SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1q51'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 1q51 MENB
(Mycobacterium
tuberculosis) 		5 / 8 LEU A 165
PHE A  52
THR A  65
VAL A  66
ALA A  60
 None
None
None
None
CAA  A 501 ( 3.7A)
 1.39A 1fiqC-1q51A:
undetectable		 1fiqC-1q51A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_A_SALA3005_1
(XANTHINE
DEHYDROGENASE)		 1q51 MENB
(Mycobacterium
tuberculosis) 		5 / 9 LEU A 165
PHE A  52
THR A  65
VAL A  66
ALA A  60
 None
None
None
None
CAA  A 501 ( 3.7A)
 1.37A 1fo4A-1q51A:
0.0		 1fo4A-1q51A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1q51 MENB
(Mycobacterium
tuberculosis) 		5 / 12 TYR A  70
VAL A 168
LEU A 142
PHE A 145
LEU A 277
 None
 1.38A 1mmkA-1q51A:
undetectable		 1mmkA-1q51A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1q51 MENB
(Mycobacterium
tuberculosis) 		3 / 3 THR A  65
LEU A  69
VAL A  72
 None
 0.38A 1mz9E-1q51A:
undetectable		 1mz9E-1q51A:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1q51 MENB
(Mycobacterium
tuberculosis) 		5 / 10 THR A  65
PHE A 101
LEU A  87
VAL A 150
VAL A  50
 None
 1.37A 1q23K-1q51A:
undetectable		 1q23K-1q51A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 1q51 MENB
(Mycobacterium
tuberculosis) 		5 / 12 ASN A  18
GLU A 240
VAL A  72
ASN A  53
GLU A  68
 None
 1.41A 3jb3A-1q51A:
0.7		 3jb3A-1q51A:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1q51 MENB
(Mycobacterium
tuberculosis) 		5 / 9 TRP A 157
GLY A 104
GLY A 105
VAL A 188
ILE A 136
 CAA  A 501 (-3.6A)
CAA  A 501 (-3.5A)
CAA  A 501 (-3.9A)
CAA  A 501 (-4.8A)
None
 1.32A 3owxA-1q51A:
undetectable		 3owxA-1q51A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1q51 MENB
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 212
GLY A 228
ARG A 202
ALA A 201
ALA A 209
 None
 1.02A 3sudC-1q51A:
undetectable		 3sudC-1q51A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNA_A_SALA1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1q51 MENB
(Mycobacterium
tuberculosis) 		5 / 9 LEU A 165
PHE A  52
THR A  65
VAL A  66
ALA A  60
 None
None
None
None
CAA  A 501 ( 3.7A)
 1.34A 3unaA-1q51A:
undetectable		 3unaA-1q51A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNA_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1q51 MENB
(Mycobacterium
tuberculosis) 		5 / 9 LEU A 165
PHE A  52
THR A  65
VAL A  66
ALA A  60
 None
None
None
None
CAA  A 501 ( 3.7A)
 1.35A 3unaB-1q51A:
0.0		 3unaB-1q51A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_1
(ADENOSINE KINASE,
PUTATIVE)		 1q51 MENB
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 143
LEU A  73
GLY A 161
GLY A 162
GLY A 196
 None
None
CAA  A 501 (-3.3A)
None
None
 1.07A 3uq6A-1q51A:
undetectable		 3uq6A-1q51A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 1q51 MENB
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 284
MET A 260
ARG A 259
 None
 1.35A 3uvvA-1q51A:
0.0		 3uvvA-1q51A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 1q51 MENB
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 143
LEU A  73
GLY A 161
GLY A 162
GLY A 196
 None
None
CAA  A 501 (-3.3A)
None
None
 1.05A 3vaqA-1q51A:
3.7		 3vaqA-1q51A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 1q51 MENB
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 143
LEU A  73
GLY A 161
GLY A 162
GLY A 196
 None
None
CAA  A 501 (-3.3A)
None
None
 1.06A 3vasA-1q51A:
3.7		 3vasA-1q51A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 1q51 MENB
(Mycobacterium
tuberculosis) 		5 / 9 TYR A  39
LEU A  69
VAL A 139
VAL A  85
LEU A  87
 None
 1.18A 4g1bC-1q51A:
2.4		 4g1bC-1q51A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 1q51 MENB
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 159
GLY A 161
GLY A 162
THR A  88
GLY A 105
 CAA  A 501 ( 3.8A)
CAA  A 501 (-3.3A)
None
None
CAA  A 501 (-3.9A)
 0.93A 4o33A-1q51A:
2.1		 4o33A-1q51A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 1q51 MENB
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 159
GLY A 161
GLY A 162
THR A  88
GLY A 105
 CAA  A 501 ( 3.8A)
CAA  A 501 (-3.3A)
None
None
CAA  A 501 (-3.9A)
 0.82A 4o3fA-1q51A:
2.0		 4o3fA-1q51A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_2
(CYTOCHROME P450
21-HYDROXYLASE)		 1q51 MENB
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 142
VAL A  66
ASP A  67
 None
 0.66A 4y8wC-1q51A:
undetectable		 4y8wC-1q51A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 1q51 MENB
(Mycobacterium
tuberculosis) 		5 / 12 ASP A  81
LEU A  34
HIS A  75
ALA A  76
THR A  38
 None
 1.30A 5hnzB-1q51A:
undetectable		 5hnzB-1q51A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)		 1q51 MENB
(Mycobacterium
tuberculosis) 		4 / 7 GLY A 105
GLY A 161
SER A 164
LEU A 137
 CAA  A 501 (-3.9A)
CAA  A 501 (-3.3A)
None
None
 0.81A 5izfA-1q51A:
undetectable		 5izfA-1q51A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1q51 MENB
(Mycobacterium
tuberculosis) 		3 / 3 VAL A  82
HIS A  40
VAL A  28
 None
 0.59A 5jmnC-1q51A:
undetectable		 5jmnC-1q51A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 1q51 MENB
(Mycobacterium
tuberculosis) 		5 / 12 ASP A  29
LEU A  73
ALA A  76
SER A  79
THR A  88
 None
 1.01A 5m5cB-1q51A:
undetectable		 5m5cB-1q51A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 1q51 MENB
(Mycobacterium
tuberculosis) 		5 / 10 ASP A  29
LEU A  73
ALA A  76
SER A  79
THR A  88
 None
 1.06A 5m5cE-1q51A:
undetectable		 5m5cE-1q51A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 1q51 MENB
(Mycobacterium
tuberculosis) 		5 / 12 ASP A  81
LEU A  34
HIS A  75
ALA A  76
THR A  38
 None
 1.24A 5nd3B-1q51A:
undetectable		 5nd3B-1q51A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_2
(CYTOCHROME P450 3A4)		 1q51 MENB
(Mycobacterium
tuberculosis) 		3 / 3 ARG A  41
ARG A  26
ARG A  49
 None
 1.02A 5vcgA-1q51A:
undetectable		 5vcgA-1q51A:
21.37