SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1qas'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 1qas PHOSPHOLIPASE C
DELTA-1
(Rattus
norvegicus) 		4 / 7 LEU A 387
LEU A 340
SER A 308
SER A 310
 None
 1.00A 1dvxA-1qasA:
2.9		 1dvxA-1qasA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 1qas PHOSPHOLIPASE C
DELTA-1
(Rattus
norvegicus) 		4 / 8 ASP A 595
GLY A 597
GLY A 598
GLN A 296
 None
 0.88A 1ekjA-1qasA:
undetectable
1ekjB-1qasA:
undetectable		 1ekjA-1qasA:
18.93
1ekjB-1qasA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 1qas PHOSPHOLIPASE C
DELTA-1
(Rattus
norvegicus) 		4 / 7 ASP A 595
GLY A 597
GLY A 598
GLN A 296
 None
 0.90A 1ekjE-1qasA:
undetectable
1ekjF-1qasA:
undetectable		 1ekjE-1qasA:
18.93
1ekjF-1qasA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 1qas PHOSPHOLIPASE C
DELTA-1
(Rattus
norvegicus) 		4 / 8 ASP A 595
GLY A 597
GLY A 598
GLN A 296
 None
 0.87A 1ekjG-1qasA:
undetectable
1ekjH-1qasA:
undetectable		 1ekjG-1qasA:
18.93
1ekjH-1qasA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1503_0
(FERROCHELATASE)		 1qas PHOSPHOLIPASE C
DELTA-1
(Rattus
norvegicus) 		3 / 3 LEU A 425
PRO A 426
LEU A 302
 None
 0.45A 1hrkA-1qasA:
3.7		 1hrkA-1qasA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1qas PHOSPHOLIPASE C
DELTA-1
(Rattus
norvegicus) 		3 / 3 LEU A 425
PRO A 426
LEU A 302
 None
 0.62A 2po5B-1qasA:
3.8		 2po5B-1qasA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1qas PHOSPHOLIPASE C
DELTA-1
(Rattus
norvegicus) 		3 / 3 LEU A 425
PRO A 426
LEU A 302
 None
 0.55A 2po7B-1qasA:
3.8		 2po7B-1qasA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 1qas PHOSPHOLIPASE C
DELTA-1
(Rattus
norvegicus) 		3 / 3 LEU A 425
PRO A 426
LEU A 302
 None
 0.27A 2qd5B-1qasA:
3.5		 2qd5B-1qasA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1qas PHOSPHOLIPASE C
DELTA-1
(Rattus
norvegicus) 		4 / 7 LEU A 547
LEU A 436
ILE A 496
MET A 520
 None
 1.06A 2qqdA-1qasA:
undetectable
2qqdE-1qasA:
undetectable		 2qqdA-1qasA:
6.71
2qqdE-1qasA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1qas PHOSPHOLIPASE C
DELTA-1
(Rattus
norvegicus) 		4 / 8 PHE A 523
ILE A 550
GLY A 571
GLY A 570
 None
 0.90A 2qx4A-1qasA:
undetectable
2qx4B-1qasA:
undetectable		 2qx4A-1qasA:
17.34
2qx4B-1qasA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1qas PHOSPHOLIPASE C
DELTA-1
(Rattus
norvegicus) 		4 / 8 THR A 326
TYR A 329
ARG A 374
ILE A 373
 None
 1.12A 2xytE-1qasA:
0.0		 2xytE-1qasA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 1qas PHOSPHOLIPASE C
DELTA-1
(Rattus
norvegicus) 		5 / 11 PHE A 523
SER A 548
PHE A 539
PHE A 504
VAL A 502
 None
 1.40A 3a9eB-1qasA:
undetectable		 3a9eB-1qasA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		 1qas PHOSPHOLIPASE C
DELTA-1
(Rattus
norvegicus) 		5 / 12 GLY A 570
SER A 548
PHE A 593
LEU A 532
ALA A 528
 None
 1.23A 3d91A-1qasA:
undetectable		 3d91A-1qasA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 1qas PHOSPHOLIPASE C
DELTA-1
(Rattus
norvegicus) 		5 / 12 GLN A 671
ILE A 675
VAL A 750
VAL A 733
LEU A 735
 None
 1.09A 3gwxB-1qasA:
0.0		 3gwxB-1qasA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1qas PHOSPHOLIPASE C
DELTA-1
(Rattus
norvegicus) 		3 / 3 LEU A 425
PRO A 426
LEU A 302
 None
 0.31A 3w1wB-1qasA:
3.7		 3w1wB-1qasA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		 1qas PHOSPHOLIPASE C
DELTA-1
(Rattus
norvegicus) 		4 / 5 LEU A 333
ASP A 375
ARG A 374
ILE A 408
 None
 1.25A 4mwrA-1qasA:
undetectable		 4mwrA-1qasA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_C_3CJC607_1
(LACTOPEROXIDASE)		 1qas PHOSPHOLIPASE C
DELTA-1
(Rattus
norvegicus) 		4 / 6 GLN A 240
HIS A 239
GLU A 220
ARG A 232
 None
 1.48A 4qyqC-1qasA:
0.0		 4qyqC-1qasA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 1qas PHOSPHOLIPASE C
DELTA-1
(Rattus
norvegicus) 		5 / 12 ILE A 412
ALA A 377
LEU A 409
LEU A 389
LEU A 437
 None
 1.18A 4qzuC-1qasA:
undetectable		 4qzuC-1qasA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 1qas PHOSPHOLIPASE C
DELTA-1
(Rattus
norvegicus) 		3 / 3 GLU A 341
ARG A 549
GLN A 319
 None
 0.96A 4rtbA-1qasA:
3.4		 4rtbA-1qasA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1qas PHOSPHOLIPASE C
DELTA-1
(Rattus
norvegicus) 		5 / 11 GLY A 433
SER A 381
ALA A 380
LEU A 340
ILE A 435
 None
 1.07A 4xumB-1qasA:
undetectable		 4xumB-1qasA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1qas PHOSPHOLIPASE C
DELTA-1
(Rattus
norvegicus) 		4 / 5 ALA A 290
TYR A 295
PRO A 722
GLY A 664
 None
 1.01A 5eslA-1qasA:
undetectable		 5eslA-1qasA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPW_C_3CJC609_1
(LACTOPEROXIDASE)		 1qas PHOSPHOLIPASE C
DELTA-1
(Rattus
norvegicus) 		4 / 6 GLN A 240
HIS A 239
GLU A 220
ARG A 232
 None
 1.49A 5hpwC-1qasA:
0.0		 5hpwC-1qasA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA312_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1qas PHOSPHOLIPASE C
DELTA-1
(Rattus
norvegicus) 		3 / 3 ILE A 635
VAL A 656
PRO A 654
 None
 0.71A 5uunA-1qasA:
undetectable		 5uunA-1qasA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		 1qas PHOSPHOLIPASE C
DELTA-1
(Rattus
norvegicus) 		4 / 8 LEU A 387
TYR A 329
VAL A 369
ILE A 354
 None
 0.88A 5v0vA-1qasA:
0.8		 5v0vA-1qasA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 1qas PHOSPHOLIPASE C
DELTA-1
(Rattus
norvegicus) 		4 / 6 VAL A 369
LEU A 409
LEU A 405
HIS A 404
 None
 0.95A 6e43A-1qasA:
undetectable		 6e43A-1qasA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 1qas PHOSPHOLIPASE C
DELTA-1
(Rattus
norvegicus) 		4 / 6 VAL A 369
LEU A 409
LEU A 405
HIS A 404
 None
 0.99A 6e43C-1qasA:
undetectable		 6e43C-1qasA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 1qas PHOSPHOLIPASE C
DELTA-1
(Rattus
norvegicus) 		4 / 6 VAL A 369
LEU A 409
LEU A 405
HIS A 404
 None
 0.98A 6e43D-1qasA:
undetectable		 6e43D-1qasA:
21.46