SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1q7h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 1q7h CONSERVED
HYPOTHETICAL PROTEIN
(Thermoplasma
acidophilum) 		4 / 6 HIS A  82
ILE A  83
ALA A 137
VAL A 109
 ZN  A 201 (-3.9A)
None
None
None
 0.99A 1hk1A-1q7hA:
undetectable		 1hk1A-1q7hA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMY_A_ROCA401_2
(PROTEASE)		 1q7h CONSERVED
HYPOTHETICAL PROTEIN
(Thermoplasma
acidophilum) 		6 / 12 LEU A  84
GLY A  78
ALA A  79
ILE A  94
ALA A 118
ILE A  83
 None
 1.26A 2nmyB-1q7hA:
undetectable		 2nmyB-1q7hA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_1
(PROTEASE)		 1q7h CONSERVED
HYPOTHETICAL PROTEIN
(Thermoplasma
acidophilum) 		6 / 12 LEU A  84
GLY A  78
ALA A  79
ILE A  94
ALA A 118
ILE A  83
 None
 1.29A 2nmzA-1q7hA:
undetectable		 2nmzA-1q7hA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_3
(PROTEASE)		 1q7h CONSERVED
HYPOTHETICAL PROTEIN
(Thermoplasma
acidophilum) 		6 / 12 LEU A  84
GLY A  78
ALA A  79
ILE A  94
ALA A 118
ILE A  83
 None
 1.32A 2nmzB-1q7hA:
undetectable		 2nmzB-1q7hA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_1
(PROTEASE
(RETROPEPSIN))		 1q7h CONSERVED
HYPOTHETICAL PROTEIN
(Thermoplasma
acidophilum) 		6 / 12 ALA A 137
VAL A  73
ILE A 101
GLY A 127
VAL A  95
ILE A  94
 None
 1.25A 3bvbA-1q7hA:
undetectable		 3bvbA-1q7hA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_2
(PROTEASE)		 1q7h CONSERVED
HYPOTHETICAL PROTEIN
(Thermoplasma
acidophilum) 		5 / 10 ALA A 137
VAL A  73
ILE A 101
GLY A 127
ILE A  94
 None
 1.00A 3em3B-1q7hA:
undetectable		 3em3B-1q7hA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_2
(PROTEASE)		 1q7h CONSERVED
HYPOTHETICAL PROTEIN
(Thermoplasma
acidophilum) 		6 / 12 ALA A 137
VAL A  73
ILE A 101
GLY A 127
VAL A  95
ILE A  94
 None
 1.29A 3em6B-1q7hA:
undetectable		 3em6B-1q7hA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_2
(GAG-POL POLYPROTEIN)		 1q7h CONSERVED
HYPOTHETICAL PROTEIN
(Thermoplasma
acidophilum) 		6 / 12 ALA A 137
VAL A  73
ILE A 101
GLY A 127
VAL A  95
ILE A  94
 None
 1.33A 3jw2B-1q7hA:
undetectable		 3jw2B-1q7hA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_2
(HIV-1 PROTEASE)		 1q7h CONSERVED
HYPOTHETICAL PROTEIN
(Thermoplasma
acidophilum) 		5 / 11 ALA A 137
VAL A  73
ILE A 101
GLY A 127
ILE A  94
 None
 1.03A 3lzvB-1q7hA:
undetectable		 3lzvB-1q7hA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_2
(HIV-1 PROTEASE)		 1q7h CONSERVED
HYPOTHETICAL PROTEIN
(Thermoplasma
acidophilum) 		5 / 10 ALA A 137
VAL A  73
ILE A 101
GLY A 127
ILE A  94
 None
 1.09A 3oxvB-1q7hA:
undetectable		 3oxvB-1q7hA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_2
(HIV-1 PROTEASE)		 1q7h CONSERVED
HYPOTHETICAL PROTEIN
(Thermoplasma
acidophilum) 		5 / 11 ALA A 137
VAL A  73
ILE A 101
GLY A 127
ILE A  94
 None
 1.02A 3oxvD-1q7hA:
undetectable		 3oxvD-1q7hA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_2
(HIV-1 PROTEASE)		 1q7h CONSERVED
HYPOTHETICAL PROTEIN
(Thermoplasma
acidophilum) 		5 / 10 ALA A 137
VAL A  73
ILE A 101
GLY A 127
ILE A  94
 None
 1.04A 3oxwB-1q7hA:
undetectable		 3oxwB-1q7hA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_1
(ASPARTYL PROTEASE)		 1q7h CONSERVED
HYPOTHETICAL PROTEIN
(Thermoplasma
acidophilum) 		6 / 12 ALA A 137
VAL A  73
ILE A 101
GLY A 127
VAL A  95
ILE A  94
 None
 1.26A 4dqfA-1q7hA:
undetectable		 4dqfA-1q7hA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 1q7h CONSERVED
HYPOTHETICAL PROTEIN
(Thermoplasma
acidophilum) 		5 / 8 ALA A 137
VAL A  73
GLY A 127
VAL A  95
ILE A  94
 None
 1.35A 4ll3A-1q7hA:
undetectable		 4ll3A-1q7hA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1q7h CONSERVED
HYPOTHETICAL PROTEIN
(Thermoplasma
acidophilum) 		4 / 8 LEU A  84
VAL A  60
VAL A 109
TYR A 115
 None
 1.09A 4pwdC-1q7hA:
undetectable		 4pwdC-1q7hA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 1q7h CONSERVED
HYPOTHETICAL PROTEIN
(Thermoplasma
acidophilum) 		5 / 12 GLY A  86
ILE A  94
ARG A 139
ALA A 138
ALA A 137
 None
 0.94A 6c2mD-1q7hA:
undetectable		 6c2mD-1q7hA:
17.42