SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1q2l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)		 1q2l PROTEASE III
(Escherichia
coli) 		4 / 8 LEU A 575
LEU A 634
ALA A 637
LYS A 638
 None
 0.55A 1e7cA-1q2lA:
undetectable		 1e7cA-1q2lA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 1q2l PROTEASE III
(Escherichia
coli) 		4 / 7 LEU A 323
GLY A 316
LEU A 314
TYR A 375
 None
 1.06A 1gtiD-1q2lA:
undetectable		 1gtiD-1q2lA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 1q2l PROTEASE III
(Escherichia
coli) 		5 / 12 HIS A 118
HIS A  92
GLU A  91
HIS A  88
GLU A 169
 None
ZN  A 963 (-3.2A)
ZN  A 963 (-3.8A)
ZN  A 963 (-3.2A)
ZN  A 963 (-2.1A)
 1.15A 1j36A-1q2lA:
undetectable		 1j36A-1q2lA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 1q2l PROTEASE III
(Escherichia
coli) 		5 / 12 HIS A 118
HIS A  92
GLU A  91
HIS A  88
GLU A 169
 None
ZN  A 963 (-3.2A)
ZN  A 963 (-3.8A)
ZN  A 963 (-3.2A)
ZN  A 963 (-2.1A)
 1.16A 1j36B-1q2lA:
undetectable		 1j36B-1q2lA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_2
(POL POLYPROTEIN)		 1q2l PROTEASE III
(Escherichia
coli) 		3 / 3 ASP A 736
VAL A 739
PRO A 764
 None
 0.77A 2avvA-1q2lA:
undetectable		 2avvA-1q2lA:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 1q2l PROTEASE III
(Escherichia
coli) 		5 / 12 HIS A 118
HIS A  92
GLU A  91
HIS A  88
GLU A 169
 None
ZN  A 963 (-3.2A)
ZN  A 963 (-3.8A)
ZN  A 963 (-3.2A)
ZN  A 963 (-2.1A)
 1.17A 2c6nB-1q2lA:
undetectable		 2c6nB-1q2lA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCU_A_TYLA3001_1
(LACTOTRANSFERRIN)		 1q2l PROTEASE III
(Escherichia
coli) 		3 / 3 LEU A 218
TYR A  89
GLY A 201
 None
 0.54A 2ocuA-1q2lA:
undetectable		 2ocuA-1q2lA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 1q2l PROTEASE III
(Escherichia
coli) 		5 / 10 LEU A 620
LEU A 724
LEU A 554
VAL A 604
PHE A 617
 None
 1.12A 2w9gA-1q2lA:
undetectable		 2w9gA-1q2lA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 1q2l PROTEASE III
(Escherichia
coli) 		5 / 12 HIS A 118
HIS A  92
GLU A  91
HIS A  88
GLU A 169
 None
ZN  A 963 (-3.2A)
ZN  A 963 (-3.8A)
ZN  A 963 (-3.2A)
ZN  A 963 (-2.1A)
 1.16A 2x91A-1q2lA:
undetectable		 2x91A-1q2lA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		 1q2l PROTEASE III
(Escherichia
coli) 		6 / 11 SER A  98
ALA A 148
LEU A 111
LEU A 131
LEU A 145
LEU A 138
 None
 1.38A 2xn5A-1q2lA:
0.0		 2xn5A-1q2lA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 1q2l PROTEASE III
(Escherichia
coli) 		4 / 6 ARG A 304
ILE A  34
GLN A  31
GLU A  32
 PT  A2005 (-3.9A)
None
None
None
 1.24A 2ya7C-1q2lA:
undetectable		 2ya7C-1q2lA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1q2l PROTEASE III
(Escherichia
coli) 		4 / 5 LEU A 206
GLN A  84
THR A 205
HIS A  92
 None
None
None
ZN  A 963 (-3.2A)
 1.36A 3n58C-1q2lA:
undetectable		 3n58C-1q2lA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1q2l PROTEASE III
(Escherichia
coli) 		4 / 6 GLU A 524
ILE A 526
GLU A 710
ALA A 537
 None
 1.04A 3pgyA-1q2lA:
undetectable
3pgyB-1q2lA:
undetectable		 3pgyA-1q2lA:
20.19
3pgyB-1q2lA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD393_1
(TETX2 PROTEIN)		 1q2l PROTEASE III
(Escherichia
coli) 		4 / 5 ILE A  47
GLN A  45
ILE A  34
GLU A 425
 None
 1.25A 4a99D-1q2lA:
1.2		 4a99D-1q2lA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1q2l PROTEASE III
(Escherichia
coli) 		4 / 6 LEU A  67
ARG A  42
VAL A  71
ALA A 128
 None
 0.95A 4nkxA-1q2lA:
0.0		 4nkxA-1q2lA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 1q2l PROTEASE III
(Escherichia
coli) 		4 / 8 ILE A 315
ALA A 370
PHE A 373
LEU A 376
 None
 0.64A 4v1fA-1q2lA:
undetectable
4v1fB-1q2lA:
undetectable		 4v1fA-1q2lA:
6.25
4v1fB-1q2lA:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_1
(THYROXINE-BINDING
GLOBULIN)		 1q2l PROTEASE III
(Escherichia
coli) 		5 / 10 SER A 260
LEU A  86
LEU A  90
SER A 227
LEU A 154
 None
 1.08A 4yiaA-1q2lA:
0.0		 4yiaA-1q2lA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 1q2l PROTEASE III
(Escherichia
coli) 		5 / 10 ALA A  82
GLY A  85
LEU A  86
ALA A 217
ASP A 220
 None
 1.49A 5ajqB-1q2lA:
undetectable		 5ajqB-1q2lA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1q2l PROTEASE III
(Escherichia
coli) 		3 / 3 PHE A 129
ILE A 149
ASP A 143
 None
 0.72A 5cswA-1q2lA:
0.6		 5cswA-1q2lA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 1q2l PROTEASE III
(Escherichia
coli) 		4 / 7 VAL A  58
LEU A 428
VAL A 424
THR A 427
 None
 1.04A 5e4dA-1q2lA:
2.0
5e4dB-1q2lA:
2.2		 5e4dA-1q2lA:
13.31
5e4dB-1q2lA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1q2l PROTEASE III
(Escherichia
coli) 		5 / 12 VAL A 333
ILE A 311
ARG A 318
ILE A 336
LEU A 376
 None
 0.93A 5hbsA-1q2lA:
undetectable		 5hbsA-1q2lA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 1q2l PROTEASE III
(Escherichia
coli) 		5 / 8 ILE A 372
LEU A 376
ILE A 353
ILE A 336
SER A 319
 None
 1.29A 5numA-1q2lA:
undetectable		 5numA-1q2lA:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 1q2l PROTEASE III
(Escherichia
coli) 		4 / 6 LEU A 314
SER A 324
ARG A 318
GLY A 316
 None
 0.99A 5o4yF-1q2lA:
undetectable		 5o4yF-1q2lA:
1.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 1q2l PROTEASE III
(Escherichia
coli) 		4 / 6 GLU A 769
ARG A 810
ASP A 888
ASP A 881
 None
 1.28A 5zw4A-1q2lA:
undetectable		 5zw4A-1q2lA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 1q2l PROTEASE III
(Escherichia
coli) 		3 / 3 SER A 874
LYS A 875
SER A 877
 None
 0.55A 6az3P-1q2lA:
0.0		 6az3P-1q2lA:
6.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 1q2l PROTEASE III
(Escherichia
coli) 		4 / 7 ALA A 912
PHE A 851
ILE A 782
PHE A 816
 None
 0.87A 6b5vA-1q2lA:
undetectable
6b5vB-1q2lA:
undetectable		 6b5vA-1q2lA:
6.69
6b5vB-1q2lA:
6.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 1q2l PROTEASE III
(Escherichia
coli) 		4 / 6 GLN A  31
GLU A  32
ALA A  46
GLN A  45
 None
 1.39A 6f6jC-1q2lA:
0.0
6f6jD-1q2lA:
0.0		 6f6jC-1q2lA:
18.54
6f6jD-1q2lA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1q2l PROTEASE III
(Escherichia
coli) 		4 / 7 TYR A 281
VAL A 368
ILE A 456
GLY A 178
 None
 0.81A 6hd6B-1q2lA:
undetectable		 6hd6B-1q2lA:
7.97