SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1q3x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		7 / 8 HIS A 483
ASP A 627
SER A 628
SER A 633
VAL A 653
GLY A 656
GLY A 667
 None
NA  A 800 ( 4.6A)
GOL  A 701 (-3.4A)
GOL  A 701 (-3.0A)
GOL  A 701 (-4.9A)
GOL  A 701 ( 4.1A)
GOL  A 701 ( 4.0A)
 0.36A 1aq7A-1q3xA:
34.0		 1aq7A-1q3xA:
29.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		6 / 9 ASP A 627
SER A 633
VAL A 653
TRP A 655
GLY A 656
GLY A 667
 NA  A 800 ( 4.6A)
GOL  A 701 (-3.0A)
GOL  A 701 (-4.9A)
None
GOL  A 701 ( 4.1A)
GOL  A 701 ( 4.0A)
 0.43A 1bcuH-1q3xA:
35.9		 1bcuH-1q3xA:
28.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		5 / 9 HIS A 483
ASP A 627
SER A 633
TRP A 655
GLY A 667
 None
NA  A 800 ( 4.6A)
GOL  A 701 (-3.0A)
None
GOL  A 701 ( 4.0A)
 0.39A 1dwcH-1q3xA:
34.6		 1dwcH-1q3xA:
28.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		7 / 12 HIS A 483
ASP A 627
SER A 633
VAL A 653
TRP A 655
GLY A 656
GLY A 667
 None
NA  A 800 ( 4.6A)
GOL  A 701 (-3.0A)
GOL  A 701 (-4.9A)
None
GOL  A 701 ( 4.1A)
GOL  A 701 ( 4.0A)
 0.44A 1etrH-1q3xA:
34.4		 1etrH-1q3xA:
27.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		6 / 8 ASP A 627
SER A 628
SER A 633
VAL A 653
GLY A 656
GLY A 667
 NA  A 800 ( 4.6A)
GOL  A 701 (-3.4A)
GOL  A 701 (-3.0A)
GOL  A 701 (-4.9A)
GOL  A 701 ( 4.1A)
GOL  A 701 ( 4.0A)
 0.46A 1f5lA-1q3xA:
32.4		 1f5lA-1q3xA:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		4 / 7 THR A 670
LEU A 637
GLY A 635
LEU A 479
 None
 1.03A 1gtiE-1q3xA:
undetectable		 1gtiE-1q3xA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		5 / 8 ALA A 468
GLY A 635
ILE A 652
ILE A 536
ILE A 462
 None
 0.95A 1hshD-1q3xA:
undetectable		 1hshD-1q3xA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		5 / 9 GLY A 572
TRP A 573
ALA A 582
LEU A 581
GLY A 631
 None
 1.22A 1jb0A-1q3xA:
undetectable		 1jb0A-1q3xA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		5 / 12 ILE A 652
ILE A 548
ILE A 536
LEU A 538
VAL A 542
 None
 1.06A 1oipA-1q3xA:
undetectable		 1oipA-1q3xA:
20.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		6 / 6 ASP A 627
SER A 628
SER A 633
VAL A 653
GLY A 656
GLY A 667
 NA  A 800 ( 4.6A)
GOL  A 701 (-3.4A)
GOL  A 701 (-3.0A)
GOL  A 701 (-4.9A)
GOL  A 701 ( 4.1A)
GOL  A 701 ( 4.0A)
 0.31A 1tnlA-1q3xA:
34.0		 1tnlA-1q3xA:
30.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		5 / 12 ALA A 636
GLY A 470
LEU A 472
VAL A 653
GLY A 651
 None
None
None
GOL  A 701 (-4.9A)
None
 1.12A 2f8lA-1q3xA:
undetectable		 2f8lA-1q3xA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		3 / 3 LEU A 505
LEU A 585
MET A 586
 None
 0.86A 2itzA-1q3xA:
undetectable		 2itzA-1q3xA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		6 / 6 ASP A 627
SER A 628
SER A 633
VAL A 653
GLY A 656
GLY A 667
 NA  A 800 ( 4.6A)
GOL  A 701 (-3.4A)
GOL  A 701 (-3.0A)
GOL  A 701 (-4.9A)
GOL  A 701 ( 4.1A)
GOL  A 701 ( 4.0A)
 0.39A 2otvA-1q3xA:
34.1		 2otvA-1q3xA:
29.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		6 / 12 GLY A 574
GLY A 470
GLY A 634
GLY A 631
THR A 480
LEU A 479
 None
 1.35A 2oxtD-1q3xA:
undetectable		 2oxtD-1q3xA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		7 / 12 ASP A 627
SER A 633
VAL A 653
TRP A 655
GLY A 656
GLY A 667
TYR A 669
 NA  A 800 ( 4.6A)
GOL  A 701 (-3.0A)
GOL  A 701 (-4.9A)
None
GOL  A 701 ( 4.1A)
GOL  A 701 ( 4.0A)
None
 0.49A 2p16A-1q3xA:
34.1		 2p16A-1q3xA:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		5 / 12 TYR A 669
LEU A 637
ALA A 619
ASP A 589
PHE A 456
 None
 1.30A 2qo4A-1q3xA:
0.0		 2qo4A-1q3xA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		5 / 12 TYR A 669
LEU A 637
ALA A 619
ASP A 589
PHE A 456
 None
 1.29A 2qo6A-1q3xA:
undetectable		 2qo6A-1q3xA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		5 / 10 TYR A 523
HIS A 520
ALA A 482
ALA A 534
TYR A 675
 None
 1.39A 2r2vC-1q3xA:
undetectable
2r2vF-1q3xA:
undetectable
2r2vG-1q3xA:
undetectable		 2r2vC-1q3xA:
11.07
2r2vF-1q3xA:
11.07
2r2vG-1q3xA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		5 / 9 PHE A 456
ALA A 451
ALA A 570
GLY A 572
ILE A 445
 None
 1.35A 2v7bA-1q3xA:
undetectable		 2v7bA-1q3xA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		5 / 9 PHE A 456
ALA A 451
ALA A 570
GLY A 572
ILE A 445
 None
 1.34A 2v7bB-1q3xA:
undetectable		 2v7bB-1q3xA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		6 / 8 ASP A 627
SER A 628
SER A 633
VAL A 653
GLY A 656
GLY A 667
 NA  A 800 ( 4.6A)
GOL  A 701 (-3.4A)
GOL  A 701 (-3.0A)
GOL  A 701 (-4.9A)
GOL  A 701 ( 4.1A)
GOL  A 701 ( 4.0A)
 0.38A 2vinA-1q3xA:
33.2		 2vinA-1q3xA:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		7 / 12 ASP A 627
SER A 633
VAL A 653
TRP A 655
GLY A 656
GLY A 667
TYR A 669
 NA  A 800 ( 4.6A)
GOL  A 701 (-3.0A)
GOL  A 701 (-4.9A)
None
GOL  A 701 ( 4.1A)
GOL  A 701 ( 4.0A)
None
 0.47A 2w26A-1q3xA:
34.1		 2w26A-1q3xA:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		4 / 6 TRP A 573
SER A 571
ALA A 570
ASP A 632
 None
 1.08A 3aruA-1q3xA:
undetectable		 3aruA-1q3xA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_1
(PROTEASE)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		5 / 8 LEU A 495
ALA A 468
GLY A 635
ILE A 652
ILE A 462
 None
 1.11A 3ekpA-1q3xA:
undetectable		 3ekpA-1q3xA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_1
(PROTEASE)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		5 / 10 LEU A 538
GLY A 470
VAL A 517
LEU A 463
ILE A 536
 None
 0.90A 3em3A-1q3xA:
undetectable		 3em3A-1q3xA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		7 / 11 HIS A 483
ASP A 627
SER A 628
SER A 633
TRP A 655
GLY A 656
GLY A 667
 None
NA  A 800 ( 4.6A)
GOL  A 701 (-3.4A)
GOL  A 701 (-3.0A)
None
GOL  A 701 ( 4.1A)
GOL  A 701 ( 4.0A)
 0.30A 3gy3A-1q3xA:
33.6		 3gy3A-1q3xA:
29.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_A_URFA254_1
(URIDINE
PHOSPHORYLASE)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		4 / 6 GLY A 634
GLN A 459
ILE A 652
VAL A 653
 None
None
None
GOL  A 701 (-4.9A)
 1.14A 3kvvA-1q3xA:
undetectable		 3kvvA-1q3xA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_B_URFB254_1
(URIDINE
PHOSPHORYLASE)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		4 / 6 GLY A 634
GLN A 459
ILE A 652
VAL A 653
 None
None
None
GOL  A 701 (-4.9A)
 1.13A 3kvvB-1q3xA:
undetectable		 3kvvB-1q3xA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_C_URFC254_1
(URIDINE
PHOSPHORYLASE)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		4 / 6 GLY A 634
GLN A 459
ILE A 652
VAL A 653
 None
None
None
GOL  A 701 (-4.9A)
 1.15A 3kvvC-1q3xA:
undetectable		 3kvvC-1q3xA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_D_URFD254_1
(URIDINE
PHOSPHORYLASE)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		4 / 6 GLY A 634
GLN A 459
ILE A 652
VAL A 653
 None
None
None
GOL  A 701 (-4.9A)
 1.11A 3kvvD-1q3xA:
undetectable		 3kvvD-1q3xA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_E_URFE254_1
(URIDINE
PHOSPHORYLASE)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		4 / 6 GLY A 634
GLN A 459
ILE A 652
VAL A 653
 None
None
None
GOL  A 701 (-4.9A)
 1.14A 3kvvE-1q3xA:
undetectable		 3kvvE-1q3xA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_F_URFF254_1
(URIDINE
PHOSPHORYLASE)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		4 / 6 GLY A 634
GLN A 459
ILE A 652
VAL A 653
 None
None
None
GOL  A 701 (-4.9A)
 1.11A 3kvvF-1q3xA:
undetectable		 3kvvF-1q3xA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_A_PQNA847_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		5 / 9 GLY A 572
TRP A 573
ALA A 582
LEU A 581
GLY A 631
 None
 1.22A 3pcqA-1q3xA:
undetectable		 3pcqA-1q3xA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		6 / 6 SER A 628
SER A 633
VAL A 653
TRP A 655
GLY A 656
GLY A 667
 GOL  A 701 (-3.4A)
GOL  A 701 (-3.0A)
GOL  A 701 (-4.9A)
None
GOL  A 701 ( 4.1A)
GOL  A 701 ( 4.0A)
 0.35A 3rxfA-1q3xA:
13.6		 3rxfA-1q3xA:
29.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		5 / 5 ASP A 627
SER A 628
SER A 633
VAL A 653
GLY A 667
 NA  A 800 ( 4.6A)
GOL  A 701 (-3.4A)
GOL  A 701 (-3.0A)
GOL  A 701 (-4.9A)
GOL  A 701 ( 4.0A)
 0.35A 3rxhA-1q3xA:
34.1		 3rxhA-1q3xA:
29.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		5 / 12 GLY A 634
ALA A 484
THR A 466
ALA A 534
ALA A 636
 None
 1.26A 4df3A-1q3xA:
undetectable		 4df3A-1q3xA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		5 / 12 GLY A 634
ALA A 484
THR A 466
ALA A 534
ALA A 636
 None
 1.27A 4df3B-1q3xA:
undetectable		 4df3B-1q3xA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_F_URFF1301_1
(URIDINE
PHOSPHORYLASE)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		4 / 6 GLY A 634
GLN A 459
ILE A 652
VAL A 653
 None
None
None
GOL  A 701 (-4.9A)
 1.16A 4e1vF-1q3xA:
undetectable		 4e1vF-1q3xA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		3 / 3 PHE A 529
TYR A 486
TYR A 523
 None
 1.10A 4ffwA-1q3xA:
undetectable		 4ffwA-1q3xA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		5 / 12 HIS A 483
ASP A 627
VAL A 653
TRP A 655
GLY A 667
 None
NA  A 800 ( 4.6A)
GOL  A 701 (-4.9A)
None
GOL  A 701 ( 4.0A)
 0.23A 4hfpD-1q3xA:
34.5		 4hfpD-1q3xA:
28.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		5 / 12 LEU A 473
LEU A 472
LEU A 538
ILE A 679
ILE A 682
 GOL  A 700 ( 4.4A)
None
None
None
None
 1.12A 4j24A-1q3xA:
undetectable		 4j24A-1q3xA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		5 / 12 LEU A 473
LEU A 472
LEU A 538
ILE A 679
ILE A 682
 GOL  A 700 ( 4.4A)
None
None
None
None
 1.09A 4j24B-1q3xA:
undetectable		 4j24B-1q3xA:
20.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		5 / 12 HIS A 483
VAL A 653
TRP A 655
GLY A 656
GLY A 667
 None
GOL  A 701 (-4.9A)
None
GOL  A 701 ( 4.1A)
GOL  A 701 ( 4.0A)
 0.41A 4rn6B-1q3xA:
30.9		 4rn6B-1q3xA:
34.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		5 / 12 SER A 628
THR A 466
THR A 467
ALA A 468
ALA A 469
 GOL  A 701 (-3.4A)
None
None
None
None
 1.49A 4u15B-1q3xA:
undetectable		 4u15B-1q3xA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		5 / 12 GLU A 413
ASP A 415
ASP A 407
GLN A 393
ILE A 392
 None
 1.19A 4uroA-1q3xA:
undetectable		 4uroA-1q3xA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		5 / 12 GLY A 470
ALA A 636
ILE A 462
LEU A 472
VAL A 478
 None
 1.06A 4uw0A-1q3xA:
undetectable		 4uw0A-1q3xA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		5 / 12 SER A 633
ALA A 481
ASP A 532
PHE A 529
THR A 670
 GOL  A 701 (-3.0A)
None
None
None
None
 1.21A 4xt8A-1q3xA:
undetectable		 4xt8A-1q3xA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		4 / 6 TRP A 678
ILE A 533
ILE A 497
VAL A 460
 None
 0.98A 4zj8A-1q3xA:
undetectable		 4zj8A-1q3xA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		4 / 6 ILE A 462
VAL A 517
VAL A 485
SER A 514
 None
 0.90A 5jwaH-1q3xA:
undetectable		 5jwaH-1q3xA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8R_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		5 / 9 GLY A 572
TRP A 573
ALA A 582
LEU A 581
GLY A 631
 None
 1.26A 5l8rA-1q3xA:
undetectable		 5l8rA-1q3xA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		4 / 7 GLY A 574
GLY A 572
SER A 654
THR A 467
 None
 0.77A 5o96C-1q3xA:
undetectable		 5o96C-1q3xA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		5 / 10 ILE A 682
ILE A 683
LEU A 473
HIS A 490
ILE A 519
 None
None
GOL  A 700 ( 4.4A)
None
None
 1.32A 5vkqA-1q3xA:
0.0
5vkqD-1q3xA:
0.0		 5vkqA-1q3xA:
11.20
5vkqD-1q3xA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		5 / 10 HIS A 490
ILE A 519
ILE A 682
ILE A 683
LEU A 473
 None
None
None
None
GOL  A 700 ( 4.4A)
 1.31A 5vkqA-1q3xA:
0.0
5vkqB-1q3xA:
0.0		 5vkqA-1q3xA:
11.20
5vkqB-1q3xA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		5 / 10 HIS A 490
ILE A 519
ILE A 682
ILE A 683
LEU A 473
 None
None
None
None
GOL  A 700 ( 4.4A)
 1.31A 5vkqC-1q3xA:
0.0
5vkqD-1q3xA:
0.0		 5vkqC-1q3xA:
11.20
5vkqD-1q3xA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		4 / 8 GLY A 635
THR A 569
VAL A 638
LEU A 585
 None
 0.86A 6czmD-1q3xA:
undetectable
6czmF-1q3xA:
undetectable		 6czmD-1q3xA:
21.54
6czmF-1q3xA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_0
(HIV-1 PROTEASE)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		5 / 12 GLY A 667
GLY A 650
GLY A 651
VAL A 588
ILE A 590
 GOL  A 701 ( 4.0A)
None
None
None
None
 0.87A 6dj1A-1q3xA:
undetectable		 6dj1A-1q3xA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		5 / 10 GLY A 572
TRP A 573
ALA A 582
LEU A 581
GLY A 631
 None
 1.26A 6hqbA-1q3xA:
undetectable
6hqbJ-1q3xA:
undetectable		 6hqbA-1q3xA:
15.11
6hqbJ-1q3xA:
9.78