SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1qb4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		3 / 3 MET A 657
LEU A 660
SER A 661
 None
 0.67A 1ee2A-1qb4A:
0.7		 1ee2A-1qb4A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		3 / 3 ASP A 510
ASP A 543
ASP A 482
 None
MN  A 885 (-3.0A)
None
 0.79A 1eizA-1qb4A:
undetectable		 1eizA-1qb4A:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		3 / 3 ASP A 510
ASP A 543
ASP A 482
 None
MN  A 885 (-3.0A)
None
 0.79A 1ej0A-1qb4A:
undetectable		 1ej0A-1qb4A:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		5 / 10 LEU A 798
VAL A 667
TYR A 671
GLY A 733
LEU A 726
 None
 1.45A 1fkoA-1qb4A:
2.8		 1fkoA-1qb4A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 8 SER A 554
ALA A 553
GLY A 733
ALA A 552
 None
 0.72A 1gtnI-1qb4A:
undetectable
1gtnJ-1qb4A:
undetectable		 1gtnI-1qb4A:
6.68
1gtnJ-1qb4A:
6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K2R_A_H4BA1760_1
(NITRIC-OXIDE
SYNTHASE)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.16A 1k2rA-1qb4A:
undetectable
1k2rB-1qb4A:
3.9		 1k2rA-1qb4A:
19.19
1k2rB-1qb4A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K2R_B_H4BB2760_1
(NITRIC-OXIDE
SYNTHASE)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.16A 1k2rA-1qb4A:
undetectable
1k2rB-1qb4A:
3.9		 1k2rA-1qb4A:
19.19
1k2rB-1qb4A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K2S_A_H4BA1760_1
(NITRIC-OXIDE
SYNTHASE)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.25A 1k2sA-1qb4A:
undetectable
1k2sB-1qb4A:
undetectable		 1k2sA-1qb4A:
19.19
1k2sB-1qb4A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K2T_B_H4BB2760_1
(NITRIC-OXIDE
SYNTHASE)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.17A 1k2tA-1qb4A:
3.9
1k2tB-1qb4A:
undetectable		 1k2tA-1qb4A:
19.19
1k2tB-1qb4A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K2U_A_H4BA1760_1
(NITRIC-OXIDE
SYNTHASE)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.16A 1k2uA-1qb4A:
undetectable
1k2uB-1qb4A:
undetectable		 1k2uA-1qb4A:
19.19
1k2uB-1qb4A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_2
(ADENOSINE KINASE)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 4 SER A 632
LEU A 129
TYR A 220
GLY A 636
 None
 1.26A 1liiA-1qb4A:
undetectable		 1liiA-1qb4A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_2
(ADENOSINE KINASE)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 4 SER A 632
LEU A 131
TYR A 220
GLY A 636
 None
 1.07A 1liiA-1qb4A:
undetectable		 1liiA-1qb4A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LZX_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.25A 1lzxA-1qb4A:
3.7
1lzxB-1qb4A:
undetectable		 1lzxA-1qb4A:
19.19
1lzxB-1qb4A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LZX_B_H4BB1760_1
(NITRIC-OXIDE
SYNTHASE)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.18A 1lzxA-1qb4A:
3.7
1lzxB-1qb4A:
undetectable		 1lzxA-1qb4A:
19.19
1lzxB-1qb4A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LZZ_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.24A 1lzzA-1qb4A:
3.1
1lzzB-1qb4A:
undetectable		 1lzzA-1qb4A:
19.19
1lzzB-1qb4A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LZZ_B_H4BB1760_1
(NITRIC-OXIDE
SYNTHASE)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.25A 1lzzA-1qb4A:
3.1
1lzzB-1qb4A:
undetectable		 1lzzA-1qb4A:
19.19
1lzzB-1qb4A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMV_A_H4BA1760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.15A 1mmvA-1qb4A:
3.8
1mmvB-1qb4A:
undetectable		 1mmvA-1qb4A:
19.19
1mmvB-1qb4A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMV_B_H4BB2760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.19A 1mmvA-1qb4A:
3.8
1mmvB-1qb4A:
undetectable		 1mmvA-1qb4A:
19.19
1mmvB-1qb4A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMW_A_H4BA1760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.22A 1mmwA-1qb4A:
3.8
1mmwB-1qb4A:
3.6		 1mmwA-1qb4A:
19.19
1mmwB-1qb4A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMW_B_H4BB2760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.25A 1mmwA-1qb4A:
3.8
1mmwB-1qb4A:
3.6		 1mmwA-1qb4A:
19.19
1mmwB-1qb4A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		3 / 3 PHE A 678
LEU A 728
LEU A 732
 None
 0.56A 1mx1E-1qb4A:
undetectable		 1mx1E-1qb4A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OM4_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.29A 1om4A-1qb4A:
2.0
1om4B-1qb4A:
undetectable		 1om4A-1qb4A:
19.22
1om4B-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6H_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.21A 1p6hA-1qb4A:
3.8
1p6hB-1qb4A:
undetectable		 1p6hA-1qb4A:
19.19
1p6hB-1qb4A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6I_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.27A 1p6iA-1qb4A:
3.2
1p6iB-1qb4A:
undetectable		 1p6iA-1qb4A:
19.19
1p6iB-1qb4A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6J_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.28A 1p6jA-1qb4A:
3.8
1p6jB-1qb4A:
undetectable		 1p6jA-1qb4A:
19.19
1p6jB-1qb4A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6J_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.28A 1p6jA-1qb4A:
3.8
1p6jB-1qb4A:
undetectable		 1p6jA-1qb4A:
19.19
1p6jB-1qb4A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		5 / 12 ALA A 545
LEU A 750
MET A 551
GLY A 549
LEU A 660
 None
 1.18A 1qabF-1qb4A:
0.0		 1qabF-1qb4A:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		5 / 12 ILE A 469
VAL A 134
ASP A 252
GLY A 251
THR A 457
 None
 1.06A 1r9oA-1qb4A:
undetectable		 1r9oA-1qb4A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 8 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.19A 1rs6A-1qb4A:
undetectable
1rs6B-1qb4A:
3.8		 1rs6A-1qb4A:
19.19
1rs6B-1qb4A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.24A 1rs7A-1qb4A:
3.9
1rs7B-1qb4A:
undetectable		 1rs7A-1qb4A:
19.19
1rs7B-1qb4A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		5 / 12 LEU A 490
LEU A 489
THR A 264
ARG A 265
ILE A 474
 None
 1.16A 1tw4B-1qb4A:
undetectable		 1tw4B-1qb4A:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVL_A_H4BA900_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.26A 1zvlA-1qb4A:
undetectable
1zvlB-1qb4A:
2.7		 1zvlA-1qb4A:
19.19
1zvlB-1qb4A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		5 / 10 LEU A 631
VAL A 217
GLY A 216
VAL A 208
VAL A 209
 None
 1.40A 2cp4A-1qb4A:
0.0		 2cp4A-1qb4A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G6H_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 8 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.14A 2g6hA-1qb4A:
3.7
2g6hB-1qb4A:
undetectable		 2g6hA-1qb4A:
19.22
2g6hB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G6K_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.11A 2g6kA-1qb4A:
undetectable
2g6kB-1qb4A:
undetectable		 2g6kA-1qb4A:
19.22
2g6kB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G6K_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.21A 2g6kA-1qb4A:
undetectable
2g6kB-1qb4A:
undetectable		 2g6kA-1qb4A:
19.22
2g6kB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G6M_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.14A 2g6mA-1qb4A:
undetectable
2g6mB-1qb4A:
undetectable		 2g6mA-1qb4A:
19.22
2g6mB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G6M_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.17A 2g6mA-1qb4A:
undetectable
2g6mB-1qb4A:
undetectable		 2g6mA-1qb4A:
19.22
2g6mB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HNY_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		5 / 10 LEU A 798
VAL A 667
GLY A 733
TRP A 721
LEU A 726
 None
 1.35A 2hnyA-1qb4A:
2.3		 2hnyA-1qb4A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HX4_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.27A 2hx4A-1qb4A:
undetectable
2hx4B-1qb4A:
3.8		 2hx4A-1qb4A:
19.22
2hx4B-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		3 / 3 HIS A 138
ILE A 715
LEU A 691
 None
 0.73A 2kceA-1qb4A:
undetectable		 2kceA-1qb4A:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		3 / 3 ARG A  53
GLU A 803
SER A  42
 None
 0.84A 2xkkA-1qb4A:
undetectable
2xkkC-1qb4A:
3.2		 2xkkA-1qb4A:
24.08
2xkkC-1qb4A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		5 / 10 GLY A  16
VAL A  12
ALA A  82
PHE A  78
PHE A  75
 None
 1.21A 3a3yA-1qb4A:
undetectable		 3a3yA-1qb4A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3M_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.14A 3b3mA-1qb4A:
2.1
3b3mB-1qb4A:
undetectable		 3b3mA-1qb4A:
19.22
3b3mB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3M_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.27A 3b3mA-1qb4A:
2.1
3b3mB-1qb4A:
undetectable		 3b3mA-1qb4A:
19.22
3b3mB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3N_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.18A 3b3nA-1qb4A:
0.8
3b3nB-1qb4A:
1.0		 3b3nA-1qb4A:
19.22
3b3nB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3N_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.27A 3b3nA-1qb4A:
0.8
3b3nB-1qb4A:
1.0		 3b3nA-1qb4A:
19.22
3b3nB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3O_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.14A 3b3oA-1qb4A:
undetectable
3b3oB-1qb4A:
undetectable		 3b3oA-1qb4A:
19.22
3b3oB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3O_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.29A 3b3oA-1qb4A:
undetectable
3b3oB-1qb4A:
undetectable		 3b3oA-1qb4A:
19.22
3b3oB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3P_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 8 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.30A 3b3pA-1qb4A:
2.1
3b3pB-1qb4A:
3.6		 3b3pA-1qb4A:
19.22
3b3pB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		3 / 3 ASP A 510
ASP A 543
ASP A 482
 None
MN  A 885 (-3.0A)
None
 0.76A 3douA-1qb4A:
undetectable		 3douA-1qb4A:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.18A 3fc5A-1qb4A:
undetectable
3fc5B-1qb4A:
3.6		 3fc5A-1qb4A:
18.99
3fc5B-1qb4A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC5_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.19A 3fc5A-1qb4A:
undetectable
3fc5B-1qb4A:
3.6		 3fc5A-1qb4A:
18.99
3fc5B-1qb4A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		5 / 7 VAL A 501
VAL A 483
LEU A 484
SER A 481
TRP A 526
 None
 1.42A 3hs6B-1qb4A:
undetectable		 3hs6B-1qb4A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HSO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.16A 3hsoA-1qb4A:
undetectable
3hsoB-1qb4A:
undetectable		 3hsoA-1qb4A:
19.22
3hsoB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.19A 3jt3A-1qb4A:
undetectable
3jt3B-1qb4A:
undetectable		 3jt3A-1qb4A:
19.22
3jt3B-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT5_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.28A 3jt5A-1qb4A:
undetectable
3jt5B-1qb4A:
undetectable		 3jt5A-1qb4A:
19.22
3jt5B-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT6_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.25A 3jt6A-1qb4A:
undetectable
3jt6B-1qb4A:
0.5		 3jt6A-1qb4A:
19.22
3jt6B-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT7_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.28A 3jt7A-1qb4A:
undetectable
3jt7B-1qb4A:
undetectable		 3jt7A-1qb4A:
19.22
3jt7B-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT8_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.26A 3jt8A-1qb4A:
undetectable
3jt8B-1qb4A:
3.3		 3jt8A-1qb4A:
19.22
3jt8B-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT9_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.25A 3jt9A-1qb4A:
undetectable
3jt9B-1qb4A:
0.2		 3jt9A-1qb4A:
19.22
3jt9B-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWS_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.19A 3jwsA-1qb4A:
0.4
3jwsB-1qb4A:
undetectable		 3jwsA-1qb4A:
19.11
3jwsB-1qb4A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWS_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.19A 3jwsA-1qb4A:
0.3
3jwsB-1qb4A:
undetectable		 3jwsA-1qb4A:
19.11
3jwsB-1qb4A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWU_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.18A 3jwuA-1qb4A:
undetectable
3jwuB-1qb4A:
3.1		 3jwuA-1qb4A:
19.11
3jwuB-1qb4A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWU_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.19A 3jwuA-1qb4A:
undetectable
3jwuB-1qb4A:
3.1		 3jwuA-1qb4A:
19.11
3jwuB-1qb4A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWV_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.19A 3jwvA-1qb4A:
undetectable
3jwvB-1qb4A:
undetectable		 3jwvA-1qb4A:
19.11
3jwvB-1qb4A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX0_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.17A 3jx0A-1qb4A:
0.4
3jx0B-1qb4A:
undetectable		 3jx0A-1qb4A:
19.22
3jx0B-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 ASP A 562
GLN A 561
PRO A 601
GLU A 648
 None
 1.21A 3l2vA-1qb4A:
1.1		 3l2vA-1qb4A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		5 / 10 LEU A 798
VAL A 667
GLY A 733
TRP A 721
LEU A 726
 None
 1.27A 3lp1A-1qb4A:
2.5		 3lp1A-1qb4A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2R_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.27A 3n2rA-1qb4A:
undetectable
3n2rB-1qb4A:
undetectable		 3n2rA-1qb4A:
19.22
3n2rB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5Y_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.16A 3n5yA-1qb4A:
0.7
3n5yB-1qb4A:
undetectable		 3n5yA-1qb4A:
19.22
3n5yB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.25A 3n5yA-1qb4A:
0.7
3n5yB-1qb4A:
undetectable		 3n5yA-1qb4A:
19.22
3n5yB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5Z_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.15A 3n5zA-1qb4A:
undetectable
3n5zB-1qb4A:
0.3		 3n5zA-1qb4A:
19.22
3n5zB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5Z_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.18A 3n5zA-1qb4A:
undetectable
3n5zB-1qb4A:
0.2		 3n5zA-1qb4A:
19.22
3n5zB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLK_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.20A 3nlkA-1qb4A:
undetectable
3nlkB-1qb4A:
0.6		 3nlkA-1qb4A:
19.11
3nlkB-1qb4A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLW_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.27A 3nlwA-1qb4A:
undetectable
3nlwB-1qb4A:
0.2		 3nlwA-1qb4A:
19.22
3nlwB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNZ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.19A 3nnzA-1qb4A:
undetectable
3nnzB-1qb4A:
undetectable		 3nnzA-1qb4A:
19.22
3nnzB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNZ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.16A 3nnzA-1qb4A:
undetectable
3nnzB-1qb4A:
undetectable		 3nnzA-1qb4A:
19.22
3nnzB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 719
ARG A 618
ILE A 148
THR A 136
 None
 1.16A 3nxuA-1qb4A:
0.0		 3nxuA-1qb4A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		5 / 12 THR A 457
GLY A 250
ILE A 395
ASN A 258
ASP A 200
 None
 1.21A 3q87B-1qb4A:
undetectable		 3q87B-1qb4A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q9A_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.19A 3q9aA-1qb4A:
undetectable
3q9aB-1qb4A:
undetectable		 3q9aA-1qb4A:
19.22
3q9aB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q9A_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.29A 3q9aA-1qb4A:
undetectable
3q9aB-1qb4A:
undetectable		 3q9aA-1qb4A:
19.22
3q9aB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYL_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.26A 3tylA-1qb4A:
undetectable
3tylB-1qb4A:
undetectable		 3tylA-1qb4A:
19.22
3tylB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYL_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.30A 3tylA-1qb4A:
undetectable
3tylB-1qb4A:
undetectable		 3tylA-1qb4A:
19.22
3tylB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYM_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.24A 3tymA-1qb4A:
0.5
3tymB-1qb4A:
undetectable		 3tymA-1qb4A:
19.22
3tymB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYM_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.19A 3tymA-1qb4A:
0.4
3tymB-1qb4A:
undetectable		 3tymA-1qb4A:
19.22
3tymB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYN_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.23A 3tynA-1qb4A:
undetectable
3tynB-1qb4A:
0.6		 3tynA-1qb4A:
19.22
3tynB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYN_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.27A 3tynA-1qb4A:
undetectable
3tynB-1qb4A:
0.7		 3tynA-1qb4A:
19.22
3tynB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.28A 3tyoA-1qb4A:
0.7
3tyoB-1qb4A:
undetectable		 3tyoA-1qb4A:
19.22
3tyoB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYO_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.25A 3tyoA-1qb4A:
0.7
3tyoB-1qb4A:
undetectable		 3tyoA-1qb4A:
19.22
3tyoB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.23A 3ufqA-1qb4A:
undetectable
3ufqB-1qb4A:
undetectable		 3ufqA-1qb4A:
19.22
3ufqB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFV_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.28A 3ufvA-1qb4A:
0.5
3ufvB-1qb4A:
undetectable		 3ufvA-1qb4A:
19.22
3ufvB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		5 / 12 LEU A 794
LEU A 798
PRO A 729
VAL A 709
TRP A 717
 None
 1.36A 3w1wB-1qb4A:
undetectable		 3w1wB-1qb4A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_B_ADNB301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		5 / 10 ALA A  85
LEU A 178
LEU A  81
ASN A  83
ILE A 182
 None
 1.19A 3wdmB-1qb4A:
undetectable		 3wdmB-1qb4A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 8 ILE A 495
GLY A 496
PHE A 497
ARG A 609
 None
 0.84A 4acbB-1qb4A:
2.7
4acbC-1qb4A:
2.6		 4acbB-1qb4A:
20.00
4acbC-1qb4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B53_B_ACTB1445_0
(IG GAMMA-4 CHAIN C
REGION)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		3 / 3 GLU A 398
GLY A 255
SER A 475
 None
 0.63A 4b53B-1qb4A:
undetectable		 4b53B-1qb4A:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAM_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.20A 4camA-1qb4A:
0.6
4camB-1qb4A:
0.2		 4camA-1qb4A:
19.22
4camB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAM_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.24A 4camA-1qb4A:
0.6
4camB-1qb4A:
0.2		 4camA-1qb4A:
19.22
4camB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAN_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.28A 4canA-1qb4A:
0.2
4canB-1qb4A:
undetectable		 4canA-1qb4A:
19.22
4canB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAN_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.22A 4canA-1qb4A:
0.2
4canB-1qb4A:
undetectable		 4canA-1qb4A:
19.22
4canB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAO_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.19A 4caoA-1qb4A:
0.0
4caoB-1qb4A:
0.3		 4caoA-1qb4A:
19.22
4caoB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.21A 4capA-1qb4A:
0.4
4capB-1qb4A:
undetectable		 4capA-1qb4A:
19.22
4capB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 8 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.18A 4capA-1qb4A:
undetectable
4capB-1qb4A:
undetectable		 4capA-1qb4A:
19.22
4capB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.19A 4caqA-1qb4A:
undetectable
4caqB-1qb4A:
3.1		 4caqA-1qb4A:
19.22
4caqB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.24A 4caqA-1qb4A:
undetectable
4caqB-1qb4A:
3.1		 4caqA-1qb4A:
19.22
4caqB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CDT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.20A 4cdtA-1qb4A:
undetectable
4cdtB-1qb4A:
undetectable		 4cdtA-1qb4A:
19.22
4cdtB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_A_ZMRA1471_2
(NEURAMINIDASE)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 5 LEU A 221
ASP A 378
ARG A 382
ARG A 381
 None
 1.26A 4cpzA-1qb4A:
undetectable		 4cpzA-1qb4A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.19A 4ctpA-1qb4A:
0.4
4ctpB-1qb4A:
undetectable		 4ctpA-1qb4A:
19.22
4ctpB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.26A 4ctpA-1qb4A:
0.4
4ctpB-1qb4A:
undetectable		 4ctpA-1qb4A:
19.22
4ctpB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.23A 4ctrA-1qb4A:
0.3
4ctrB-1qb4A:
0.6		 4ctrA-1qb4A:
19.22
4ctrB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.23A 4ctrA-1qb4A:
0.2
4ctrB-1qb4A:
0.7		 4ctrA-1qb4A:
19.22
4ctrB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.19A 4cttA-1qb4A:
undetectable
4cttB-1qb4A:
undetectable		 4cttA-1qb4A:
19.22
4cttB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTU_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.26A 4ctuA-1qb4A:
undetectable
4ctuB-1qb4A:
0.0		 4ctuA-1qb4A:
19.22
4ctuB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTV_A_H4BA1718_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.17A 4ctvA-1qb4A:
0.4
4ctvB-1qb4A:
0.2		 4ctvA-1qb4A:
19.22
4ctvB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTV_B_H4BB1720_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.23A 4ctvA-1qb4A:
0.5
4ctvB-1qb4A:
0.2		 4ctvA-1qb4A:
19.22
4ctvB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D2Y_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.18A 4d2yA-1qb4A:
undetectable
4d2yB-1qb4A:
undetectable		 4d2yA-1qb4A:
19.22
4d2yB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D2Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.18A 4d2yA-1qb4A:
undetectable
4d2yB-1qb4A:
undetectable		 4d2yA-1qb4A:
19.22
4d2yB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D30_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.31A 4d30A-1qb4A:
undetectable
4d30B-1qb4A:
0.3		 4d30A-1qb4A:
19.22
4d30B-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D31_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.31A 4d31A-1qb4A:
undetectable
4d31B-1qb4A:
undetectable		 4d31A-1qb4A:
19.22
4d31B-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D31_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.31A 4d31A-1qb4A:
undetectable
4d31B-1qb4A:
undetectable		 4d31A-1qb4A:
19.22
4d31B-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D3B_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.22A 4d3bA-1qb4A:
3.6
4d3bB-1qb4A:
undetectable		 4d3bA-1qb4A:
19.22
4d3bB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7O_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.18A 4d7oA-1qb4A:
undetectable
4d7oB-1qb4A:
3.7		 4d7oA-1qb4A:
19.22
4d7oB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVW_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.29A 4fvwA-1qb4A:
undetectable
4fvwB-1qb4A:
0.3		 4fvwA-1qb4A:
19.22
4fvwB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVX_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.24A 4fvxA-1qb4A:
undetectable
4fvxB-1qb4A:
0.2		 4fvxA-1qb4A:
19.22
4fvxB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVY_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.29A 4fvyA-1qb4A:
undetectable
4fvyB-1qb4A:
undetectable		 4fvyA-1qb4A:
19.22
4fvyB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVZ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.19A 4fvzA-1qb4A:
undetectable
4fvzB-1qb4A:
undetectable		 4fvzA-1qb4A:
19.22
4fvzB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FW0_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.27A 4fw0A-1qb4A:
undetectable
4fw0B-1qb4A:
undetectable		 4fw0A-1qb4A:
19.22
4fw0B-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GQE_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.26A 4gqeA-1qb4A:
undetectable
4gqeB-1qb4A:
0.2		 4gqeA-1qb4A:
19.22
4gqeB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMT_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.24A 4imtA-1qb4A:
0.0
4imtB-1qb4A:
0.0		 4imtA-1qb4A:
19.22
4imtB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSG_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.26A 4jsgA-1qb4A:
undetectable
4jsgB-1qb4A:
undetectable		 4jsgA-1qb4A:
19.22
4jsgB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSI_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.18A 4jsiA-1qb4A:
undetectable
4jsiB-1qb4A:
0.3		 4jsiA-1qb4A:
19.22
4jsiB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSI_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.25A 4jsiA-1qb4A:
undetectable
4jsiB-1qb4A:
0.3		 4jsiA-1qb4A:
19.22
4jsiB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_E_ACTE503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 4 LYS A 693
LEU A 694
GLU A 690
LEU A 868
 None
 1.09A 4k4yE-1qb4A:
undetectable		 4k4yE-1qb4A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 5 LYS A 693
LEU A 694
GLU A 690
LEU A 868
 None
 1.07A 4k4yI-1qb4A:
0.0		 4k4yI-1qb4A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5D_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.17A 4k5dA-1qb4A:
undetectable
4k5dB-1qb4A:
0.4		 4k5dA-1qb4A:
19.22
4k5dB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5D_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.24A 4k5dA-1qb4A:
undetectable
4k5dB-1qb4A:
0.4		 4k5dA-1qb4A:
19.22
4k5dB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5F_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.20A 4k5fA-1qb4A:
1.1
4k5fB-1qb4A:
0.0		 4k5fA-1qb4A:
19.22
4k5fB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5F_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.28A 4k5fA-1qb4A:
1.1
4k5fB-1qb4A:
0.0		 4k5fA-1qb4A:
19.22
4k5fB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCK_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.24A 4kckA-1qb4A:
0.1
4kckB-1qb4A:
0.3		 4kckA-1qb4A:
19.22
4kckB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCL_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.24A 4kclA-1qb4A:
undetectable
4kclB-1qb4A:
3.7		 4kclA-1qb4A:
19.22
4kclB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCM_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.26A 4kcmA-1qb4A:
undetectable
4kcmB-1qb4A:
undetectable		 4kcmA-1qb4A:
19.22
4kcmB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.25A 4kcnA-1qb4A:
undetectable
4kcnB-1qb4A:
3.2		 4kcnA-1qb4A:
19.22
4kcnB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCO_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.30A 4kcoA-1qb4A:
0.5
4kcoB-1qb4A:
undetectable		 4kcoA-1qb4A:
19.22
4kcoB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCO_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.26A 4kcoA-1qb4A:
0.5
4kcoB-1qb4A:
undetectable		 4kcoA-1qb4A:
19.22
4kcoB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 8 LEU A 221
LEU A 224
LEU A 228
LYS A 384
 None
 0.86A 4klaA-1qb4A:
undetectable		 4klaA-1qb4A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		3 / 3 TRP A 186
GLN A 180
THR A  22
 None
 0.86A 4m2xA-1qb4A:
0.0		 4m2xA-1qb4A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGZ_B_H4BB760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.25A 4ugzA-1qb4A:
undetectable
4ugzB-1qb4A:
undetectable		 4ugzA-1qb4A:
19.22
4ugzB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH0_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.26A 4uh0A-1qb4A:
0.7
4uh0B-1qb4A:
undetectable		 4uh0A-1qb4A:
19.22
4uh0B-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH1_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.15A 4uh1A-1qb4A:
undetectable
4uh1B-1qb4A:
0.4		 4uh1A-1qb4A:
19.22
4uh1B-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH2_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.28A 4uh2A-1qb4A:
undetectable
4uh2B-1qb4A:
undetectable		 4uh2A-1qb4A:
19.22
4uh2B-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.25A 4uh3A-1qb4A:
3.0
4uh3B-1qb4A:
0.3		 4uh3A-1qb4A:
19.22
4uh3B-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.27A 4uh4A-1qb4A:
undetectable
4uh4B-1qb4A:
undetectable		 4uh4A-1qb4A:
19.22
4uh4B-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.28A 4uh6A-1qb4A:
0.5
4uh6B-1qb4A:
3.7		 4uh6A-1qb4A:
19.12
4uh6B-1qb4A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPM_B_H4BB760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.24A 4upmA-1qb4A:
undetectable
4upmB-1qb4A:
0.8		 4upmA-1qb4A:
19.22
4upmB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPN_B_H4BB760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.19A 4upnA-1qb4A:
0.0
4upnB-1qb4A:
0.0		 4upnA-1qb4A:
19.22
4upnB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPO_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.25A 4upoA-1qb4A:
undetectable
4upoB-1qb4A:
1.0		 4upoA-1qb4A:
19.22
4upoB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.21A 4uppA-1qb4A:
undetectable
4uppB-1qb4A:
undetectable		 4uppA-1qb4A:
19.22
4uppB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.17A 4uppA-1qb4A:
undetectable
4uppB-1qb4A:
undetectable		 4uppA-1qb4A:
19.22
4uppB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3W_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 6 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.20A 4v3wA-1qb4A:
0.0
4v3wB-1qb4A:
0.3		 4v3wA-1qb4A:
19.22
4v3wB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3X_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.19A 4v3xA-1qb4A:
undetectable
4v3xB-1qb4A:
0.2		 4v3xA-1qb4A:
19.22
4v3xB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 8 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.15A 4v3yA-1qb4A:
undetectable
4v3yB-1qb4A:
undetectable		 4v3yA-1qb4A:
19.22
4v3yB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 6 ARG A 581
ARG A 699
ASP A 543
ASP A 254
 None
None
MN  A 885 (-3.0A)
MN  A 885 ( 4.7A)
 1.37A 4xqeA-1qb4A:
undetectable		 4xqeA-1qb4A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 6 ARG A 581
ARG A 699
ASP A 543
ASP A 254
 None
None
MN  A 885 (-3.0A)
MN  A 885 ( 4.7A)
 1.38A 4xqeB-1qb4A:
undetectable		 4xqeB-1qb4A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_A_4LEA401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		5 / 8 LEU A 846
LEU A  60
LEU A  63
LEU A  68
ALA A  72
 None
 1.14A 4z90A-1qb4A:
3.6
4z90B-1qb4A:
3.7
4z90C-1qb4A:
3.9
4z90D-1qb4A:
3.9
4z90E-1qb4A:
3.8		 4z90A-1qb4A:
16.69
4z90B-1qb4A:
16.69
4z90C-1qb4A:
16.69
4z90D-1qb4A:
16.69
4z90E-1qb4A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 ILE A 565
CYH A 568
LEU A 575
GLY A 606
 None
 0.71A 5a06A-1qb4A:
undetectable		 5a06A-1qb4A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 ILE A 565
CYH A 568
LEU A 575
GLY A 606
 None
 0.74A 5a06B-1qb4A:
undetectable		 5a06B-1qb4A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 ILE A 565
CYH A 568
LEU A 575
GLY A 606
 None
 0.71A 5a06C-1qb4A:
undetectable		 5a06C-1qb4A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 ILE A 565
CYH A 568
LEU A 575
GLY A 606
 None
 0.69A 5a06E-1qb4A:
undetectable		 5a06E-1qb4A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 ILE A 565
CYH A 568
LEU A 575
GLY A 606
 None
 0.70A 5a06F-1qb4A:
undetectable		 5a06F-1qb4A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.33A 5ad4A-1qb4A:
undetectable
5ad4B-1qb4A:
3.7		 5ad4A-1qb4A:
19.22
5ad4B-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.26A 5ad5A-1qb4A:
undetectable
5ad5B-1qb4A:
3.8		 5ad5A-1qb4A:
19.22
5ad5B-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD6_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.30A 5ad6A-1qb4A:
0.5
5ad6B-1qb4A:
0.3		 5ad6A-1qb4A:
19.22
5ad6B-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADA_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.28A 5adaA-1qb4A:
0.3
5adaB-1qb4A:
undetectable		 5adaA-1qb4A:
19.22
5adaB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADA_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.27A 5adaA-1qb4A:
0.3
5adaB-1qb4A:
undetectable		 5adaA-1qb4A:
19.22
5adaB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADC_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.29A 5adcA-1qb4A:
0.2
5adcB-1qb4A:
undetectable		 5adcA-1qb4A:
19.22
5adcB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADG_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.28A 5adgA-1qb4A:
0.4
5adgB-1qb4A:
undetectable		 5adgA-1qb4A:
19.12
5adgB-1qb4A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADI_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.29A 5adiA-1qb4A:
undetectable
5adiB-1qb4A:
3.8		 5adiA-1qb4A:
19.12
5adiB-1qb4A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGK_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.27A 5agkA-1qb4A:
undetectable
5agkB-1qb4A:
3.6		 5agkA-1qb4A:
19.22
5agkB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGL_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.18A 5aglA-1qb4A:
undetectable
5aglB-1qb4A:
undetectable		 5aglA-1qb4A:
19.22
5aglB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGL_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.25A 5aglA-1qb4A:
undetectable
5aglB-1qb4A:
undetectable		 5aglA-1qb4A:
19.22
5aglB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGM_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.24A 5agmA-1qb4A:
undetectable
5agmB-1qb4A:
0.0		 5agmA-1qb4A:
19.22
5agmB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGN_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.24A 5agnA-1qb4A:
undetectable
5agnB-1qb4A:
undetectable		 5agnA-1qb4A:
19.22
5agnB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGO_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.31A 5agoA-1qb4A:
undetectable
5agoB-1qb4A:
undetectable		 5agoA-1qb4A:
19.22
5agoB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.25A 5agpA-1qb4A:
undetectable
5agpB-1qb4A:
undetectable		 5agpA-1qb4A:
19.22
5agpB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 6 ALA A 714
SER A 542
GLN A 613
PRO A 139
 None
 0.96A 5c6pA-1qb4A:
undetectable		 5c6pA-1qb4A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		5 / 9 LEU A 631
VAL A 217
GLY A 216
VAL A 208
VAL A 209
 None
 1.36A 5cp4A-1qb4A:
undetectable		 5cp4A-1qb4A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_B_010B607_0
(HNL ISOENZYME 5)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		5 / 10 VAL A 501
LEU A 434
VAL A 483
TYR A 527
TRP A 526
 None
 1.39A 5eb5B-1qb4A:
undetectable		 5eb5B-1qb4A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		3 / 3 ASN A 219
ASP A 375
GLY A 374
 None
 0.66A 5fctB-1qb4A:
undetectable		 5fctB-1qb4A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVS_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.33A 5fvsA-1qb4A:
undetectable
5fvsB-1qb4A:
undetectable		 5fvsA-1qb4A:
19.22
5fvsB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVS_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.32A 5fvsA-1qb4A:
undetectable
5fvsB-1qb4A:
undetectable		 5fvsA-1qb4A:
19.22
5fvsB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVT_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.29A 5fvtA-1qb4A:
undetectable
5fvtB-1qb4A:
undetectable		 5fvtA-1qb4A:
19.22
5fvtB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.30A 5fvtA-1qb4A:
undetectable
5fvtB-1qb4A:
undetectable		 5fvtA-1qb4A:
19.22
5fvtB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVW_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.29A 5fvwA-1qb4A:
0.5
5fvwB-1qb4A:
3.1		 5fvwA-1qb4A:
19.12
5fvwB-1qb4A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVX_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.28A 5fvxA-1qb4A:
0.0
5fvxB-1qb4A:
3.6		 5fvxA-1qb4A:
19.12
5fvxB-1qb4A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FW0_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.29A 5fw0A-1qb4A:
undetectable
5fw0B-1qb4A:
0.0		 5fw0A-1qb4A:
19.22
5fw0B-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0N_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.30A 5g0nA-1qb4A:
undetectable
5g0nB-1qb4A:
undetectable		 5g0nA-1qb4A:
19.22
5g0nB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0N_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.28A 5g0nA-1qb4A:
undetectable
5g0nB-1qb4A:
undetectable		 5g0nA-1qb4A:
19.22
5g0nB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0O_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.30A 5g0oA-1qb4A:
3.7
5g0oB-1qb4A:
undetectable		 5g0oA-1qb4A:
19.22
5g0oB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 6 LEU A 363
LEU A 380
LEU A 377
LEU A 286
 None
 0.78A 5gs4A-1qb4A:
0.6		 5gs4A-1qb4A:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 ILE A 263
VAL A 486
ILE A 461
ASN A 256
 None
 0.98A 5hieC-1qb4A:
1.5		 5hieC-1qb4A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		3 / 3 LEU A 484
LEU A 521
ARG A 396
 None
 0.60A 5hnzB-1qb4A:
2.4		 5hnzB-1qb4A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 8 HIS A 579
GLN A 561
LEU A 608
LEU A 596
 None
 0.97A 5hs6A-1qb4A:
undetectable		 5hs6A-1qb4A:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		3 / 3 PRO A 196
ARG A 195
GLU A 201
 None
 0.70A 5j6hA-1qb4A:
undetectable		 5j6hA-1qb4A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		5 / 8 ARG A 785
LEU A  56
LEU A  60
LEU A 778
TYR A 782
 None
 1.30A 5jqbA-1qb4A:
undetectable
5jqbB-1qb4A:
undetectable		 5jqbA-1qb4A:
16.87
5jqbB-1qb4A:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		5 / 12 VAL A 610
GLU A 612
THR A 107
GLY A 589
LEU A 633
 None
 1.39A 5m50B-1qb4A:
3.3		 5m50B-1qb4A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNR_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.24A 5unrA-1qb4A:
0.2
5unrB-1qb4A:
undetectable		 5unrA-1qb4A:
19.22
5unrB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNS_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.24A 5unsA-1qb4A:
4.1
5unsB-1qb4A:
undetectable		 5unsA-1qb4A:
19.22
5unsB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNT_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.29A 5untA-1qb4A:
1.1
5untB-1qb4A:
0.6		 5untA-1qb4A:
19.22
5untB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNT_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.25A 5untA-1qb4A:
1.1
5untB-1qb4A:
0.7		 5untA-1qb4A:
19.22
5untB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNU_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.26A 5unuA-1qb4A:
3.1
5unuB-1qb4A:
0.7		 5unuA-1qb4A:
19.22
5unuB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNW_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.35A 5unwA-1qb4A:
3.5
5unwB-1qb4A:
undetectable		 5unwA-1qb4A:
19.22
5unwB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNY_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.31A 5unyA-1qb4A:
0.0
5unyB-1qb4A:
0.0		 5unyA-1qb4A:
19.22
5unyB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNZ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.28A 5unzA-1qb4A:
0.0
5unzB-1qb4A:
0.6		 5unzA-1qb4A:
19.22
5unzB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO0_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.31A 5uo0A-1qb4A:
0.6
5uo0B-1qb4A:
0.7		 5uo0A-1qb4A:
19.22
5uo0B-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO1_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.27A 5uo1A-1qb4A:
0.7
5uo1B-1qb4A:
0.0		 5uo1A-1qb4A:
19.12
5uo1B-1qb4A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 5 ARG A 799
PHE A 682
LEU A 728
LEU A 786
 None
 0.95A 5veuH-1qb4A:
undetectable		 5veuH-1qb4A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUI_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.20A 5vuiA-1qb4A:
3.6
5vuiB-1qb4A:
undetectable		 5vuiA-1qb4A:
19.22
5vuiB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUI_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.29A 5vuiA-1qb4A:
3.6
5vuiB-1qb4A:
undetectable		 5vuiA-1qb4A:
19.22
5vuiB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUJ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.14A 5vujA-1qb4A:
0.4
5vujB-1qb4A:
0.6		 5vujA-1qb4A:
19.22
5vujB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUJ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.18A 5vujA-1qb4A:
0.4
5vujB-1qb4A:
0.8		 5vujA-1qb4A:
19.22
5vujB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUK_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.27A 5vukA-1qb4A:
0.7
5vukB-1qb4A:
3.1		 5vukA-1qb4A:
19.22
5vukB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUK_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.25A 5vukA-1qb4A:
0.7
5vukB-1qb4A:
3.7		 5vukA-1qb4A:
19.22
5vukB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUL_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.18A 5vulA-1qb4A:
3.8
5vulB-1qb4A:
undetectable		 5vulA-1qb4A:
19.22
5vulB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUL_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.17A 5vulA-1qb4A:
3.8
5vulB-1qb4A:
undetectable		 5vulA-1qb4A:
19.22
5vulB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUM_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.20A 5vumA-1qb4A:
undetectable
5vumB-1qb4A:
3.7		 5vumA-1qb4A:
19.22
5vumB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUM_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.27A 5vumA-1qb4A:
undetectable
5vumB-1qb4A:
3.7		 5vumA-1qb4A:
19.22
5vumB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.16A 5vunA-1qb4A:
undetectable
5vunB-1qb4A:
undetectable		 5vunA-1qb4A:
19.22
5vunB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.30A 5vunA-1qb4A:
undetectable
5vunB-1qb4A:
undetectable		 5vunA-1qb4A:
19.22
5vunB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUP_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.18A 5vupA-1qb4A:
undetectable
5vupB-1qb4A:
undetectable		 5vupA-1qb4A:
19.22
5vupB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUP_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.19A 5vupA-1qb4A:
undetectable
5vupB-1qb4A:
undetectable		 5vupA-1qb4A:
19.22
5vupB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUQ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.29A 5vuqA-1qb4A:
undetectable
5vuqB-1qb4A:
undetectable		 5vuqA-1qb4A:
19.22
5vuqB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUQ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.28A 5vuqA-1qb4A:
undetectable
5vuqB-1qb4A:
undetectable		 5vuqA-1qb4A:
19.22
5vuqB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUR_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.26A 5vurA-1qb4A:
0.4
5vurB-1qb4A:
3.7		 5vurA-1qb4A:
19.22
5vurB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUS_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.29A 5vusA-1qb4A:
3.8
5vusB-1qb4A:
0.7		 5vusA-1qb4A:
19.22
5vusB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUT_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.28A 5vutA-1qb4A:
undetectable
5vutB-1qb4A:
undetectable		 5vutA-1qb4A:
19.22
5vutB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUU_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.15A 5vuuA-1qb4A:
0.0
5vuuB-1qb4A:
0.0		 5vuuA-1qb4A:
19.22
5vuuB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUU_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.25A 5vuuA-1qb4A:
1.6
5vuuB-1qb4A:
undetectable		 5vuuA-1qb4A:
19.22
5vuuB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUW_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.27A 5vuwA-1qb4A:
undetectable
5vuwB-1qb4A:
undetectable		 5vuwA-1qb4A:
19.12
5vuwB-1qb4A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUZ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.26A 5vuzA-1qb4A:
0.7
5vuzB-1qb4A:
undetectable		 5vuzA-1qb4A:
19.12
5vuzB-1qb4A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 8 LYS A 478
THR A 400
THR A 403
TYR A 418
 None
 0.98A 5x2sI-1qb4A:
undetectable
5x2sJ-1qb4A:
undetectable
5x2sK-1qb4A:
undetectable		 5x2sI-1qb4A:
9.86
5x2sJ-1qb4A:
10.42
5x2sK-1qb4A:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_B_ADNB503_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 5 LEU A 842
VAL A  71
GLU A  67
LEU A  63
 None
 0.87A 5xooB-1qb4A:
0.0		 5xooB-1qb4A:
6.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 8 GLU A 453
ARG A 265
THR A 264
ILE A 395
 None
 1.08A 6a4iA-1qb4A:
undetectable		 6a4iA-1qb4A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 ARG A 195
GLU A 201
THR A 140
PRO A 139
 None
 1.31A 6a4iB-1qb4A:
0.0		 6a4iB-1qb4A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUR_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.27A 6aurA-1qb4A:
undetectable
6aurB-1qb4A:
undetectable		 6aurA-1qb4A:
6.16
6aurB-1qb4A:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUR_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.30A 6aurA-1qb4A:
undetectable
6aurB-1qb4A:
undetectable		 6aurA-1qb4A:
6.16
6aurB-1qb4A:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUS_B_H4BB803_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.30A 6ausA-1qb4A:
undetectable
6ausB-1qb4A:
undetectable		 6ausA-1qb4A:
6.16
6ausB-1qb4A:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUT_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.26A 6autA-1qb4A:
undetectable
6autB-1qb4A:
undetectable		 6autA-1qb4A:
6.16
6autB-1qb4A:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUT_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.30A 6autA-1qb4A:
undetectable
6autB-1qb4A:
undetectable		 6autA-1qb4A:
6.16
6autB-1qb4A:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		3 / 3 GLN A 784
TRP A 792
VAL A 787
 None
 1.14A 6auuA-1qb4A:
3.4		 6auuA-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.25A 6auuA-1qb4A:
3.4
6auuB-1qb4A:
undetectable		 6auuA-1qb4A:
6.16
6auuB-1qb4A:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUV_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.32A 6auvA-1qb4A:
0.7
6auvB-1qb4A:
0.0		 6auvA-1qb4A:
6.16
6auvB-1qb4A:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUX_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.29A 6auxA-1qb4A:
undetectable
6auxB-1qb4A:
3.8		 6auxA-1qb4A:
6.16
6auxB-1qb4A:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUX_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.27A 6auxA-1qb4A:
undetectable
6auxB-1qb4A:
3.8		 6auxA-1qb4A:
6.16
6auxB-1qb4A:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUZ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.30A 6auzA-1qb4A:
0.3
6auzB-1qb4A:
3.2		 6auzA-1qb4A:
7.24
6auzB-1qb4A:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA608_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		3 / 3 GLY A 607
THR A 576
GLU A 574
 None
 0.54A 6b58A-1qb4A:
3.5		 6b58A-1qb4A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_1
(NS3 PROTEASE)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		5 / 9 VAL A 672
ARG A 669
ALA A 545
SER A 554
ASP A 547
 None
 1.49A 6c2mA-1qb4A:
0.0		 6c2mA-1qb4A:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIC_A_H4BA802_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.23A 6cicA-1qb4A:
undetectable
6cicB-1qb4A:
0.7		 6cicA-1qb4A:
7.24
6cicB-1qb4A:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIC_B_H4BB802_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.25A 6cicA-1qb4A:
undetectable
6cicB-1qb4A:
0.7		 6cicA-1qb4A:
7.24
6cicB-1qb4A:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CID_A_H4BA802_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 MET A 249
VAL A 267
PHE A 206
GLU A 201
 None
 1.21A 6cidA-1qb4A:
3.7
6cidB-1qb4A:
3.6		 6cidA-1qb4A:
7.24
6cidB-1qb4A:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CID_B_H4BB803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 206
GLU A 201
MET A 249
VAL A 267
 None
 1.27A 6cidA-1qb4A:
3.7
6cidB-1qb4A:
3.6		 6cidA-1qb4A:
7.24
6cidB-1qb4A:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE
(Escherichia
coli) 		5 / 10 GLY A 540
ARG A 581
ALA A 714
GLY A 582
LEU A 776
 None
 1.31A 6hqbA-1qb4A:
2.1
6hqbJ-1qb4A:
undetectable		 6hqbA-1qb4A:
6.97
6hqbJ-1qb4A:
3.60