SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1qcd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		 1qcd ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Leishmania
donovani) 		5 / 9 HIS A 188
ASN A   9
ALA A 155
LEU A 159
LEU A 144
 None
 1.20A 1hwiA-1qcdA:
0.0		 1hwiA-1qcdA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1qcd ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Leishmania
donovani) 		5 / 12 ILE A 145
GLY A  83
LEU A  55
ILE A 175
MET A  89
 None
 1.30A 3adsB-1qcdA:
0.0		 3adsB-1qcdA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 1qcd ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Leishmania
donovani) 		3 / 3 LEU A 209
VAL A  39
ARG A  41
 None
 0.87A 3b0wB-1qcdA:
undetectable		 3b0wB-1qcdA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_2
(PROTEASE)		 1qcd ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Leishmania
donovani) 		5 / 9 ALA A 167
ASP A 166
LEU A 159
VAL A  99
ILE A 136
 None
 1.19A 3em4B-1qcdA:
undetectable		 3em4B-1qcdA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1qcd ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Leishmania
donovani) 		5 / 10 GLY A 158
GLN A 160
ILE A 136
VAL A 142
VAL A 169
 None
 1.22A 3fhjA-1qcdA:
undetectable		 3fhjA-1qcdA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1qcd ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Leishmania
donovani) 		5 / 10 GLY A 158
GLN A 160
ILE A 136
VAL A 142
VAL A 169
 None
 1.22A 3fhjB-1qcdA:
undetectable		 3fhjB-1qcdA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1qcd ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Leishmania
donovani) 		5 / 10 GLY A 158
GLN A 160
ILE A 136
VAL A 142
VAL A 169
 None
 1.23A 3fhjC-1qcdA:
undetectable		 3fhjC-1qcdA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1qcd ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Leishmania
donovani) 		5 / 10 GLY A 158
GLN A 160
ILE A 136
VAL A 142
VAL A 169
 None
 1.26A 3fhjE-1qcdA:
undetectable		 3fhjE-1qcdA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1qcd ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Leishmania
donovani) 		5 / 9 GLY A 158
GLN A 160
ILE A 136
VAL A 142
VAL A 169
 None
 1.22A 3fi0A-1qcdA:
undetectable		 3fi0A-1qcdA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1qcd ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Leishmania
donovani) 		5 / 9 GLY A 158
GLN A 160
ILE A 136
VAL A 142
VAL A 169
 None
 1.23A 3fi0C-1qcdA:
undetectable		 3fi0C-1qcdA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1qcd ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Leishmania
donovani) 		5 / 9 GLY A 158
GLN A 160
ILE A 136
VAL A 142
VAL A 169
 None
 1.41A 3fi0D-1qcdA:
undetectable		 3fi0D-1qcdA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_H_TRPH1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1qcd ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Leishmania
donovani) 		5 / 9 GLY A 158
GLN A 160
ILE A 136
VAL A 142
VAL A 169
 None
 1.22A 3fi0H-1qcdA:
undetectable		 3fi0H-1qcdA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_J_TRPJ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1qcd ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Leishmania
donovani) 		5 / 9 GLY A 158
GLN A 160
ILE A 136
VAL A 142
VAL A 169
 None
 1.44A 3fi0J-1qcdA:
undetectable		 3fi0J-1qcdA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_K_TRPK1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1qcd ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Leishmania
donovani) 		5 / 9 GLY A 158
GLN A 160
ILE A 136
VAL A 142
VAL A 169
 None
 1.28A 3fi0K-1qcdA:
undetectable		 3fi0K-1qcdA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_L_TRPL1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1qcd ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Leishmania
donovani) 		5 / 9 GLY A 158
GLN A 160
ILE A 136
VAL A 142
VAL A 169
 None
 1.29A 3fi0L-1qcdA:
undetectable		 3fi0L-1qcdA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_M_TRPM1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1qcd ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Leishmania
donovani) 		5 / 9 GLY A 158
GLN A 160
ILE A 136
VAL A 142
VAL A 169
 None
 1.24A 3fi0M-1qcdA:
undetectable		 3fi0M-1qcdA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_N_TRPN1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1qcd ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Leishmania
donovani) 		5 / 9 GLY A 158
GLN A 160
ILE A 136
VAL A 142
VAL A 169
 None
 1.23A 3fi0N-1qcdA:
undetectable		 3fi0N-1qcdA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_O_TRPO1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1qcd ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Leishmania
donovani) 		5 / 9 GLY A 158
GLN A 160
ILE A 136
VAL A 142
VAL A 169
 None
 1.23A 3fi0O-1qcdA:
undetectable		 3fi0O-1qcdA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_R_TRPR1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1qcd ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Leishmania
donovani) 		5 / 9 GLY A 158
GLN A 160
ILE A 136
VAL A 142
VAL A 169
 None
 1.44A 3fi0R-1qcdA:
undetectable		 3fi0R-1qcdA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 1qcd ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Leishmania
donovani) 		5 / 12 ARG A 102
GLY A  83
GLY A  78
LEU A 144
SER A 174
 None
 1.17A 3kkzA-1qcdA:
2.6		 3kkzA-1qcdA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 1qcd ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Leishmania
donovani) 		5 / 9 PHE A 200
LEU A 159
GLU A 163
THR A 190
ILE A 187
 None
 0.99A 3tbgD-1qcdA:
undetectable		 3tbgD-1qcdA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1qcd ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Leishmania
donovani) 		4 / 7 GLU A 120
GLU A 118
TYR A 117
GLY A 153
 None
None
None
SO4  A 602 (-3.6A)
 1.00A 4fgzA-1qcdA:
2.6		 4fgzA-1qcdA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J5J_B_478B401_2
(PROTEASE)		 1qcd ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Leishmania
donovani) 		6 / 10 ILE A 136
VAL A  99
GLY A  78
ILE A 145
VAL A 169
VAL A 162
 None
 1.46A 4j5jB-1qcdA:
undetectable		 4j5jB-1qcdA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 1qcd ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Leishmania
donovani) 		3 / 3 ARG A 102
LYS A 103
LYS A 106
 None
 0.92A 4k50A-1qcdA:
undetectable		 4k50A-1qcdA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)		 1qcd ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Leishmania
donovani) 		3 / 3 ARG A 102
LYS A 103
LYS A 106
 None
 0.83A 4k50I-1qcdA:
0.0		 4k50I-1qcdA:
20.87