SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1q8k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_A_TEIA3006_1
(XANTHINE
DEHYDROGENASE)		 1q8k EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
SUBUNIT 1
(Homo
sapiens) 		5 / 12 LEU A 167
PHE A 152
VAL A 136
ALA A 155
ALA A 151
 None
 1.24A 1n5xA-1q8kA:
2.7		 1n5xA-1q8kA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_B_TEIB4006_1
(XANTHINE
DEHYDROGENASE)		 1q8k EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
SUBUNIT 1
(Homo
sapiens) 		5 / 12 LEU A 167
PHE A 152
VAL A 136
ALA A 155
ALA A 151
 None
 1.23A 1n5xB-1q8kA:
2.7		 1n5xB-1q8kA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 1q8k EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
SUBUNIT 1
(Homo
sapiens) 		4 / 7 THR A 133
LEU A 129
VAL A 114
ILE A 179
 None
 0.93A 1t87B-1q8kA:
undetectable		 1t87B-1q8kA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 1q8k EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
SUBUNIT 1
(Homo
sapiens) 		4 / 8 PHE A 152
LEU A 111
LEU A 167
LEU A 165
 None
 1.00A 2bfpA-1q8kA:
undetectable		 2bfpA-1q8kA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 1q8k EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
SUBUNIT 1
(Homo
sapiens) 		4 / 8 PHE A 152
LEU A 111
LEU A 167
LEU A 165
 None
 0.97A 2bfpB-1q8kA:
undetectable		 2bfpB-1q8kA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1q8k EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
SUBUNIT 1
(Homo
sapiens) 		4 / 6 LEU A 215
ALA A 253
LEU A 250
ALA A 192
 None
 0.96A 2vcvB-1q8kA:
undetectable		 2vcvB-1q8kA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1q8k EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
SUBUNIT 1
(Homo
sapiens) 		4 / 7 LEU A 215
ALA A 253
LEU A 250
ALA A 192
 None
 0.93A 2vcvG-1q8kA:
undetectable		 2vcvG-1q8kA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1q8k EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
SUBUNIT 1
(Homo
sapiens) 		4 / 6 LEU A 215
ALA A 253
LEU A 250
ALA A 192
 None
 0.97A 2vcvK-1q8kA:
undetectable		 2vcvK-1q8kA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 1q8k EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
SUBUNIT 1
(Homo
sapiens) 		3 / 3 TYR A 120
GLU A 171
THR A 133
 None
 1.01A 2y7hB-1q8kA:
undetectable		 2y7hB-1q8kA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUJ_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 1q8k EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
SUBUNIT 1
(Homo
sapiens) 		4 / 8 THR A 133
LEU A 111
VAL A 114
LEU A 167
 None
 0.87A 2zujA-1q8kA:
undetectable		 2zujA-1q8kA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 1q8k EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
SUBUNIT 1
(Homo
sapiens) 		4 / 7 VAL A 267
ILE A 257
GLY A 214
ARG A 212
 None
 0.84A 3bjwB-1q8kA:
undetectable		 3bjwB-1q8kA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_3
(PHOSPHOLIPASE A2)		 1q8k EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
SUBUNIT 1
(Homo
sapiens) 		4 / 7 VAL A 267
ILE A 257
GLY A 214
ARG A 212
 None
 0.85A 3bjwF-1q8kA:
undetectable		 3bjwF-1q8kA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 1q8k EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
SUBUNIT 1
(Homo
sapiens) 		4 / 4 ILE A 224
ARG A 233
ILE A 226
THR A 239
 None
 1.21A 3ia4C-1q8kA:
undetectable		 3ia4C-1q8kA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)		 1q8k EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
SUBUNIT 1
(Homo
sapiens) 		3 / 3 THR A 244
LYS A 153
GLU A 245
 None
 0.94A 3ijdB-1q8kA:
undetectable		 3ijdB-1q8kA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 1q8k EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
SUBUNIT 1
(Homo
sapiens) 		5 / 8 GLY A  43
MET A  44
ILE A  62
LEU A  50
VAL A  70
 None
 1.42A 3v1nA-1q8kA:
undetectable		 3v1nA-1q8kA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 1q8k EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
SUBUNIT 1
(Homo
sapiens) 		5 / 12 GLY A  30
LEU A  50
LEU A  47
LYS A  86
GLU A  68
 None
 1.05A 4lg1B-1q8kA:
undetectable		 4lg1B-1q8kA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1q8k EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
SUBUNIT 1
(Homo
sapiens) 		4 / 5 ILE A  62
VAL A  33
PHE A  12
CYH A  69
 None
 1.38A 4rzvA-1q8kA:
undetectable		 4rzvA-1q8kA:
21.53