SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1q77'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_2
(ANDROGEN RECEPTOR)		 1q77 HYPOTHETICAL PROTEIN
AQ_178
(Aquifex
aeolicus) 		4 / 6 LEU A   4
LEU A 120
LEU A 127
ILE A 133
 None
 0.94A 1z95A-1q77A:
undetectable		 1z95A-1q77A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1q77 HYPOTHETICAL PROTEIN
AQ_178
(Aquifex
aeolicus) 		5 / 12 VAL A 102
LEU A   4
VAL A 123
GLY A 126
LEU A 129
 None
 0.99A 3ln1A-1q77A:
undetectable		 3ln1A-1q77A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1q77 HYPOTHETICAL PROTEIN
AQ_178
(Aquifex
aeolicus) 		5 / 12 VAL A 102
LEU A   4
VAL A 123
GLY A 126
LEU A 129
 None
 0.98A 3ln1B-1q77A:
undetectable		 3ln1B-1q77A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1q77 HYPOTHETICAL PROTEIN
AQ_178
(Aquifex
aeolicus) 		5 / 12 VAL A 102
LEU A   4
VAL A 123
GLY A 126
LEU A 129
 None
 0.99A 3ln1C-1q77A:
undetectable		 3ln1C-1q77A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1q77 HYPOTHETICAL PROTEIN
AQ_178
(Aquifex
aeolicus) 		5 / 12 VAL A 102
LEU A   4
VAL A 123
GLY A 126
LEU A 129
 None
 0.98A 3ln1D-1q77A:
undetectable		 3ln1D-1q77A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 1q77 HYPOTHETICAL PROTEIN
AQ_178
(Aquifex
aeolicus) 		5 / 12 VAL A 102
LEU A   4
VAL A 123
GLY A 126
LEU A 129
 None
 0.86A 3nt1A-1q77A:
undetectable		 3nt1A-1q77A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 1q77 HYPOTHETICAL PROTEIN
AQ_178
(Aquifex
aeolicus) 		5 / 12 VAL A 102
LEU A   4
VAL A 123
GLY A 126
LEU A 129
 None
 0.88A 3nt1B-1q77A:
undetectable		 3nt1B-1q77A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_C_FLPC701_1
(CYCLOOXYGENASE-2)		 1q77 HYPOTHETICAL PROTEIN
AQ_178
(Aquifex
aeolicus) 		5 / 12 VAL A 102
LEU A   4
VAL A 123
GLY A 126
LEU A 129
 None
 0.97A 3pghC-1q77A:
undetectable		 3pghC-1q77A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)		 1q77 HYPOTHETICAL PROTEIN
AQ_178
(Aquifex
aeolicus) 		5 / 12 VAL A 102
LEU A   4
VAL A 123
GLY A 126
LEU A 129
 None
 0.97A 3pghD-1q77A:
undetectable		 3pghD-1q77A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1q77 HYPOTHETICAL PROTEIN
AQ_178
(Aquifex
aeolicus) 		5 / 12 VAL A 102
LEU A   4
VAL A 123
GLY A 126
LEU A 129
 None
 0.97A 3rr3A-1q77A:
undetectable		 3rr3A-1q77A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1q77 HYPOTHETICAL PROTEIN
AQ_178
(Aquifex
aeolicus) 		5 / 12 VAL A 102
LEU A   4
VAL A 123
GLY A 126
LEU A 129
 None
 0.98A 3rr3B-1q77A:
undetectable		 3rr3B-1q77A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 1q77 HYPOTHETICAL PROTEIN
AQ_178
(Aquifex
aeolicus) 		3 / 3 PHE A  24
VAL A   3
GLU A 108
 None
 0.79A 4fvqA-1q77A:
undetectable		 4fvqA-1q77A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		 1q77 HYPOTHETICAL PROTEIN
AQ_178
(Aquifex
aeolicus) 		4 / 7 ILE A  67
LEU A  71
ALA A  36
VAL A  37
 None
 0.77A 4g77A-1q77A:
undetectable		 4g77A-1q77A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1q77 HYPOTHETICAL PROTEIN
AQ_178
(Aquifex
aeolicus) 		5 / 12 VAL A   6
ALA A 113
SER A  95
LEU A 127
VAL A 110
 None
 1.48A 4kyaD-1q77A:
undetectable		 4kyaD-1q77A:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA602_1
(SERUM ALBUMIN)		 1q77 HYPOTHETICAL PROTEIN
AQ_178
(Aquifex
aeolicus) 		4 / 8 ASP A   9
ALA A  36
VAL A   6
GLU A  97
 None
 0.91A 4zbqA-1q77A:
undetectable		 4zbqA-1q77A:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1q77 HYPOTHETICAL PROTEIN
AQ_178
(Aquifex
aeolicus) 		5 / 12 VAL A 102
LEU A   4
VAL A 123
GLY A 126
LEU A 129
 None
 0.96A 5ikrB-1q77A:
undetectable		 5ikrB-1q77A:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1q77 HYPOTHETICAL PROTEIN
AQ_178
(Aquifex
aeolicus) 		5 / 12 VAL A 102
LEU A   4
VAL A 123
GLY A 126
LEU A 129
 None
 0.93A 5jvzA-1q77A:
undetectable		 5jvzA-1q77A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1q77 HYPOTHETICAL PROTEIN
AQ_178
(Aquifex
aeolicus) 		5 / 12 VAL A 102
LEU A   4
VAL A 123
GLY A 126
LEU A 129
 None
 0.93A 5jw1A-1q77A:
undetectable		 5jw1A-1q77A:
13.22