SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1q5m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA153_1
(CALMODULIN)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		5 / 8 ILE A 265
LEU A 213
GLU A 192
ALA A 218
VAL A 267
 None
 1.47A 1a29A-1q5mA:
undetectable		 1a29A-1q5mA:
19.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IHI_A_IU5A326_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		6 / 10 TYR A  24
TYR A  55
TRP A  86
HIS A 117
ILE A 129
GLU A 224
 None
NDP  A1003 (-4.9A)
None
NDP  A1003 (-4.3A)
None
None
 0.38A 1ihiA-1q5mA:
52.3		 1ihiA-1q5mA:
78.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IHI_B_IU5B327_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		6 / 9 TYR A  24
TYR A  55
TRP A  86
HIS A 117
ILE A 129
GLU A 224
 None
NDP  A1003 (-4.9A)
None
NDP  A1003 (-4.3A)
None
None
 0.39A 1ihiB-1q5mA:
52.3		 1ihiB-1q5mA:
78.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		5 / 6 TYR A  24
TYR A  55
HIS A 117
GLU A 224
VAL A 306
 None
NDP  A1003 (-4.9A)
NDP  A1003 (-4.3A)
None
None
 0.19A 1q13A-1q5mA:
55.8		 1q13A-1q5mA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1S2A_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		6 / 12 TRP A  86
HIS A 117
GLU A 192
TYR A 216
SER A 217
TRP A 227
 None
NDP  A1003 (-4.3A)
None
NDP  A1003 (-3.2A)
NDP  A1003 (-2.8A)
None
 1.00A 1s2aA-1q5mA:
51.3		 1s2aA-1q5mA:
77.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1S2A_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		6 / 12 TYR A  24
TRP A  86
HIS A 117
GLU A 192
TYR A 216
SER A 217
 None
None
NDP  A1003 (-4.3A)
None
NDP  A1003 (-3.2A)
NDP  A1003 (-2.8A)
 0.40A 1s2aA-1q5mA:
51.3		 1s2aA-1q5mA:
77.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		4 / 5 ALA A 137
PHE A 139
ILE A 312
ASP A 309
 None
 0.93A 1yc2D-1q5mA:
undetectable		 1yc2D-1q5mA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2002_1
(SERUM ALBUMIN)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		5 / 11 PHE A  54
ALA A  52
ALA A  34
LYS A  31
GLU A  60
 None
 1.06A 2bxeB-1q5mA:
undetectable		 2bxeB-1q5mA:
21.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F38_A_15MA325_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		5 / 12 TYR A  24
TRP A  86
LEU A 122
ASN A 167
PRO A 318
 None
None
None
NDP  A1003 (-3.4A)
None
 0.53A 2f38A-1q5mA:
52.2		 2f38A-1q5mA:
77.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		5 / 12 LEU A 268
SER A 166
HIS A 194
LEU A 197
LEU A 235
 NDP  A1003 (-4.1A)
NDP  A1003 (-2.8A)
None
None
None
 1.36A 2zlcA-1q5mA:
undetectable		 2zlcA-1q5mA:
22.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BUR_A_TESA339_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		5 / 10 TYR A  24
TRP A  86
TRP A 227
VAL A 228
VAL A 306
 None
 1.06A 3burA-1q5mA:
50.9		 3burA-1q5mA:
59.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CAS_A_ASDA332_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		5 / 10 TYR A  24
TRP A  86
TRP A 227
VAL A 228
VAL A 306
 None
 1.14A 3casA-1q5mA:
50.2		 3casA-1q5mA:
59.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		5 / 10 GLY A 264
GLN A 262
VAL A   8
VAL A  18
GLN A   6
 None
 1.38A 3fhjE-1q5mA:
undetectable		 3fhjE-1q5mA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		5 / 9 GLY A  20
ILE A  16
VAL A 266
VAL A 214
GLN A 190
 None
None
None
None
NDP  A1003 (-3.7A)
 1.11A 3fi0A-1q5mA:
undetectable		 3fi0A-1q5mA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		5 / 9 GLY A 264
GLN A 262
VAL A   8
VAL A  18
GLN A   6
 None
 1.34A 3fi0A-1q5mA:
undetectable		 3fi0A-1q5mA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		4 / 8 GLY A  20
ILE A  16
VAL A 266
GLN A 190
 None
None
None
NDP  A1003 (-3.7A)
 0.63A 3fi0B-1q5mA:
undetectable		 3fi0B-1q5mA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		5 / 9 GLY A  20
ILE A  16
VAL A 266
VAL A 214
GLN A 190
 None
None
None
None
NDP  A1003 (-3.7A)
 1.11A 3fi0C-1q5mA:
undetectable		 3fi0C-1q5mA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		5 / 9 GLY A 264
GLN A 262
VAL A   8
VAL A  18
GLN A   6
 None
 1.38A 3fi0C-1q5mA:
undetectable		 3fi0C-1q5mA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		5 / 9 GLY A  20
ILE A  16
VAL A 266
VAL A 214
GLN A 190
 None
None
None
None
NDP  A1003 (-3.7A)
 1.10A 3fi0D-1q5mA:
undetectable		 3fi0D-1q5mA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		4 / 7 GLY A  20
ILE A  16
VAL A 266
GLN A 190
 None
None
None
NDP  A1003 (-3.7A)
 0.68A 3fi0E-1q5mA:
undetectable		 3fi0E-1q5mA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_H_TRPH1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		5 / 9 GLY A 264
GLN A 262
VAL A   8
VAL A  18
GLN A   6
 None
 1.31A 3fi0H-1q5mA:
undetectable		 3fi0H-1q5mA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_I_TRPI1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		5 / 8 GLY A  20
ILE A  16
VAL A 266
VAL A 214
GLN A 190
 None
None
None
None
NDP  A1003 (-3.7A)
 1.12A 3fi0I-1q5mA:
undetectable		 3fi0I-1q5mA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_J_TRPJ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		5 / 9 GLY A  20
ILE A  16
VAL A 266
VAL A 214
GLN A 190
 None
None
None
None
NDP  A1003 (-3.7A)
 1.14A 3fi0J-1q5mA:
undetectable		 3fi0J-1q5mA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_K_TRPK1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		5 / 9 GLY A  20
ILE A  16
VAL A 266
VAL A 214
GLN A 190
 None
None
None
None
NDP  A1003 (-3.7A)
 1.05A 3fi0K-1q5mA:
undetectable		 3fi0K-1q5mA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_K_TRPK1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		5 / 9 GLY A 264
GLN A 262
VAL A   8
VAL A  18
GLN A   6
 None
 1.38A 3fi0K-1q5mA:
undetectable		 3fi0K-1q5mA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_L_TRPL1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		5 / 9 GLY A  20
ILE A  16
VAL A 266
VAL A 214
GLN A 190
 None
None
None
None
NDP  A1003 (-3.7A)
 1.14A 3fi0L-1q5mA:
undetectable		 3fi0L-1q5mA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_M_TRPM1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		5 / 9 GLY A  20
ILE A  16
VAL A 266
VAL A 214
GLN A 190
 None
None
None
None
NDP  A1003 (-3.7A)
 1.08A 3fi0M-1q5mA:
undetectable		 3fi0M-1q5mA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_M_TRPM1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		5 / 9 GLY A 264
GLN A 262
VAL A   8
VAL A  18
GLN A   6
 None
 1.33A 3fi0M-1q5mA:
undetectable		 3fi0M-1q5mA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_N_TRPN1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		5 / 9 GLY A  20
ILE A  16
VAL A 266
VAL A 214
GLN A 190
 None
None
None
None
NDP  A1003 (-3.7A)
 1.11A 3fi0N-1q5mA:
undetectable		 3fi0N-1q5mA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_N_TRPN1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		5 / 9 GLY A 264
GLN A 262
VAL A   8
VAL A  18
GLN A   6
 None
 1.35A 3fi0N-1q5mA:
undetectable		 3fi0N-1q5mA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_O_TRPO1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		5 / 9 GLY A  20
ILE A  16
VAL A 266
VAL A 214
GLN A 190
 None
None
None
None
NDP  A1003 (-3.7A)
 1.13A 3fi0O-1q5mA:
undetectable		 3fi0O-1q5mA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_O_TRPO1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		5 / 9 GLY A 264
GLN A 262
VAL A   8
VAL A  18
GLN A   6
 None
 1.40A 3fi0O-1q5mA:
undetectable		 3fi0O-1q5mA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_R_TRPR1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		5 / 9 GLY A  20
ILE A  16
VAL A 266
VAL A 214
GLN A 190
 None
None
None
None
NDP  A1003 (-3.7A)
 1.22A 3fi0R-1q5mA:
undetectable		 3fi0R-1q5mA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		4 / 8 GLU A  27
TYR A  24
GLU A  28
ILE A 129
 None
 0.97A 3jz0B-1q5mA:
0.0		 3jz0B-1q5mA:
23.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R43_A_ID8A332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		6 / 12 TYR A  24
TYR A  55
TRP A  86
HIS A 117
ASN A 167
TYR A 216
 None
NDP  A1003 (-4.9A)
None
NDP  A1003 (-4.3A)
NDP  A1003 (-3.4A)
NDP  A1003 (-3.2A)
 0.39A 3r43A-1q5mA:
50.9		 3r43A-1q5mA:
77.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R43_A_ID8A332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		5 / 12 TYR A  55
TRP A  86
HIS A 117
TYR A 216
TRP A 227
 NDP  A1003 (-4.9A)
None
NDP  A1003 (-4.3A)
NDP  A1003 (-3.2A)
None
 1.27A 3r43A-1q5mA:
50.9		 3r43A-1q5mA:
77.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R58_A_NPSA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		5 / 10 TYR A  55
HIS A 117
ASN A 167
TYR A 216
PRO A 318
 NDP  A1003 (-4.9A)
NDP  A1003 (-4.3A)
NDP  A1003 (-3.4A)
NDP  A1003 (-3.2A)
None
 0.32A 3r58A-1q5mA:
49.7		 3r58A-1q5mA:
77.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R6I_A_JMSA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		6 / 12 TYR A  24
TYR A  55
TRP A  86
HIS A 117
ASN A 167
TYR A 216
 None
NDP  A1003 (-4.9A)
None
NDP  A1003 (-4.3A)
NDP  A1003 (-3.4A)
NDP  A1003 (-3.2A)
 0.34A 3r6iA-1q5mA:
49.7		 3r6iA-1q5mA:
77.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R6I_A_JMSA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		5 / 12 TYR A  55
TRP A  86
HIS A 117
TYR A 216
TRP A 227
 NDP  A1003 (-4.9A)
None
NDP  A1003 (-4.3A)
NDP  A1003 (-3.2A)
None
 1.25A 3r6iA-1q5mA:
49.7		 3r6iA-1q5mA:
77.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R7M_A_SUZA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		5 / 10 TYR A  24
TYR A  55
TRP A  86
HIS A 117
ASN A 167
 None
NDP  A1003 (-4.9A)
None
NDP  A1003 (-4.3A)
NDP  A1003 (-3.4A)
 0.41A 3r7mA-1q5mA:
49.7		 3r7mA-1q5mA:
77.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R7M_A_SUZA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		5 / 10 TYR A  55
TRP A  86
HIS A 117
ASN A 167
TRP A 227
 NDP  A1003 (-4.9A)
None
NDP  A1003 (-4.3A)
NDP  A1003 (-3.4A)
None
 1.19A 3r7mA-1q5mA:
49.7		 3r7mA-1q5mA:
77.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R8G_A_IZPA409_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		5 / 9 TYR A  55
HIS A 117
ASN A 167
TYR A 216
PRO A 318
 NDP  A1003 (-4.9A)
NDP  A1003 (-4.3A)
NDP  A1003 (-3.4A)
NDP  A1003 (-3.2A)
None
 0.35A 3r8gA-1q5mA:
49.7		 3r8gA-1q5mA:
77.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R94_A_FLRA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		5 / 12 TYR A  55
HIS A 117
ASN A 167
TYR A 216
PRO A 318
 NDP  A1003 (-4.9A)
NDP  A1003 (-4.3A)
NDP  A1003 (-3.4A)
NDP  A1003 (-3.2A)
None
 0.41A 3r94A-1q5mA:
49.6		 3r94A-1q5mA:
77.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		5 / 12 ALA A 269
LEU A 261
ALA A 253
THR A 251
VAL A 283
 None
None
NDP  A1003 (-3.3A)
None
None
 0.96A 3rukA-1q5mA:
undetectable		 3rukA-1q5mA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		5 / 12 ALA A 269
LEU A 261
ALA A 253
THR A 251
VAL A 283
 None
None
NDP  A1003 (-3.3A)
None
None
 0.97A 3rukB-1q5mA:
undetectable		 3rukB-1q5mA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		3 / 3 PHE A 118
CYH A  87
HIS A 117
 NDP  A1003 ( 4.8A)
None
NDP  A1003 (-4.3A)
 1.04A 3u9fG-1q5mA:
undetectable		 3u9fG-1q5mA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		3 / 3 PHE A 118
CYH A  87
HIS A 117
 NDP  A1003 ( 4.8A)
None
NDP  A1003 (-4.3A)
 1.08A 3u9fS-1q5mA:
undetectable		 3u9fS-1q5mA:
19.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UG8_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		8 / 12 TYR A  55
TRP A  86
HIS A 117
ASN A 167
TYR A 216
SER A 217
SER A 221
PRO A 318
 NDP  A1003 (-4.9A)
None
NDP  A1003 (-4.3A)
NDP  A1003 (-3.4A)
NDP  A1003 (-3.2A)
NDP  A1003 (-2.8A)
None
None
 0.49A 3ug8A-1q5mA:
49.7		 3ug8A-1q5mA:
77.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UGR_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		6 / 12 TRP A  86
HIS A 117
TYR A 216
SER A 217
SER A 221
TRP A 227
 None
NDP  A1003 (-4.3A)
NDP  A1003 (-3.2A)
NDP  A1003 (-2.8A)
None
None
 0.99A 3ugrA-1q5mA:
49.8		 3ugrA-1q5mA:
77.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UGR_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		6 / 12 TYR A  24
HIS A 117
TYR A 216
SER A 217
SER A 221
PHE A 310
 None
NDP  A1003 (-4.3A)
NDP  A1003 (-3.2A)
NDP  A1003 (-2.8A)
None
None
 1.07A 3ugrA-1q5mA:
49.8		 3ugrA-1q5mA:
77.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UGR_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		6 / 12 TYR A  24
TRP A  86
HIS A 117
TYR A 216
SER A 217
SER A 221
 None
None
NDP  A1003 (-4.3A)
NDP  A1003 (-3.2A)
NDP  A1003 (-2.8A)
None
 0.48A 3ugrA-1q5mA:
49.8		 3ugrA-1q5mA:
77.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		5 / 7 TYR A  55
ASN A 167
GLU A 192
TYR A 305
PRO A 318
 NDP  A1003 (-4.9A)
NDP  A1003 (-3.4A)
None
None
None
 0.58A 3ugrA-1q5mA:
49.8		 3ugrA-1q5mA:
77.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UZZ_A_TESA501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		4 / 7 TYR A  24
TYR A  55
HIS A 117
TRP A 227
 None
NDP  A1003 (-4.9A)
NDP  A1003 (-4.3A)
None
 1.33A 3uzzA-1q5mA:
50.5		 3uzzA-1q5mA:
56.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		4 / 8 TYR A  24
TYR A  55
HIS A 117
TRP A 227
 None
NDP  A1003 (-4.9A)
NDP  A1003 (-4.3A)
None
 1.32A 3uzzB-1q5mA:
50.8		 3uzzB-1q5mA:
56.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		5 / 12 VAL A 191
LEU A 268
VAL A   8
ILE A 115
LEU A 113
 None
NDP  A1003 (-4.1A)
None
None
None
 1.11A 3w68B-1q5mA:
1.4		 3w68B-1q5mA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		4 / 6 ALA A 218
ALA A 253
PRO A 252
LEU A 235
 None
NDP  A1003 (-3.3A)
None
None
 0.86A 4dtzA-1q5mA:
0.0		 4dtzA-1q5mA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		4 / 7 ALA A 218
ALA A 253
PRO A 252
LEU A 235
 None
NDP  A1003 (-3.3A)
None
None
 0.83A 4du2A-1q5mA:
0.0		 4du2A-1q5mA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		4 / 7 ALA A 218
ALA A 253
PRO A 252
LEU A 235
 None
NDP  A1003 (-3.3A)
None
None
 0.86A 4du2B-1q5mA:
undetectable		 4du2B-1q5mA:
22.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JQ1_A_NPSA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		5 / 9 TYR A  24
TYR A  55
TRP A  86
HIS A 117
ILE A 129
 None
NDP  A1003 (-4.9A)
None
NDP  A1003 (-4.3A)
None
 0.52A 4jq1A-1q5mA:
52.2		 4jq1A-1q5mA:
78.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		5 / 8 TYR A  55
TRP A  86
HIS A 117
ILE A 129
TRP A 227
 NDP  A1003 (-4.9A)
None
NDP  A1003 (-4.3A)
None
None
 0.82A 4jq1B-1q5mA:
52.1		 4jq1B-1q5mA:
78.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JQ2_A_SUZA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		5 / 10 TYR A  24
TRP A  86
ILE A 129
GLU A 224
TRP A 227
 None
 0.88A 4jq2A-1q5mA:
52.2		 4jq2A-1q5mA:
78.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JQ2_A_SUZA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		6 / 10 TYR A  24
TYR A  55
TRP A  86
HIS A 117
ILE A 129
GLU A 224
 None
NDP  A1003 (-4.9A)
None
NDP  A1003 (-4.3A)
None
None
 0.38A 4jq2A-1q5mA:
52.2		 4jq2A-1q5mA:
78.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JQ4_A_IMNA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		5 / 10 TYR A  24
TYR A  55
HIS A 117
TYR A 216
GLU A 224
 None
NDP  A1003 (-4.9A)
NDP  A1003 (-4.3A)
NDP  A1003 (-3.2A)
None
 0.26A 4jq4A-1q5mA:
52.2		 4jq4A-1q5mA:
78.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JQ4_B_IMNB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		6 / 10 TYR A  24
TYR A  55
HIS A 117
ILE A 129
ASN A 167
TYR A 216
 None
NDP  A1003 (-4.9A)
NDP  A1003 (-4.3A)
None
NDP  A1003 (-3.4A)
NDP  A1003 (-3.2A)
 0.50A 4jq4B-1q5mA:
51.4		 4jq4B-1q5mA:
78.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JQA_A_ID8A401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		6 / 9 TYR A  24
TYR A  55
TRP A  86
HIS A 117
ILE A 129
TRP A 227
 None
NDP  A1003 (-4.9A)
None
NDP  A1003 (-4.3A)
None
None
 0.65A 4jqaA-1q5mA:
52.3		 4jqaA-1q5mA:
78.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JQA_B_ID8B401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		6 / 9 TYR A  24
TYR A  55
TRP A  86
HIS A 117
ILE A 129
TRP A 227
 None
NDP  A1003 (-4.9A)
None
NDP  A1003 (-4.3A)
None
None
 0.70A 4jqaB-1q5mA:
52.4		 4jqaB-1q5mA:
78.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JTQ_A_FLPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		6 / 10 TYR A  24
TYR A  55
TRP A  86
HIS A 117
ILE A 129
TRP A 227
 None
NDP  A1003 (-4.9A)
None
NDP  A1003 (-4.3A)
None
None
 0.72A 4jtqA-1q5mA:
52.2		 4jtqA-1q5mA:
78.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JTQ_B_FLPB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		6 / 9 TYR A  24
TYR A  55
TRP A  86
HIS A 117
ILE A 129
TRP A 227
 None
NDP  A1003 (-4.9A)
None
NDP  A1003 (-4.3A)
None
None
 0.77A 4jtqB-1q5mA:
52.6		 4jtqB-1q5mA:
78.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		4 / 8 TYR A  24
TYR A  55
TRP A  86
HIS A 117
 None
NDP  A1003 (-4.9A)
None
NDP  A1003 (-4.3A)
 0.33A 4jtrA-1q5mA:
52.2		 4jtrA-1q5mA:
78.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JTR_B_IZPB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		4 / 6 TYR A  24
TYR A  55
TRP A  86
HIS A 117
 None
NDP  A1003 (-4.9A)
None
NDP  A1003 (-4.3A)
 0.44A 4jtrB-1q5mA:
52.3		 4jtrB-1q5mA:
78.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		4 / 8 LEU A 108
LEU A 106
ASP A  50
ILE A  49
 None
None
NDP  A1003 (-3.7A)
None
 0.89A 4lzrA-1q5mA:
undetectable		 4lzrA-1q5mA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		3 / 3 ARG A 170
GLU A 322
ARG A 171
 None
 0.74A 4mwvA-1q5mA:
undetectable		 4mwvA-1q5mA:
22.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVP_A_GBMA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		6 / 11 TYR A  24
TYR A  55
TRP A  86
HIS A 117
ILE A 129
GLU A 224
 None
NDP  A1003 (-4.9A)
None
NDP  A1003 (-4.3A)
None
None
 0.62A 4yvpA-1q5mA:
53.1		 4yvpA-1q5mA:
80.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVP_A_GBMA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		6 / 11 TYR A  55
TRP A  86
HIS A 117
ILE A 129
GLU A 224
TRP A 227
 NDP  A1003 (-4.9A)
None
NDP  A1003 (-4.3A)
None
None
None
 0.82A 4yvpA-1q5mA:
53.1		 4yvpA-1q5mA:
80.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		6 / 12 TYR A  24
TYR A  55
TRP A  86
HIS A 117
ILE A 129
ASN A 167
 None
NDP  A1003 (-4.9A)
None
NDP  A1003 (-4.3A)
None
NDP  A1003 (-3.4A)
 0.44A 4yvpB-1q5mA:
53.1		 4yvpB-1q5mA:
80.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		5 / 12 TYR A  55
TRP A  86
HIS A 117
ASN A 167
TRP A 227
 NDP  A1003 (-4.9A)
None
NDP  A1003 (-4.3A)
NDP  A1003 (-3.4A)
None
 0.70A 4yvpB-1q5mA:
53.1		 4yvpB-1q5mA:
80.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVV_A_GBMA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		6 / 9 TYR A  24
TYR A  55
TRP A  86
HIS A 117
ASN A 167
TYR A 216
 None
NDP  A1003 (-4.9A)
None
NDP  A1003 (-4.3A)
NDP  A1003 (-3.4A)
NDP  A1003 (-3.2A)
 0.44A 4yvvA-1q5mA:
51.7		 4yvvA-1q5mA:
77.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVV_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		5 / 9 TYR A  24
TYR A  55
TRP A  86
HIS A 117
ASN A 167
 None
NDP  A1003 (-4.9A)
None
NDP  A1003 (-4.3A)
NDP  A1003 (-3.4A)
 0.43A 4yvvB-1q5mA:
51.5		 4yvvB-1q5mA:
77.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVX_A_GMRA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		6 / 12 TYR A  24
TYR A  55
TRP A  86
HIS A 117
LEU A 122
ASN A 167
 None
NDP  A1003 (-4.9A)
None
NDP  A1003 (-4.3A)
None
NDP  A1003 (-3.4A)
 0.52A 4yvxA-1q5mA:
51.2		 4yvxA-1q5mA:
77.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVX_B_GMRB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		6 / 12 TYR A  24
TYR A  55
TRP A  86
HIS A 117
LEU A 122
ASN A 167
 None
NDP  A1003 (-4.9A)
None
NDP  A1003 (-4.3A)
None
NDP  A1003 (-3.4A)
 0.41A 4yvxB-1q5mA:
50.9		 4yvxB-1q5mA:
77.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZFC_A_GCZA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		5 / 9 TYR A  24
TYR A  55
TRP A  86
HIS A 117
ASN A 167
 None
NDP  A1003 (-4.9A)
None
NDP  A1003 (-4.3A)
NDP  A1003 (-3.4A)
 0.51A 4zfcA-1q5mA:
51.7		 4zfcA-1q5mA:
77.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZFC_B_GCZB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		5 / 9 TYR A  24
TYR A  55
TRP A  86
HIS A 117
ASN A 167
 None
NDP  A1003 (-4.9A)
None
NDP  A1003 (-4.3A)
NDP  A1003 (-3.4A)
 0.45A 4zfcB-1q5mA:
51.7		 4zfcB-1q5mA:
77.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		3 / 3 ASP A   2
LEU A 261
ARG A 258
 None
 0.76A 5e8qA-1q5mA:
undetectable		 5e8qA-1q5mA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		4 / 8 TYR A  81
LEU A 103
LEU A  99
MET A 151
 None
 1.18A 5hs6A-1q5mA:
undetectable		 5hs6A-1q5mA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		5 / 12 VAL A 306
ALA A 311
TRP A  86
TYR A 216
ALA A 308
 None
None
None
NDP  A1003 (-3.2A)
None
 1.25A 5tzoA-1q5mA:
undetectable		 5tzoA-1q5mA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		3 / 3 HIS A 194
SER A 217
ARG A 223
 None
NDP  A1003 (-2.8A)
None
 0.84A 5u63A-1q5mA:
undetectable		 5u63A-1q5mA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA824_0
(GEPHYRIN)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		4 / 4 LEU A  94
ASP A 140
PRO A 124
ARG A  91
 None
 1.38A 6fgdA-1q5mA:
undetectable		 6fgdA-1q5mA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 1q5m PROSTAGLANDIN-E2
9-REDUCTASE
(Oryctolagus
cuniculus) 		4 / 6 LEU A 197
CYH A 193
GLY A 200
ARG A 263
 None
 1.36A 6gtqB-1q5mA:
undetectable
6gtqD-1q5mA:
undetectable		 6gtqB-1q5mA:
18.38
6gtqD-1q5mA:
11.58