SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1q8f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 GLY A 152
ALA A 174
THR A 273
ILE A 167
THR A 287
 None
 1.09A 1c9sA-1q8fA:
undetectable
1c9sK-1q8fA:
undetectable		 1c9sA-1q8fA:
13.50
1c9sK-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.09A 1c9sA-1q8fA:
undetectable
1c9sB-1q8fA:
undetectable		 1c9sA-1q8fA:
13.50
1c9sB-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.05A 1c9sB-1q8fA:
undetectable
1c9sC-1q8fA:
undetectable		 1c9sB-1q8fA:
13.50
1c9sC-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.04A 1c9sC-1q8fA:
undetectable
1c9sD-1q8fA:
undetectable		 1c9sC-1q8fA:
13.50
1c9sD-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.10A 1c9sD-1q8fA:
undetectable
1c9sE-1q8fA:
undetectable		 1c9sD-1q8fA:
13.50
1c9sE-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.08A 1c9sE-1q8fA:
undetectable
1c9sF-1q8fA:
undetectable		 1c9sE-1q8fA:
13.50
1c9sF-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.04A 1c9sF-1q8fA:
undetectable
1c9sG-1q8fA:
undetectable		 1c9sF-1q8fA:
13.50
1c9sG-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.09A 1c9sG-1q8fA:
undetectable
1c9sH-1q8fA:
undetectable		 1c9sG-1q8fA:
13.50
1c9sH-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.09A 1c9sH-1q8fA:
undetectable
1c9sI-1q8fA:
undetectable		 1c9sH-1q8fA:
13.50
1c9sI-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.09A 1c9sJ-1q8fA:
undetectable
1c9sK-1q8fA:
undetectable		 1c9sJ-1q8fA:
13.50
1c9sK-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 GLY A 152
ALA A 174
THR A 273
ILE A 167
THR A 287
 None
 1.08A 1gtfA-1q8fA:
undetectable
1gtfK-1q8fA:
undetectable		 1gtfA-1q8fA:
13.50
1gtfK-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.04A 1gtfA-1q8fA:
undetectable
1gtfB-1q8fA:
undetectable		 1gtfA-1q8fA:
13.50
1gtfB-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.05A 1gtfB-1q8fA:
undetectable
1gtfC-1q8fA:
undetectable		 1gtfB-1q8fA:
13.50
1gtfC-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.09A 1gtfC-1q8fA:
undetectable
1gtfD-1q8fA:
undetectable		 1gtfC-1q8fA:
13.50
1gtfD-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.12A 1gtfD-1q8fA:
undetectable
1gtfE-1q8fA:
undetectable		 1gtfD-1q8fA:
13.50
1gtfE-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.10A 1gtfE-1q8fA:
undetectable
1gtfF-1q8fA:
undetectable		 1gtfE-1q8fA:
13.50
1gtfF-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.09A 1gtfF-1q8fA:
undetectable
1gtfG-1q8fA:
0.0		 1gtfF-1q8fA:
13.50
1gtfG-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.06A 1gtfG-1q8fA:
0.0
1gtfH-1q8fA:
undetectable		 1gtfG-1q8fA:
13.50
1gtfH-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.10A 1gtfH-1q8fA:
undetectable
1gtfI-1q8fA:
undetectable		 1gtfH-1q8fA:
13.50
1gtfI-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.07A 1gtfI-1q8fA:
undetectable
1gtfJ-1q8fA:
undetectable		 1gtfI-1q8fA:
13.50
1gtfJ-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.05A 1gtfJ-1q8fA:
undetectable
1gtfK-1q8fA:
undetectable		 1gtfJ-1q8fA:
13.50
1gtfK-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.15A 1gtfL-1q8fA:
undetectable
1gtfV-1q8fA:
undetectable		 1gtfL-1q8fA:
13.50
1gtfV-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 8 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.05A 1gtnA-1q8fA:
undetectable
1gtnB-1q8fA:
undetectable		 1gtnA-1q8fA:
13.50
1gtnB-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.05A 1gtnB-1q8fA:
undetectable
1gtnC-1q8fA:
undetectable		 1gtnB-1q8fA:
13.50
1gtnC-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		4 / 6 THR A 287
GLY A 152
THR A 273
ILE A 167
 None
 0.91A 1gtnD-1q8fA:
undetectable
1gtnE-1q8fA:
undetectable		 1gtnD-1q8fA:
13.50
1gtnE-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.07A 1gtnG-1q8fA:
undetectable
1gtnH-1q8fA:
undetectable		 1gtnG-1q8fA:
13.50
1gtnH-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.11A 1gtnH-1q8fA:
undetectable
1gtnI-1q8fA:
undetectable		 1gtnH-1q8fA:
13.50
1gtnI-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 GLY A 152
ALA A 174
THR A 273
ILE A 167
THR A 287
 None
 1.14A 1gtnU-1q8fA:
undetectable
1gtnV-1q8fA:
undetectable		 1gtnU-1q8fA:
13.50
1gtnV-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 12 ALA A 104
VAL A  37
GLY A  66
ALA A 173
ILE A 167
 None
 1.16A 1kxhA-1q8fA:
undetectable		 1kxhA-1q8fA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 12 ILE A 130
ILE A   6
LEU A  31
VAL A  61
ILE A  34
 None
 0.99A 1oipA-1q8fA:
1.9		 1oipA-1q8fA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_A_TRPA81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 GLY A 152
ALA A 174
THR A 273
ILE A 167
THR A 287
 None
 1.10A 1utdA-1q8fA:
undetectable
1utdB-1q8fA:
undetectable		 1utdA-1q8fA:
13.50
1utdB-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_B_TRPB81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 8 GLY A 152
ALA A 174
THR A 273
ILE A 167
THR A 287
 None
 1.10A 1utdB-1q8fA:
undetectable
1utdC-1q8fA:
undetectable		 1utdB-1q8fA:
13.50
1utdC-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_C_TRPC81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 GLY A 152
ALA A 174
THR A 273
ILE A 167
THR A 287
 None
 1.12A 1utdC-1q8fA:
undetectable
1utdD-1q8fA:
undetectable		 1utdC-1q8fA:
13.50
1utdD-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_D_TRPD81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 GLY A 152
ALA A 174
THR A 273
ILE A 167
THR A 287
 None
 1.04A 1utdD-1q8fA:
undetectable
1utdE-1q8fA:
undetectable		 1utdD-1q8fA:
13.50
1utdE-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_E_TRPE81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 GLY A 152
ALA A 174
THR A 273
ILE A 167
THR A 287
 None
 1.10A 1utdE-1q8fA:
undetectable
1utdF-1q8fA:
undetectable		 1utdE-1q8fA:
13.50
1utdF-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_F_TRPF81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 8 GLY A 152
ALA A 174
THR A 273
ILE A 167
THR A 287
 None
 1.08A 1utdF-1q8fA:
undetectable
1utdG-1q8fA:
undetectable		 1utdF-1q8fA:
13.50
1utdG-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_G_TRPG81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 GLY A 152
ALA A 174
THR A 273
ILE A 167
THR A 287
 None
 1.07A 1utdG-1q8fA:
undetectable
1utdH-1q8fA:
undetectable		 1utdG-1q8fA:
13.50
1utdH-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_H_TRPH81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 GLY A 152
ALA A 174
THR A 273
ILE A 167
THR A 287
 None
 1.07A 1utdH-1q8fA:
undetectable
1utdI-1q8fA:
undetectable		 1utdH-1q8fA:
13.50
1utdI-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_J_TRPJ81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 8 GLY A 152
ALA A 174
THR A 273
ILE A 167
THR A 287
 None
 1.08A 1utdJ-1q8fA:
undetectable
1utdK-1q8fA:
undetectable		 1utdJ-1q8fA:
13.50
1utdK-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_K_TRPK81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.04A 1utdA-1q8fA:
undetectable
1utdK-1q8fA:
undetectable		 1utdA-1q8fA:
13.50
1utdK-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_M_TRPM81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 11 GLY A 152
ALA A 174
THR A 273
ILE A 167
THR A 287
 None
 1.16A 1utdM-1q8fA:
undetectable
1utdN-1q8fA:
undetectable		 1utdM-1q8fA:
13.50
1utdN-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		4 / 5 ALA A 104
ASN A 129
ILE A 130
ASP A   9
 None
 1.09A 2h4jA-1q8fA:
4.0		 2h4jA-1q8fA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_1
(PROTEASE)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		6 / 12 ALA A  19
ASP A 240
VAL A 238
GLY A 245
ILE A 248
ILE A  18
 None
GOL  A3001 ( 2.5A)
None
None
None
None
 1.48A 2ienA-1q8fA:
undetectable		 2ienA-1q8fA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		4 / 9 ILE A  18
PHE A 298
VAL A 302
GLU A 303
 None
 0.78A 2vufA-1q8fA:
undetectable		 2vufA-1q8fA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 11 ALA A 131
ALA A 133
HIS A 103
GLY A  66
ILE A  71
 None
 1.09A 2x1lC-1q8fA:
undetectable		 2x1lC-1q8fA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 12 THR A  46
ASP A  11
VAL A  37
SER A 128
PHE A 165
 None
CA  A2001 (-3.1A)
None
None
GOL  A3005 ( 4.5A)
 1.44A 2y00B-1q8fA:
undetectable		 2y00B-1q8fA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y01_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 12 THR A  46
ASP A  11
VAL A  37
SER A 128
PHE A 165
 None
CA  A2001 (-3.1A)
None
None
GOL  A3005 ( 4.5A)
 1.42A 2y01B-1q8fA:
undetectable		 2y01B-1q8fA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 11 HIS A  82
ILE A  81
HIS A 239
ASN A 193
VAL A 196
 GOL  A3005 (-3.9A)
GOL  A3005 ( 4.2A)
GOL  A3001 ( 3.9A)
None
None
 1.08A 2zweA-1q8fA:
undetectable
2zweB-1q8fA:
undetectable		 2zweA-1q8fA:
20.78
2zweB-1q8fA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 11 LEU A 121
ASN A 129
LEU A 141
ILE A 144
LEU A 184
 None
 1.30A 3a50C-1q8fA:
undetectable		 3a50C-1q8fA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		4 / 8 GLY A 157
THR A 156
GLY A 152
ALA A 153
 None
 0.75A 3aruA-1q8fA:
undetectable		 3aruA-1q8fA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 12 LEU A 191
THR A 242
VAL A 238
THR A 295
ILE A 293
 None
 1.03A 3bf1A-1q8fA:
undetectable
3bf1B-1q8fA:
undetectable		 3bf1A-1q8fA:
22.62
3bf1B-1q8fA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_1
(PROTEASE)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		6 / 10 ALA A  19
ASP A 240
VAL A 238
GLY A 245
ILE A 248
ILE A  18
 None
GOL  A3001 ( 2.5A)
None
None
None
None
 1.40A 3ekpC-1q8fA:
undetectable		 3ekpC-1q8fA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_2
(PROTEASE)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		6 / 10 ALA A  19
ASP A 240
VAL A 238
GLY A 245
ILE A 248
ILE A  18
 None
GOL  A3001 ( 2.5A)
None
None
None
None
 1.42A 3ekpD-1q8fA:
undetectable		 3ekpD-1q8fA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_2
(PROTEASE)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		6 / 9 ALA A  19
ASP A 240
VAL A 238
GLY A 245
ILE A 248
ILE A  18
 None
GOL  A3001 ( 2.5A)
None
None
None
None
 1.42A 3ektB-1q8fA:
undetectable		 3ektB-1q8fA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_1
(PROTEASE)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		6 / 11 ALA A  19
ASP A 240
VAL A 238
GLY A 245
ILE A 248
ILE A  18
 None
GOL  A3001 ( 2.5A)
None
None
None
None
 1.41A 3ektC-1q8fA:
undetectable		 3ektC-1q8fA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_1
(PROTEASE)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		6 / 10 ALA A  19
ASP A 240
VAL A 238
GLY A 245
ILE A 248
ILE A  18
 None
GOL  A3001 ( 2.5A)
None
None
None
None
 1.40A 3ekvA-1q8fA:
undetectable		 3ekvA-1q8fA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_1
(PROTEASE)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		6 / 11 ALA A  19
ASP A 240
VAL A 238
GLY A 245
ILE A 248
ILE A  18
 None
GOL  A3001 ( 2.5A)
None
None
None
None
 1.36A 3ekxA-1q8fA:
undetectable		 3ekxA-1q8fA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_B_NIOB5661_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		4 / 8 ILE A 140
ALA A 133
LEU A 121
ALA A 104
 None
 0.94A 3hrdA-1q8fA:
0.0
3hrdB-1q8fA:
undetectable		 3hrdA-1q8fA:
20.28
3hrdB-1q8fA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		6 / 12 PRO A 237
GLY A 236
GLY A 235
ASP A  16
PRO A  90
LEU A 215
 None
None
None
CA  A2001 (-2.2A)
None
None
 1.47A 3m6vA-1q8fA:
3.4		 3m6vA-1q8fA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		6 / 12 PRO A 237
GLY A 236
GLY A 235
ASP A  16
PRO A  90
LEU A 215
 None
None
None
CA  A2001 (-2.2A)
None
None
 1.42A 3m6vB-1q8fA:
3.4		 3m6vB-1q8fA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		6 / 12 PRO A 237
GLY A 236
GLY A 235
ASP A  16
PRO A  90
LEU A 215
 None
None
None
CA  A2001 (-2.2A)
None
None
 1.47A 3m6wA-1q8fA:
3.4		 3m6wA-1q8fA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 12 ASP A  30
ILE A  29
VAL A  63
ILE A  36
ILE A 244
 None
 1.22A 3ohtA-1q8fA:
0.0
3ohtB-1q8fA:
undetectable		 3ohtA-1q8fA:
21.79
3ohtB-1q8fA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_A_ACRA1_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 12 ASP A 240
PRO A  12
ILE A 167
MET A 150
ASP A  11
 GOL  A3001 ( 2.5A)
None
None
GOL  A3001 (-3.4A)
CA  A2001 (-3.1A)
 1.41A 3topA-1q8fA:
undetectable		 3topA-1q8fA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		3 / 3 TYR A 259
GLU A 277
TYR A 154
 None
 0.95A 3ug8A-1q8fA:
2.0		 3ug8A-1q8fA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 12 LEU A  31
CYH A 305
ILE A 244
ILE A  20
PHE A 216
 None
 1.45A 4a79A-1q8fA:
2.5		 4a79A-1q8fA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_A_RGZA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 11 LEU A  31
CYH A 305
ILE A 244
ILE A  20
PHE A 216
 None
 1.44A 4a7aA-1q8fA:
2.3		 4a7aA-1q8fA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		4 / 8 ILE A 130
LEU A 121
ILE A 109
GLY A  33
 None
 0.85A 4hb8A-1q8fA:
undetectable		 4hb8A-1q8fA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 12 ASP A  15
VAL A 238
PHE A 298
LEU A 247
VAL A 124
 GOL  A3001 (-3.6A)
None
None
None
CA  A2001 ( 4.7A)
 1.34A 4nc3A-1q8fA:
undetectable		 4nc3A-1q8fA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_2
(PROTEASE)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 11 GLY A 125
ASP A 170
ILE A 147
THR A 273
ILE A 167
 CA  A2001 ( 4.2A)
None
None
None
None
 1.00A 4njvB-1q8fA:
undetectable		 4njvB-1q8fA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 12 ALA A 153
GLY A 188
ILE A 167
ASN A 166
MET A 150
 None
None
None
GOL  A3001 (-3.3A)
GOL  A3001 (-3.4A)
 1.22A 4obwA-1q8fA:
3.4		 4obwA-1q8fA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 12 ALA A 153
GLY A 188
ILE A 167
ASN A 166
MET A 150
 None
None
None
GOL  A3001 (-3.3A)
GOL  A3001 (-3.4A)
 1.24A 4obwD-1q8fA:
3.0		 4obwD-1q8fA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 273
ALA A 174
ALA A 173
GLY A 152
GLY A 151
 None
 1.05A 4qvpK-1q8fA:
undetectable
4qvpL-1q8fA:
undetectable		 4qvpK-1q8fA:
21.20
4qvpL-1q8fA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 273
ALA A 174
ALA A 173
GLY A 152
GLY A 151
 None
 1.05A 4qvpY-1q8fA:
undetectable
4qvpZ-1q8fA:
undetectable		 4qvpY-1q8fA:
21.20
4qvpZ-1q8fA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 273
ALA A 174
ALA A 173
GLY A 152
GLY A 151
 None
 1.16A 4qwuY-1q8fA:
undetectable
4qwuZ-1q8fA:
undetectable		 4qwuY-1q8fA:
21.52
4qwuZ-1q8fA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		4 / 5 GLY A  83
THR A  85
HIS A  14
GLY A  89
 None
 1.03A 4v20A-1q8fA:
undetectable		 4v20A-1q8fA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		4 / 8 GLY A  39
GLN A  41
PHE A 165
ASN A  40
 None
None
GOL  A3005 ( 4.5A)
GOL  A3005 (-3.8A)
 1.03A 4wryA-1q8fA:
undetectable		 4wryA-1q8fA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		4 / 8 GLY A  39
GLN A  41
PHE A 165
ASN A  40
 None
None
GOL  A3005 ( 4.5A)
GOL  A3005 (-3.8A)
 1.01A 4wrzA-1q8fA:
undetectable		 4wrzA-1q8fA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.06A 5eeuA-1q8fA:
undetectable
5eeuB-1q8fA:
undetectable		 5eeuA-1q8fA:
13.50
5eeuB-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.09A 5eeuB-1q8fA:
undetectable
5eeuC-1q8fA:
undetectable		 5eeuB-1q8fA:
13.50
5eeuC-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.08A 5eeuC-1q8fA:
undetectable
5eeuD-1q8fA:
undetectable		 5eeuC-1q8fA:
13.50
5eeuD-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.04A 5eeuD-1q8fA:
undetectable
5eeuE-1q8fA:
undetectable		 5eeuD-1q8fA:
13.50
5eeuE-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.08A 5eeuE-1q8fA:
undetectable
5eeuF-1q8fA:
undetectable		 5eeuE-1q8fA:
13.50
5eeuF-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.10A 5eeuF-1q8fA:
undetectable
5eeuG-1q8fA:
undetectable		 5eeuF-1q8fA:
13.50
5eeuG-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.10A 5eeuG-1q8fA:
undetectable
5eeuH-1q8fA:
undetectable		 5eeuG-1q8fA:
13.50
5eeuH-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.09A 5eeuH-1q8fA:
undetectable
5eeuI-1q8fA:
0.0		 5eeuH-1q8fA:
13.50
5eeuI-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 12 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.05A 5eeuI-1q8fA:
undetectable
5eeuJ-1q8fA:
undetectable		 5eeuI-1q8fA:
13.50
5eeuJ-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.12A 5eeuJ-1q8fA:
undetectable
5eeuK-1q8fA:
undetectable		 5eeuJ-1q8fA:
13.50
5eeuK-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 GLY A 152
ALA A 174
THR A 273
ILE A 167
THR A 287
 None
 1.06A 5eeuA-1q8fA:
undetectable
5eeuK-1q8fA:
undetectable		 5eeuA-1q8fA:
13.50
5eeuK-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.06A 5eevA-1q8fA:
undetectable
5eevB-1q8fA:
undetectable		 5eevA-1q8fA:
13.50
5eevB-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.09A 5eevB-1q8fA:
undetectable
5eevC-1q8fA:
undetectable		 5eevB-1q8fA:
13.50
5eevC-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.08A 5eevC-1q8fA:
undetectable
5eevD-1q8fA:
undetectable		 5eevC-1q8fA:
13.50
5eevD-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.03A 5eevD-1q8fA:
undetectable
5eevE-1q8fA:
undetectable		 5eevD-1q8fA:
13.50
5eevE-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.09A 5eevE-1q8fA:
undetectable
5eevF-1q8fA:
undetectable		 5eevE-1q8fA:
13.50
5eevF-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.10A 5eevF-1q8fA:
undetectable
5eevG-1q8fA:
undetectable		 5eevF-1q8fA:
13.50
5eevG-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.10A 5eevG-1q8fA:
undetectable
5eevH-1q8fA:
undetectable		 5eevG-1q8fA:
13.50
5eevH-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.09A 5eevH-1q8fA:
undetectable
5eevI-1q8fA:
undetectable		 5eevH-1q8fA:
13.50
5eevI-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 12 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.05A 5eevI-1q8fA:
undetectable
5eevJ-1q8fA:
undetectable		 5eevI-1q8fA:
13.50
5eevJ-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.12A 5eevJ-1q8fA:
undetectable
5eevK-1q8fA:
undetectable		 5eevJ-1q8fA:
13.50
5eevK-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 GLY A 152
ALA A 174
THR A 273
ILE A 167
THR A 287
 None
 1.06A 5eevA-1q8fA:
undetectable
5eevK-1q8fA:
undetectable		 5eevA-1q8fA:
13.50
5eevK-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 GLY A 152
ALA A 174
THR A 273
ILE A 167
THR A 287
 None
 1.15A 5eevU-1q8fA:
undetectable
5eevV-1q8fA:
undetectable		 5eevU-1q8fA:
13.50
5eevV-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.05A 5eewA-1q8fA:
undetectable
5eewB-1q8fA:
undetectable		 5eewA-1q8fA:
13.50
5eewB-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.09A 5eewB-1q8fA:
undetectable
5eewC-1q8fA:
undetectable		 5eewB-1q8fA:
13.50
5eewC-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.08A 5eewC-1q8fA:
undetectable
5eewD-1q8fA:
undetectable		 5eewC-1q8fA:
13.50
5eewD-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.03A 5eewD-1q8fA:
undetectable
5eewE-1q8fA:
undetectable		 5eewD-1q8fA:
13.50
5eewE-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.09A 5eewE-1q8fA:
undetectable
5eewF-1q8fA:
undetectable		 5eewE-1q8fA:
13.50
5eewF-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.10A 5eewF-1q8fA:
undetectable
5eewG-1q8fA:
undetectable		 5eewF-1q8fA:
13.50
5eewG-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.10A 5eewG-1q8fA:
undetectable
5eewH-1q8fA:
undetectable		 5eewG-1q8fA:
13.50
5eewH-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.09A 5eewH-1q8fA:
undetectable
5eewI-1q8fA:
undetectable		 5eewH-1q8fA:
13.50
5eewI-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 12 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.06A 5eewI-1q8fA:
undetectable
5eewJ-1q8fA:
undetectable		 5eewI-1q8fA:
13.50
5eewJ-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.12A 5eewJ-1q8fA:
undetectable
5eewK-1q8fA:
undetectable		 5eewJ-1q8fA:
13.50
5eewK-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 GLY A 152
ALA A 174
THR A 273
ILE A 167
THR A 287
 None
 1.06A 5eewA-1q8fA:
undetectable
5eewK-1q8fA:
undetectable		 5eewA-1q8fA:
13.50
5eewK-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 GLY A 152
ALA A 174
THR A 273
ILE A 167
THR A 287
 None
 1.15A 5eewU-1q8fA:
undetectable
5eewV-1q8fA:
undetectable		 5eewU-1q8fA:
13.50
5eewV-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.06A 5eexA-1q8fA:
undetectable
5eexB-1q8fA:
undetectable		 5eexA-1q8fA:
13.50
5eexB-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.09A 5eexB-1q8fA:
undetectable
5eexC-1q8fA:
undetectable		 5eexB-1q8fA:
13.50
5eexC-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.08A 5eexC-1q8fA:
undetectable
5eexD-1q8fA:
undetectable		 5eexC-1q8fA:
13.50
5eexD-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.04A 5eexD-1q8fA:
undetectable
5eexE-1q8fA:
undetectable		 5eexD-1q8fA:
13.50
5eexE-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.08A 5eexE-1q8fA:
undetectable
5eexF-1q8fA:
undetectable		 5eexE-1q8fA:
13.50
5eexF-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.10A 5eexF-1q8fA:
undetectable
5eexG-1q8fA:
undetectable		 5eexF-1q8fA:
13.50
5eexG-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.10A 5eexG-1q8fA:
undetectable
5eexH-1q8fA:
undetectable		 5eexG-1q8fA:
13.50
5eexH-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.09A 5eexH-1q8fA:
undetectable
5eexI-1q8fA:
undetectable		 5eexH-1q8fA:
13.50
5eexI-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 11 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.05A 5eexI-1q8fA:
undetectable
5eexJ-1q8fA:
undetectable		 5eexI-1q8fA:
13.50
5eexJ-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.12A 5eexJ-1q8fA:
undetectable
5eexK-1q8fA:
0.0		 5eexJ-1q8fA:
13.50
5eexK-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 GLY A 152
ALA A 174
THR A 273
ILE A 167
THR A 287
 None
 1.06A 5eexA-1q8fA:
undetectable
5eexK-1q8fA:
undetectable		 5eexA-1q8fA:
13.50
5eexK-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 GLY A 152
ALA A 174
THR A 273
ILE A 167
THR A 287
 None
 1.15A 5eexU-1q8fA:
undetectable
5eexV-1q8fA:
undetectable		 5eexU-1q8fA:
13.50
5eexV-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.05A 5eeyA-1q8fA:
undetectable
5eeyB-1q8fA:
undetectable		 5eeyA-1q8fA:
13.50
5eeyB-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.09A 5eeyB-1q8fA:
undetectable
5eeyC-1q8fA:
undetectable		 5eeyB-1q8fA:
13.50
5eeyC-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.08A 5eeyC-1q8fA:
undetectable
5eeyD-1q8fA:
undetectable		 5eeyC-1q8fA:
13.50
5eeyD-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.03A 5eeyD-1q8fA:
undetectable
5eeyE-1q8fA:
undetectable		 5eeyD-1q8fA:
13.50
5eeyE-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.08A 5eeyE-1q8fA:
undetectable
5eeyF-1q8fA:
undetectable		 5eeyE-1q8fA:
13.50
5eeyF-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.10A 5eeyF-1q8fA:
undetectable
5eeyG-1q8fA:
undetectable		 5eeyF-1q8fA:
13.50
5eeyG-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.10A 5eeyG-1q8fA:
undetectable
5eeyH-1q8fA:
undetectable		 5eeyG-1q8fA:
13.50
5eeyH-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.09A 5eeyH-1q8fA:
undetectable
5eeyI-1q8fA:
undetectable		 5eeyH-1q8fA:
13.50
5eeyI-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 11 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.05A 5eeyI-1q8fA:
undetectable
5eeyJ-1q8fA:
undetectable		 5eeyI-1q8fA:
13.50
5eeyJ-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.12A 5eeyJ-1q8fA:
undetectable
5eeyK-1q8fA:
undetectable		 5eeyJ-1q8fA:
13.50
5eeyK-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 GLY A 152
ALA A 174
THR A 273
ILE A 167
THR A 287
 None
 1.06A 5eeyA-1q8fA:
undetectable
5eeyK-1q8fA:
undetectable		 5eeyA-1q8fA:
13.50
5eeyK-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 GLY A 152
ALA A 174
THR A 273
ILE A 167
THR A 287
 None
 1.15A 5eeyU-1q8fA:
undetectable
5eeyV-1q8fA:
undetectable		 5eeyU-1q8fA:
13.50
5eeyV-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.05A 5eezA-1q8fA:
undetectable
5eezB-1q8fA:
undetectable		 5eezA-1q8fA:
13.50
5eezB-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.09A 5eezB-1q8fA:
undetectable
5eezC-1q8fA:
undetectable		 5eezB-1q8fA:
13.50
5eezC-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.08A 5eezC-1q8fA:
undetectable
5eezD-1q8fA:
undetectable		 5eezC-1q8fA:
13.50
5eezD-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.03A 5eezD-1q8fA:
undetectable
5eezE-1q8fA:
undetectable		 5eezD-1q8fA:
13.50
5eezE-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.08A 5eezE-1q8fA:
undetectable
5eezF-1q8fA:
undetectable		 5eezE-1q8fA:
13.50
5eezF-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.10A 5eezF-1q8fA:
undetectable
5eezG-1q8fA:
undetectable		 5eezF-1q8fA:
13.50
5eezG-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.10A 5eezG-1q8fA:
undetectable
5eezH-1q8fA:
undetectable		 5eezG-1q8fA:
13.50
5eezH-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.09A 5eezH-1q8fA:
0.0
5eezI-1q8fA:
undetectable		 5eezH-1q8fA:
13.50
5eezI-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 11 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.06A 5eezI-1q8fA:
undetectable
5eezJ-1q8fA:
undetectable		 5eezI-1q8fA:
13.50
5eezJ-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.12A 5eezJ-1q8fA:
undetectable
5eezK-1q8fA:
undetectable		 5eezJ-1q8fA:
13.50
5eezK-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 GLY A 152
ALA A 174
THR A 273
ILE A 167
THR A 287
 None
 1.06A 5eezA-1q8fA:
undetectable
5eezK-1q8fA:
undetectable		 5eezA-1q8fA:
13.50
5eezK-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 GLY A 152
ALA A 174
THR A 273
ILE A 167
THR A 287
 None
 1.15A 5eezU-1q8fA:
undetectable
5eezV-1q8fA:
undetectable		 5eezU-1q8fA:
13.50
5eezV-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.05A 5ef0A-1q8fA:
undetectable
5ef0B-1q8fA:
undetectable		 5ef0A-1q8fA:
13.50
5ef0B-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.09A 5ef0B-1q8fA:
undetectable
5ef0C-1q8fA:
undetectable		 5ef0B-1q8fA:
13.50
5ef0C-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.08A 5ef0C-1q8fA:
undetectable
5ef0D-1q8fA:
undetectable		 5ef0C-1q8fA:
13.50
5ef0D-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.03A 5ef0D-1q8fA:
undetectable
5ef0E-1q8fA:
undetectable		 5ef0D-1q8fA:
13.50
5ef0E-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.09A 5ef0E-1q8fA:
undetectable
5ef0F-1q8fA:
undetectable		 5ef0E-1q8fA:
13.50
5ef0F-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.10A 5ef0F-1q8fA:
undetectable
5ef0G-1q8fA:
undetectable		 5ef0F-1q8fA:
13.50
5ef0G-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.10A 5ef0G-1q8fA:
undetectable
5ef0H-1q8fA:
undetectable		 5ef0G-1q8fA:
13.50
5ef0H-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.09A 5ef0H-1q8fA:
undetectable
5ef0I-1q8fA:
undetectable		 5ef0H-1q8fA:
13.50
5ef0I-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 11 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.05A 5ef0I-1q8fA:
undetectable
5ef0J-1q8fA:
undetectable		 5ef0I-1q8fA:
13.50
5ef0J-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.12A 5ef0J-1q8fA:
undetectable
5ef0K-1q8fA:
undetectable		 5ef0J-1q8fA:
13.50
5ef0K-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 GLY A 152
ALA A 174
THR A 273
ILE A 167
THR A 287
 None
 1.06A 5ef0A-1q8fA:
undetectable
5ef0K-1q8fA:
undetectable		 5ef0A-1q8fA:
13.50
5ef0K-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 GLY A 152
ALA A 174
THR A 273
ILE A 167
THR A 287
 None
 1.15A 5ef0T-1q8fA:
undetectable
5ef0U-1q8fA:
undetectable		 5ef0T-1q8fA:
13.50
5ef0U-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 GLY A 152
ALA A 174
THR A 273
ILE A 167
THR A 287
 None
 1.16A 5ef0U-1q8fA:
undetectable
5ef0V-1q8fA:
undetectable		 5ef0U-1q8fA:
13.50
5ef0V-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.05A 5ef1A-1q8fA:
undetectable
5ef1B-1q8fA:
undetectable		 5ef1A-1q8fA:
13.50
5ef1B-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.09A 5ef1B-1q8fA:
undetectable
5ef1C-1q8fA:
undetectable		 5ef1B-1q8fA:
13.50
5ef1C-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.08A 5ef1C-1q8fA:
undetectable
5ef1D-1q8fA:
undetectable		 5ef1C-1q8fA:
13.50
5ef1D-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.03A 5ef1D-1q8fA:
undetectable
5ef1E-1q8fA:
undetectable		 5ef1D-1q8fA:
13.50
5ef1E-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.09A 5ef1E-1q8fA:
undetectable
5ef1F-1q8fA:
undetectable		 5ef1E-1q8fA:
13.50
5ef1F-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.10A 5ef1F-1q8fA:
undetectable
5ef1G-1q8fA:
undetectable		 5ef1F-1q8fA:
13.50
5ef1G-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.10A 5ef1G-1q8fA:
undetectable
5ef1H-1q8fA:
undetectable		 5ef1G-1q8fA:
13.50
5ef1H-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.10A 5ef1H-1q8fA:
undetectable
5ef1I-1q8fA:
undetectable		 5ef1H-1q8fA:
13.50
5ef1I-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 11 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.05A 5ef1I-1q8fA:
undetectable
5ef1J-1q8fA:
undetectable		 5ef1I-1q8fA:
13.50
5ef1J-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.12A 5ef1J-1q8fA:
undetectable
5ef1K-1q8fA:
undetectable		 5ef1J-1q8fA:
13.50
5ef1K-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 GLY A 152
ALA A 174
THR A 273
ILE A 167
THR A 287
 None
 1.06A 5ef1A-1q8fA:
undetectable
5ef1K-1q8fA:
undetectable		 5ef1A-1q8fA:
13.50
5ef1K-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.05A 5ef2A-1q8fA:
undetectable
5ef2B-1q8fA:
undetectable		 5ef2A-1q8fA:
13.50
5ef2B-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.09A 5ef2B-1q8fA:
undetectable
5ef2C-1q8fA:
undetectable		 5ef2B-1q8fA:
13.50
5ef2C-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.08A 5ef2C-1q8fA:
undetectable
5ef2D-1q8fA:
undetectable		 5ef2C-1q8fA:
13.50
5ef2D-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.03A 5ef2D-1q8fA:
undetectable
5ef2E-1q8fA:
undetectable		 5ef2D-1q8fA:
13.50
5ef2E-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.08A 5ef2E-1q8fA:
undetectable
5ef2F-1q8fA:
undetectable		 5ef2E-1q8fA:
13.50
5ef2F-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.10A 5ef2F-1q8fA:
undetectable
5ef2G-1q8fA:
undetectable		 5ef2F-1q8fA:
13.50
5ef2G-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.10A 5ef2G-1q8fA:
undetectable
5ef2H-1q8fA:
undetectable		 5ef2G-1q8fA:
13.50
5ef2H-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.10A 5ef2H-1q8fA:
undetectable
5ef2I-1q8fA:
undetectable		 5ef2H-1q8fA:
13.50
5ef2I-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 11 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.05A 5ef2I-1q8fA:
undetectable
5ef2J-1q8fA:
undetectable		 5ef2I-1q8fA:
13.50
5ef2J-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.12A 5ef2J-1q8fA:
undetectable
5ef2K-1q8fA:
undetectable		 5ef2J-1q8fA:
13.50
5ef2K-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 GLY A 152
ALA A 174
THR A 273
ILE A 167
THR A 287
 None
 1.07A 5ef2A-1q8fA:
undetectable
5ef2K-1q8fA:
undetectable		 5ef2A-1q8fA:
13.50
5ef2K-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.05A 5ef3A-1q8fA:
undetectable
5ef3B-1q8fA:
undetectable		 5ef3A-1q8fA:
13.50
5ef3B-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.09A 5ef3B-1q8fA:
undetectable
5ef3C-1q8fA:
undetectable		 5ef3B-1q8fA:
13.50
5ef3C-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.09A 5ef3C-1q8fA:
undetectable
5ef3D-1q8fA:
undetectable		 5ef3C-1q8fA:
13.50
5ef3D-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.03A 5ef3D-1q8fA:
undetectable
5ef3E-1q8fA:
undetectable		 5ef3D-1q8fA:
13.50
5ef3E-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.09A 5ef3E-1q8fA:
undetectable
5ef3F-1q8fA:
undetectable		 5ef3E-1q8fA:
13.50
5ef3F-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.10A 5ef3F-1q8fA:
undetectable
5ef3G-1q8fA:
undetectable		 5ef3F-1q8fA:
13.50
5ef3G-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.10A 5ef3G-1q8fA:
undetectable
5ef3H-1q8fA:
undetectable		 5ef3G-1q8fA:
13.50
5ef3H-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.10A 5ef3H-1q8fA:
undetectable
5ef3I-1q8fA:
undetectable		 5ef3H-1q8fA:
13.50
5ef3I-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 11 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.05A 5ef3I-1q8fA:
undetectable
5ef3J-1q8fA:
undetectable		 5ef3I-1q8fA:
13.50
5ef3J-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 9 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.12A 5ef3J-1q8fA:
undetectable
5ef3K-1q8fA:
undetectable		 5ef3J-1q8fA:
13.50
5ef3K-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 GLY A 152
ALA A 174
THR A 273
ILE A 167
THR A 287
 None
 1.06A 5ef3A-1q8fA:
undetectable
5ef3K-1q8fA:
undetectable		 5ef3A-1q8fA:
13.50
5ef3K-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 12 THR A 160
PHE A 168
ILE A  76
GLN A  74
PHE A 159
 None
None
None
GOL  A3009 ( 3.5A)
GOL  A3005 (-4.9A)
 1.25A 5hgcA-1q8fA:
undetectable		 5hgcA-1q8fA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 12 ILE A  20
ALA A  17
LEU A 215
GLY A  33
VAL A  61
 None
 1.06A 5i71A-1q8fA:
undetectable		 5i71A-1q8fA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		4 / 6 PHE A 298
VAL A 302
MET A 220
ILE A  18
 None
 1.31A 5iwuA-1q8fA:
undetectable		 5iwuA-1q8fA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 12 ILE A 130
ILE A   6
LEU A  31
VAL A  61
ILE A  34
 None
 0.95A 5mugA-1q8fA:
1.7		 5mugA-1q8fA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		3 / 3 CYH A 197
MET A 220
ASN A 221
 None
 1.17A 5qh8A-1q8fA:
0.0		 5qh8A-1q8fA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 12 ASP A  15
VAL A 238
LEU A  31
LEU A   8
VAL A 124
 GOL  A3001 (-3.6A)
None
None
None
CA  A2001 ( 4.7A)
 1.12A 5tudA-1q8fA:
undetectable		 5tudA-1q8fA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 11 HIS A  82
ILE A  81
HIS A 239
ASN A 193
VAL A 196
 GOL  A3005 (-3.9A)
GOL  A3005 ( 4.2A)
GOL  A3001 ( 3.9A)
None
None
 1.10A 5z0fA-1q8fA:
undetectable
5z0fB-1q8fA:
undetectable		 5z0fA-1q8fA:
12.78
5z0fB-1q8fA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 11 HIS A  82
ILE A  81
HIS A 239
ASN A 193
VAL A 196
 GOL  A3005 (-3.9A)
GOL  A3005 ( 4.2A)
GOL  A3001 ( 3.9A)
None
None
 1.06A 5z0jA-1q8fA:
0.0
5z0jB-1q8fA:
0.0		 5z0jA-1q8fA:
12.78
5z0jB-1q8fA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_0
(ADENOSYLHOMOCYSTEINA
SE)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 12 HIS A 239
THR A 242
HIS A  82
ASN A 166
GLY A 151
 GOL  A3001 ( 3.9A)
None
GOL  A3005 (-3.9A)
GOL  A3001 (-3.3A)
None
 1.45A 6exiA-1q8fA:
7.5		 6exiA-1q8fA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 PHE A 222
ILE A  81
ASN A 158
LEU A 189
ASP A 240
 None
GOL  A3005 ( 4.2A)
GOL  A3001 ( 3.1A)
None
GOL  A3001 ( 2.5A)
 1.38A 6r2eC-1q8fA:
0.0		 6r2eC-1q8fA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_D_FFOD403_0
(THYMIDYLATE SYNTHASE)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 10 PHE A 222
ILE A  81
ASN A 158
LEU A 189
ASP A 240
 None
GOL  A3005 ( 4.2A)
GOL  A3001 ( 3.1A)
None
GOL  A3001 ( 2.5A)
 1.30A 6r2eD-1q8fA:
0.0		 6r2eD-1q8fA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE
(Escherichia
coli) 		5 / 11 PHE A 222
ILE A  81
ASN A 158
LEU A 189
ASP A 240
 None
GOL  A3005 ( 4.2A)
GOL  A3001 ( 3.1A)
None
GOL  A3001 ( 2.5A)
 1.31A 6r2eG-1q8fA:
0.0		 6r2eG-1q8fA:
21.25