SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1q40'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 1q40 MRNA TRANSPORT
REGULATOR MTR2
(Candida
albicans) 		4 / 7 LEU A  85
ALA A 105
VAL A 146
VAL A 148
 None
 0.87A 1epbA-1q40A:
undetectable		 1epbA-1q40A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 1q40 MRNA TRANSPORT
REGULATOR MTR2
(Candida
albicans) 		3 / 3 ASP A  66
ILE A 163
VAL A  54
 None
 0.52A 2avvD-1q40A:
undetectable		 2avvD-1q40A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 1q40 MRNA TRANSPORT
REGULATOR MTR2
(Candida
albicans) 		3 / 3 PHE A  71
SER A  19
LEU A  17
 None
 0.77A 2w1bA-1q40A:
0.0		 2w1bA-1q40A:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_1
(PROTEASE)		 1q40 MRNA TRANSPORT
REGULATOR MTR2
(Candida
albicans) 		5 / 11 ILE A 163
GLY A  43
LEU A  42
VAL A  54
ILE A  52
 None
 0.88A 3em4U-1q40A:
undetectable		 3em4U-1q40A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_2
(PROTEASE)		 1q40 MRNA TRANSPORT
REGULATOR MTR2
(Candida
albicans) 		5 / 10 ILE A 163
GLY A  43
LEU A  42
VAL A  54
ILE A  52
 None
 0.83A 3em4V-1q40A:
undetectable		 3em4V-1q40A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 1q40 MRNA EXPORT FACTOR
MEX67
MRNA TRANSPORT
REGULATOR MTR2
(Candida
albicans) 		4 / 5 GLN B 398
THR B 495
HIS A  91
LEU B 385
 None
 1.35A 4lvcA-1q40B:
undetectable		 4lvcA-1q40B:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 1q40 MRNA EXPORT FACTOR
MEX67
MRNA TRANSPORT
REGULATOR MTR2
(Candida
albicans) 		4 / 5 GLN B 398
THR B 495
HIS A  91
LEU B 385
 None
 1.32A 4lvcC-1q40B:
undetectable		 4lvcC-1q40B:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA603_1
(CHITINASE)		 1q40 MRNA EXPORT FACTOR
MEX67
MRNA TRANSPORT
REGULATOR MTR2
(Candida
albicans) 		4 / 8 GLY A  56
GLU B 416
ASP B 476
ARG B 499
 None
 1.04A 5gqbA-1q40A:
undetectable		 5gqbA-1q40A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 1q40 MRNA EXPORT FACTOR
MEX67
(Candida
albicans) 		4 / 7 ASP B 494
THR B 495
LEU B 496
TYR B 316
 None
 0.84A 5ov9A-1q40B:
undetectable		 5ov9A-1q40B:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)		 1q40 MRNA EXPORT FACTOR
MEX67
(Candida
albicans) 		4 / 8 ILE B 498
ASN B 368
PRO B 469
PRO B 400
 None
 1.14A 5x23A-1q40B:
undetectable		 5x23A-1q40B:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA503_1
(CYTOCHROME P450 2C9)		 1q40 MRNA EXPORT FACTOR
MEX67
(Candida
albicans) 		5 / 12 ILE B 313
PHE B 479
PHE B 337
LEU B 317
PHE B 475
 None
 1.13A 5xxiA-1q40B:
undetectable		 5xxiA-1q40B:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_2
(-)		 1q40 MRNA EXPORT FACTOR
MEX67
MRNA TRANSPORT
REGULATOR MTR2
(Candida
albicans) 		4 / 5 GLN B 398
THR B 495
HIS A  91
LEU B 385
 None
 1.36A 6gbnA-1q40B:
undetectable		 6gbnA-1q40B:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_D_ADND501_2
(-)		 1q40 MRNA EXPORT FACTOR
MEX67
MRNA TRANSPORT
REGULATOR MTR2
(Candida
albicans) 		4 / 5 GLN B 398
THR B 495
HIS A  91
LEU B 385
 None
 1.36A 6gbnD-1q40B:
undetectable		 6gbnD-1q40B:
18.85