		 3cl9A-1q20A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 1q20 SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
B
(Homo
sapiens) 		5 / 12 ILE A  77
SER A 255
PRO A  96
LEU A 260
PRO A 261
 None
 1.26A 3cl9A-1q20A:
undetectable		 3cl9A-1q20A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 1q20 SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
B
(Homo
sapiens) 		4 / 6 PHE A 190
TYR A 297
VAL A 152
PHE A 293
 None
 1.34A 3ltwA-1q20A:
undetectable		 3ltwA-1q20A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1q20 SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
B
(Homo
sapiens) 		4 / 7 ASP A  62
SER A 124
PHE A  64
ASP A  57
 None
 1.29A 4odjA-1q20A:
undetectable		 4odjA-1q20A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 1q20 SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
B
(Homo
sapiens) 		5 / 12 TYR A  31
GLY A 164
GLY A  29
SER A 160
ALA A 163
 None
NA  A 313 ( 4.4A)
None
None
NA  A 313 (-4.5A)
 1.11A 4qtuD-1q20A:
undetectable		 4qtuD-1q20A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 1q20 SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
B
(Homo
sapiens) 		4 / 5 SER A 220
GLY A 219
ARG A 223
GLU A 212
 None
 0.97A 4r82A-1q20A:
undetectable
4r82B-1q20A:
undetectable		 4r82A-1q20A:
22.48
4r82B-1q20A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 1q20 SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
B
(Homo
sapiens) 		4 / 5 ARG A 147
GLY A 146
GLU A 211
SER A 123
 A3P  A 314 (-3.0A)
None
None
None
 1.21A 4z3oA-1q20A:
1.7
4z3oB-1q20A:
undetectable		 4z3oA-1q20A:
17.33
4z3oB-1q20A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1q20 SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
B
(Homo
sapiens) 		4 / 5 SER A 123
ARG A 147
GLY A 146
GLU A 211
 None
A3P  A 314 (-3.0A)
None
None
 1.00A 5btiC-1q20A:
undetectable
5btiD-1q20A:
undetectable		 5btiC-1q20A:
20.24
5btiD-1q20A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		 1q20 SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
B
(Homo
sapiens) 		4 / 7 LEU A 121
ILE A 224
LEU A 206
MET A 145
 None
 0.91A 5fxtA-1q20A:
undetectable		 5fxtA-1q20A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 1q20 SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
B
(Homo
sapiens) 		3 / 3 TYR A  44
TYR A 159
GLN A 185
 None
 1.00A 5jsdA-1q20A:
0.0
5jsdB-1q20A:
0.0		 5jsdA-1q20A:
16.62
5jsdB-1q20A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 1q20 SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
B
(Homo
sapiens) 		3 / 3 TYR A 159
TYR A  44
GLN A 165
 None
None
PLO  A 401 (-4.1A)
 0.82A 5jsdA-1q20A:
0.0
5jsdB-1q20A:
0.0		 5jsdA-1q20A:
16.62
5jsdB-1q20A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		 1q20 SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
B
(Homo
sapiens) 		3 / 3 TYR A  44
TYR A 159
GLN A 185
 None
 1.01A 5jsdB-1q20A:
undetectable
5jsdC-1q20A:
undetectable		 5jsdB-1q20A:
16.62
5jsdC-1q20A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		 1q20 SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
B
(Homo
sapiens) 		3 / 3 TYR A 159
TYR A  44
GLN A 165
 None
None
PLO  A 401 (-4.1A)
 0.81A 5jsdB-1q20A:
undetectable
5jsdC-1q20A:
undetectable		 5jsdB-1q20A:
16.62
5jsdC-1q20A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 1q20 SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
B
(Homo
sapiens) 		5 / 12 VAL A  58
ASP A  57
SER A 138
THR A  67
ARG A 120
 None
None
None
A3P  A 314 ( 4.9A)
None
 1.34A 5m50B-1q20A:
undetectable		 5m50B-1q20A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 1q20 SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
B
(Homo
sapiens) 		5 / 12 VAL A  58
ASP A  57
SER A 138
THR A  67
ARG A 120
 None
None
None
A3P  A 314 ( 4.9A)
None
 1.30A 5m50E-1q20A:
undetectable		 5m50E-1q20A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 1q20 SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
B
(Homo
sapiens) 		5 / 12 VAL A  58
ASP A  57
SER A 138
THR A  67
ARG A 120
 None
None
None
A3P  A 314 ( 4.9A)
None
 1.35A 5m54B-1q20A:
undetectable		 5m54B-1q20A:
20.27