SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1q7s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1q7s BIT1
(Homo
sapiens) 		5 / 12 GLY A 154
SER A 155
LEU A  75
LEU A 142
HIS A  88
 None
 1.19A 1kyvA-1q7sA:
2.7
1kyvE-1q7sA:
2.6		 1kyvA-1q7sA:
25.66
1kyvE-1q7sA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_B_RBFB502_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1q7s BIT1
(Homo
sapiens) 		5 / 11 LEU A 142
HIS A  88
GLY A 154
SER A 155
LEU A  75
 None
 1.19A 1kyvA-1q7sA:
2.7
1kyvB-1q7sA:
2.6		 1kyvA-1q7sA:
25.66
1kyvB-1q7sA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1q7s BIT1
(Homo
sapiens) 		5 / 12 LEU A 142
HIS A  88
GLY A 154
SER A 155
LEU A  75
 None
 1.21A 1kyvB-1q7sA:
2.6
1kyvC-1q7sA:
2.6		 1kyvB-1q7sA:
25.66
1kyvC-1q7sA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1q7s BIT1
(Homo
sapiens) 		5 / 12 LEU A 142
HIS A  88
GLY A 154
SER A 155
LEU A  75
 None
 1.22A 1kyvC-1q7sA:
2.6
1kyvD-1q7sA:
2.6		 1kyvC-1q7sA:
25.66
1kyvD-1q7sA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1q7s BIT1
(Homo
sapiens) 		5 / 12 LEU A 142
HIS A  88
GLY A 154
SER A 155
LEU A  75
 None
 1.22A 1kyvD-1q7sA:
2.6
1kyvE-1q7sA:
2.6		 1kyvD-1q7sA:
25.66
1kyvE-1q7sA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1q7s BIT1
(Homo
sapiens) 		3 / 3 THR A 125
LEU A 129
LEU A 136
 None
 0.66A 1mz9C-1q7sA:
undetectable		 1mz9C-1q7sA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1q7s BIT1
(Homo
sapiens) 		5 / 12 LEU A 142
HIS A  88
GLY A 154
SER A 155
LEU A  75
 None
 1.21A 2a58A-1q7sA:
2.5
2a58B-1q7sA:
2.5		 2a58A-1q7sA:
25.66
2a58B-1q7sA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1q7s BIT1
(Homo
sapiens) 		5 / 12 LEU A 142
HIS A  88
GLY A 154
SER A 155
LEU A  75
 None
 1.19A 2a58B-1q7sA:
2.5
2a58C-1q7sA:
2.3		 2a58B-1q7sA:
25.66
2a58C-1q7sA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1q7s BIT1
(Homo
sapiens) 		5 / 12 LEU A 142
HIS A  88
GLY A 154
SER A 155
LEU A  75
 None
 1.21A 2a58D-1q7sA:
2.4
2a58E-1q7sA:
2.3		 2a58D-1q7sA:
25.66
2a58E-1q7sA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_B_ECNB1406_1
(CYTOCHROME P450 130)		 1q7s BIT1
(Homo
sapiens) 		5 / 11 PRO A 121
THR A 125
THR A 173
TYR A 179
VAL A 118
 None
 1.44A 2uvnB-1q7sA:
0.0		 2uvnB-1q7sA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_1
(HIV-1 PROTEASE)		 1q7s BIT1
(Homo
sapiens) 		5 / 10 GLY A 137
ASN A 101
ILE A  97
GLY A 162
ILE A 161
 None
 0.97A 3lzvA-1q7sA:
undetectable		 3lzvA-1q7sA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_B_ACHB301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1q7s BIT1
(Homo
sapiens) 		4 / 8 THR A 139
TYR A  94
TRP A 108
MET A  67
 None
 1.46A 3wipB-1q7sA:
undetectable
3wipC-1q7sA:
undetectable		 3wipB-1q7sA:
19.83
3wipC-1q7sA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_C_ACHC301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1q7s BIT1
(Homo
sapiens) 		4 / 8 THR A 139
TYR A  94
TRP A 108
MET A  67
 None
 1.44A 3wipC-1q7sA:
undetectable
3wipD-1q7sA:
undetectable		 3wipC-1q7sA:
19.83
3wipD-1q7sA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_E_ACHE301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1q7s BIT1
(Homo
sapiens) 		4 / 8 TRP A 108
MET A  67
THR A 139
TYR A  94
 None
 1.48A 3wipA-1q7sA:
undetectable
3wipE-1q7sA:
undetectable		 3wipA-1q7sA:
19.83
3wipE-1q7sA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1q7s BIT1
(Homo
sapiens) 		4 / 8 LEU A 129
LEU A 159
VAL A  70
ILE A  68
 None
 0.93A 4oj4A-1q7sA:
undetectable		 4oj4A-1q7sA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_1
(ESTROGEN RECEPTOR)		 1q7s BIT1
(Homo
sapiens) 		5 / 12 THR A 125
ALA A 128
LEU A 130
GLY A 174
LEU A 176
 None
 1.02A 4xi3C-1q7sA:
undetectable		 4xi3C-1q7sA:
16.94