SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1q3k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EVE_A_E20A2001_1
(ACETYLCHOLINESTERASE)		 1q3k CREATININASE
(Pseudomonas
putida) 		5 / 10 GLY A 119
TYR A 153
GLU A  34
LEU A 242
HIS A  36
 None
None
ZN  A 300 (-2.5A)
None
ZN  A 301 (-3.3A)
 1.48A 1eveA-1q3kA:
undetectable		 1eveA-1q3kA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1q3k CREATININASE
(Pseudomonas
putida) 		4 / 4 ILE A 103
LEU A 106
VAL A 111
ALA A  21
 None
 0.98A 1mz9A-1q3kA:
undetectable		 1mz9A-1q3kA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1q3k CREATININASE
(Pseudomonas
putida) 		4 / 5 ILE A 103
LEU A 106
VAL A 111
ALA A  21
 None
 0.98A 1mz9C-1q3kA:
undetectable		 1mz9C-1q3kA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 1q3k CREATININASE
(Pseudomonas
putida) 		4 / 8 GLU A 183
VAL A  44
GLU A 122
ASP A  45
 ZN  A 301 (-2.1A)
None
ZN  A 300 ( 4.5A)
ZN  A 301 ( 2.3A)
 1.22A 1s3zA-1q3kA:
undetectable
1s3zB-1q3kA:
undetectable		 1s3zA-1q3kA:
20.75
1s3zB-1q3kA:
20.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 1q3k CREATININASE
(Pseudomonas
putida) 		8 / 8 GLU A  34
HIS A  36
ASP A  45
HIS A 120
TYR A 121
TRP A 154
HIS A 178
GLU A 183
 ZN  A 300 (-2.5A)
ZN  A 301 (-3.3A)
ZN  A 301 ( 2.3A)
ZN  A 300 (-3.5A)
None
None
ZN  A 300 ( 4.9A)
ZN  A 301 (-2.1A)
 0.16A 1v7zA-1q3kA:
43.4		 1v7zA-1q3kA:
96.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 1q3k CREATININASE
(Pseudomonas
putida) 		8 / 8 GLU A  34
HIS A  36
ASP A  45
HIS A 120
TYR A 121
TRP A 154
HIS A 178
GLU A 183
 ZN  A 300 (-2.5A)
ZN  A 301 (-3.3A)
ZN  A 301 ( 2.3A)
ZN  A 300 (-3.5A)
None
None
ZN  A 300 ( 4.9A)
ZN  A 301 (-2.1A)
 0.13A 1v7zB-1q3kA:
43.5		 1v7zB-1q3kA:
96.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 1q3k CREATININASE
(Pseudomonas
putida) 		8 / 8 GLU A  34
HIS A  36
ASP A  45
HIS A 120
TYR A 121
TRP A 154
HIS A 178
GLU A 183
 ZN  A 300 (-2.5A)
ZN  A 301 (-3.3A)
ZN  A 301 ( 2.3A)
ZN  A 300 (-3.5A)
None
None
ZN  A 300 ( 4.9A)
ZN  A 301 (-2.1A)
 0.12A 1v7zC-1q3kA:
43.5		 1v7zC-1q3kA:
96.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 1q3k CREATININASE
(Pseudomonas
putida) 		8 / 8 GLU A  34
HIS A  36
ASP A  45
HIS A 120
TYR A 121
TRP A 154
HIS A 178
GLU A 183
 ZN  A 300 (-2.5A)
ZN  A 301 (-3.3A)
ZN  A 301 ( 2.3A)
ZN  A 300 (-3.5A)
None
None
ZN  A 300 ( 4.9A)
ZN  A 301 (-2.1A)
 0.16A 1v7zD-1q3kA:
43.4		 1v7zD-1q3kA:
96.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 1q3k CREATININASE
(Pseudomonas
putida) 		8 / 8 GLU A  34
HIS A  36
ASP A  45
HIS A 120
TYR A 121
TRP A 154
HIS A 178
GLU A 183
 ZN  A 300 (-2.5A)
ZN  A 301 (-3.3A)
ZN  A 301 ( 2.3A)
ZN  A 300 (-3.5A)
None
None
ZN  A 300 ( 4.9A)
ZN  A 301 (-2.1A)
 0.14A 1v7zE-1q3kA:
43.6		 1v7zE-1q3kA:
96.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 1q3k CREATININASE
(Pseudomonas
putida) 		8 / 8 GLU A  34
HIS A  36
ASP A  45
HIS A 120
TYR A 121
TRP A 154
HIS A 178
GLU A 183
 ZN  A 300 (-2.5A)
ZN  A 301 (-3.3A)
ZN  A 301 ( 2.3A)
ZN  A 300 (-3.5A)
None
None
ZN  A 300 ( 4.9A)
ZN  A 301 (-2.1A)
 0.11A 1v7zF-1q3kA:
43.5		 1v7zF-1q3kA:
96.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 1q3k CREATININASE
(Pseudomonas
putida) 		5 / 12 THR A  98
ILE A 127
VAL A  30
VAL A  99
LEU A  28
 GOL  A 902 ( 4.8A)
None
None
None
None
 1.13A 1z9hD-1q3kA:
undetectable		 1z9hD-1q3kA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 1q3k CREATININASE
(Pseudomonas
putida) 		4 / 7 TYR A 153
GLU A  34
HIS A 178
GLY A  79
 None
ZN  A 300 (-2.5A)
ZN  A 300 ( 4.9A)
None
 1.17A 2ha4B-1q3kA:
3.5		 2ha4B-1q3kA:
18.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 1q3k CREATININASE
(Pseudomonas
putida) 		8 / 8 GLU A  34
HIS A  36
ASP A  45
HIS A 120
TYR A 121
TRP A 154
HIS A 178
GLU A 183
 ZN  A 300 (-2.5A)
ZN  A 301 (-3.3A)
ZN  A 301 ( 2.3A)
ZN  A 300 (-3.5A)
None
None
ZN  A 300 ( 4.9A)
ZN  A 301 (-2.1A)
 0.26A 3a6jA-1q3kA:
43.2		 3a6jA-1q3kA:
96.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 1q3k CREATININASE
(Pseudomonas
putida) 		7 / 7 GLU A  34
HIS A  36
ASP A  45
HIS A 120
TYR A 121
HIS A 178
GLU A 183
 ZN  A 300 (-2.5A)
ZN  A 301 (-3.3A)
ZN  A 301 ( 2.3A)
ZN  A 300 (-3.5A)
None
ZN  A 300 ( 4.9A)
ZN  A 301 (-2.1A)
 0.30A 3a6jB-1q3kA:
42.7		 3a6jB-1q3kA:
96.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 1q3k CREATININASE
(Pseudomonas
putida) 		8 / 8 GLU A  34
HIS A  36
ASP A  45
HIS A 120
TYR A 121
TRP A 154
HIS A 178
GLU A 183
 ZN  A 300 (-2.5A)
ZN  A 301 (-3.3A)
ZN  A 301 ( 2.3A)
ZN  A 300 (-3.5A)
None
None
ZN  A 300 ( 4.9A)
ZN  A 301 (-2.1A)
 0.25A 3a6jC-1q3kA:
42.8		 3a6jC-1q3kA:
96.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 1q3k CREATININASE
(Pseudomonas
putida) 		8 / 8 GLU A  34
HIS A  36
ASP A  45
HIS A 120
TYR A 121
TRP A 154
HIS A 178
GLU A 183
 ZN  A 300 (-2.5A)
ZN  A 301 (-3.3A)
ZN  A 301 ( 2.3A)
ZN  A 300 (-3.5A)
None
None
ZN  A 300 ( 4.9A)
ZN  A 301 (-2.1A)
 0.28A 3a6jE-1q3kA:
42.7		 3a6jE-1q3kA:
96.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 1q3k CREATININASE
(Pseudomonas
putida) 		8 / 8 GLU A  34
HIS A  36
ASP A  45
HIS A 120
TYR A 121
TRP A 154
HIS A 178
GLU A 183
 ZN  A 300 (-2.5A)
ZN  A 301 (-3.3A)
ZN  A 301 ( 2.3A)
ZN  A 300 (-3.5A)
None
None
ZN  A 300 ( 4.9A)
ZN  A 301 (-2.1A)
 0.24A 3a6jF-1q3kA:
42.8		 3a6jF-1q3kA:
96.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 1q3k CREATININASE
(Pseudomonas
putida) 		4 / 6 GLY A 130
ARG A 139
GLU A 137
ARG A 104
 None
 1.27A 4bqfA-1q3kA:
2.1		 4bqfA-1q3kA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DPR_A_X8ZA702_1
(LEUKOTRIENE A-4
HYDROLASE)		 1q3k CREATININASE
(Pseudomonas
putida) 		5 / 9 TYR A 121
GLY A  79
HIS A  36
GLU A  34
GLU A 183
 None
None
ZN  A 301 (-3.3A)
ZN  A 300 (-2.5A)
ZN  A 301 (-2.1A)
 1.45A 4dprA-1q3kA:
undetectable		 4dprA-1q3kA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_B_TEPB402_1
(PYRIDOXAL KINASE)		 1q3k CREATININASE
(Pseudomonas
putida) 		4 / 5 SER A  78
HIS A  83
VAL A 216
ASP A 212
 None
 1.32A 4eohB-1q3kA:
2.5		 4eohB-1q3kA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 1q3k CREATININASE
(Pseudomonas
putida) 		5 / 12 HIS A 178
THR A 226
HIS A 120
GLY A 180
MET A  40
 ZN  A 300 ( 4.9A)
None
ZN  A 300 (-3.5A)
None
None
 1.35A 4lvcB-1q3kA:
3.2		 4lvcB-1q3kA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_D_ACTD301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 1q3k CREATININASE
(Pseudomonas
putida) 		4 / 4 ASP A  45
HIS A  36
HIS A 178
HIS A 120
 ZN  A 301 ( 2.3A)
ZN  A 301 (-3.3A)
ZN  A 300 ( 4.9A)
ZN  A 300 (-3.5A)
 1.44A 5ncdD-1q3kA:
undetectable		 5ncdD-1q3kA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_0
(REGULATORY PROTEIN
TETR)		 1q3k CREATININASE
(Pseudomonas
putida) 		5 / 12 ALA A 250
GLU A 256
LEU A 151
VAL A  25
PHE A 257
 None
 1.37A 5vlmH-1q3kA:
0.0		 5vlmH-1q3kA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGQ_B_ESTB601_1
(ESTROGEN RECEPTOR)		 1q3k CREATININASE
(Pseudomonas
putida) 		5 / 10 GLU A 239
LEU A 190
MET A  40
HIS A  39
LEU A 197
 None
 1.49A 5wgqB-1q3kA:
0.0		 5wgqB-1q3kA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA503_1
(CYTOCHROME P450 2C9)		 1q3k CREATININASE
(Pseudomonas
putida) 		4 / 6 PHE A  84
PRO A  85
GLY A  86
THR A  87
 None
 0.73A 5x24A-1q3kA:
undetectable		 5x24A-1q3kA:
19.95