SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1q2e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_A_RBFA301_1
(PROTEIN (FLAVODOXIN))		 1q2e EXOCELLOBIOHYDROLASE
I
(Trichoderma
reesei) 		4 / 7 ASN A 198
THR A  55
TRP A 192
GLY A  53
 None
 1.00A 1bu5A-1q2eA:
undetectable		 1bu5A-1q2eA:
16.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DY4_A_SNPA437_1
(EXOGLUCANASE 1)		 1q2e EXOCELLOBIOHYDROLASE
I
(Trichoderma
reesei) 		10 / 12 ALA A 143
TYR A 145
TYR A 171
ASP A 173
SER A 174
GLN A 175
GLU A 212
ASP A 214
GLU A 217
ASP A 369
 None
None
None
None
None
GLC  A 904 (-3.5A)
None
GLC  A 904 (-3.9A)
GLC  A 904 (-2.9A)
None
 0.30A 1dy4A-1q2eA:
70.9		 1dy4A-1q2eA:
97.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DY4_A_SNPA437_2
(EXOGLUCANASE 1)		 1q2e EXOCELLOBIOHYDROLASE
I
(Trichoderma
reesei) 		5 / 5 HIS A 228
TRP A 367
TYR A 371
ALA A 372
TRP A 376
 GLC  A 904 (-4.0A)
None
None
None
GLC  A 904 (-3.5A)
 0.32A 1dy4A-1q2eA:
70.9		 1dy4A-1q2eA:
97.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_C_CCSC47_0
(GLUTATHIONE
S-TRANSFERASE)		 1q2e EXOCELLOBIOHYDROLASE
I
(Trichoderma
reesei) 		4 / 6 THR A   5
GLY A  75
LYS A 166
TYR A 167
 None
 1.23A 1gtiC-1q2eA:
undetectable		 1gtiC-1q2eA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 1q2e EXOCELLOBIOHYDROLASE
I
(Trichoderma
reesei) 		5 / 7 THR A   5
LEU A  73
GLY A  75
LYS A 166
TYR A 167
 None
PCA  A   1 ( 4.9A)
None
None
None
 1.39A 1gtiD-1q2eA:
0.0		 1gtiD-1q2eA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_F_CCSF47_0
(GLUTATHIONE
S-TRANSFERASE)		 1q2e EXOCELLOBIOHYDROLASE
I
(Trichoderma
reesei) 		5 / 5 THR A   5
LEU A  73
GLY A  75
LYS A 166
TYR A 167
 None
PCA  A   1 ( 4.9A)
None
None
None
 1.42A 1gtiF-1q2eA:
0.0		 1gtiF-1q2eA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1q2e EXOCELLOBIOHYDROLASE
I
(Trichoderma
reesei) 		4 / 6 PHE A 418
VAL A 416
LEU A 136
PHE A 129
 None
 1.01A 1wrlB-1q2eA:
undetectable		 1wrlB-1q2eA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)		 1q2e EXOCELLOBIOHYDROLASE
I
(Trichoderma
reesei) 		4 / 6 TYR A 167
ASP A  74
THR A  10
GLU A   9
 None
 1.50A 2dttB-1q2eA:
0.0
2dttC-1q2eA:
0.0		 2dttB-1q2eA:
13.38
2dttC-1q2eA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1002_0
(ALDEHYDE
DEHYDROGENASE A)		 1q2e EXOCELLOBIOHYDROLASE
I
(Trichoderma
reesei) 		3 / 3 GLY A 168
ARG A  39
TYR A 109
 None
 0.77A 2opxA-1q2eA:
undetectable		 2opxA-1q2eA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VD0_B_D27B1200_0
(GLUTATHIONE-REQUIRIN
G PROSTAGLANDIN D
SYNTHASE)		 1q2e EXOCELLOBIOHYDROLASE
I
(Trichoderma
reesei) 		5 / 10 GLY A  75
TRP A  40
ALA A  43
TYR A  82
LEU A   6
 None
 1.35A 2vd0B-1q2eA:
undetectable		 2vd0B-1q2eA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 1q2e EXOCELLOBIOHYDROLASE
I
(Trichoderma
reesei) 		5 / 12 THR A  66
THR A  55
TRP A  56
VAL A 189
ALA A 187
 None
 1.27A 2x2iA-1q2eA:
undetectable		 2x2iA-1q2eA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1q2e EXOCELLOBIOHYDROLASE
I
(Trichoderma
reesei) 		4 / 5 GLN A 293
THR A 292
THR A 356
LEU A 349
 None
 1.33A 3ce6A-1q2eA:
undetectable		 3ce6A-1q2eA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1q2e EXOCELLOBIOHYDROLASE
I
(Trichoderma
reesei) 		4 / 5 GLN A 293
THR A 292
THR A 356
LEU A 349
 None
 1.28A 3ce6C-1q2eA:
undetectable		 3ce6C-1q2eA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB2_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1q2e EXOCELLOBIOHYDROLASE
I
(Trichoderma
reesei) 		3 / 3 LEU A 318
LEU A 268
ARG A 394
 None
None
SGC  A 902 ( 3.5A)
 0.69A 3hcnB-1q2eA:
undetectable		 3hcnB-1q2eA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_B_DX4B270_0
(PTERIDINE REDUCTASE
1)		 1q2e EXOCELLOBIOHYDROLASE
I
(Trichoderma
reesei) 		4 / 6 SER A 365
ASP A 214
TYR A 145
PRO A 177
 None
GLC  A 904 (-3.9A)
None
None
 1.50A 3jqaB-1q2eA:
undetectable		 3jqaB-1q2eA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 1q2e EXOCELLOBIOHYDROLASE
I
(Trichoderma
reesei) 		4 / 6 SER A 365
ASP A 214
TYR A 145
PRO A 177
 None
GLC  A 904 (-3.9A)
None
None
 1.49A 3jqaD-1q2eA:
undetectable		 3jqaD-1q2eA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1q2e EXOCELLOBIOHYDROLASE
I
(Trichoderma
reesei) 		3 / 3 TYR A 158
GLY A 154
ASP A 152
 None
 0.62A 3ou6C-1q2eA:
undetectable		 3ou6C-1q2eA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 1q2e EXOCELLOBIOHYDROLASE
I
(Trichoderma
reesei) 		5 / 9 ILE A 300
TYR A 330
ALA A 224
LEU A 225
ALA A 299
 None
 1.09A 3ozvB-1q2eA:
undetectable		 3ozvB-1q2eA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_2
(SECRETED ASPARTIC
PROTEASE)		 1q2e EXOCELLOBIOHYDROLASE
I
(Trichoderma
reesei) 		4 / 6 PRO A  13
SER A  80
THR A  85
THR A  86
 None
 0.91A 3tneA-1q2eA:
undetectable		 3tneA-1q2eA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 1q2e EXOCELLOBIOHYDROLASE
I
(Trichoderma
reesei) 		4 / 4 LEU A 136
GLY A 142
MET A 374
PHE A  95
 None
 1.45A 3vaqB-1q2eA:
0.0		 3vaqB-1q2eA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1q2e EXOCELLOBIOHYDROLASE
I
(Trichoderma
reesei) 		5 / 11 GLY A 170
ALA A 165
GLY A 153
MET A 149
VAL A 361
 None
 1.34A 4c5lA-1q2eA:
undetectable		 4c5lA-1q2eA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1q2e EXOCELLOBIOHYDROLASE
I
(Trichoderma
reesei) 		5 / 9 GLY A 170
ALA A 165
GLY A 153
MET A 149
VAL A 361
 None
 1.31A 4c5lB-1q2eA:
undetectable		 4c5lB-1q2eA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1q2e EXOCELLOBIOHYDROLASE
I
(Trichoderma
reesei) 		5 / 10 GLY A 170
ALA A 165
GLY A 153
MET A 149
VAL A 361
 None
 1.34A 4c5lC-1q2eA:
undetectable		 4c5lC-1q2eA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1q2e EXOCELLOBIOHYDROLASE
I
(Trichoderma
reesei) 		5 / 10 GLY A 170
ALA A 165
GLY A 153
MET A 149
VAL A 361
 None
 1.32A 4c5lD-1q2eA:
undetectable		 4c5lD-1q2eA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1q2e EXOCELLOBIOHYDROLASE
I
(Trichoderma
reesei) 		5 / 10 GLY A 170
ALA A 165
GLY A 153
MET A 149
VAL A 361
 None
 1.42A 4c5nD-1q2eA:
undetectable		 4c5nD-1q2eA:
21.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IPM_A_ACTA503_0
(GH7 FAMILY PROTEIN)		 1q2e EXOCELLOBIOHYDROLASE
I
(Trichoderma
reesei) 		9 / 9 ASN A 141
ALA A 143
TYR A 145
TYR A 171
ASP A 173
GLU A 212
ASP A 214
GLU A 217
TRP A 367
 None
None
None
None
None
None
GLC  A 904 (-3.9A)
GLC  A 904 (-2.9A)
None
 0.53A 4ipmA-1q2eA:
61.3		 4ipmA-1q2eA:
53.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 1q2e EXOCELLOBIOHYDROLASE
I
(Trichoderma
reesei) 		3 / 3 SER A 342
ASP A 259
GLN A 175
 None
SGC  A 902 ( 4.7A)
GLC  A 904 (-3.5A)
 0.70A 4oltA-1q2eA:
undetectable
4oltB-1q2eA:
undetectable		 4oltA-1q2eA:
19.62
4oltB-1q2eA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 1q2e EXOCELLOBIOHYDROLASE
I
(Trichoderma
reesei) 		4 / 8 THR A 332
SER A 344
ASP A 328
ASP A 329
 None
 1.35A 4qb9D-1q2eA:
undetectable		 4qb9D-1q2eA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 1q2e EXOCELLOBIOHYDROLASE
I
(Trichoderma
reesei) 		4 / 5 TYR A 171
SER A 365
ASP A 214
ASP A 262
 None
None
GLC  A 904 (-3.9A)
GLC  A 903 ( 4.0A)
 1.02A 4qtuB-1q2eA:
undetectable		 4qtuB-1q2eA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1q2e EXOCELLOBIOHYDROLASE
I
(Trichoderma
reesei) 		4 / 8 THR A 231
GLY A 254
GLY A 253
ASP A 259
 None
None
None
SGC  A 902 ( 4.7A)
 0.84A 4qvvY-1q2eA:
undetectable
4qvvZ-1q2eA:
undetectable		 4qvvY-1q2eA:
19.91
4qvvZ-1q2eA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 1q2e EXOCELLOBIOHYDROLASE
I
(Trichoderma
reesei) 		3 / 3 GLN A 175
SER A 342
ASP A 259
 GLC  A 904 (-3.5A)
None
SGC  A 902 ( 4.7A)
 0.67A 4qwpA-1q2eA:
undetectable
4qwpB-1q2eA:
undetectable		 4qwpA-1q2eA:
20.84
4qwpB-1q2eA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		 1q2e EXOCELLOBIOHYDROLASE
I
(Trichoderma
reesei) 		5 / 12 ILE A 421
VAL A 290
VAL A 291
LEU A 362
THR A 429
 None
 1.20A 5bykA-1q2eA:
undetectable		 5bykA-1q2eA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 1q2e EXOCELLOBIOHYDROLASE
I
(Trichoderma
reesei) 		4 / 7 GLY A 164
ASP A  35
ILE A  34
VAL A  33
 None
 0.82A 5ik1A-1q2eA:
undetectable		 5ik1A-1q2eA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 1q2e EXOCELLOBIOHYDROLASE
I
(Trichoderma
reesei) 		3 / 3 PRO A 382
ARG A 394
GLU A 385
 None
SGC  A 902 ( 3.5A)
MGL  A 901 ( 4.9A)
 0.95A 5j6hA-1q2eA:
undetectable		 5j6hA-1q2eA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 1q2e EXOCELLOBIOHYDROLASE
I
(Trichoderma
reesei) 		5 / 11 GLN A 186
ASP A 150
TYR A 171
PRO A 177
LEU A 180
 None
 1.16A 5jh7D-1q2eA:
undetectable		 5jh7D-1q2eA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 1q2e EXOCELLOBIOHYDROLASE
I
(Trichoderma
reesei) 		5 / 12 GLY A 185
ASP A 150
GLY A 153
GLY A 170
ALA A  36
 PCA  A   1 ( 3.3A)
None
None
None
None
 1.08A 6nj9K-1q2eA:
undetectable		 6nj9K-1q2eA:
20.17