SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1q3s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1q3s THERMOSOME ALPHA
SUBUNIT
(Thermococcus
sp.
JCM
11816) 		3 / 3 THR A 450
LEU A 451
VAL A 481
 None
ADP  A1528 (-4.2A)
ADP  A1528 (-3.8A)
 0.66A 1mz9E-1q3sA:
undetectable		 1mz9E-1q3sA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1q3s THERMOSOME ALPHA
SUBUNIT
(Thermococcus
sp.
JCM
11816) 		3 / 3 THR A 459
LEU A 463
VAL A 466
 None
 0.39A 1mz9E-1q3sA:
undetectable		 1mz9E-1q3sA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)		 1q3s THERMOSOME ALPHA
SUBUNIT
(Thermococcus
sp.
JCM
11816) 		6 / 12 THR A  99
ILE A 479
GLY A 411
ILE A 447
GLU A 483
PRO A  45
 ADP  A1528 (-3.7A)
None
ADP  A1528 (-3.4A)
ADP  A1528 ( 4.7A)
None
ADP  A1528 (-4.1A)
 1.23A 1nv8B-1q3sA:
undetectable		 1nv8B-1q3sA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 1q3s THERMOSOME ALPHA
SUBUNIT
(Thermococcus
sp.
JCM
11816) 		5 / 12 THR A  99
ILE A 479
GLY A 411
GLU A 483
PRO A  45
 ADP  A1528 (-3.7A)
None
ADP  A1528 (-3.4A)
None
ADP  A1528 (-4.1A)
 1.00A 1sg9B-1q3sA:
undetectable		 1sg9B-1q3sA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 1q3s THERMOSOME ALPHA
SUBUNIT
(Thermococcus
sp.
JCM
11816) 		6 / 12 THR A  99
ILE A 479
GLY A 411
ILE A 447
GLU A 483
PRO A  45
 ADP  A1528 (-3.7A)
None
ADP  A1528 (-3.4A)
ADP  A1528 ( 4.7A)
None
ADP  A1528 (-4.1A)
 1.18A 1vq1B-1q3sA:
undetectable		 1vq1B-1q3sA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_B_ROFB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 1q3s THERMOSOME ALPHA
SUBUNIT
(Thermococcus
sp.
JCM
11816) 		4 / 5 ASN A 258
THR A 260
GLN A 264
PHE A 268
 None
 1.44A 1xmuB-1q3sA:
undetectable		 1xmuB-1q3sA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)		 1q3s THERMOSOME ALPHA
SUBUNIT
(Thermococcus
sp.
JCM
11816) 		4 / 4 VAL A 234
LEU A 339
ILE A 242
LEU A 241
 None
 0.82A 2byoA-1q3sA:
undetectable		 2byoA-1q3sA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1q3s THERMOSOME ALPHA
SUBUNIT
(Thermococcus
sp.
JCM
11816) 		4 / 6 LEU A 108
VAL A 500
VAL A  85
ILE A 505
 None
 0.96A 2hyyA-1q3sA:
undetectable		 2hyyA-1q3sA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)		 1q3s THERMOSOME ALPHA
SUBUNIT
(Thermococcus
sp.
JCM
11816) 		5 / 12 ALA A 175
LEU A 155
LEU A 154
ILE A 495
GLY A 493
 None
 1.08A 2yjaB-1q3sA:
2.3		 2yjaB-1q3sA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_2
(PHOSPHOLIPASE A2)		 1q3s THERMOSOME ALPHA
SUBUNIT
(Thermococcus
sp.
JCM
11816) 		5 / 9 VAL A 349
GLY A 365
THR A 328
GLY A 345
ARG A 233
 None
 1.46A 3bjwG-1q3sA:
2.3		 3bjwG-1q3sA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_1
(PROTEASE)		 1q3s THERMOSOME ALPHA
SUBUNIT
(Thermococcus
sp.
JCM
11816) 		5 / 8 GLY A 411
ALA A 410
GLY A 476
ILE A 477
ILE A 494
 ADP  A1528 (-3.4A)
ADP  A1528 (-3.2A)
None
None
ADP  A1528 ( 4.1A)
 1.01A 3ekpA-1q3sA:
undetectable		 3ekpA-1q3sA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_A_ESLA700_1
(ESTROGEN RECEPTOR)		 1q3s THERMOSOME ALPHA
SUBUNIT
(Thermococcus
sp.
JCM
11816) 		5 / 12 ALA A 175
LEU A 155
LEU A 154
ILE A 495
GLY A 493
 None
 1.04A 3q95A-1q3sA:
2.1		 3q95A-1q3sA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_1
(ASPARTYL PROTEASE)		 1q3s THERMOSOME ALPHA
SUBUNIT
(Thermococcus
sp.
JCM
11816) 		5 / 12 LEU A  74
ALA A  31
ILE A 515
GLY A 105
VAL A  83
 None
 0.95A 4dqfA-1q3sA:
undetectable		 4dqfA-1q3sA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OQR_A_2UOA502_1
(CYP105AS1)		 1q3s THERMOSOME ALPHA
SUBUNIT
(Thermococcus
sp.
JCM
11816) 		5 / 9 ILE A 332
ALA A 330
THR A 328
VAL A 219
ALA A 371
 None
 1.21A 4oqrA-1q3sA:
undetectable		 4oqrA-1q3sA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1q3s THERMOSOME ALPHA
SUBUNIT
(Thermococcus
sp.
JCM
11816) 		5 / 12 ILE A 446
ALA A  36
MET A  82
LEU A 108
ILE A 103
 None
 1.03A 4ptjA-1q3sA:
undetectable		 4ptjA-1q3sA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1q3s THERMOSOME ALPHA
SUBUNIT
(Thermococcus
sp.
JCM
11816) 		3 / 3 VAL A 336
LEU A 339
VAL A 333
 None
 0.62A 4wq4A-1q3sA:
undetectable		 4wq4A-1q3sA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_1
(ESTROGEN RECEPTOR)		 1q3s THERMOSOME ALPHA
SUBUNIT
(Thermococcus
sp.
JCM
11816) 		5 / 12 ALA A 175
LEU A 155
LEU A 154
ILE A 495
GLY A 493
 None
 0.96A 4xi3B-1q3sA:
undetectable		 4xi3B-1q3sA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 1q3s THERMOSOME ALPHA
SUBUNIT
(Thermococcus
sp.
JCM
11816) 		4 / 6 ASP A 278
THR A 286
PRO A 341
THR A 340
 None
 1.09A 4yoaA-1q3sA:
undetectable		 4yoaA-1q3sA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1q3s THERMOSOME ALPHA
SUBUNIT
(Thermococcus
sp.
JCM
11816) 		5 / 12 GLY A 431
GLU A 438
ILE A 437
GLN A 117
ILE A 119
 None
 1.04A 4zvmA-1q3sA:
undetectable
4zvmB-1q3sA:
undetectable		 4zvmA-1q3sA:
17.84
4zvmB-1q3sA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 1q3s THERMOSOME ALPHA
SUBUNIT
(Thermococcus
sp.
JCM
11816) 		5 / 10 LEU A 408
ALA A 413
GLU A 415
GLY A 493
LEU A 490
 None
 1.37A 5dxbA-1q3sA:
undetectable		 5dxbA-1q3sA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)		 1q3s THERMOSOME ALPHA
SUBUNIT
(Thermococcus
sp.
JCM
11816) 		5 / 11 ALA A 175
LEU A 155
LEU A 154
ILE A 495
GLY A 493
 None
 1.04A 5dxbB-1q3sA:
0.4		 5dxbB-1q3sA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 1q3s THERMOSOME ALPHA
SUBUNIT
(Thermococcus
sp.
JCM
11816) 		5 / 12 ALA A 175
LEU A 155
LEU A 154
ILE A 495
GLY A 493
 None
 1.01A 5gtrA-1q3sA:
2.5		 5gtrA-1q3sA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 1q3s THERMOSOME ALPHA
SUBUNIT
(Thermococcus
sp.
JCM
11816) 		5 / 8 ALA A 504
LEU A 139
LEU A 408
LEU A 444
LEU A 418
 None
 1.36A 5jqbA-1q3sA:
undetectable
5jqbB-1q3sA:
undetectable		 5jqbA-1q3sA:
19.29
5jqbB-1q3sA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1q3s THERMOSOME ALPHA
SUBUNIT
(Thermococcus
sp.
JCM
11816) 		4 / 5 LEU A 139
LYS A 501
LEU A 418
GLU A 415
 None
ADP  A1528 ( 4.3A)
None
None
 1.20A 5weaA-1q3sA:
2.8		 5weaA-1q3sA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1q3s THERMOSOME ALPHA
SUBUNIT
(Thermococcus
sp.
JCM
11816) 		5 / 9 GLY A 478
VAL A 466
GLU A 469
ASP A 480
PRO A 448
 None
None
None
ADP  A1528 (-4.5A)
None
 1.21A 5zniA-1q3sA:
undetectable		 5zniA-1q3sA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1q3s THERMOSOME ALPHA
SUBUNIT
(Thermococcus
sp.
JCM
11816) 		5 / 9 GLY A 478
VAL A 466
GLU A 469
GLY A 411
PRO A 448
 None
None
None
ADP  A1528 (-3.4A)
None
 1.09A 5zniA-1q3sA:
undetectable		 5zniA-1q3sA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_D_AQ4D602_0
(CYTOCHROME P450 1A1)		 1q3s THERMOSOME ALPHA
SUBUNIT
(Thermococcus
sp.
JCM
11816) 		5 / 12 ASP A 519
GLY A  21
ALA A  24
ASP A  23
ILE A 522
 None
 1.08A 6dwnD-1q3sA:
undetectable		 6dwnD-1q3sA:
10.08