SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1qc5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 1qc5 PROTEIN (ALPHA1
BETA1 INTEGRIN)
(Homo
sapiens) 		4 / 7 VAL B 338
ARG B 466
ILE B 456
GLY B 415
 None
 0.92A 11gsA-1qc5B:
undetectable		 11gsA-1qc5B:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1qc5 PROTEIN (ALPHA1
BETA1 INTEGRIN)
(Homo
sapiens) 		4 / 8 VAL B 338
ARG B 466
ILE B 456
GLY B 415
 None
 0.95A 2gssA-1qc5B:
undetectable		 2gssA-1qc5B:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1qc5 PROTEIN (ALPHA1
BETA1 INTEGRIN)
(Homo
sapiens) 		4 / 8 VAL B 338
ARG B 466
ILE B 456
GLY B 415
 None
 0.95A 2gssB-1qc5B:
undetectable		 2gssB-1qc5B:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 1qc5 PROTEIN (ALPHA1
BETA1 INTEGRIN)
(Homo
sapiens) 		4 / 8 MET B 411
ASP B 340
SER B 342
HIS B 447
 None
MG  B 602 ( 4.5A)
MG  B 602 (-2.1A)
None
 1.32A 2v0gA-1qc5B:
undetectable		 2v0gA-1qc5B:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 1qc5 PROTEIN (ALPHA1
BETA1 INTEGRIN)
(Homo
sapiens) 		5 / 12 ILE B 416
THR B 412
VAL B 455
GLU B 495
THR B 497
 None
 1.14A 2vn0A-1qc5B:
undetectable		 2vn0A-1qc5B:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1qc5 PROTEIN (ALPHA1
BETA1 INTEGRIN)
(Homo
sapiens) 		4 / 7 LEU B 452
GLU B 488
ILE B 416
ILE B 521
 None
 0.78A 2xkwA-1qc5B:
undetectable		 2xkwA-1qc5B:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 1qc5 PROTEIN (ALPHA1
BETA1 INTEGRIN)
(Homo
sapiens) 		5 / 9 LEU B 359
VAL B 395
ILE B 402
PHE B 384
THR B 369
 None
 1.28A 3freX-1qc5B:
undetectable		 3freX-1qc5B:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 1qc5 PROTEIN (ALPHA1
BETA1 INTEGRIN)
(Homo
sapiens) 		4 / 8 VAL B 338
ARG B 466
ILE B 456
GLY B 415
 None
 0.91A 3n9jA-1qc5B:
undetectable		 3n9jA-1qc5B:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB504_1
(HEMOLYTIC LECTIN
CEL-III)		 1qc5 PROTEIN (ALPHA1
BETA1 INTEGRIN)
(Homo
sapiens) 		4 / 5 ASP B 334
GLU B 426
GLY B 429
GLN B 370
 None
 1.42A 3w9tB-1qc5B:
0.0		 3w9tB-1qc5B:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1qc5 PROTEIN (ALPHA1
BETA1 INTEGRIN)
(Homo
sapiens) 		3 / 3 ASP B 340
ARG B 477
THR B 410
 MG  B 602 ( 4.5A)
None
MG  B 602 ( 4.8A)
 0.87A 4i13A-1qc5B:
undetectable		 4i13A-1qc5B:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 1qc5 PROTEIN (ALPHA1
BETA1 INTEGRIN)
(Homo
sapiens) 		5 / 9 VAL B 336
ILE B 335
LEU B 333
ILE B 337
GLY B 518
 None
 1.04A 4kukA-1qc5B:
undetectable		 4kukA-1qc5B:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1qc5 PROTEIN (ALPHA1
BETA1 INTEGRIN)
(Homo
sapiens) 		3 / 3 ASP B 340
ARG B 477
THR B 410
 MG  B 602 ( 4.5A)
None
MG  B 602 ( 4.8A)
 0.88A 4p3rA-1qc5B:
undetectable		 4p3rA-1qc5B:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1qc5 PROTEIN (ALPHA1
BETA1 INTEGRIN)
(Homo
sapiens) 		5 / 8 ILE B 471
VAL B 395
ILE B 335
ILE B 364
PHE B 354
 None
 1.49A 5hi2A-1qc5B:
undetectable		 5hi2A-1qc5B:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)		 1qc5 PROTEIN (ALPHA1
BETA1 INTEGRIN)
(Homo
sapiens) 		4 / 6 THR B 418
ASP B 417
LEU B 414
ASP B 448
 None
 1.17A 5tdzA-1qc5B:
5.7		 5tdzA-1qc5B:
18.35