SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1q9j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1q9j POLYKETIDE SYNTHASE
ASSOCIATED PROTEIN 5
(Mycobacterium
tuberculosis) 		3 / 3 ILE A 406
LEU A 409
VAL A 413
 None
 0.22A 1mz9B-1q9jA:
undetectable		 1mz9B-1q9jA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 1q9j POLYKETIDE SYNTHASE
ASSOCIATED PROTEIN 5
(Mycobacterium
tuberculosis) 		4 / 4 LEU A 168
SER A 323
LEU A 284
LEU A 272
 None
 1.09A 1yajA-1q9jA:
0.3		 1yajA-1q9jA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		 1q9j POLYKETIDE SYNTHASE
ASSOCIATED PROTEIN 5
(Mycobacterium
tuberculosis) 		4 / 5 VAL A 413
TYR A 417
VAL A 301
ASP A 302
 None
 1.23A 2x45A-1q9jA:
0.0		 2x45A-1q9jA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		 1q9j POLYKETIDE SYNTHASE
ASSOCIATED PROTEIN 5
(Mycobacterium
tuberculosis) 		4 / 5 VAL A 413
TYR A 417
VAL A 301
ASP A 302
 None
 1.13A 2x45C-1q9jA:
0.0		 2x45C-1q9jA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1q9j POLYKETIDE SYNTHASE
ASSOCIATED PROTEIN 5
(Mycobacterium
tuberculosis) 		4 / 8 ILE A 245
VAL A 240
TYR A 264
CYH A 344
 None
 1.15A 2xz5A-1q9jA:
undetectable
2xz5C-1q9jA:
undetectable		 2xz5A-1q9jA:
17.71
2xz5C-1q9jA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1q9j POLYKETIDE SYNTHASE
ASSOCIATED PROTEIN 5
(Mycobacterium
tuberculosis) 		4 / 8 ILE A 245
VAL A 240
TYR A 264
CYH A 344
 None
 1.18A 2xz5C-1q9jA:
undetectable
2xz5D-1q9jA:
undetectable		 2xz5C-1q9jA:
17.71
2xz5D-1q9jA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)		 1q9j POLYKETIDE SYNTHASE
ASSOCIATED PROTEIN 5
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 285
ILE A 307
LEU A 303
ARG A 253
ILE A 300
 None
 1.13A 2ygnA-1q9jA:
0.0		 2ygnA-1q9jA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 1q9j POLYKETIDE SYNTHASE
ASSOCIATED PROTEIN 5
(Mycobacterium
tuberculosis) 		4 / 8 VAL A 240
TYR A 264
CYH A 344
ILE A 245
 None
 1.04A 4afgD-1q9jA:
0.0
4afgE-1q9jA:
0.0		 4afgD-1q9jA:
18.86
4afgE-1q9jA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1q9j POLYKETIDE SYNTHASE
ASSOCIATED PROTEIN 5
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 288
SER A 289
VAL A 263
SER A  13
PHE A 327
 None
 1.20A 4c49A-1q9jA:
undetectable		 4c49A-1q9jA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_B_CLQB303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1q9j POLYKETIDE SYNTHASE
ASSOCIATED PROTEIN 5
(Mycobacterium
tuberculosis) 		5 / 11 HIS A 123
GLN A 100
GLY A  64
GLY A  63
GLU A  15
 None
 1.41A 4fglA-1q9jA:
undetectable
4fglB-1q9jA:
undetectable		 4fglA-1q9jA:
19.09
4fglB-1q9jA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 1q9j POLYKETIDE SYNTHASE
ASSOCIATED PROTEIN 5
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 361
ILE A  34
PHE A 140
LEU A 107
ILE A  28
 None
 1.09A 4km0B-1q9jA:
undetectable		 4km0B-1q9jA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)		 1q9j POLYKETIDE SYNTHASE
ASSOCIATED PROTEIN 5
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 114
ILE A  28
THR A 355
PRO A 356
ARG A 112
 None
 1.02A 4q5mA-1q9jA:
undetectable		 4q5mA-1q9jA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 1q9j POLYKETIDE SYNTHASE
ASSOCIATED PROTEIN 5
(Mycobacterium
tuberculosis) 		4 / 6 ASP A  41
THR A  49
PRO A 157
THR A 156
 None
 1.07A 4yoaA-1q9jA:
0.0		 4yoaA-1q9jA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_A_ESTA601_1
(ESTROGEN RECEPTOR)		 1q9j POLYKETIDE SYNTHASE
ASSOCIATED PROTEIN 5
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 247
ALA A 243
GLY A 230
HIS A 233
LEU A 235
 None
 1.24A 5dx3A-1q9jA:
undetectable		 5dx3A-1q9jA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1q9j POLYKETIDE SYNTHASE
ASSOCIATED PROTEIN 5
(Mycobacterium
tuberculosis) 		5 / 8 GLY A 132
LEU A 122
THR A 282
VAL A  52
LEU A  53
 None
 1.36A 6czmD-1q9jA:
2.1
6czmF-1q9jA:
undetectable		 6czmD-1q9jA:
22.65
6czmF-1q9jA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 1q9j POLYKETIDE SYNTHASE
ASSOCIATED PROTEIN 5
(Mycobacterium
tuberculosis) 		4 / 8 ASP A 363
ILE A 364
ARG A 215
TYR A 121
 None
 1.12A 6hisA-1q9jA:
undetectable
6hisB-1q9jA:
undetectable		 6hisA-1q9jA:
10.84
6hisB-1q9jA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 1q9j POLYKETIDE SYNTHASE
ASSOCIATED PROTEIN 5
(Mycobacterium
tuberculosis) 		4 / 8 ASP A 363
ILE A 364
ARG A 215
TYR A 121
 None
 1.12A 6hisB-1q9jA:
0.0
6hisC-1q9jA:
0.0		 6hisB-1q9jA:
10.84
6hisC-1q9jA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 1q9j POLYKETIDE SYNTHASE
ASSOCIATED PROTEIN 5
(Mycobacterium
tuberculosis) 		4 / 8 ASP A 363
ILE A 364
ARG A 215
TYR A 121
 None
 1.11A 6hisD-1q9jA:
undetectable
6hisE-1q9jA:
undetectable		 6hisD-1q9jA:
10.84
6hisE-1q9jA:
10.84