SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1q25'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N6C_A_SAMA402_0
(SET
DOMAIN-CONTAINING
PROTEIN 7)		 1q25 CATION-INDEPENDENT
MANNOSE 6-PHOSPHATE
RECEPTOR
(Bos
taurus) 		5 / 11 ALA A 157
GLY A 156
GLU A 178
ASN A 172
TYR A 226
 None
 1.50A 1n6cA-1q25A:
2.8		 1n6cA-1q25A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 1q25 CATION-INDEPENDENT
MANNOSE 6-PHOSPHATE
RECEPTOR
(Bos
taurus) 		4 / 7 ALA A 360
TYR A 421
TYR A 327
PHE A 423
 None
 1.19A 2ajvH-1q25A:
undetectable
2ajvL-1q25A:
undetectable		 2ajvH-1q25A:
18.78
2ajvL-1q25A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_B_CLUB809_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 1q25 CATION-INDEPENDENT
MANNOSE 6-PHOSPHATE
RECEPTOR
(Bos
taurus) 		4 / 6 ALA A 108
ASP A  21
TYR A  28
HIS A 113
 None
 0.94A 2pncB-1q25A:
0.0		 2pncB-1q25A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 1q25 CATION-INDEPENDENT
MANNOSE 6-PHOSPHATE
RECEPTOR
(Bos
taurus) 		3 / 3 SER A  59
GLY A  61
SER A  44
 None
 0.52A 3loqA-1q25A:
undetectable		 3loqA-1q25A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUN_A_CCSA165_0
(LYSOZYME)		 1q25 CATION-INDEPENDENT
MANNOSE 6-PHOSPHATE
RECEPTOR
(Bos
taurus) 		3 / 3 ASN A 172
ALA A 157
LYS A 153
 None
 0.59A 3runA-1q25A:
undetectable		 3runA-1q25A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_1
(GLUCOCORTICOID
RECEPTOR)		 1q25 CATION-INDEPENDENT
MANNOSE 6-PHOSPHATE
RECEPTOR
(Bos
taurus) 		5 / 12 LEU A 214
GLY A 213
TRP A  17
THR A  99
ILE A 152
 None
 1.28A 4udcA-1q25A:
undetectable		 4udcA-1q25A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1q25 CATION-INDEPENDENT
MANNOSE 6-PHOSPHATE
RECEPTOR
(Bos
taurus) 		5 / 10 LEU A 214
GLY A 213
VAL A 217
LEU A 216
ALA A 138
 None
 1.18A 5o96E-1q25A:
undetectable
5o96F-1q25A:
undetectable		 5o96E-1q25A:
20.21
5o96F-1q25A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_1
(MRNA CAPPING ENZYME
P5)		 1q25 CATION-INDEPENDENT
MANNOSE 6-PHOSPHATE
RECEPTOR
(Bos
taurus) 		3 / 3 TYR A  28
ASP A  51
ASP A  21
 None
 0.73A 5x6yA-1q25A:
undetectable		 5x6yA-1q25A:
18.89