SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1q33'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_A_BEZA1162_0
(PEROXIREDOXIN 5)		 1q33 ADP-RIBOSE
PYROPHOSPHATASE
(Homo
sapiens) 		5 / 10 PRO A 213
GLY A 214
LEU A 253
PHE A 257
GLY A 232
 None
BGC  A 400 (-4.1A)
None
None
None
 1.32A 1h4oA-1q33A:
undetectable
1h4oB-1q33A:
undetectable		 1h4oA-1q33A:
21.43
1h4oB-1q33A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_2
(PROTEASE)		 1q33 ADP-RIBOSE
PYROPHOSPHATASE
(Homo
sapiens) 		6 / 12 GLY A 303
ALA A 306
ASP A 305
GLY A 215
VAL A 200
ILE A 202
 None
None
None
BGC  A 400 (-3.3A)
None
None
 1.40A 1muiB-1q33A:
undetectable		 1muiB-1q33A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 1q33 ADP-RIBOSE
PYROPHOSPHATASE
(Homo
sapiens) 		4 / 5 LEU A 300
ALA A 302
LEU A 236
SER A 238
 None
 1.09A 1tt6B-1q33A:
undetectable		 1tt6B-1q33A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		 1q33 ADP-RIBOSE
PYROPHOSPHATASE
(Homo
sapiens) 		3 / 3 ARG A 148
SER A  68
TYR A  70
 None
 0.67A 1x70A-1q33A:
0.0		 1x70A-1q33A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_A_BEZA1162_0
(PEROXIREDOXIN-5)		 1q33 ADP-RIBOSE
PYROPHOSPHATASE
(Homo
sapiens) 		5 / 10 PRO A 213
GLY A 214
LEU A 253
PHE A 257
GLY A 232
 None
BGC  A 400 (-4.1A)
None
None
None
 1.26A 2vl2A-1q33A:
undetectable
2vl2C-1q33A:
0.0		 2vl2A-1q33A:
22.00
2vl2C-1q33A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 1q33 ADP-RIBOSE
PYROPHOSPHATASE
(Homo
sapiens) 		4 / 8 GLY A 166
ASN A 125
HIS A 169
GLU A 281
 None
 0.89A 2x0pA-1q33A:
undetectable		 2x0pA-1q33A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA301_1
(CHITOSANASE)		 1q33 ADP-RIBOSE
PYROPHOSPHATASE
(Homo
sapiens) 		3 / 3 TYR A 140
GLY A 166
PRO A 167
 None
 0.40A 4qwpA-1q33A:
0.0		 4qwpA-1q33A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 1q33 ADP-RIBOSE
PYROPHOSPHATASE
(Homo
sapiens) 		4 / 5 GLY A 158
PRO A  71
THR A 275
THR A 100
 None
 1.27A 5h5fA-1q33A:
undetectable		 5h5fA-1q33A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)		 1q33 ADP-RIBOSE
PYROPHOSPHATASE
(Homo
sapiens) 		3 / 3 THR A 100
PRO A 147
ARG A 148
 None
 0.87A 5nd7B-1q33A:
undetectable		 5nd7B-1q33A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)		 1q33 ADP-RIBOSE
PYROPHOSPHATASE
(Homo
sapiens) 		3 / 3 THR A 275
THR A 154
ARG A  77
 None
 0.77A 5wm2A-1q33A:
undetectable		 5wm2A-1q33A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 1q33 ADP-RIBOSE
PYROPHOSPHATASE
(Homo
sapiens) 		5 / 9 ILE A 142
GLY A 166
PHE A 124
TYR A 268
ALA A 151
 None
 1.25A 5x66C-1q33A:
undetectable		 5x66C-1q33A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 1q33 ADP-RIBOSE
PYROPHOSPHATASE
(Homo
sapiens) 		5 / 10 ILE A 142
GLY A 166
PHE A 124
TYR A 268
ALA A 151
 None
 1.24A 5x66D-1q33A:
undetectable		 5x66D-1q33A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 1q33 ADP-RIBOSE
PYROPHOSPHATASE
(Homo
sapiens) 		3 / 3 ALA A 278
VAL A 269
TYR A 268
 None
BGC  A 400 (-4.5A)
None
 0.68A 5zmqH-1q33A:
undetectable		 5zmqH-1q33A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 1q33 ADP-RIBOSE
PYROPHOSPHATASE
(Homo
sapiens) 		4 / 6 GLY A 152
ASN A 149
ASP A 276
ARG A  66
 None
 0.96A 6dwdA-1q33A:
undetectable
6dwdC-1q33A:
undetectable		 6dwdA-1q33A:
19.35
6dwdC-1q33A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 1q33 ADP-RIBOSE
PYROPHOSPHATASE
(Homo
sapiens) 		4 / 5 GLY A 152
ASN A 149
ASP A 276
ARG A  66
 None
 0.95A 6dwdB-1q33A:
undetectable
6dwdD-1q33A:
undetectable		 6dwdB-1q33A:
19.35
6dwdD-1q33A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 1q33 ADP-RIBOSE
PYROPHOSPHATASE
(Homo
sapiens) 		4 / 5 ARG A  66
GLY A 152
ASN A 149
ASP A 276
 None
 0.95A 6dwjB-1q33A:
undetectable
6dwjD-1q33A:
undetectable		 6dwjB-1q33A:
19.35
6dwjD-1q33A:
19.35