SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1q47'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 1q47 SEMAPHORIN 3A
(Mus
musculus) 		3 / 3 ASP A 223
ASN A 222
THR A 213
 None
 0.74A 2pymB-1q47A:
0.0		 2pymB-1q47A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_B_NOGB2001_1
(PROGESTERONE
RECEPTOR)		 1q47 SEMAPHORIN 3A
(Mus
musculus) 		5 / 12 GLN A 500
LEU A 512
LEU A  32
MET A 480
TYR A 520
 None
 1.24A 3d90B-1q47A:
undetectable		 3d90B-1q47A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 1q47 SEMAPHORIN 3A
(Mus
musculus) 		5 / 12 THR A 261
PHE A 226
ILE A 227
ASP A 306
ARG A 290
 None
 1.29A 3iv6D-1q47A:
undetectable		 3iv6D-1q47A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 1q47 SEMAPHORIN 3A
(Mus
musculus) 		4 / 5 ILE A 201
MET A 409
ASN A 411
PHE A 245
 None
 1.38A 3octA-1q47A:
undetectable		 3octA-1q47A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 1q47 SEMAPHORIN 3A
(Mus
musculus) 		3 / 3 HIS A 209
HIS A 208
ILE A 211
 None
 0.80A 3u52A-1q47A:
0.0
3u52C-1q47A:
undetectable		 3u52A-1q47A:
21.42
3u52C-1q47A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 1q47 SEMAPHORIN 3A
(Mus
musculus) 		3 / 3 HIS A 515
GLU A 478
ASN A  44
 None
 0.92A 4bupB-1q47A:
0.0		 4bupB-1q47A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 1q47 SEMAPHORIN 3A
(Mus
musculus) 		5 / 12 CYH A 517
VAL A 439
LEU A 494
PHE A 450
LEU A  32
 None
 1.31A 4rtbA-1q47A:
undetectable		 4rtbA-1q47A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1q47 SEMAPHORIN 3A
(Mus
musculus) 		4 / 5 ILE A 154
PHE A  80
HIS A 149
ASP A  63
 None
 1.25A 4rzvB-1q47A:
undetectable		 4rzvB-1q47A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIN_H_QI9H1226_0
(FAB 314.3)		 1q47 SEMAPHORIN 3A
(Mus
musculus) 		5 / 12 THR A 213
GLY A 266
ARG A 264
PHE A 226
PRO A 224
 None
 1.26A 4uinH-1q47A:
0.0
4uinL-1q47A:
0.0		 4uinH-1q47A:
18.79
4uinL-1q47A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CU6_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1q47 SEMAPHORIN 3A
(Mus
musculus) 		4 / 6 TYR A  36
ILE A 503
VAL A  45
ALA A 510
 None
 0.93A 5cu6A-1q47A:
undetectable		 5cu6A-1q47A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 1q47 SEMAPHORIN 3A
(Mus
musculus) 		5 / 12 ILE A 423
PHE A 328
GLY A 337
ILE A 292
ALA A 263
 None
 0.98A 5e72A-1q47A:
undetectable		 5e72A-1q47A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 1q47 SEMAPHORIN 3A
(Mus
musculus) 		3 / 3 PRO A 415
LEU A 308
SER A 294
 None
 0.67A 5fsaB-1q47A:
undetectable		 5fsaB-1q47A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 1q47 SEMAPHORIN 3A
(Mus
musculus) 		3 / 3 HIS A 515
GLU A 478
ASN A  44
 None
 0.92A 5wbvA-1q47A:
0.0		 5wbvA-1q47A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 1q47 SEMAPHORIN 3A
(Mus
musculus) 		3 / 3 HIS A 515
GLU A 478
ASN A  44
 None
 0.92A 5wbvB-1q47A:
0.0		 5wbvB-1q47A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)		 1q47 SEMAPHORIN 3A
(Mus
musculus) 		4 / 8 PHE A 226
PHE A 245
PRO A 210
THR A 204
 None
 1.10A 5x23A-1q47A:
undetectable		 5x23A-1q47A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_2
(-)		 1q47 SEMAPHORIN 3A
(Mus
musculus) 		4 / 5 GLN A 433
THR A 432
THR A 481
GLY A 504
 None
 1.15A 6gbnC-1q47A:
undetectable		 6gbnC-1q47A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1q47 SEMAPHORIN 3A
(Mus
musculus) 		4 / 7 VAL A 327
ILE A 227
GLY A  72
ALA A 491
 None
 0.86A 6hd6B-1q47A:
undetectable		 6hd6B-1q47A:
12.07