SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1q8i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 1q8i DNA POLYMERASE II
(Escherichia
coli) 		4 / 8 LEU A 328
VAL A 178
GLY A 169
GLU A 158
 None
 1.07A 1jlfA-1q8iA:
4.8
1jlfB-1q8iA:
5.7		 1jlfA-1q8iA:
20.69
1jlfB-1q8iA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1q8i DNA POLYMERASE II
(Escherichia
coli) 		3 / 3 VAL A 370
ALA A 371
HIS A 366
 None
 0.73A 1q23C-1q8iA:
undetectable		 1q23C-1q8iA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1q8i DNA POLYMERASE II
(Escherichia
coli) 		3 / 3 VAL A 370
ALA A 371
HIS A 366
 None
 0.65A 1q23H-1q8iA:
undetectable		 1q23H-1q8iA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1q8i DNA POLYMERASE II
(Escherichia
coli) 		3 / 3 VAL A 370
ALA A 371
HIS A 366
 None
 0.71A 1q23G-1q8iA:
undetectable		 1q23G-1q8iA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1q8i DNA POLYMERASE II
(Escherichia
coli) 		3 / 3 VAL A 370
ALA A 371
HIS A 366
 None
 0.60A 1q23J-1q8iA:
undetectable		 1q23J-1q8iA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_A_CHDA459_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 1q8i DNA POLYMERASE II
(Escherichia
coli) 		4 / 6 ASP A 335
LEU A 338
VAL A 339
ILE A 342
 None
 0.26A 1s9qA-1q8iA:
0.0		 1s9qA-1q8iA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SS4_A_ACTA411_0
(GLYOXALASE FAMILY
PROTEIN)		 1q8i DNA POLYMERASE II
(Escherichia
coli) 		4 / 5 VAL A 103
THR A 102
GLN A  49
ILE A  56
 None
 1.29A 1ss4A-1q8iA:
0.9		 1ss4A-1q8iA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1q8i DNA POLYMERASE II
(Escherichia
coli) 		3 / 3 GLU A 579
THR A 580
LEU A 533
 None
 0.66A 1v8bC-1q8iA:
undetectable		 1v8bC-1q8iA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 1q8i DNA POLYMERASE II
(Escherichia
coli) 		5 / 12 LEU A  96
VAL A 101
GLY A 100
LEU A  57
ALA A  53
 None
 1.05A 2egvA-1q8iA:
undetectable		 2egvA-1q8iA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 1q8i DNA POLYMERASE II
(Escherichia
coli) 		5 / 12 LEU A  96
VAL A 101
GLY A 100
LEU A  57
ALA A  53
 None
 1.07A 2egvB-1q8iA:
undetectable		 2egvB-1q8iA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 1q8i DNA POLYMERASE II
(Escherichia
coli) 		4 / 7 VAL A  34
ALA A 138
PRO A  31
THR A  27
 None
 0.93A 2q6oA-1q8iA:
undetectable		 2q6oA-1q8iA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 1q8i DNA POLYMERASE II
(Escherichia
coli) 		4 / 6 LEU A 253
LEU A 244
ILE A 274
ARG A 272
 None
 1.05A 2rlfA-1q8iA:
0.0
2rlfB-1q8iA:
0.0		 2rlfA-1q8iA:
4.13
2rlfB-1q8iA:
4.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 1q8i DNA POLYMERASE II
(Escherichia
coli) 		4 / 6 LEU A 253
LEU A 244
ILE A 274
ARG A 272
 None
 0.98A 2rlfB-1q8iA:
0.0
2rlfC-1q8iA:
0.0		 2rlfB-1q8iA:
4.13
2rlfC-1q8iA:
4.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9X_A_NIMA1_1
(LACTOTRANSFERRIN')		 1q8i DNA POLYMERASE II
(Escherichia
coli) 		4 / 4 GLU A  40
GLY A  18
THR A  19
GLU A  20
 None
 0.84A 3e9xA-1q8iA:
undetectable		 3e9xA-1q8iA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 1q8i DNA POLYMERASE II
(Escherichia
coli) 		5 / 8 GLY A 367
GLY A 368
GLY A 360
ILE A 495
LEU A 376
 None
 0.85A 3v1nA-1q8iA:
undetectable		 3v1nA-1q8iA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 1q8i DNA POLYMERASE II
(Escherichia
coli) 		4 / 4 ASN A 359
ALA A 356
GLY A 360
THR A 121
 None
 1.24A 4bboC-1q8iA:
undetectable		 4bboC-1q8iA:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 1q8i DNA POLYMERASE II
(Escherichia
coli) 		4 / 8 ASN A 332
ALA A 329
LEU A 191
LEU A 195
 None
 0.95A 4jjkA-1q8iA:
undetectable		 4jjkA-1q8iA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 1q8i DNA POLYMERASE II
(Escherichia
coli) 		5 / 12 LEU A 230
ASP A 229
LEU A 165
LEU A 205
ILE A 220
 None
 0.89A 4odrA-1q8iA:
undetectable
4odrB-1q8iA:
undetectable		 4odrA-1q8iA:
8.05
4odrB-1q8iA:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		 1q8i DNA POLYMERASE II
(Escherichia
coli) 		4 / 8 ASP A 434
PRO A 435
PHE A 373
LEU A 503
 None
 0.83A 4qopC-1q8iA:
undetectable		 4qopC-1q8iA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 1q8i DNA POLYMERASE II
(Escherichia
coli) 		5 / 12 LEU A 170
VAL A 153
ILE A 220
LEU A 205
LEU A 233
 None
 1.26A 4yvpB-1q8iA:
undetectable		 4yvpB-1q8iA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1q8i DNA POLYMERASE II
(Escherichia
coli) 		4 / 5 TRP A  12
LEU A 115
PRO A 111
LEU A   8
 None
 1.45A 5eshA-1q8iA:
0.3		 5eshA-1q8iA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 1q8i DNA POLYMERASE II
(Escherichia
coli) 		3 / 3 THR A 102
PRO A  46
ASP A  48
 None
 0.64A 5l8dB-1q8iA:
0.2		 5l8dB-1q8iA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 1q8i DNA POLYMERASE II
(Escherichia
coli) 		5 / 10 LEU A  32
ILE A 135
ALA A 138
VAL A 124
PRO A 148
 None
 1.34A 5m0oA-1q8iA:
undetectable		 5m0oA-1q8iA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 1q8i DNA POLYMERASE II
(Escherichia
coli) 		3 / 3 THR A 102
PRO A  46
ASP A  48
 None
 0.64A 5mwuB-1q8iA:
0.2		 5mwuB-1q8iA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 1q8i DNA POLYMERASE II
(Escherichia
coli) 		4 / 8 THR A 505
GLY A 504
GLY A 501
ALA A 498
 None
 0.75A 5vw5A-1q8iA:
undetectable		 5vw5A-1q8iA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 1q8i DNA POLYMERASE II
(Escherichia
coli) 		3 / 3 TYR A 424
HIS A 524
MET A 527
 None
 1.09A 6af6A-1q8iA:
0.0		 6af6A-1q8iA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1q8i DNA POLYMERASE II
(Escherichia
coli) 		3 / 3 LEU A  32
ASN A 137
LEU A 140
 None
 0.53A 6exiA-1q8iA:
undetectable		 6exiA-1q8iA:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 1q8i DNA POLYMERASE II
(Escherichia
coli) 		4 / 7 GLY A 437
PHE A 459
HIS A 464
SER A 450
 None
 0.84A 6hu9S-1q8iA:
0.0
6hu9q-1q8iA:
undetectable		 6hu9S-1q8iA:
8.58
6hu9q-1q8iA:
9.72