SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1q8m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 1q8m TRIGGERING RECEPTOR
EXPRESSED ON MYELOID
CELLS 1
(Homo
sapiens) 		3 / 3 LEU A  37
MET A 100
ASP A  42
 None
 0.75A 4j7xB-1q8mA:
undetectable		 4j7xB-1q8mA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L78_A_ACTA1327_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 1q8m TRIGGERING RECEPTOR
EXPRESSED ON MYELOID
CELLS 1
(Homo
sapiens) 		4 / 4 VAL A 105
THR A 134
GLU A  33
GLU A 136
 None
 1.15A 4l78A-1q8mA:
0.0		 4l78A-1q8mA:
7.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_O_BEZO801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1q8m TRIGGERING RECEPTOR
EXPRESSED ON MYELOID
CELLS 1
(Homo
sapiens) 		4 / 6 PHE A  48
SER A  74
HIS A  91
LEU A  96
 None
 1.35A 5dzka-1q8mA:
undetectable
5dzko-1q8mA:
undetectable		 5dzka-1q8mA:
15.02
5dzko-1q8mA:
2.47