SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1q7y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1D1G_A_MTXA171_1 (DIHYDROFOLATE REDUCTASE)	1q7y	50S RIBOSOMAL PROTEIN L31E (Haloarcula marismortui)	5 / 12	ARG Y 34 GLU Y 88 LEU Y 37 ILE Y 12 THR Y 66	G A1385 ( 3.3A) None None None None	1.31A	1d1gA-1q7yY: undetectable	1d1gA-1q7yY: 23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4NKV_C_AERC601_1 (STEROID 17-ALPHA-HYDROXYLASE /17,20 LYASE)	1q7y	50S RIBOSOMAL PROTEIN L31E (Haloarcula marismortui)	5 / 12	LEU Y 50 ILE Y 12 ARG Y 34 VAL Y 72 VAL Y 10	C A1384 ( 4.3A) None G A1385 ( 3.3A) None None	0.73A	4nkvC-1q7yY: undetectable	4nkvC-1q7yY: 10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4NKV_D_AERD601_1 (STEROID 17-ALPHA-HYDROXYLASE /17,20 LYASE)	1q7y	50S RIBOSOMAL PROTEIN L31E (Haloarcula marismortui)	5 / 12	LEU Y 50 ILE Y 12 ARG Y 34 VAL Y 72 VAL Y 10	C A1384 ( 4.3A) None G A1385 ( 3.3A) None None	0.70A	4nkvD-1q7yY: undetectable	4nkvD-1q7yY: 10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4TWL_B_ASCB304_0 (DIOSCORIN 5)	1q7y	50S RIBOSOMAL PROTEIN L31E (Haloarcula marismortui)	5 / 10	HIS Y 36 VAL Y 10 VAL Y 72 PHE Y 41 ALA Y 38	None	1.04A	4twlB-1q7yY: undetectable	4twlB-1q7yY: 18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KC4_A_RBFA201_2 (RIBOFLAVIN TRANSPORTER RIBU)	1q7y	50S RIBOSOMAL PROTEIN L31E (Haloarcula marismortui)	3 / 3	LYS Y 28 LEU Y 50 ILE Y 12	A A1729 ( 2.5A) C A1384 ( 4.3A) None	0.78A	5kc4A-1q7yY: undetectable	5kc4A-1q7yY: 18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6A7J_A_TESA502_0 (CYTOCHROME P450)	1q7y	50S RIBOSOMAL PROTEIN L31E (Haloarcula marismortui)	4 / 7	LEU Y 50 ALA Y 57 ALA Y 58 THR Y 66	C A1384 ( 4.3A) None None None	0.66A	6a7jA-1q7yY: undetectable	6a7jA-1q7yY: 28.72

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1D1G_A_MTXA171_1","DIHYDROFOLATE REDUCTASE","1q7y","50S RIBOSOMAL PROTEIN L31E","Haloarcula marismortui",5,"ARG Y  34;GLU Y  88;LEU Y  37;ILE Y  12;THR Y  66","  G A1385 ( 3.3A);None;None;None;None","1.31A","1d1gA-1q7yY:undetectable","1d1gA-1q7yY:23.23"],["4NKV_C_AERC601_1","STEROID 17-ALPHA-HYDROXYLASE\/17,20 LYASE","1q7y","50S RIBOSOMAL PROTEIN L31E","Haloarcula marismortui",5,"LEU Y  50;ILE Y  12;ARG Y  34;VAL Y  72;VAL Y  10","  C A1384 ( 4.3A);None;  G A1385 ( 3.3A);None;None","0.73A","4nkvC-1q7yY:undetectable","4nkvC-1q7yY:10.77"],["4NKV_D_AERD601_1","STEROID 17-ALPHA-HYDROXYLASE\/17,20 LYASE","1q7y","50S RIBOSOMAL PROTEIN L31E","Haloarcula marismortui",5,"LEU Y  50;ILE Y  12;ARG Y  34;VAL Y  72;VAL Y  10","  C A1384 ( 4.3A);None;  G A1385 ( 3.3A);None;None","0.70A","4nkvD-1q7yY:undetectable","4nkvD-1q7yY:10.77"],["4TWL_B_ASCB304_0","DIOSCORIN 5","1q7y","50S RIBOSOMAL PROTEIN L31E","Haloarcula marismortui",5,"HIS Y  36;VAL Y  10;VAL Y  72;PHE Y  41;ALA Y  38","None","1.04A","4twlB-1q7yY:undetectable","4twlB-1q7yY:18.53"],["5KC4_A_RBFA201_2","RIBOFLAVIN TRANSPORTER RIBU","1q7y","50S RIBOSOMAL PROTEIN L31E","Haloarcula marismortui",3,"LYS Y  28;LEU Y  50;ILE Y  12","  A A1729 ( 2.5A);  C A1384 ( 4.3A);None","0.78A","5kc4A-1q7yY:undetectable","5kc4A-1q7yY:18.23"],["6A7J_A_TESA502_0","CYTOCHROME P450","1q7y","50S RIBOSOMAL PROTEIN L31E","Haloarcula marismortui",4,"LEU Y  50;ALA Y  57;ALA Y  58;THR Y  66","  C A1384 ( 4.3A);None;None;None","0.66A","6a7jA-1q7yY:undetectable","6a7jA-1q7yY:28.72"]]