SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1q6y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 1q6y HYPOTHETICAL PROTEIN
YFDW
(Escherichia
coli) 		5 / 10 LEU A 179
VAL A 198
VAL A  96
GLY A 124
LEU A 183
 None
 1.34A 1fk9A-1q6yA:
0.0		 1fk9A-1q6yA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		 1q6y HYPOTHETICAL PROTEIN
YFDW
(Escherichia
coli) 		5 / 9 LEU A 179
VAL A 198
VAL A  96
GLY A 124
LEU A 183
 None
 1.38A 1ikvA-1q6yA:
undetectable		 1ikvA-1q6yA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		 1q6y HYPOTHETICAL PROTEIN
YFDW
(Escherichia
coli) 		5 / 10 LEU A 179
VAL A 198
VAL A  96
GLY A 124
LEU A 183
 None
 1.37A 1ikwA-1q6yA:
undetectable		 1ikwA-1q6yA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1q6y HYPOTHETICAL PROTEIN
YFDW
(Escherichia
coli) 		4 / 7 LEU A 183
LEU A  28
PHE A 378
MET A 376
 None
 0.95A 1wrlE-1q6yA:
undetectable
1wrlF-1q6yA:
undetectable		 1wrlE-1q6yA:
12.78
1wrlF-1q6yA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 1q6y HYPOTHETICAL PROTEIN
YFDW
(Escherichia
coli) 		5 / 12 PHE A  15
LEU A 186
ARG A 189
ILE A 104
ASP A 105
 COA  A 500 (-4.6A)
None
None
None
None
 1.34A 2zznB-1q6yA:
2.9		 2zznB-1q6yA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 1q6y HYPOTHETICAL PROTEIN
YFDW
(Escherichia
coli) 		4 / 7 ASP A  34
SER A  71
GLU A  39
ASP A  45
 None
 1.29A 3bc9A-1q6yA:
undetectable		 3bc9A-1q6yA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 1q6y HYPOTHETICAL PROTEIN
YFDW
(Escherichia
coli) 		4 / 8 GLN A  50
HIS A  49
VAL A  46
VAL A  18
 None
None
None
COA  A 500 (-4.0A)
 1.04A 3uy4A-1q6yA:
3.4		 3uy4A-1q6yA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1q6y HYPOTHETICAL PROTEIN
YFDW
(Escherichia
coli) 		5 / 12 LEU A  28
GLY A 175
GLY A 170
LEU A 182
GLY A 124
 None
 1.11A 4blvA-1q6yA:
2.8		 4blvA-1q6yA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 1q6y HYPOTHETICAL PROTEIN
YFDW
(Escherichia
coli) 		4 / 7 TYR A 225
ASP A 239
GLY A 238
PHE A 237
 None
 0.82A 4iqqA-1q6yA:
undetectable		 4iqqA-1q6yA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 1q6y HYPOTHETICAL PROTEIN
YFDW
(Escherichia
coli) 		4 / 7 TYR A 225
ASP A 239
GLY A 238
PHE A 237
 None
 0.86A 4iqqB-1q6yA:
undetectable		 4iqqB-1q6yA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 1q6y HYPOTHETICAL PROTEIN
YFDW
(Escherichia
coli) 		4 / 7 TYR A 225
ASP A 239
GLY A 238
PHE A 237
 None
 0.84A 4iqqC-1q6yA:
undetectable		 4iqqC-1q6yA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1q6y HYPOTHETICAL PROTEIN
YFDW
(Escherichia
coli) 		4 / 8 TYR A 225
ASP A 239
GLY A 238
PHE A 237
 None
 0.85A 4iqqD-1q6yA:
undetectable		 4iqqD-1q6yA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 1q6y HYPOTHETICAL PROTEIN
YFDW
(Escherichia
coli) 		5 / 12 LEU A 257
THR A 282
ILE A 274
ALA A 312
ILE A 286
 None
 1.22A 4rp8C-1q6yA:
0.0		 4rp8C-1q6yA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 1q6y HYPOTHETICAL PROTEIN
YFDW
(Escherichia
coli) 		4 / 4 ILE A  94
ILE A 122
ARG A 189
LEU A  13
 None
 1.35A 5dzkh-1q6yA:
undetectable
5dzkn-1q6yA:
undetectable
5dzkv-1q6yA:
undetectable		 5dzkh-1q6yA:
21.03
5dzkn-1q6yA:
21.03
5dzkv-1q6yA:
1.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1q6y HYPOTHETICAL PROTEIN
YFDW
(Escherichia
coli) 		4 / 8 ILE A  72
GLY A  81
THR A  78
MET A 107
 None
None
None
COA  A 500 (-4.6A)
 0.92A 5esjA-1q6yA:
0.0		 5esjA-1q6yA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 1q6y HYPOTHETICAL PROTEIN
YFDW
(Escherichia
coli) 		3 / 3 ILE A  54
PRO A  55
ILE A  57
 None
 0.26A 5hw8F-1q6yA:
undetectable		 5hw8F-1q6yA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 1q6y HYPOTHETICAL PROTEIN
YFDW
(Escherichia
coli) 		5 / 12 PHE A 378
LEU A 179
LEU A 183
PHE A 381
ALA A  29
 None
 1.35A 5ieoA-1q6yA:
undetectable		 5ieoA-1q6yA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 1q6y HYPOTHETICAL PROTEIN
YFDW
(Escherichia
coli) 		4 / 7 TYR A 225
ASP A 239
GLY A 238
PHE A 237
 None
 0.81A 5nooA-1q6yA:
undetectable		 5nooA-1q6yA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 1q6y HYPOTHETICAL PROTEIN
YFDW
(Escherichia
coli) 		4 / 7 TYR A 225
ASP A 239
GLY A 238
PHE A 237
 None
 0.84A 5nooB-1q6yA:
undetectable		 5nooB-1q6yA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 1q6y HYPOTHETICAL PROTEIN
YFDW
(Escherichia
coli) 		4 / 6 TYR A 225
ASP A 239
GLY A 238
PHE A 237
 None
 0.83A 5nooC-1q6yA:
undetectable		 5nooC-1q6yA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1q6y HYPOTHETICAL PROTEIN
YFDW
(Escherichia
coli) 		4 / 8 TYR A 225
ASP A 239
GLY A 238
PHE A 237
 None
 0.85A 5nooD-1q6yA:
undetectable		 5nooD-1q6yA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)		 1q6y HYPOTHETICAL PROTEIN
YFDW
(Escherichia
coli) 		4 / 7 ARG A 243
SER A 153
ALA A 240
LEU A 226
 None
 0.95A 5te8C-1q6yA:
undetectable		 5te8C-1q6yA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1q6y HYPOTHETICAL PROTEIN
YFDW
(Escherichia
coli) 		5 / 12 ILE A  72
PHE A  99
GLY A  81
THR A  78
MET A 107
 None
COA  A 500 (-3.6A)
None
None
COA  A 500 (-4.6A)
 1.18A 5v5zA-1q6yA:
undetectable		 5v5zA-1q6yA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1q6y HYPOTHETICAL PROTEIN
YFDW
(Escherichia
coli) 		5 / 12 PRO A 230
GLN A 231
GLY A 249
ILE A 307
GLY A 248
 None
MPD  A1100 ( 4.5A)
None
None
None
 0.99A 5wyqB-1q6yA:
undetectable		 5wyqB-1q6yA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_A_SAMA401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 1q6y HYPOTHETICAL PROTEIN
YFDW
(Escherichia
coli) 		5 / 12 LEU A 179
GLY A 175
SER A  67
GLN A  26
ASP A 171
 None
None
None
None
COA  A 500 (-3.0A)
 1.40A 6bxlA-1q6yA:
2.8		 6bxlA-1q6yA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 1q6y HYPOTHETICAL PROTEIN
YFDW
(Escherichia
coli) 		5 / 12 GLY A  44
VAL A  18
GLY A 392
SER A  71
ALA A 388
 None
COA  A 500 (-4.0A)
None
None
None
 1.09A 6c2mA-1q6yA:
undetectable		 6c2mA-1q6yA:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 1q6y HYPOTHETICAL PROTEIN
YFDW
(Escherichia
coli) 		5 / 12 GLY A  44
VAL A  18
GLY A 392
SER A  71
ALA A 388
 None
COA  A 500 (-4.0A)
None
None
None
 1.05A 6c2mB-1q6yA:
undetectable		 6c2mB-1q6yA:
9.95