SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1q8r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 1q8r CROSSOVER JUNCTION
ENDODEOXYRIBONUCLEAS
E RUSA
(Escherichia
coli) 		5 / 10 ALA A  85
LEU A 110
LEU A 112
LEU A  82
LEU A   8
 None
 1.14A 2riwA-1q8rA:
undetectable
2riwB-1q8rA:
undetectable		 2riwA-1q8rA:
13.80
2riwB-1q8rA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1q8r CROSSOVER JUNCTION
ENDODEOXYRIBONUCLEAS
E RUSA
(Escherichia
coli) 		4 / 8 ARG A  58
ILE A  59
LEU A  82
PHE A  79
 None
 0.83A 2tsrB-1q8rA:
undetectable		 2tsrB-1q8rA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 1q8r CROSSOVER JUNCTION
ENDODEOXYRIBONUCLEAS
E RUSA
(Escherichia
coli) 		3 / 3 PRO A  12
GLY A  31
TYR A  17
 None
 0.71A 2vouA-1q8rA:
undetectable		 2vouA-1q8rA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 1q8r CROSSOVER JUNCTION
ENDODEOXYRIBONUCLEAS
E RUSA
(Escherichia
coli) 		3 / 3 PRO A  12
GLY A  31
TYR A  17
 None
 0.69A 2vouB-1q8rA:
undetectable		 2vouB-1q8rA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 1q8r CROSSOVER JUNCTION
ENDODEOXYRIBONUCLEAS
E RUSA
(Escherichia
coli) 		3 / 3 PRO A  12
GLY A  31
TYR A  17
 None
 0.70A 2vouC-1q8rA:
undetectable		 2vouC-1q8rA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 1q8r CROSSOVER JUNCTION
ENDODEOXYRIBONUCLEAS
E RUSA
(Escherichia
coli) 		5 / 10 ALA A  85
LEU A 110
LEU A 112
LEU A  82
LEU A   8
 None
 1.11A 2xn6A-1q8rA:
undetectable
2xn6B-1q8rA:
undetectable		 2xn6A-1q8rA:
15.66
2xn6B-1q8rA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 1q8r CROSSOVER JUNCTION
ENDODEOXYRIBONUCLEAS
E RUSA
(Escherichia
coli) 		5 / 10 ALA A  85
LEU A 110
LEU A 112
LEU A  82
LEU A   8
 None
 1.15A 2xn7A-1q8rA:
undetectable
2xn7B-1q8rA:
undetectable		 2xn7A-1q8rA:
14.76
2xn7B-1q8rA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_B_ADNB1302_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1q8r CROSSOVER JUNCTION
ENDODEOXYRIBONUCLEAS
E RUSA
(Escherichia
coli) 		4 / 6 GLU A  30
ALA A  81
PRO A  12
ALA A  77
 None
 1.18A 2zgwB-1q8rA:
undetectable		 2zgwB-1q8rA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_1
(PROTEASE)		 1q8r CROSSOVER JUNCTION
ENDODEOXYRIBONUCLEAS
E RUSA
(Escherichia
coli) 		5 / 8 LEU A  47
GLY A  86
ALA A  85
VAL A  38
ILE A  42
 None
 1.24A 3ekpA-1q8rA:
undetectable		 3ekpA-1q8rA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1q8r CROSSOVER JUNCTION
ENDODEOXYRIBONUCLEAS
E RUSA
(Escherichia
coli) 		4 / 7 LEU A 112
ALA A  85
LEU A   8
ALA A  78
 None
 0.60A 4z90F-1q8rA:
undetectable
4z90G-1q8rA:
undetectable
4z90H-1q8rA:
undetectable
4z90J-1q8rA:
undetectable		 4z90F-1q8rA:
16.33
4z90G-1q8rA:
16.33
4z90H-1q8rA:
16.33
4z90J-1q8rA:
16.33