SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1qbg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 1qbg NAD(P)H
DEHYDROGENASE
[QUINONE] 1
(Homo
sapiens) 		5 / 7 PHE A 181
PHE A 137
PHE A 120
PHE A 124
VAL A  97
 None
 1.50A 1lh6A-1qbgA:
undetectable		 1lh6A-1qbgA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1qbg NAD(P)H
DEHYDROGENASE
[QUINONE] 1
(Homo
sapiens) 		5 / 12 THR A 148
ILE A 192
PHE A  17
MET A  21
SER A 145
 FAD  A 501 (-3.9A)
FAD  A 501 (-4.5A)
FAD  A 501 (-4.9A)
None
None
 1.10A 1xomB-1qbgA:
undetectable		 1xomB-1qbgA:
20.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1qbg NAD(P)H
DEHYDROGENASE
[QUINONE] 1
(Homo
sapiens) 		4 / 8 PHE A 106
GLY A 149
GLY A 150
MET A 154
 FAD  A 501 (-3.9A)
FAD  A 501 (-3.9A)
FAD  A 501 (-4.0A)
None
 0.56A 2qx4A-1qbgA:
32.8
2qx4B-1qbgA:
32.9		 2qx4A-1qbgA:
40.07
2qx4B-1qbgA:
40.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)		 1qbg NAD(P)H
DEHYDROGENASE
[QUINONE] 1
(Homo
sapiens) 		5 / 9 LEU A 176
ILE A 175
GLY A 174
LEU A 144
LEU A 168
 None
 1.06A 3ai9X-1qbgA:
2.3		 3ai9X-1qbgA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)		 1qbg NAD(P)H
DEHYDROGENASE
[QUINONE] 1
(Homo
sapiens) 		3 / 3 PHE A 120
CYH A 179
PHE A 181
 None
 1.13A 3cr5X-1qbgA:
undetectable		 3cr5X-1qbgA:
18.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FW1_A_STIA233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1qbg NAD(P)H
DEHYDROGENASE
[QUINONE] 1
(Homo
sapiens) 		5 / 10 PHE A 106
GLY A 149
GLY A 150
MET A 154
TYR A 155
 FAD  A 501 (-3.9A)
FAD  A 501 (-3.9A)
FAD  A 501 (-4.0A)
None
FAD  A 501 (-4.9A)
 0.62A 3fw1A-1qbgA:
32.8		 3fw1A-1qbgA:
40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FW1_A_STIA233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1qbg NAD(P)H
DEHYDROGENASE
[QUINONE] 1
(Homo
sapiens) 		5 / 10 TRP A 105
GLY A 149
GLY A 150
MET A 154
TYR A 155
 FAD  A 501 (-4.5A)
FAD  A 501 (-3.9A)
FAD  A 501 (-4.0A)
None
FAD  A 501 (-4.9A)
 0.57A 3fw1A-1qbgA:
32.8		 3fw1A-1qbgA:
40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OWX_A_XRAA233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1qbg NAD(P)H
DEHYDROGENASE
[QUINONE] 1
(Homo
sapiens) 		5 / 9 TRP A 105
GLY A 149
GLY A 150
MET A 154
TYR A 155
 FAD  A 501 (-4.5A)
FAD  A 501 (-3.9A)
FAD  A 501 (-4.0A)
None
FAD  A 501 (-4.9A)
 0.60A 3owxA-1qbgA:
32.9		 3owxA-1qbgA:
39.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1qbg NAD(P)H
DEHYDROGENASE
[QUINONE] 1
(Homo
sapiens) 		5 / 11 TRP A 105
GLY A 149
GLY A 150
MET A 154
TYR A 155
 FAD  A 501 (-4.5A)
FAD  A 501 (-3.9A)
FAD  A 501 (-4.0A)
None
FAD  A 501 (-4.9A)
 0.49A 3owxA-1qbgA:
32.9
3owxB-1qbgA:
32.8		 3owxA-1qbgA:
39.93
3owxB-1qbgA:
39.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 1qbg NAD(P)H
DEHYDROGENASE
[QUINONE] 1
(Homo
sapiens) 		4 / 6 ALA A  74
ILE A 121
LEU A  80
GLU A  70
 None
 0.74A 3r9sA-1qbgA:
undetectable		 3r9sA-1qbgA:
24.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1qbg NAD(P)H
DEHYDROGENASE
[QUINONE] 1
(Homo
sapiens) 		5 / 7 TRP A 105
GLY A 149
GLY A 150
MET A 154
TYR A 155
 FAD  A 501 (-4.5A)
FAD  A 501 (-3.9A)
FAD  A 501 (-4.0A)
None
FAD  A 501 (-4.9A)
 0.52A 4fgkB-1qbgA:
32.6		 4fgkB-1qbgA:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1qbg NAD(P)H
DEHYDROGENASE
[QUINONE] 1
(Homo
sapiens) 		4 / 8 ILE A 192
LEU A 144
MET A  21
PHE A  17
 FAD  A 501 (-4.5A)
None
None
FAD  A 501 (-4.9A)
 0.85A 4r38B-1qbgA:
undetectable		 4r38B-1qbgA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 1qbg NAD(P)H
DEHYDROGENASE
[QUINONE] 1
(Homo
sapiens) 		3 / 3 ASP A  40
ASN A  45
PHE A 101
 None
 0.65A 5jglB-1qbgA:
2.5		 5jglB-1qbgA:
21.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LBT_A_6T0A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1qbg NAD(P)H
DEHYDROGENASE
[QUINONE] 1
(Homo
sapiens) 		5 / 10 TRP A 105
GLY A 149
GLY A 150
MET A 154
TYR A 155
 FAD  A 501 (-4.5A)
FAD  A 501 (-3.9A)
FAD  A 501 (-4.0A)
None
FAD  A 501 (-4.9A)
 0.54A 5lbtA-1qbgA:
32.8
5lbtB-1qbgA:
32.2		 5lbtA-1qbgA:
43.18
5lbtB-1qbgA:
43.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LBT_A_6T0A304_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1qbg NAD(P)H
DEHYDROGENASE
[QUINONE] 1
(Homo
sapiens) 		5 / 10 TRP A 105
GLY A 149
GLY A 150
MET A 154
TYR A 155
 FAD  A 501 (-4.5A)
FAD  A 501 (-3.9A)
FAD  A 501 (-4.0A)
None
FAD  A 501 (-4.9A)
 0.58A 5lbtA-1qbgA:
32.8
5lbtB-1qbgA:
32.2		 5lbtA-1qbgA:
43.18
5lbtB-1qbgA:
43.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 1qbg NAD(P)H
DEHYDROGENASE
[QUINONE] 1
(Homo
sapiens) 		4 / 8 ILE A 171
ASN A  18
LEU A  41
ALA A  10
 None
FAD  A 501 (-3.6A)
None
None
 0.82A 5y7pC-1qbgA:
0.0		 5y7pC-1qbgA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 1qbg NAD(P)H
DEHYDROGENASE
[QUINONE] 1
(Homo
sapiens) 		4 / 8 ILE A 171
ASN A  18
LEU A  41
ALA A  10
 None
FAD  A 501 (-3.6A)
None
None
 0.80A 5y7pE-1qbgA:
0.0		 5y7pE-1qbgA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA607_0
(ALPHA-AMYLASE)		 1qbg NAD(P)H
DEHYDROGENASE
[QUINONE] 1
(Homo
sapiens) 		4 / 4 ARG A 118
SER A  51
ASP A  54
ASN A  47
 None
 0.87A 6ag0A-1qbgA:
1.8		 6ag0A-1qbgA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 1qbg NAD(P)H
DEHYDROGENASE
[QUINONE] 1
(Homo
sapiens) 		4 / 4 ASP A  40
ILE A 111
PRO A  48
LEU A  41
 None
 1.47A 6mkeB-1qbgA:
0.0		 6mkeB-1qbgA:
11.40