SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1qax'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)
(Pseudomonas
mevalonii) 		4 / 8 GLU A  83
ASN A 271
ALA A 371
LEU A 372
 HMG  A1002 ( 3.4A)
HMG  A1002 (-3.9A)
HMG  A1002 ( 3.8A)
HMG  A1002 (-4.9A)
 0.43A 1hwiB-1qaxA:
17.9		 1hwiB-1qaxA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)
(Pseudomonas
mevalonii) 		4 / 8 GLU A  83
ASN A 271
ALA A 371
LEU A 372
 HMG  A1002 ( 3.4A)
HMG  A1002 (-3.9A)
HMG  A1002 ( 3.8A)
HMG  A1002 (-4.9A)
 0.42A 1hwiD-1qaxA:
27.8		 1hwiD-1qaxA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)
(Pseudomonas
mevalonii) 		4 / 8 GLU A  83
ASN A 271
ALA A 371
LEU A 372
 HMG  A1002 ( 3.4A)
HMG  A1002 (-3.9A)
HMG  A1002 ( 3.8A)
HMG  A1002 (-4.9A)
 0.42A 1hwiC-1qaxA:
28.1		 1hwiC-1qaxA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)
(Pseudomonas
mevalonii) 		5 / 12 TYR A  92
ILE A 248
GLY A 367
ALA A  88
MET A  93
 HMG  A1002 (-4.0A)
None
HMG  A1002 (-4.5A)
HMG  A1002 (-3.6A)
None
 1.16A 1kiaB-1qaxA:
undetectable		 1kiaB-1qaxA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_D_AG2D7015_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)
(Pseudomonas
mevalonii) 		4 / 7 LEU A 131
GLU A 137
LEU A 200
GLY A 206
 None
 0.88A 1n13D-1qaxA:
undetectable
1n13E-1qaxA:
undetectable		 1n13D-1qaxA:
14.89
1n13E-1qaxA:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)
(Pseudomonas
mevalonii) 		5 / 12 TYR A  92
ILE A 248
GLY A 367
ALA A  88
MET A  93
 HMG  A1002 (-4.0A)
None
HMG  A1002 (-4.5A)
HMG  A1002 (-3.6A)
None
 1.22A 1nbhA-1qaxA:
undetectable		 1nbhA-1qaxA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)
(Pseudomonas
mevalonii) 		5 / 12 TYR A  92
ILE A 248
GLY A 367
ALA A  88
MET A  93
 HMG  A1002 (-4.0A)
None
HMG  A1002 (-4.5A)
HMG  A1002 (-3.6A)
None
 1.22A 1nbhC-1qaxA:
undetectable		 1nbhC-1qaxA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)
(Pseudomonas
mevalonii) 		5 / 12 TYR A  92
ILE A 248
GLY A 367
ALA A  88
MET A  93
 HMG  A1002 (-4.0A)
None
HMG  A1002 (-4.5A)
HMG  A1002 (-3.6A)
None
 1.21A 1nbhD-1qaxA:
undetectable		 1nbhD-1qaxA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_B_SPMB1433_1
(NITROALKANE OXIDASE)		 1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)
(Pseudomonas
mevalonii) 		5 / 11 GLN A 364
VAL A  87
ALA A  90
SER A  66
VAL A  64
 HMG  A1002 (-4.2A)
None
None
HMG  A1002 ( 4.9A)
None
 1.40A 2c12B-1qaxA:
0.0		 2c12B-1qaxA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_D_SPMD1434_1
(NITROALKANE OXIDASE)		 1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)
(Pseudomonas
mevalonii) 		5 / 10 GLN A 364
VAL A  87
ALA A  90
SER A  66
VAL A  64
 HMG  A1002 (-4.2A)
None
None
HMG  A1002 ( 4.9A)
None
 1.47A 2c12D-1qaxA:
0.0		 2c12D-1qaxA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_G_RBFG200_1
(DODECIN)		 1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)
(Pseudomonas
mevalonii) 		4 / 8 HIS A 162
GLN A 115
ARG A 128
THR A 205
 None
 1.47A 2vxaF-1qaxA:
1.5
2vxaG-1qaxA:
0.0
2vxaI-1qaxA:
0.0		 2vxaF-1qaxA:
14.53
2vxaG-1qaxA:
14.53
2vxaI-1qaxA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)
(Pseudomonas
mevalonii) 		5 / 12 THR A 105
ALA A  97
GLY A 101
GLY A  72
LEU A 234
 None
 1.06A 2y7hB-1qaxA:
undetectable		 2y7hB-1qaxA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)
(Pseudomonas
mevalonii) 		5 / 12 THR A 105
ALA A  97
GLY A 101
GLY A  72
LEU A 234
 None
 1.07A 2y7hC-1qaxA:
undetectable		 2y7hC-1qaxA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)
(Pseudomonas
mevalonii) 		5 / 12 VAL A 360
ALA A 363
TYR A 294
VAL A  75
ILE A  70
 None
 1.18A 3dl9A-1qaxA:
undetectable		 3dl9A-1qaxA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)
(Pseudomonas
mevalonii) 		4 / 5 ASP A 158
ILE A 138
VAL A 116
THR A 163
 None
 1.01A 3eigA-1qaxA:
undetectable		 3eigA-1qaxA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)
(Pseudomonas
mevalonii) 		5 / 12 LEU A  26
GLN A  69
VAL A  64
LEU A 345
ILE A 356
 None
 1.10A 3gwxB-1qaxA:
0.1		 3gwxB-1qaxA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKT_A_198A1001_1
(ANDROGEN RECEPTOR)		 1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)
(Pseudomonas
mevalonii) 		5 / 12 GLY A 290
MET A 323
VAL A 325
MET A 185
ILE A 269
 None
 1.41A 4oktA-1qaxA:
undetectable		 4oktA-1qaxA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_1
(ANDROGEN RECEPTOR)		 1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)
(Pseudomonas
mevalonii) 		5 / 12 LEU A 319
GLY A 361
VAL A 287
ILE A  86
VAL A  81
 None
None
None
HMG  A1002 ( 4.9A)
None
 1.34A 4okwA-1qaxA:
0.0		 4okwA-1qaxA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)
(Pseudomonas
mevalonii) 		4 / 7 GLY A 367
GLN A 364
ALA A 371
ILE A 377
 HMG  A1002 (-4.5A)
HMG  A1002 (-4.2A)
HMG  A1002 ( 3.8A)
HMG  A1002 (-4.9A)
 0.93A 4txnA-1qaxA:
undetectable		 4txnA-1qaxA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)
(Pseudomonas
mevalonii) 		4 / 7 GLY A 367
GLN A 364
ALA A 371
ILE A 377
 HMG  A1002 (-4.5A)
HMG  A1002 (-4.2A)
HMG  A1002 ( 3.8A)
HMG  A1002 (-4.9A)
 0.94A 4txnB-1qaxA:
undetectable		 4txnB-1qaxA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)
(Pseudomonas
mevalonii) 		4 / 7 GLY A 367
GLN A 364
ALA A 371
ILE A 377
 HMG  A1002 (-4.5A)
HMG  A1002 (-4.2A)
HMG  A1002 ( 3.8A)
HMG  A1002 (-4.9A)
 0.95A 4txnC-1qaxA:
undetectable		 4txnC-1qaxA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)
(Pseudomonas
mevalonii) 		4 / 7 GLY A 367
GLN A 364
ALA A 371
ILE A 377
 HMG  A1002 (-4.5A)
HMG  A1002 (-4.2A)
HMG  A1002 ( 3.8A)
HMG  A1002 (-4.9A)
 0.92A 4txnD-1qaxA:
undetectable		 4txnD-1qaxA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)
(Pseudomonas
mevalonii) 		4 / 8 GLN A 232
ASN A 100
ALA A  99
HIS A 314
 None
 0.99A 5km8A-1qaxA:
undetectable
5km8B-1qaxA:
undetectable		 5km8A-1qaxA:
15.90
5km8B-1qaxA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)
(Pseudomonas
mevalonii) 		5 / 7 GLY A  27
LEU A  28
LEU A 342
ILE A  22
ILE A 356
 None
 1.09A 5vkqA-1qaxA:
undetectable
5vkqB-1qaxA:
undetectable		 5vkqA-1qaxA:
13.64
5vkqB-1qaxA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)
(Pseudomonas
mevalonii) 		5 / 8 GLY A  27
LEU A  28
LEU A 342
ILE A  22
ILE A 356
 None
 1.06A 5vkqB-1qaxA:
undetectable
5vkqC-1qaxA:
undetectable		 5vkqB-1qaxA:
13.64
5vkqC-1qaxA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)
(Pseudomonas
mevalonii) 		4 / 7 TRP A 307
SER A 303
GLY A 268
ARG A 261
 None
None
HMG  A1002 (-3.5A)
HMG  A1002 (-3.0A)
 1.07A 6btxA-1qaxA:
undetectable		 6btxA-1qaxA:
24.60