SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1q3b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)		 1q3b ENDONUCLEASE VIII
(Escherichia
coli) 		3 / 3 PHE A 153
LEU A 197
LEU A 201
 None
 0.68A 1mx1E-1q3bA:
undetectable		 1mx1E-1q3bA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 1q3b ENDONUCLEASE VIII
(Escherichia
coli) 		3 / 3 ASP A  61
THR A  63
GLU A  48
 None
 0.82A 1pj7A-1q3bA:
undetectable		 1pj7A-1q3bA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 1q3b ENDONUCLEASE VIII
(Escherichia
coli) 		5 / 11 LEU A  89
ILE A  17
THR A  99
VAL A  47
THR A  56
 None
 1.33A 1tw4A-1q3bA:
0.0		 1tw4A-1q3bA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1131_0
(FATTY ACID-BINDING
PROTEIN)		 1q3b ENDONUCLEASE VIII
(Escherichia
coli) 		5 / 10 LEU A  89
ILE A  17
THR A  99
VAL A  47
THR A  56
 None
 1.34A 1tw4B-1q3bA:
0.0		 1tw4B-1q3bA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1q3b ENDONUCLEASE VIII
(Escherichia
coli) 		3 / 3 LEU A  54
LEU A 111
MET A 110
 None
 0.83A 2itzA-1q3bA:
undetectable		 2itzA-1q3bA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 1q3b ENDONUCLEASE VIII
(Escherichia
coli) 		5 / 12 LEU A  32
PHE A  29
ILE A 108
LEU A  64
ASP A  24
 None
 1.23A 3ko0A-1q3bA:
1.4
3ko0B-1q3bA:
1.5
3ko0C-1q3bA:
undetectable
3ko0D-1q3bA:
1.3		 3ko0A-1q3bA:
17.05
3ko0B-1q3bA:
17.05
3ko0C-1q3bA:
17.05
3ko0D-1q3bA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)		 1q3b ENDONUCLEASE VIII
(Escherichia
coli) 		5 / 12 ASP A  24
LEU A  32
PHE A  29
ILE A 108
LEU A  64
 None
 1.22A 3ko0G-1q3bA:
1.4
3ko0H-1q3bA:
1.4
3ko0I-1q3bA:
1.4
3ko0J-1q3bA:
1.4		 3ko0G-1q3bA:
17.05
3ko0H-1q3bA:
17.05
3ko0I-1q3bA:
17.05
3ko0J-1q3bA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ202_1
(PROTEIN S100-A4)		 1q3b ENDONUCLEASE VIII
(Escherichia
coli) 		5 / 11 ASP A  24
LEU A  64
LEU A  32
PHE A  29
ILE A 108
 None
 1.25A 3ko0A-1q3bA:
1.4
3ko0B-1q3bA:
1.5
3ko0I-1q3bA:
1.4
3ko0J-1q3bA:
1.4		 3ko0A-1q3bA:
17.05
3ko0B-1q3bA:
17.05
3ko0I-1q3bA:
17.05
3ko0J-1q3bA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)		 1q3b ENDONUCLEASE VIII
(Escherichia
coli) 		5 / 12 LEU A  32
PHE A  29
ILE A 108
LEU A  64
ASP A  24
 None
 1.21A 3ko0K-1q3bA:
0.3
3ko0L-1q3bA:
undetectable
3ko0S-1q3bA:
0.8
3ko0T-1q3bA:
undetectable		 3ko0K-1q3bA:
17.05
3ko0L-1q3bA:
17.05
3ko0S-1q3bA:
17.05
3ko0T-1q3bA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 1q3b ENDONUCLEASE VIII
(Escherichia
coli) 		5 / 12 LEU A  64
LEU A  32
PHE A  29
ILE A 108
ASP A  24
 None
 1.22A 3ko0K-1q3bA:
0.3
3ko0L-1q3bA:
undetectable
3ko0M-1q3bA:
0.3
3ko0N-1q3bA:
undetectable		 3ko0K-1q3bA:
17.05
3ko0L-1q3bA:
17.05
3ko0M-1q3bA:
17.05
3ko0N-1q3bA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 1q3b ENDONUCLEASE VIII
(Escherichia
coli) 		5 / 12 LEU A  32
PHE A  29
ILE A 108
LEU A  64
ASP A  24
 None
 1.22A 3ko0M-1q3bA:
0.3
3ko0N-1q3bA:
undetectable
3ko0O-1q3bA:
undetectable
3ko0P-1q3bA:
undetectable		 3ko0M-1q3bA:
17.05
3ko0N-1q3bA:
17.05
3ko0O-1q3bA:
17.05
3ko0P-1q3bA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP202_1
(PROTEIN S100-A4)		 1q3b ENDONUCLEASE VIII
(Escherichia
coli) 		5 / 12 ASP A  24
LEU A  64
LEU A  32
PHE A  29
ILE A 108
 None
 1.20A 3ko0M-1q3bA:
0.3
3ko0N-1q3bA:
undetectable
3ko0O-1q3bA:
undetectable
3ko0P-1q3bA:
undetectable		 3ko0M-1q3bA:
17.05
3ko0N-1q3bA:
17.05
3ko0O-1q3bA:
17.05
3ko0P-1q3bA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 1q3b ENDONUCLEASE VIII
(Escherichia
coli) 		4 / 8 ALA A  28
THR A  56
VAL A  44
PHE A  58
 None
 0.96A 4ltwA-1q3bA:
undetectable		 4ltwA-1q3bA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1q3b ENDONUCLEASE VIII
(Escherichia
coli) 		4 / 6 PHE A 148
ARG A 147
PRO A 146
THR A 117
 None
 0.96A 5ih0A-1q3bA:
1.8		 5ih0A-1q3bA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 1q3b ENDONUCLEASE VIII
(Escherichia
coli) 		4 / 7 ARG A 142
LEU A 157
PHE A 153
ARG A 149
 None
 0.92A 5vc0A-1q3bA:
undetectable		 5vc0A-1q3bA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1q3b ENDONUCLEASE VIII
(Escherichia
coli) 		5 / 8 GLY A  19
LEU A  55
VAL A  47
ILE A  17
LEU A  22
 None
 1.08A 5vkqB-1q3bA:
undetectable
5vkqC-1q3bA:
undetectable		 5vkqB-1q3bA:
10.37
5vkqC-1q3bA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1q3b ENDONUCLEASE VIII
(Escherichia
coli) 		4 / 8 GLY A 182
LEU A 175
GLN A 261
LEU A 197
 None
 0.86A 6czmD-1q3bA:
undetectable
6czmF-1q3bA:
undetectable		 6czmD-1q3bA:
21.98
6czmF-1q3bA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 1q3b ENDONUCLEASE VIII
(Escherichia
coli) 		3 / 3 LYS A  98
VAL A  76
ASP A  78
 None
GOL  A 351 (-4.2A)
None
 0.65A 6fgdA-1q3bA:
undetectable		 6fgdA-1q3bA:
22.09