SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1qav'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1qav NEURONAL NITRIC
OXIDE SYNTHASE
(RESIDUES 1-130)
(Rattus
norvegicus) 		3 / 3 GLU B1108
THR B1109
LEU B1057
 None
 0.64A 1v8bC-1qavB:
undetectable		 1v8bC-1qavB:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1qav NEURONAL NITRIC
OXIDE SYNTHASE
(RESIDUES 1-130)
(Rattus
norvegicus) 		5 / 10 ILE B1043
LEU B1081
LEU B1072
ILE B1064
PHE B1030
 None
 1.01A 2w9sD-1qavB:
undetectable		 2w9sD-1qavB:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1qav NEURONAL NITRIC
OXIDE SYNTHASE
(RESIDUES 1-130)
(Rattus
norvegicus) 		5 / 10 ILE B1043
LEU B1081
LEU B1072
ILE B1064
PHE B1030
 None
 1.04A 2w9sF-1qavB:
undetectable		 2w9sF-1qavB:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1qav NEURONAL NITRIC
OXIDE SYNTHASE
(RESIDUES 1-130)
(Rattus
norvegicus) 		4 / 5 LEU B1084
LEU B1028
GLY B1029
GLY B1027
 None
 0.79A 3si7C-1qavB:
undetectable
3si7D-1qavB:
undetectable		 3si7C-1qavB:
16.84
3si7D-1qavB:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 1qav NEURONAL NITRIC
OXIDE SYNTHASE
(RESIDUES 1-130)
(Rattus
norvegicus) 		5 / 10 PRO B1039
LEU B1097
ILE B1058
ALA B1052
VAL B1032
 None
 1.31A 5m0oA-1qavB:
undetectable		 5m0oA-1qavB:
17.89