SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1q8y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		4 / 8 ARG A 287
ASP A 282
ALA A 697
GLY A 726
 None
 0.73A 1d4sB-1q8yA:
undetectable		 1d4sB-1q8yA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		4 / 8 ARG A 287
ASP A 282
ALA A 697
GLY A 726
 None
 0.71A 1hshD-1q8yA:
undetectable		 1hshD-1q8yA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_2
(HIV-1 PROTEASE)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		5 / 11 ARG A 287
ASP A 282
GLY A 698
ALA A 697
GLY A 726
 None
 0.94A 1hxwB-1q8yA:
undetectable		 1hxwB-1q8yA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		7 / 12 LEU A 164
VAL A 172
ALA A 185
GLU A 202
GLY A 250
LEU A 301
ALA A 549
 ADP  A 810 ( 4.3A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
None
None
ADP  A 810 (-4.7A)
None
 1.13A 1iepA-1q8yA:
5.4		 1iepA-1q8yA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		6 / 12 LEU A 164
VAL A 172
ALA A 185
GLU A 202
GLY A 250
ALA A 549
 ADP  A 810 ( 4.3A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
None
None
None
 0.96A 1iepB-1q8yA:
14.5		 1iepB-1q8yA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		6 / 9 LEU A 164
GLY A 165
VAL A 172
ALA A 185
LEU A 226
LEU A 301
 ADP  A 810 ( 4.3A)
ADP  A 810 (-3.3A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
ADP  A 810 (-4.4A)
ADP  A 810 (-4.7A)
 0.82A 1muoA-1q8yA:
6.8		 1muoA-1q8yA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 255
LEU A 254
PRO A 297
PHE A 682
ILE A 265
 None
 1.16A 1mx8A-1q8yA:
undetectable		 1mx8A-1q8yA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		4 / 5 GLY A 584
TRP A 581
VAL A 575
SER A 589
 None
 1.05A 1p6kB-1q8yA:
0.0		 1p6kB-1q8yA:
21.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Q97_B_ADNB486_1
(SR PROTEIN KINASE)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		4 / 4 VAL A 172
ALA A 185
LEU A 226
PHE A 246
 ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
ADP  A 810 (-4.4A)
None
 0.42A 1q97B-1q8yA:
55.8		 1q97B-1q8yA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		4 / 5 GLY A 584
TRP A 581
VAL A 575
SER A 589
 None
 1.00A 1rs6B-1q8yA:
0.0		 1rs6B-1q8yA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		4 / 5 GLY A 584
TRP A 581
VAL A 575
SER A 589
 None
 1.05A 1rs7A-1q8yA:
0.0		 1rs7A-1q8yA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		8 / 12 LEU A 164
VAL A 172
ALA A 185
GLU A 202
LEU A 206
GLY A 250
LEU A 301
ASP A 550
 ADP  A 810 ( 4.3A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
None
None
None
ADP  A 810 (-4.7A)
ADP  A 810 ( 3.0A)
 1.04A 1t46A-1q8yA:
21.1		 1t46A-1q8yA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		8 / 12 LEU A 164
VAL A 172
ALA A 185
LYS A 187
GLU A 202
LEU A 206
GLY A 250
LEU A 301
 ADP  A 810 ( 4.3A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
ADP  A 810 (-3.1A)
None
None
None
ADP  A 810 (-4.7A)
 0.92A 1t46A-1q8yA:
21.1		 1t46A-1q8yA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		6 / 12 ALA A 185
LYS A 187
GLU A 202
LEU A 206
LEU A 226
HIS A 292
 ADP  A 810 (-3.3A)
ADP  A 810 (-3.1A)
None
None
ADP  A 810 (-4.4A)
None
 0.73A 1uwhB-1q8yA:
20.7		 1uwhB-1q8yA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		4 / 7 LYS A 187
LEU A 206
ILE A 225
ILE A 290
 ADP  A 810 (-3.1A)
None
None
None
 0.51A 1uwjA-1q8yA:
5.5		 1uwjA-1q8yA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		4 / 5 GLY A 584
TRP A 581
VAL A 575
SER A 589
 None
 1.19A 1zzqB-1q8yA:
0.0		 1zzqB-1q8yA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		4 / 5 GLY A 584
TRP A 581
VAL A 575
SER A 589
 None
 1.00A 1zzuB-1q8yA:
1.1		 1zzuB-1q8yA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 551
ILE A 225
ARG A 208
ILE A 290
 None
 0.83A 2bu8A-1q8yA:
undetectable		 2bu8A-1q8yA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		7 / 12 VAL A 172
LYS A 187
PHE A 246
ASN A 299
LEU A 301
ALA A 549
ASP A 550
 ADP  A 810 (-4.1A)
ADP  A 810 (-3.1A)
None
MG  A 809 ( 3.0A)
ADP  A 810 (-4.7A)
None
ADP  A 810 ( 3.0A)
 0.64A 2eufB-1q8yA:
29.2		 2eufB-1q8yA:
28.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 292
ILE A 225
LEU A 206
 None
 0.71A 2kceA-1q8yA:
undetectable		 2kceA-1q8yA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		4 / 8 ARG A 287
ASP A 282
ALA A 697
GLY A 726
 None
 0.72A 2o4nB-1q8yA:
undetectable		 2o4nB-1q8yA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 281
LEU A 278
LEU A 706
ILE A 295
LEU A 267
 None
 1.01A 2pnjA-1q8yA:
undetectable		 2pnjA-1q8yA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 164
ALA A 185
LEU A 301
ASP A 550
 ADP  A 810 ( 4.3A)
ADP  A 810 (-3.3A)
ADP  A 810 (-4.7A)
ADP  A 810 ( 3.0A)
 0.50A 2yfxA-1q8yA:
13.9		 2yfxA-1q8yA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 294
THR A 196
GLU A 202
 None
 0.79A 2zifB-1q8yA:
undetectable		 2zifB-1q8yA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_A_SAMA300_0
(PUTATIVE RRNA
METHYLASE)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 699
ASP A 719
ILE A 587
GLY A 584
HIS A 285
 None
 1.14A 3eeyA-1q8yA:
undetectable		 3eeyA-1q8yA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_0
(PUTATIVE RRNA
METHYLASE)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 699
ASP A 719
ILE A 587
GLY A 584
HIS A 285
 None
 1.14A 3eeyC-1q8yA:
undetectable		 3eeyC-1q8yA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_1
(PROTEASE)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		5 / 11 ARG A 287
ASP A 282
GLY A 698
ALA A 697
GLY A 726
 None
 0.86A 3em4A-1q8yA:
undetectable		 3em4A-1q8yA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		5 / 12 THR A 590
LEU A 279
LEU A 706
THR A 709
ARG A 720
 None
 1.36A 3fsuA-1q8yA:
undetectable		 3fsuA-1q8yA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		8 / 12 LEU A 164
GLY A 165
GLY A 167
VAL A 172
ALA A 185
LYS A 187
LEU A 249
LEU A 301
 ADP  A 810 ( 4.3A)
ADP  A 810 (-3.3A)
ADP  A 810 (-3.0A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
ADP  A 810 (-3.1A)
None
ADP  A 810 (-4.7A)
 0.71A 3fupB-1q8yA:
23.1		 3fupB-1q8yA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		6 / 12 VAL A 172
ALA A 185
GLU A 202
LEU A 205
LEU A 206
HIS A 292
 ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
None
None
None
None
 0.83A 3gp0A-1q8yA:
25.9		 3gp0A-1q8yA:
28.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		6 / 12 LEU A 164
VAL A 172
ALA A 185
GLU A 202
LEU A 301
ALA A 549
 ADP  A 810 ( 4.3A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
None
ADP  A 810 (-4.7A)
None
 0.74A 3gvuA-1q8yA:
14.6		 3gvuA-1q8yA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		6 / 12 LEU A 164
VAL A 172
ALA A 185
GLU A 202
LEU A 301
ALA A 549
 ADP  A 810 ( 4.3A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
None
ADP  A 810 (-4.7A)
None
 0.87A 3ms9A-1q8yA:
14.5		 3ms9A-1q8yA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		7 / 12 LEU A 164
VAL A 172
ALA A 185
GLU A 202
GLY A 250
LEU A 301
ALA A 549
 ADP  A 810 ( 4.3A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
None
None
ADP  A 810 (-4.7A)
None
 1.10A 3ms9B-1q8yA:
20.6		 3ms9B-1q8yA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		6 / 12 LEU A 164
VAL A 172
ALA A 185
GLU A 202
LEU A 301
ALA A 549
 ADP  A 810 ( 4.3A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
None
ADP  A 810 (-4.7A)
None
 0.90A 3mssA-1q8yA:
20.6		 3mssA-1q8yA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		6 / 12 LEU A 164
VAL A 172
ALA A 185
GLU A 202
LEU A 301
ALA A 549
 ADP  A 810 ( 4.3A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
None
ADP  A 810 (-4.7A)
None
 0.90A 3mssC-1q8yA:
20.5		 3mssC-1q8yA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		4 / 4 GLY A 584
TRP A 581
VAL A 575
SER A 589
 None
 1.07A 3n62A-1q8yA:
0.0		 3n62A-1q8yA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		4 / 4 GLY A 584
TRP A 581
VAL A 575
SER A 589
 None
 1.07A 3n65A-1q8yA:
0.0		 3n65A-1q8yA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		4 / 4 GLY A 584
TRP A 581
VAL A 575
SER A 589
 None
 1.07A 3n66A-1q8yA:
0.0		 3n66A-1q8yA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 172
ALA A 185
LYS A 187
LEU A 206
LEU A 226
 ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
ADP  A 810 (-3.1A)
None
ADP  A 810 (-4.4A)
 0.63A 3og7A-1q8yA:
21.0		 3og7A-1q8yA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		6 / 12 GLY A 165
VAL A 172
ALA A 185
LYS A 187
GLY A 250
LEU A 226
 ADP  A 810 (-3.3A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
ADP  A 810 (-3.1A)
None
ADP  A 810 (-4.4A)
 1.15A 3ohtB-1q8yA:
5.7		 3ohtB-1q8yA:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		6 / 12 GLY A 165
VAL A 172
LYS A 187
LEU A 206
GLY A 250
LEU A 226
 ADP  A 810 (-3.3A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.1A)
None
None
ADP  A 810 (-4.4A)
 1.27A 3ohtB-1q8yA:
5.7		 3ohtB-1q8yA:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		6 / 12 LEU A 164
VAL A 172
ALA A 185
GLU A 202
LEU A 301
ALA A 549
 ADP  A 810 ( 4.3A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
None
ADP  A 810 (-4.7A)
None
 0.73A 3pyyB-1q8yA:
20.6		 3pyyB-1q8yA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		4 / 6 ASN A 252
TYR A 570
GLU A 596
ILE A 257
 ADP  A 810 (-4.2A)
None
None
None
 0.94A 3q5sA-1q8yA:
undetectable		 3q5sA-1q8yA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		7 / 12 VAL A 172
ALA A 185
GLU A 202
LEU A 206
PHE A 246
HIS A 292
ALA A 549
 ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
None
None
None
None
None
 0.57A 3rgfA-1q8yA:
8.6		 3rgfA-1q8yA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 241
HIS A 234
ILE A 188
 None
SO4  A 801 (-3.9A)
None
 0.86A 3u52A-1q8yA:
undetectable
3u52C-1q8yA:
0.1		 3u52A-1q8yA:
18.61
3u52C-1q8yA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		4 / 8 VAL A 172
LYS A 187
PHE A 246
ASP A 550
 ADP  A 810 (-4.1A)
ADP  A 810 (-3.1A)
None
ADP  A 810 ( 3.0A)
 0.56A 3warA-1q8yA:
21.5		 3warA-1q8yA:
27.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		7 / 12 LEU A 164
ALA A 185
LYS A 187
GLU A 202
HIS A 292
LEU A 301
ALA A 549
 ADP  A 810 ( 4.3A)
ADP  A 810 (-3.3A)
ADP  A 810 (-3.1A)
None
None
ADP  A 810 (-4.7A)
None
 0.79A 3zosA-1q8yA:
20.1		 3zosA-1q8yA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		6 / 12 LEU A 164
VAL A 172
ALA A 185
LYS A 187
LEU A 206
LEU A 301
 ADP  A 810 ( 4.3A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
ADP  A 810 (-3.1A)
None
ADP  A 810 (-4.7A)
 0.58A 4agcA-1q8yA:
20.6		 4agcA-1q8yA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		6 / 9 LEU A 164
VAL A 172
ALA A 185
LEU A 301
ALA A 549
ASP A 550
 ADP  A 810 ( 4.3A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
ADP  A 810 (-4.7A)
None
ADP  A 810 ( 3.0A)
 0.69A 4anqA-1q8yA:
21.0		 4anqA-1q8yA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		8 / 12 LEU A 164
VAL A 172
ALA A 185
LYS A 187
GLU A 202
LEU A 206
GLY A 250
HIS A 292
 ADP  A 810 ( 4.3A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
ADP  A 810 (-3.1A)
None
None
None
None
 0.89A 4asdA-1q8yA:
20.9		 4asdA-1q8yA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		8 / 12 ALA A 185
GLU A 202
LEU A 206
LEU A 226
HIS A 292
LEU A 301
ALA A 549
ASP A 550
 ADP  A 810 (-3.3A)
None
None
ADP  A 810 (-4.4A)
None
ADP  A 810 (-4.7A)
None
ADP  A 810 ( 3.0A)
 1.04A 4c8bA-1q8yA:
21.2		 4c8bA-1q8yA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		8 / 12 ALA A 185
LYS A 187
GLU A 202
LEU A 206
LEU A 226
HIS A 292
LEU A 301
ALA A 549
 ADP  A 810 (-3.3A)
ADP  A 810 (-3.1A)
None
None
ADP  A 810 (-4.4A)
None
ADP  A 810 (-4.7A)
None
 0.73A 4c8bA-1q8yA:
21.2		 4c8bA-1q8yA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		8 / 12 ALA A 185
LEU A 206
ILE A 225
LEU A 226
HIS A 292
LEU A 301
ALA A 549
ASP A 550
 ADP  A 810 (-3.3A)
None
None
ADP  A 810 (-4.4A)
None
ADP  A 810 (-4.7A)
None
ADP  A 810 ( 3.0A)
 0.98A 4c8bB-1q8yA:
20.9		 4c8bB-1q8yA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		9 / 12 ALA A 185
LYS A 187
GLU A 202
LEU A 206
ILE A 225
LEU A 226
HIS A 292
LEU A 301
ALA A 549
 ADP  A 810 (-3.3A)
ADP  A 810 (-3.1A)
None
None
None
ADP  A 810 (-4.4A)
None
ADP  A 810 (-4.7A)
None
 0.76A 4c8bB-1q8yA:
20.9		 4c8bB-1q8yA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		7 / 12 VAL A 172
ALA A 185
ASP A 294
LYS A 296
ASN A 299
LEU A 301
ASP A 550
 ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
None
None
MG  A 809 ( 3.0A)
ADP  A 810 (-4.7A)
ADP  A 810 ( 3.0A)
 0.64A 4i41A-1q8yA:
24.7		 4i41A-1q8yA:
26.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		6 / 11 VAL A 172
ALA A 185
LYS A 187
GLU A 298
LEU A 301
ASP A 550
 ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
ADP  A 810 (-3.1A)
None
ADP  A 810 (-4.7A)
ADP  A 810 ( 3.0A)
 1.08A 4iaaA-1q8yA:
24.3		 4iaaA-1q8yA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		4 / 8 ASN A 645
ARG A 651
LEU A 650
ILE A 623
 None
 1.06A 4k0bA-1q8yA:
undetectable		 4k0bA-1q8yA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		4 / 6 GLY A 584
TRP A 581
VAL A 575
SER A 589
 None
 1.09A 4kcnA-1q8yA:
0.0		 4kcnA-1q8yA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		5 / 8 GLY A 167
VAL A 172
ALA A 185
LYS A 187
LEU A 301
 ADP  A 810 (-3.0A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
ADP  A 810 (-3.1A)
ADP  A 810 (-4.7A)
 0.41A 4l9iB-1q8yA:
22.5		 4l9iB-1q8yA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 249
GLY A 250
ILE A 546
GLN A 545
 None
 1.16A 4ma8C-1q8yA:
undetectable		 4ma8C-1q8yA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		7 / 11 LEU A 164
GLY A 165
VAL A 172
ALA A 185
LEU A 226
ASN A 299
LEU A 301
 ADP  A 810 ( 4.3A)
ADP  A 810 (-3.3A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
ADP  A 810 (-4.4A)
MG  A 809 ( 3.0A)
ADP  A 810 (-4.7A)
 0.45A 4o0sA-1q8yA:
25.8		 4o0sA-1q8yA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		4 / 6 VAL A 172
ALA A 185
LEU A 226
LEU A 301
 ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
ADP  A 810 (-4.4A)
ADP  A 810 (-4.7A)
 0.47A 4o0uA-1q8yA:
17.8		 4o0uA-1q8yA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		5 / 6 LEU A 164
GLY A 165
VAL A 172
ALA A 185
LEU A 301
 ADP  A 810 ( 4.3A)
ADP  A 810 (-3.3A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
ADP  A 810 (-4.7A)
 0.38A 4o0wA-1q8yA:
24.6		 4o0wA-1q8yA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		8 / 12 LEU A 164
GLY A 165
GLY A 167
VAL A 172
ALA A 185
LYS A 187
LEU A 301
ALA A 549
 ADP  A 810 ( 4.3A)
ADP  A 810 (-3.3A)
ADP  A 810 (-3.0A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
ADP  A 810 (-3.1A)
ADP  A 810 (-4.7A)
None
 0.53A 4otiA-1q8yA:
20.2		 4otiA-1q8yA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		6 / 11 ALA A 185
LYS A 187
GLU A 202
LEU A 249
LEU A 301
ASP A 550
 ADP  A 810 (-3.3A)
ADP  A 810 (-3.1A)
None
None
ADP  A 810 (-4.7A)
ADP  A 810 ( 3.0A)
 0.82A 4qmsA-1q8yA:
25.6		 4qmsA-1q8yA:
26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 164
VAL A 172
HIS A 292
LEU A 301
 ADP  A 810 ( 4.3A)
ADP  A 810 (-4.1A)
None
ADP  A 810 (-4.7A)
 0.64A 4qrcA-1q8yA:
21.4		 4qrcA-1q8yA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		8 / 12 LEU A 164
VAL A 172
ALA A 185
LYS A 187
ASN A 299
LEU A 301
ALA A 549
ASP A 550
 ADP  A 810 ( 4.3A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
ADP  A 810 (-3.1A)
MG  A 809 ( 3.0A)
ADP  A 810 (-4.7A)
None
ADP  A 810 ( 3.0A)
 0.73A 4twpA-1q8yA:
22.9		 4twpA-1q8yA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		6 / 12 ALA A 185
GLU A 202
HIS A 292
LEU A 301
ALA A 549
ASP A 550
 ADP  A 810 (-3.3A)
None
None
ADP  A 810 (-4.7A)
None
ADP  A 810 ( 3.0A)
 1.14A 4tyjA-1q8yA:
21.0		 4tyjA-1q8yA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 164
VAL A 172
ILE A 225
ILE A 548
 ADP  A 810 ( 4.3A)
ADP  A 810 (-4.1A)
None
None
 0.45A 4tyjA-1q8yA:
21.0		 4tyjA-1q8yA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		8 / 11 LEU A 164
GLY A 167
VAL A 172
ALA A 185
ASN A 299
LEU A 301
ALA A 549
ASP A 550
 ADP  A 810 ( 4.3A)
ADP  A 810 (-3.0A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
MG  A 809 ( 3.0A)
ADP  A 810 (-4.7A)
None
ADP  A 810 ( 3.0A)
 0.63A 4u5jA-1q8yA:
24.1		 4u5jA-1q8yA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 164
ALA A 185
HIS A 292
LEU A 301
ALA A 549
 ADP  A 810 ( 4.3A)
ADP  A 810 (-3.3A)
None
ADP  A 810 (-4.7A)
None
 0.54A 4uxqA-1q8yA:
21.0		 4uxqA-1q8yA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		6 / 12 VAL A 172
ALA A 185
GLU A 202
HIS A 292
ALA A 549
GLY A 552
 ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
None
None
None
None
 1.35A 4v04A-1q8yA:
20.2		 4v04A-1q8yA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 185
LYS A 187
LEU A 206
LEU A 226
ASP A 550
 ADP  A 810 (-3.3A)
ADP  A 810 (-3.1A)
None
ADP  A 810 (-4.4A)
ADP  A 810 ( 3.0A)
 0.86A 4xv2B-1q8yA:
21.2		 4xv2B-1q8yA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		5 / 8 LEU A 164
GLY A 165
VAL A 172
ALA A 185
GLY A 250
 ADP  A 810 ( 4.3A)
ADP  A 810 (-3.3A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
None
 0.71A 4zauA-1q8yA:
22.5		 4zauA-1q8yA:
26.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		6 / 12 LEU A 164
ALA A 185
GLY A 250
LEU A 301
ALA A 549
ASP A 550
 ADP  A 810 ( 4.3A)
ADP  A 810 (-3.3A)
None
ADP  A 810 (-4.7A)
None
ADP  A 810 ( 3.0A)
 0.90A 5ajqA-1q8yA:
17.0		 5ajqA-1q8yA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		5 / 10 ALA A 185
GLY A 250
LEU A 301
ALA A 549
ASP A 550
 ADP  A 810 (-3.3A)
None
ADP  A 810 (-4.7A)
None
ADP  A 810 ( 3.0A)
 0.93A 5ajqB-1q8yA:
22.5		 5ajqB-1q8yA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		8 / 12 LEU A 164
VAL A 172
ALA A 185
LYS A 187
GLU A 202
GLY A 250
LEU A 301
ALA A 549
 ADP  A 810 ( 4.3A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
ADP  A 810 (-3.1A)
None
None
ADP  A 810 (-4.7A)
None
 1.07A 5bvwA-1q8yA:
20.5		 5bvwA-1q8yA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 172
ALA A 185
LYS A 187
LEU A 206
LEU A 226
 ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
ADP  A 810 (-3.1A)
None
ADP  A 810 (-4.4A)
 0.69A 5cswA-1q8yA:
20.8		 5cswA-1q8yA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 172
ALA A 185
LYS A 187
LEU A 206
LEU A 226
 ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
ADP  A 810 (-3.1A)
None
ADP  A 810 (-4.4A)
 0.78A 5cswB-1q8yA:
20.7		 5cswB-1q8yA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		6 / 12 ARG A 162
LEU A 164
ALA A 185
LEU A 226
GLY A 250
LEU A 301
 None
ADP  A 810 ( 4.3A)
ADP  A 810 (-3.3A)
ADP  A 810 (-4.4A)
None
ADP  A 810 (-4.7A)
 1.15A 5h2uA-1q8yA:
15.5		 5h2uA-1q8yA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		6 / 12 ARG A 162
LEU A 164
VAL A 172
ALA A 185
GLY A 250
LEU A 301
 None
ADP  A 810 ( 4.3A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
None
ADP  A 810 (-4.7A)
 1.10A 5h2uA-1q8yA:
15.5		 5h2uA-1q8yA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		6 / 12 ARG A 162
LEU A 164
ALA A 185
LEU A 226
GLY A 250
LEU A 301
 None
ADP  A 810 ( 4.3A)
ADP  A 810 (-3.3A)
ADP  A 810 (-4.4A)
None
ADP  A 810 (-4.7A)
 1.04A 5h2uC-1q8yA:
21.2		 5h2uC-1q8yA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		6 / 12 ALA A 185
LYS A 187
GLU A 202
LEU A 206
LEU A 226
HIS A 292
 ADP  A 810 (-3.3A)
ADP  A 810 (-3.1A)
None
None
ADP  A 810 (-4.4A)
None
 0.82A 5hi2A-1q8yA:
21.0		 5hi2A-1q8yA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		5 / 8 VAL A 172
ILE A 225
ILE A 290
ILE A 548
ASP A 550
 ADP  A 810 (-4.1A)
None
None
None
ADP  A 810 ( 3.0A)
 0.90A 5hi2A-1q8yA:
21.0		 5hi2A-1q8yA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		6 / 12 GLY A 165
VAL A 172
ALA A 185
PHE A 246
LEU A 301
ALA A 549
 ADP  A 810 (-3.3A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
None
ADP  A 810 (-4.7A)
None
 0.72A 5l2iA-1q8yA:
10.0		 5l2iA-1q8yA:
27.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 185
GLU A 202
LEU A 301
ASP A 550
 ADP  A 810 (-3.3A)
None
ADP  A 810 (-4.7A)
ADP  A 810 ( 3.0A)
 0.53A 5owrA-1q8yA:
21.1		 5owrA-1q8yA:
27.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 278
ILE A 715
GLY A 280
GLY A 221
LEU A 706
 None
 0.94A 5twjD-1q8yA:
undetectable		 5twjD-1q8yA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		6 / 12 LEU A 164
VAL A 172
ALA A 185
LYS A 187
GLU A 202
GLY A 250
 ADP  A 810 ( 4.3A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
ADP  A 810 (-3.1A)
None
None
 0.80A 5vcyA-1q8yA:
25.5		 5vcyA-1q8yA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		4 / 5 GLY A 584
TRP A 581
VAL A 575
SER A 589
 None
 1.06A 5vunA-1q8yA:
undetectable		 5vunA-1q8yA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		6 / 12 LEU A 164
GLY A 165
VAL A 172
ALA A 185
PHE A 246
GLY A 250
 ADP  A 810 ( 4.3A)
ADP  A 810 (-3.3A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
None
None
 0.63A 5xv7A-1q8yA:
31.5		 5xv7A-1q8yA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 164
VAL A 172
ALA A 185
PHE A 246
ALA A 549
 ADP  A 810 ( 4.3A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
None
None
 0.51A 5xv7A-1q8yA:
31.5		 5xv7A-1q8yA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		7 / 12 ARG A 162
LEU A 164
VAL A 172
ALA A 185
LYS A 187
GLU A 202
GLY A 250
 None
ADP  A 810 ( 4.3A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
ADP  A 810 (-3.1A)
None
None
 0.88A 5y7zA-1q8yA:
24.2		 5y7zA-1q8yA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		7 / 12 ARG A 162
LEU A 164
VAL A 172
ALA A 185
LYS A 187
GLU A 202
GLY A 250
 None
ADP  A 810 ( 4.3A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
ADP  A 810 (-3.1A)
None
None
 0.88A 5y7zA-1q8yA:
24.2		 5y7zA-1q8yA:
27.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		7 / 12 LEU A 164
VAL A 172
ALA A 185
LYS A 187
GLU A 202
GLY A 250
LEU A 301
 ADP  A 810 ( 4.3A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
ADP  A 810 (-3.1A)
None
None
ADP  A 810 (-4.7A)
 0.84A 5y7zA-1q8yA:
24.2		 5y7zA-1q8yA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		7 / 12 LEU A 164
VAL A 172
ALA A 185
LYS A 187
GLU A 202
GLY A 250
LEU A 301
 ADP  A 810 ( 4.3A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
ADP  A 810 (-3.1A)
None
None
ADP  A 810 (-4.7A)
 0.84A 5y7zA-1q8yA:
24.2		 5y7zA-1q8yA:
27.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		7 / 12 LEU A 164
ALA A 185
LYS A 187
GLU A 202
GLY A 250
LEU A 301
ASP A 550
 ADP  A 810 ( 4.3A)
ADP  A 810 (-3.3A)
ADP  A 810 (-3.1A)
None
None
ADP  A 810 (-4.7A)
ADP  A 810 ( 3.0A)
 0.91A 5y7zB-1q8yA:
15.3		 5y7zB-1q8yA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		8 / 12 LEU A 164
VAL A 172
ALA A 185
LYS A 187
GLU A 202
GLY A 250
LEU A 301
ASP A 550
 ADP  A 810 ( 4.3A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
ADP  A 810 (-3.1A)
None
None
ADP  A 810 (-4.7A)
ADP  A 810 ( 3.0A)
 0.95A 5y80A-1q8yA:
23.1		 5y80A-1q8yA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		4 / 8 VAL A 172
LYS A 187
PHE A 246
ASP A 550
 ADP  A 810 (-4.1A)
ADP  A 810 (-3.1A)
None
ADP  A 810 ( 3.0A)
 0.38A 5y9mA-1q8yA:
19.1		 5y9mA-1q8yA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		4 / 8 VAL A 172
LYS A 187
PHE A 246
ASP A 550
 ADP  A 810 (-4.1A)
ADP  A 810 (-3.1A)
None
ADP  A 810 ( 3.0A)
 0.37A 5y9mX-1q8yA:
27.5		 5y9mX-1q8yA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 172
LYS A 187
PHE A 246
ASP A 550
 ADP  A 810 (-4.1A)
ADP  A 810 (-3.1A)
None
ADP  A 810 ( 3.0A)
 0.58A 5yf9B-1q8yA:
20.8		 5yf9B-1q8yA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 172
LYS A 187
PHE A 246
ASP A 550
 ADP  A 810 (-4.1A)
ADP  A 810 (-3.1A)
None
ADP  A 810 ( 3.0A)
 0.46A 5ywmX-1q8yA:
27.3		 5ywmX-1q8yA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		6 / 12 LEU A 164
VAL A 172
ALA A 185
LYS A 187
GLU A 202
ALA A 549
 ADP  A 810 ( 4.3A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
ADP  A 810 (-3.1A)
None
None
 0.70A 5zv2B-1q8yA:
20.6		 5zv2B-1q8yA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_1
(HIV-1 PROTEASE)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		5 / 12 ARG A 287
ASP A 282
GLY A 698
ALA A 697
GLY A 726
 None
 0.93A 6dj1B-1q8yA:
undetectable		 6dj1B-1q8yA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_1
(HIV-1 PROTEASE)		 1q8y SR PROTEIN KINASE
(Saccharomyces
cerevisiae) 		5 / 12 ARG A 287
ASP A 282
GLY A 698
ALA A 697
GLY A 726
 None
 0.89A 6dj2B-1q8yA:
undetectable		 6dj2B-1q8yA:
12.76