SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1q8d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3T3Z_A_9PLA501_1 (CYTOCHROME P450 2E1)	1q8d	GDNF FAMILY RECEPTOR ALPHA 1 (Rattus norvegicus)	4 / 6	LEU A 260 PHE A 332 ALA A 310 LEU A 246	None	0.95A	3t3zA-1q8dA: undetectable	3t3zA-1q8dA: 12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3T3Z_B_9PLB501_1 (CYTOCHROME P450 2E1)	1q8d	GDNF FAMILY RECEPTOR ALPHA 1 (Rattus norvegicus)	4 / 6	LEU A 260 PHE A 332 ALA A 310 LEU A 246	None	0.98A	3t3zB-1q8dA: undetectable	3t3zB-1q8dA: 12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3T3Z_D_9PLD501_1 (CYTOCHROME P450 2E1)	1q8d	GDNF FAMILY RECEPTOR ALPHA 1 (Rattus norvegicus)	4 / 6	LEU A 260 PHE A 332 ALA A 310 LEU A 246	None	1.01A	3t3zD-1q8dA: undetectable	3t3zD-1q8dA: 12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DZK_S_BEZS801_0 (ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 BEZ-LEU-LEU)	1q8d	GDNF FAMILY RECEPTOR ALPHA 1 (Rattus norvegicus)	4 / 6	PHE A 328 SER A 318 LEU A 326 LEU A 329	None	1.35A	5dzke-1q8dA: undetectable 5dzks-1q8dA: undetectable	5dzke-1q8dA: 22.10 5dzks-1q8dA: 4.08

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3T3Z_A_9PLA501_1","CYTOCHROME P450 2E1","1q8d","GDNF FAMILY RECEPTOR ALPHA 1","Rattus norvegicus",4,"LEU A 260;PHE A 332;ALA A 310;LEU A 246","None","0.95A","3t3zA-1q8dA:undetectable","3t3zA-1q8dA:12.72"],["3T3Z_B_9PLB501_1","CYTOCHROME P450 2E1","1q8d","GDNF FAMILY RECEPTOR ALPHA 1","Rattus norvegicus",4,"LEU A 260;PHE A 332;ALA A 310;LEU A 246","None","0.98A","3t3zB-1q8dA:undetectable","3t3zB-1q8dA:12.72"],["3T3Z_D_9PLD501_1","CYTOCHROME P450 2E1","1q8d","GDNF FAMILY RECEPTOR ALPHA 1","Rattus norvegicus",4,"LEU A 260;PHE A 332;ALA A 310;LEU A 246","None","1.01A","3t3zD-1q8dA:undetectable","3t3zD-1q8dA:12.72"],["5DZK_S_BEZS801_0","ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2;BEZ-LEU-LEU","1q8d","GDNF FAMILY RECEPTOR ALPHA 1","Rattus norvegicus",4,"PHE A 328;SER A 318;LEU A 326;LEU A 329","None","1.35A","5dzke-1q8dA:undetectable;5dzks-1q8dA:undetectable","5dzke-1q8dA:22.10;5dzks-1q8dA:4.08"]]